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Cited by 310

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae.

Open access
Briles, D E, Forman, C, Hudak, S, Claflin, J L·1982·The Journal of experimental medicine
DOI 10.1084/jem.156.4.1177
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Abstract

In the mouse, most anti-PC antibody is found in one of the three murine anti-PC idiotype families: T15, M603, or M511. The antibodies within each of these idiotypic families have characteristic fine specificities for phosphorylcholine (PC)-analogues. In this paper we compare the ability of hybridoma IgM anti-PC antibodies of the three idiotype families to protect mice from fatal infection with S. pneumoniae. Antibody bearing the T15 idiotype was approximately 8 times as effective as antibody with the M603 idiotype and approximately 30 times as protective as antibody with the M511 idiotype. Reports by others have shown that the heavy chains of virtually all mouse anti-PC antibodies are produced by translocation of a single variable region gene and that the direct translation of this gene (in the absence of somatic mutations) results in heavy chains characteristic of the T15 idiotype. Thus, our findings suggest that the T15 germ line heavy chain variable region gene may have been selected through evolution to code for antibody binding PC-containing pathogens such as S. pneumoniae. Our observations may also explain the existence of regulatory mechanisms that result in maintenance of T15 idiotype expression in murine anti-PC immune responses.

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Metadata

Authors
Briles, D. E., Forman, C., Hudak, S., & Claflin, J. L.
Venue
The Journal of experimental medicine
Publisher
Rockefeller University Press
Published
1982-10-01
Volume
156
Issue
4
Pages
1177-1185
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.156.4.1177
OpenAlex
W2118107917
Cited by
310
References
14
FWCI
11.34
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae. https://app.cochat.ai/papers/10.1084/jem.156.4.1177
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Briles, D. E., Forman, C., Hudak, S., & Claflin, J. L. (1982). Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae. The Journal of experimental medicine. https://doi.org/10.1084/jem.156.4.1177

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.