Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity
Open accessAbstract
Mitochondria are dynamic organelles that continually move, fuse and divide. The dynamic balance of fusion and fission of mitochondria determines their morphology and allows their immediate adaptation to energetic needs, keeps mitochondria in good health by restoring or removing damaged organelles or precipitates cells in apoptosis in cases of severe defects. Mitochondrial fusion and fission are essential in mammals and their disturbances are associated with several diseases. However, while mitochondrial fusion/fission dynamics, and the proteins that control these processes, are ubiquitous, associated diseases are primarily neurological disorders. Accordingly, inactivation of the main actors of mitochondrial fusion/fission dynamics is associated with defects in neuronal development, plasticity and functioning, both ex vivo and in vivo. Here, we present the central actors of mitochondrial fusion and fission and review the role of mitochondrial dynamics in neuronal physiology and pathophysiology. Particular emphasis is placed on the three main actors of these processes i.e. DRP1,MFN1-2, and OPA1 as well as on GDAP1, a protein of the mitochondrial outer membrane preferentially expressed in neurons. This article is part of a Special Issue entitled: Mitochondria & Brain.
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Increasing evidence indicates that mitochondrial fission participates in the initiation of mitochondria-dependent apoptosis.
“The dynamic balance between fusion and fission of mitochondria is vital to ensure mitochondrial health, and increasing evidence has indicated that mitochondrial fission participates in the initiation of mitochondria-dependent apoptosis [131].”
From RhoA Signaling in Neurodegenerative Diseases (2022) · cites this paper as [131]
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- Authors
- Bertholet, A. M., Delerue, T., Millet, A. M., Moulis, M. F., David, C., Daloyau, M., Arnauné-Pelloquin, L., Davezac, N., Mils, V., Miquel, M. C., Rojo, M., & Belenguer, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Rojo, M.
- Belenguer, P.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 90
- Pages
- 3-19
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2157879044
- Cited by
- 363
- References
- 34
- Citations by year
- 2026: 19 · 2025: 29 · 2024: 40 · 2023: 43 · 2022: 39 · 2021: 49 · 2020: 35 · 2019: 31 · 2018: 30 · 2017: 29 · 2016: 19
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Centre National de la Recherche Scientifique (CNRS)
- Université de Bordeaux
- Fondation pour la Recherche Médicale (FRM)
- Association française contre les myopathies (AFM)
- CNRS
- Université Paul Sabatier-Toulouse 3
- Région Midi-Pyrénées
- Gueules cassées sourire quand même
- Berthe Fouassier-Fondation de France
- Rétina France
- Ligue Contre le Cancer
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pharmacological Receptor Mechanisms and Effects
- Keywords
- mitochondrial fusion, mitochondrial fission, mitochondrial dynamics, neurodegeneration, neuroplasticity, Drp1, Mfn1, mitofusin 2, OPA1, GDAP1, mitochondrial morphology, neuronal development, apoptosis, mitochondrial disease
- MeSH terms
- Animals, Brain, Humans, Mitochondria, Neuronal Plasticity, Neurons, Neurodegenerative Diseases, Mitochondrial Dynamics
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