The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor alpha by transcriptional and post-transcriptional mechanisms.
Open accessAbstract
The immunoregulatory cytokine interleukin 6 (IL-6) directly upregulates production of human immunodeficiency virus (HIV) in acutely as well as in chronically infected cells of monocytic lineage. In addition, IL-6 synergizes with tumor necrosis factor alpha (TNF-alpha) in the induction of latent HIV expression. Unlike TNF-alpha, upregulation of viral expression induced by IL-6 alone does not occur at the transcriptional level and it is not associated with accumulation of HIV RNA. However, when IL-6 and TNF-alpha synergistically stimulate HIV production, accumulation of HIV RNA and increased transcription are observed, indicating that IL-6 affects HIV expression at multiple (transcriptional and post-transcriptional) levels.
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Self-citationKishimoto, T. (1989) · Blood · doi:10.1182/blood.v74.1.1.1 · Cited by 2,069
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Effect of Neuropeptides on Production of Inflammatory Cytokines by Human Monocytes
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Cytokine-Induced Expression of HIV-1 in a Chronically Infected Promonocyte Cell Line
Folks, T. M., Justement, J., Kinter, A., Dinarello, C. A., & Fauci, A. S. (1987) · Science · doi:10.1126/science.3313729 · Cited by 905
Self-citationDuh, E. J., Maury, W. J., Folks, T. M., Fauci, A. S., & Rabson, A. B. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.15.5974 · Cited by 767
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The Reservoir for HIV-1 in Human Peripheral Blood Is a T Cell That Maintains Expression of CD4
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Cited by
Molecular Targets for AIDS Therapy
Mitsuya, H., Yarchoan, R., & Broder, S. (1990) · Science · doi:10.1126/science.1699273 · Cited by 732
The soluble interleukin 6 receptor: mechanisms of production and implications in disease
JONES, S. A., HORIUCHI, S., TOPLEY, N., YAMAMOTO, N., & FULLER, G. M. (2001) · The FASEB Journal · doi:10.1096/fj.99-1003rev · Cited by 623
Glutathione Deficiency and Human Immunodeficiency Virus Infection
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Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection
Bell, L. C. K., & Noursadeghi, M. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.128 · Cited by 389
Induction of HIV-1 Replication in Latently Infected CD4+ T Cells Using a Combination of Cytokines
Chun, T.-W., Engel, D., Mizell, S. B., Ehler, L. A., & Fauci, A. S. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.1.83 · Cited by 359
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Metadata
- Authors
- Poli, G., Bressler, P., Kinter, A., Duh, E., Timmer, W. C., Rabson, A., Justement, J. S., Stanley, S., & Fauci, A. S.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1990-07-01
- Volume
- 172
- Issue
- 1
- Pages
- 151-158
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2050937329
- Cited by
- 512
- References
- 33
- FWCI
- 11.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor alpha by transcriptional and post-transcriptional mechanisms. https://app.cochat.ai/papers/10.1084/jem.172.1.151
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- Poli, G., Bressler, P., Kinter, A., Duh, E., Timmer, W. C., Rabson, A., Justement, J. S., Stanley, S., & Fauci, A. S. (1990). Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor alpha by transcriptional and post-transcriptional mechanisms. The Journal of experimental medicine. https://doi.org/10.1084/jem.172.1.151
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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