The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg
Abstract
Antigen-specific T cell activation depends on T cell receptor-ligand interaction and costimulatory signals generated when accessory molecules bind to their ligands, such as CD28 to the B7 (also called BB1) molecule. A soluble fusion protein of human CTLA-4 (a protein homologous to CD28) and the immunoglobulin (Ig) G1 Fc region (CTLA4Ig) binds to human and murine B7 with high avidity and blocks T cell activation in vitro. CTLA4Ig therapy blocked human pancreatic islet rejection in mice by directly affecting T cell recognition of B7 + antigen-presenting cells. In addition, CTLA4Ig induced long-term, donor-specific tolerance, which may have applications to human organ transplantation.
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Citations
Cites
Hsu, S. M., Raine, L., & Fanger, H. (1981) · Journal of Histochemistry & Cytochemistry · doi:10.1177/29.4.6166661 · Cited by 14,140
CTLA-4 is a second receptor for the B cell activation antigen B7.
Linsley, P. S., Brady, W., Urnes, M., Grosmaire, L. S., Damle, N. K., & Ledbetter, J. A. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.3.561 · Cited by 1,685
Self-citationHarding, F. A., McArthur, J. G., Gross, J. A., Raulet, D. H., & Allison, J. P. (1992) · Nature · doi:10.1038/356607a0 · Cited by 1,559
Automated Method for Isolation of Human Pancreatic Islets
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A new member of the immunoglobulin superfamily—CTLA-4
Brunet, J.-F., Denizot, F., Luciani, M.-F., Roux-Dosseto, M., Suzan, M., Mattei, M.-G., & Golstein, P. (1987) · Nature · doi:10.1038/328267a0 · Cited by 1,306
Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule
Linsley, P. S., Wallace, P. M., Johnson, J., Gibson, M. G., Greene, J. L., Ledbetter, J. A., Singh, C., & Tepper, M. A. (1992) · Science · doi:10.1126/science.1496399 · Cited by 790
Self-citationRole of the CD28 receptor in T-cell activation
June, C. H., Ledbetter, J. A., Linsley, P. S., & Thompson, C. B. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90085-n · Cited by 676
Self-citationCD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells
Jenkins, M. K., Taylor, P. S., Norton, S. D., & Urdahl, K. B. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.8.2461 · Cited by 562
Immunobiology of Tissue Transplantation: A Return to the Passenger Leukocyte Concept
Laffery, K. J., Prowse, S. J., Simeonovic, C. J., & Warren, H. S. (1983) · Annual Review of Immunology · doi:10.1146/annurev.iy.01.040183.001043 · Cited by 509
Harper, K., Balzano, C., Rouvier, E., Mattéi, M. G., Luciani, M. F., & Golstein, P. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.3.1037 · Cited by 432
Cited by
Tivol, E. A., Borriello, F., Schweitzer, A. N., Lynch, W. P., Bluestone, J. A., & Sharpe, A. H. (1995) · Immunity · doi:10.1016/1074-7613(95)90125-6 · Cited by 2,914
Self-citationCD28/B7 SYSTEM OF T CELL COSTIMULATION
Lenschow, D. J., Walunas, T. L., & Bluestone, J. A. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.233 · Cited by 2,717
Self-citationCD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.
Krummel, M. F., & Allison, J. P. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.2.459 · Cited by 2,245
CTLA-4 can function as a negative regulator of T cell activation
Walunas, T. L., Lenschow, D. J., Bakker, C. Y., Linsley, P. S., Freeman, G. J., Green, J. M., Thompson, C. B., & Bluestone, J. A. (1994) · Immunity · doi:10.1016/1074-7613(94)90071-x · Cited by 2,222
Self-citationKuchroo, V. K., Prabhu Das, M., Brown, J. A., Ranger, A. M., Zamvil, S. S., Sobel, R. A., Weiner, H. L., Nabavi, N., & Glimcher, L. H. (1995) · Cell · doi:10.1016/0092-8674(95)90349-6 · Cited by 1,641
Metadata
- Authors
- Lenschow, D. J., Zeng, Y., Thistlethwaite, J. R., Montag, A., Brady, W., Gibson, M. G., Linsley, P. S., & Bluestone, J. A.
- Venue
- Science
- Published
- 1992-08-07
- Volume
- 257
- Issue
- 5071
- Pages
- 789-792
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077389439
- Cited by
- 1,121
- References
- 18
- FWCI
- 27.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lenschow, D. J., Zeng, Y., Thistlethwaite, J. R., Montag, A., Brady, W., Gibson, M. G., Linsley, P. S., & Bluestone, J. A. (1992). Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg. Science. https://doi.org/10.1126/science.1323143
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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