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Cited by 371

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

GENETICS OF SOMATIC MAMMALIAN CELLS

Open access
Puck, T. T., Fisher, H. W.·1956·The Journal of Experimental Medicine

Abstract

The parental HeLa cell population, a morphologically uniform, human cancer cell strain, grown for several years in tissue culture by procedures always involving massive inocula, has been shown to contain different mutant cell types. Two clonal lines have been isolated and established as reliable stock cultures. Both strains exhibit 100 per cent plating efficiency in high or low serum concentrations in the presence of a feeder system. In the absence of a feeder system and in low serum concentrations, the two strains are quantitatively differentiable: S3 still exhibits 100 per cent plating efficiency, while that of S1 lies in the neighborhood of zero. These differences have remained stable throughout 100 successive generations of growth of each strain including 2 single cell isolations. Application of these techniques to studies in the genetics of mammalian somatic cells and to specific cell-cell interactions has been indicated.

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Crossref · 10.1084/jem.104.3.427

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Metadata

Authors
Puck, T. T., & Fisher, H. W.
Venue
The Journal of Experimental Medicine
Published
1956-09-01
Volume
104
Issue
3
Pages
427-434
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
OpenAlex
W2157602621
Cited by
371
References
9
FWCI
41.60
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: GENETICS OF SOMATIC MAMMALIAN CELLS. https://app.cochat.ai/papers/10.1084/jem.104.3.427
The paper
Puck, T. T., & Fisher, H. W. (1956). GENETICS OF SOMATIC MAMMALIAN CELLS. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.104.3.427

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.