The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion.
Open accessAbstract
Allograft rejection is a T cell-dependent process. Productive T cell activation by antigen requires antigen engagement of the T cell receptor as well as costimulatory signals delivered through other T cell surface molecules such as CD28. Engagement of CD28 by its natural ligand B7 can be blocked using a soluble recombinant fusion protein, CTLA4Ig. Administration of CTLA4Ig blocks antigen-specific immune responses in vitro and in vivo, and we have shown that treatment of rats with a 7-d course of CTLA4Ig at the time of transplantation leads to prolonged survival of cardiac allografts (median 30 d), although most grafts are eventually rejected. Here, we have explored additional strategies employing CTLA4Ig in order to achieve long-term allograft survival. Our data indicate that donor-specific transfusion (DST) plus CTLA4Ig can provide effective antigen-specific immunosuppression. When DST is administered at the time of transplantation followed by a single dose of CTLA4Ig 2 d later, all animals had long-term graft survival (> 60 d). These animals had delayed responses to donor-type skin transplants, compared with normal rejection responses to third-party skin transplants. Furthermore, donor-matched second cardiac allografts were well tolerated with minimal histologic evidence of rejection. These data indicate that peritransplant use of DST followed by subsequent treatment with CTLA4Ig can induce prolonged, often indefinite, cardiac allograft acceptance. These results may be clinically applicable for cadaveric organ and tissue transplantation in humans.
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Cites
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CTLA-4 is a second receptor for the B cell activation antigen B7.
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Self-citationLong-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg
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Self-citationImmunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule
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Self-citationT-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.
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T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.
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Cited by
CD28/B7 SYSTEM OF T CELL COSTIMULATION
Lenschow, D. J., Walunas, T. L., & Bluestone, J. A. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.233 · Cited by 2,717
CTLA-4 can function as a negative regulator of T cell activation
Walunas, T. L., Lenschow, D. J., Bakker, C. Y., Linsley, P. S., Freeman, G. J., Green, J. M., Thompson, C. B., & Bluestone, J. A. (1994) · Immunity · doi:10.1016/1074-7613(94)90071-x · Cited by 2,222
Self-citationCD40 AND CD154 IN CELL-MEDIATED IMMUNITY
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The B7 and CD28 receptor families
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Self-citationCD28 Costimulation: From Mechanism to Therapy
Esensten, J. H., Helou, Y. A., Chopra, G., Weiss, A., & Bluestone, J. A. (2016) · Immunity · doi:10.1016/j.immuni.2016.04.020 · Cited by 937
Metadata
- Authors
- Lin, H., Bolling, S. F., Linsley, P. S., Wei, R. Q., Gordon, D., Thompson, C. B., & Turka, L. A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1993-11-01
- Volume
- 178
- Issue
- 5
- Pages
- 1801-1806
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2106531897
- Cited by
- 485
- References
- 17
- FWCI
- 35.58
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion. https://app.cochat.ai/papers/10.1084/jem.178.5.1801
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- Lin, H., Bolling, S. F., Linsley, P. S., Wei, R. Q., Gordon, D., Thompson, C. B., & Turka, L. A. (1993). Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion. The Journal of experimental medicine. https://doi.org/10.1084/jem.178.5.1801
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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