Chain Migration of Neuronal Precursors
Abstract
In the brain of adult mice, cells that divide in the subventricular zone of the lateral ventricle migrate up to 5 millimeters to the olfactory bulb where they differentiate into neurons. These migrating cells were found to move as chains through a well-defined pathway, the rostral migratory stream. Electron microscopic analysis of serial sections showed that these chains contained only closely apposed, elongated neuroblasts connected by membrane specializations. A second cell type, which contained glial fibrillary acidic protein, ensheathed the chains of migrating neuroblasts. Thus, during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.
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The migrating neurons in the RMS are separated from the parenchyma by astrocytes that form tunnels through which the cells migrate.
“The migrating neurons in the RMS are separated from the parenchyma by astrocytes that form tunnels through which the cells migrate71,86.”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [86]
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- Authors
- Lois, C., García-Verdugo, J.-M., & Alvarez-Buylla, A.
- Affiliations
- Rockefeller University (US)
- J.-M. García-Verdugo, Facultad de Biológicas, Universitas Valencia, Burjassot, Valencia 46100, Spain.
- C. Lois and A. Alvarez-Buylla, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
- ORCID
- Lois, Carlos
- Venue
- Science
- Published
- 1996-02-16
- Volume
- 271
- Issue
- 5251
- Pages
- 978-981
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077439063
- Cited by
- 1,331
- References
- 48
- Citations by year
- 2026: 12 · 2025: 26 · 2024: 17 · 2023: 24 · 2022: 20 · 2021: 29 · 2020: 32 · 2019: 31 · 2018: 35 · 2017: 49 · 2016: 38 · 2015: 45 · 2014: 46 · 2013: 68 · 2012: 66
- FWCI
- 12.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS-28478)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD32116)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- chain migration, neuronal precursors, rostral migratory stream, subventricular zone, olfactory bulb, glial fibrillary acidic protein, neuroblast differentiation, adult neurogenesis, lateral ventricle
- MeSH terms
- Animals, Cell Differentiation, Cell Membrane, Cell Movement, Cerebral Ventricles, Glial Fibrillary Acidic Protein, Male, Microscopy, Electron, Mitosis, Neuroglia, Neurons, Olfactory Bulb, Neural Cell Adhesion Molecules, Mice
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