The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes.
Open accessAbstract
Recent studies suggest that some T and B lymphocyte cell lines bind to the integrin lymphocyte function-associated molecule 1 (LFA-1) chiefly through a pathway independent of its two known counter-receptors, intercellular adhesion molecules (ICAMs)-1 and -2. A monoclonal antibody (mAb) was raised that, in combination with blocking mAb to ICAM-1 and ICAM-2, can completely inhibit binding of these cell lines to purified LFA-1. This third ligand, designated ICAM-3 based on its functional relatedness to ICAM-1 and -2, is a highly glycosylated protein of 124,000 Mr. It is well expressed on all leukocytes and absent from endothelial cells. In assays of adhesion of resting lymphocytes to purified LFA-1, ICAM-3 is by far the most functionally important ICAM, implying an important role for ICAM-3 in the generation of immune responses.
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Citations
Cites
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Self-citation
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Intercellular adhesion molecule-1
van de Stolpe, A., & van der Saag, P. T. (1996) · Journal of Molecular Medicine · doi:10.1007/bf00202069 · Cited by 802
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Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice.
Xu, H., Gonzalo, J. A., St Pierre, Y., Williams, I. R., Kupper, T. S., Cotran, R. S., Springer, T. A., & Gutierrez-Ramos, J. C. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.1.95 · Cited by 481
Self-citationPivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity
Guinan, E., Gribben, J., Boussiotis, V., Freeman, G., & Nadler, L. (1994) · Blood · doi:10.1182/blood.v84.10.3261.3261 · Cited by 358
Metadata
- Authors
- de Fougerolles, A. R., & Springer, T. A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1992-01-01
- Volume
- 175
- Issue
- 1
- Pages
- 185-190
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2135252042
- Cited by
- 427
- References
- 1
- FWCI
- 17.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- de Fougerolles, A. R., & Springer, T. A. (1992). Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes. The Journal of experimental medicine. https://doi.org/10.1084/jem.175.1.185
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
