THE ROLE OF INTESTINAL BACTERIA IN THE DEVELOPMENT OF DIETARY CIRRHOSIS IN RATS
Open accessAbstract
Diffuse hepatic cirrhosis develops in rats on a choline-deficient diet within 300 days. Absorbable broad spectrum antibiotics added to the daily diet do not prevent the development of fatty infiltration, but they delay the development of cirrhosis for about 100 days more. Non-absorbable antibiotics added to the daily diet prevent the development of cirrhosis in most rats for as long as 750 days. The superiority of non-absorbable antibiotics to absorbable antibiotics excludes a systemic effect of the antibiotics and demonstrates that intestinal bacteria are largely, if not wholly, responsible for the cirrhosis in rats on a choline-deficient diet.
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The microbiota-TLR4 axis contributes importantly to liver fibrosis.
“There is strong evidence for an important contribution of the microbiota–TLR4 axis to liver fibrosis.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [72]
Antibiotics prevent hepatic injury and fibrosis induced by CCl4 treatment, bile duct ligation or a choline-deficient diet, and endotoxin enhances hepatic fibrosis induced by a choline-deficient diet.
“Studies from the past six decades have shown that antibiotics prevent hepatic injury and fibrosis induced by CCl4 treatment, bile duct ligation or a choline-deficient diet, and that endotoxin enhances hepatic fibrosis induced by a choline-deficient diet71–73.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [72]
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- Authors
- Rutenburg, A. M., Sonnenblick, E., Koven, I., Aprahamian, H. A., Reiner, L., & Fine, J.
- Affiliations
- Harvard University (US)
- ORCID
- Fine, Jacob
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1957-07-01
- Volume
- 106
- Issue
- 1
- Pages
- 1-14
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2136738
- OpenAlex
- W2108335279
- Cited by
- 108
- References
- 16
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 1 · 2012: 5
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- choline-deficient diet, intestinal bacteria, non-absorbable antibiotics, hepatic steatosis, rats
- MeSH terms
- Animals, Bacteria, Intestines, Liver Cirrhosis, Liver Cirrhosis, Experimental, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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