The DOI matches its Crossref record; 52 of the 54 references it cites were found in a registry or an index.
B lymphocytes secrete antigen-presenting vesicles.
Open accessAbstract
Antigen-presenting cells contain a specialized late endocytic compartment, MIIC (major histocompatibility complex [MHC] class II-enriched compartment), that harbors newly synthesized MHC class II molecules in transit to the plasma membrane. MIICs have a limiting membrane enclosing characteristic internal membrane vesicles. Both the limiting membrane and the internal vesicles contain MHC class II. In this study on B lymphoblastoid cells, we demonstrate by immunoelectron microscopy that the limiting membrane of MIICs can fuse directly with the plasma membrane, resulting in release from the cells of internal MHC class II-containing vesicles. These secreted vesicles, named exosomes, were isolated from the cell culture media by differential centrifugation followed by flotation on sucrose density gradients. The overall surface protein composition of exosomes differed significantly from that of the plasma membrane. Exosome-bound MHC class II was in a compact, peptide-bound conformation. Metabolically labeled MHC class II was released into the extracellular medium with relatively slow kinetics, 10 +/- 4% in 24 h, indicating that direct fusion of MIICs with the plasma membrane is not the major pathway by which MHC class II reaches the plasma membrane. Exosomes derived from both human and murine B lymphocytes induced antigen-specific MHC class II-restricted T cell responses. These data suggest a role for exosomes in antigen presentation in vivo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These vesicles are secreted by both normal cells and cancerous cells as means of cell-to-cell communication [2-5].”
From Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013) · cites this paper as [2]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Harding, C., Heuser, J., & Stahl, P. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.2.329 · Cited by 1,775
Self-citationGermain, R. N. (1994) · Cell · doi:10.1016/0092-8674(94)90336-0 · Cited by 1,431
Pan, B., Teng, K., Wu, C., Adam, M., & Johnstone, R. M. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.3.942 · Cited by 1,242
Slot, J. W., Geuze, H. J., Gigengack, S., Lienhard, G. E., & James, D. E. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.113.1.123 · Cited by 862
Self-citationAssembly, Transport, and Function of MHC Class II Molecules
Cresswell, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001355 · Cited by 809
Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.
Peters, P. J., Borst, J. G., Oorschot, V. M. J., Fukuda, M., Krähenbühl, O., Tschopp, J. F., Slot, J. W., & Geuze, H. J. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.5.1099 · Cited by 713
Self-citationHLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading
Denzin, L. K., & Cresswell, P. (1995) · Cell · doi:10.1016/0092-8674(95)90061-6 · Cited by 689
Peters, P. J., Neefjes, J., Oorschot, V. M. J., Ploegh, H. L., & Geuze, H. J. (1991) · Nature · doi:10.1038/349669a0 · Cited by 658
Self-citationRole Of Lymphocyte Adhesion Receptors In Transient Interactions And Cell Locomotion
Dustin, M. L., & Springer, T. A. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.000331 · Cited by 536
Felder, S., Miller, K., Moehren, G., Ullrich, A., Schlessinger, J., & Hopkins, C. R. (1990) · Cell · doi:10.1016/0092-8674(90)90474-s · Cited by 445
Flagged first, then by citations
2 of the 54 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 301–400 of 1,009
Kesimer, M., Scull, M., Brighton, B., DeMaria, G., Burns, K., O'Neal, W., Pickles, R. J., & Sheehan, J. K. (2009) · The FASEB Journal · doi:10.1096/fj.08-119131 · Cited by 346
Bonsergent, É., Grisard, E., Buchrieser, J., Schwartz, O., Théry, C., & Lavieu, G. (2021) · Nature Communications · doi:10.1038/s41467-021-22126-y · Cited by 366
Tumor cell-derived exosomes: A message in a bottle
Kharaziha, P., Ceder, S., Li, Q., & Panaretakis, T. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.03.006 · Cited by 347
Exosomes biological significance: A concise review
Johnstone, R. M. (2006) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.12.001 · Cited by 339
Adhesion and signaling by B cell‐derived exosomes: the role of integrins
Clayton, A., Turkes, A., Dewitt, S., Steadman, R., Mason, M. D., & Hallett, M. B. (2004) · The FASEB Journal · doi:10.1096/fj.03-1094fje · Cited by 339
Akers, J. C., Ramakrishnan, V., Kim, R., Skog, J., Nakano, I., Pingle, S. C., Kalinina, J., Hua, W., Kesari, S., Mao, Y. Q., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078115 · Cited by 347
Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth
Mizrak, A., Bolukbasi, M. F., Ozdener, G. B., Brenner, G. J., Madlener, S., Erkan, E. P., Ströbel, T., Breakefield, X. O., & Saydam, O. (2013) · Molecular Therapy · doi:10.1038/mt.2012.161 · Cited by 337
Evidence That HIV Budding in Primary Macrophages Occurs through the Exosome Release Pathway
Nguyen, D. G., Booth, A. M., Gould, S. J., & Hildreth, J. E. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309009200 · Cited by 337
Wang, X., Gu, H., Qin, D., Yang, L., Huang, W. C., Essandoh, K., Wang, Y., Caldwell, C. C., Peng, T., Zingarelli, B., et al. (2015) · Scientific Reports · doi:10.1038/srep13721 · Cited by 337
Q&A: What are exosomes, exactly?
Edgar, J. R. (2016) · BMC Biology · doi:10.1186/s12915-016-0268-z · Cited by 349
Mears, R., Craven, R. A., Hanrahan, S. J., Totty, N., Upton, C., Young, S. L., Patel, P. M., Selby, P. J., & Banks, R. E. (2004) · PROTEOMICS · doi:10.1002/pmic.200400876 · Cited by 335
New insights into the function of Rab GTPases in the context of exosomal secretion
Blanc, L., & Vidal, M. (2017) · Small GTPases · doi:10.1080/21541248.2016.1264352 · Cited by 347
Skokos, D., Panse, S. L., Villa, I., Rousselle, J.-C., Péronet, R., David, B., Namane, A., & Mécheri, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.2.868 · Cited by 333
Bhatnagar, S., & Schorey, J. S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702277200 · Cited by 333
Dendritic Cell-Derived Exosomes for Cancer Immunotherapy: What's Next?
Viaud, S., Théry, C., Ploix, S., Tursz, T., Lapierre, V., Lantz, O. J., Zitvogel, L., & Chaput, N. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3276 · Cited by 342
Heparanase activates the syndecan-syntenin-ALIX exosome pathway
Roucourt, B., Meeussen, S., Bao, J., Zimmermann, P., & David, G. (2015) · Cell Research · doi:10.1038/cr.2015.29 · Cited by 339
Extracellular Vesicles—Connecting Kingdoms
Woith, E., Fuhrmann, G., & Melzig, M. F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225695 · Cited by 341
Veerman, R. E., Teeuwen, L., Czarnewski, P., Akpinar, G. G., Sandberg, A., Cao, X., Pernemalm, M., Orre, L. M., Gabrielsson, S., & Eldh, M. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12128 · Cited by 340
The power of imaging to understand extracellular vesicle biology in vivo
Verweij, F. J., Balaj, L., Boulanger, C. M., Carter, D. R. F., Compeer, E. B., D’Angelo, G., Andaloussi, S. E., Goetz, J. G., Gross, J. C., Hyenne, V., et al. (2021) · Nature Methods · doi:10.1038/s41592-021-01206-3 · Cited by 336
Self-citationExtracellular Vesicles in Cancer Immune Microenvironment and Cancer Immunotherapy
Xie, F., Zhou, X., Fang, M., Li, H., Su, P., Tu, Y., Zhang, L., & Zhou, F. (2019) · Advanced Science · doi:10.1002/advs.201901779 · Cited by 330
Pmel17 initiates premelanosome morphogenesis within multivesicular bodies
Berson, J. F., Harper, D. C., Tenza, D., Raposo, G., & Marks, M. S. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.11.3451 · Cited by 326
Self-citationRaimondo, F., Morosi, L., Chinello, C., Magni, F., & Pitto, M. (2010) · PROTEOMICS · doi:10.1002/pmic.201000422 · Cited by 331
Human Macrophages Accumulate HIV‐1 Particles in MHC II Compartments
Raposo, G., Moore, M. J., Innes, D., Leijendekker, R., Brown, A., Benaroch, P., & Geuze, H. J. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.31004.x · Cited by 326
Self-citationStem Cell Extracellular Vesicles: Extended Messages of Regeneration
Riazifar, M., Pone, E. J., Lötvall, J. O., & Zhao, W. (2016) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-061616-030146 · Cited by 330
Discrimination between exosomes and HIV-1: Purification of both vesicles from cell-free supernatants
Cantin, R., Diou, J., Bélanger, D., Tremblay, A., & Gilbert, C. (2008) · Journal of Immunological Methods · doi:10.1016/j.jim.2008.07.007 · Cited by 320
The Roles of Tumor-Derived Exosomes in Cancer Pathogenesis
Yang, C., & Robbins, P. D. (2011) · Clinical and Developmental Immunology · doi:10.1155/2011/842849 · Cited by 322
Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients
Levänen, B., Bhakta, N. R., Paredes, P. T., Barbeau, R., Hiltbrunner, S., Pollack, J. L., Sköld, C. M., Svartengren, M., Grünewald, J., Gabrielsson, S., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.11.039 · Cited by 317
Role of Exosomes/Microvesicles in the Nervous System and Use in Emerging Therapies
Lai, C. P., & Breakefield, X. O. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00228 · Cited by 325
Casado‐Díaz, A., Quesada‐Gómez, J. M., & Dorado, G. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00146 · Cited by 325
Can urinary exosomes act as treatment response markers in prostate cancer?
Mitchell, P., Welton, J. L., Staffurth, J. N., Court, J., Mason, M. D., Tabi, Z., & Clayton, A. (2009) · Journal of Translational Medicine · doi:10.1186/1479-5876-7-4 · Cited by 312
The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells
Putz, U., Howitt, J. A., Doan, A., Goh, C., Low, L., Silke, J., & Tan, S. (2012) · Science Signaling · doi:10.1126/scisignal.2003084 · Cited by 316
Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection
Wiley, R. D., & Gummuluru, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507995103 · Cited by 320
Exosomes and Other Extracellular Vesicles: The New Communicators in Parasite Infections
Coakley, G., Maizels, R. M., & Buck, A. H. (2015) · Trends in Parasitology · doi:10.1016/j.pt.2015.06.009 · Cited by 315
Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity
Sun, W., Zhao, C., Li, Y., Wang, L., Nie, G., Peng, J., Wang, A., Zhang, P., Tian, W., Li, Q., et al. (2016) · Cell Discovery · doi:10.1038/celldisc.2016.15 · Cited by 311
Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate
Nojima, H., Freeman, C. M., Schuster, R. M., Japtok, L., Kleuser, B., Edwards, M. J., Gulbins, E., & Lentsch, A. B. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.07.030 · Cited by 312
Mechanisms of interleukin-1β release
Eder, C. (2009) · Immunobiology · doi:10.1016/j.imbio.2008.11.007 · Cited by 317
Activated Human T Cells Release Bioactive Fas Ligand and APO2 Ligand in Microvesicles
Martínez‐Lorenzo, M. J., Anel, A., Gamen, S., Monleón, I., Lasierra, P., Larrad, L., Piñeiro, A., Álava, M. A., & Naval, J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.3.1274 · Cited by 306
Hakulinen, J., Sankkila, L., Sugiyama, N., Lehti, K., & Keski‐Oja, J. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21923 · Cited by 315
Gosset, P., Charbonnier, A.-S., Delerive, P., Fontaine, J., Staels, B., Pestel, J., Tonnel, A., & Trottein, F. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(2001010)31:10 · Cited by 225
Donor dendritic cell–derived exosomes promote allograft-targeting immune response
Liu, Q., Rojas-Canales, D. M., Divito, S. J., Shufesky, W. J., Stolz, D. B., Erdos, G., Sullivan, M. L. G., Gibson, G. A., Watkins, S. C., Larregina, A. T., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84577 · Cited by 302
Möbius, W., Ohno‐Iwashita, Y., van Donselaar, E. G., Oorschot, V. M. J., Shimada, Y., Fujimoto, T., Heijnen, H. F. G., Geuze, H. J., & Slot, J. W. (2002) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540205000105 · Cited by 302
Self-citationProteomic analysis of the secretome of Leishmania donovani
Silverman, J. M., Chan, S. K., Robinson, D. P., Dwyer, D. M., Nandan, D., Foster, L. J., & Reiner, N. E. (2008) · Genome biology · doi:10.1186/gb-2008-9-2-r35 · Cited by 301
van Balkom, B. W. M., Eisele, A. S., Pegtel, D. M., Bervoets, S., & Verhaar, M. C. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26760 · Cited by 303
Down-Regulation of miR-92 in Human Plasma Is a Novel Marker for Acute Leukemia Patients
Tanaka, M., Oikawa, K., Takanashi, M., Kudo, M., Ohyashiki, J. H., Ohyashiki, K., & Kuroda, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005532 · Cited by 296
Pregnancy-Associated Exosomes and Their Modulation of T Cell Signaling
Taylor, D. D., Akyol, S., & Gercel-Taylor, C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1534 · Cited by 297
RetractedMaximizing exosome colloidal stability following electroporation
Hood, J. L., Scott, M. J., & Wickline, S. A. (2013) · Analytical Biochemistry · doi:10.1016/j.ab.2013.12.001 · Cited by 306
The Exosome ‐ A Naturally Secreted Nanoparticle and its Application to Wound Healing
Rani, S., & Ritter, T. (2015) · Advanced Materials · doi:10.1002/adma.201504009 · Cited by 295
Exosomes purified from a single cell type have diverse morphology
Zabeo, D., Cvjetkovic, A., Lässer, C., Schorb, M., Lötvall, J. O., & Höög, J. L. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1329476 · Cited by 304
Dendritic Cell–Derived Exosomes as Immunotherapies in the Fight against Cancer
Pitt, J. M., Charrier, M., Viaud, S., André, F., Besse, B., Chaput, N., & Zitvogel, L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400703 · Cited by 305
MSC-exosome: A novel cell-free therapy for cutaneous regeneration
Wu, P., Zhang, B., Shi, H., Qian, H., & Xu, W. (2018) · Cytotherapy · doi:10.1016/j.jcyt.2017.11.002 · Cited by 295
The emerging role of extracellular vesicles as biomarkers for urogenital cancers
Nawaz, M., Camussi, G., Valadi, H., Nazarenko, I. A., Ekström, K. M., Wang, X., Principe, S., Shah, N. K., Ashraf, N. M., Fatima, F., et al. (2014) · Nature Reviews Urology · doi:10.1038/nrurol.2014.301 · Cited by 300
Digital Detection of Exosomes by Interferometric Imaging
Daaboul, G. G., Gagni, P., Benussi, L., Bettotti, P., Ciani, M., Cretich, M., Freedman, D. S., Ghidoni, R., Ayça Yalçın, A., Piotto, C., et al. (2016) · Scientific Reports · doi:10.1038/srep37246 · Cited by 297
Ilekis, J. V., Tsilou, E. T., Fisher, S. J., Abrahams, V. M., Soares, M. J., Cross, J. C., Zamudio, S., Illsley, N. P., Myatt, L., Colvis, C. M., et al. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.03.001 · Cited by 298
Mechanism of Evenness Interrupted (Evi)-Exosome Release at Synaptic Boutons
Koles, K., Nunnari, J. N., Korkut, C., Barría, R., Brewer, C., Li, Y., Leszyk, J., Zhang, B., & Budnik, V. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.342667 · Cited by 300
Clinical relevance of microparticles from platelets and megakaryocytes
Italiano, J. E., Mairuhu, A. T. A., & Flaumenhaft, R. C. (2010) · Current Opinion in Hematology · doi:10.1097/moh.0b013e32833e77ee · Cited by 299
Exosomes: roles and therapeutic potential in osteoarthritis
Ni, Z., Zhou, S., Li, S., Kuang, L., Chen, H., Luo, X., Ouyang, J., He, M., Du, X., & Chen, L. (2020) · Bone Research · doi:10.1038/s41413-020-0100-9 · Cited by 302
Selective Inhibition of Ii-dependent Antigen Presentation by Helicobacter pylori Toxin VacA
Molinari, M., Salio, M., Galli, C., Norais, N., Rappuoli, R., Lanzavecchia, A., & Montecucco, C. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.1.135 · Cited by 288
Kleijmeer, M. J., Ramm, G., Schuurhuis, D. H., Griffith, J. M., Rescigno, M., Ricciardi‐Castagnoli, P., Rudensky, A. Y., OSSENDORP, F. A., Melief, C. J. M., Stoorvogel, W., et al. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200103071 · Cited by 288
Self-citationExploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading
Rädler, J., Gupta, D., Zickler, A. M., & Andaloussi, S. E. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.02.013 · Cited by 298
Recent advances on the role of tumor exosomes in immunosuppression and disease progression
Filipazzi, P., Bürdek, M., Villa, A., Rivoltini, L., & Huber, V. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.02.005 · Cited by 287
Exosomes bearing HLA-DR1 molecules need dendritic cells to efficiently stimulate specific T cells
Vincent-Schneider, H. (2002) · International Immunology · doi:10.1093/intimm/dxf048 · Cited by 285
Yewdell, J. W., Norbury, C. C., & Bennink, J. R. (1999) · Advances in immunology · doi:10.1016/s0065-2776(08)60785-3 · Cited by 285
Cell to Cell Signalling via Exosomes Through esRNA
Lötvall, J. O., & Valadi, H. (2007) · Cell Adhesion & Migration · doi:10.4161/cam.1.3.5114 · Cited by 289
Bioinspired exosome-like therapeutics and delivery nanoplatforms
Lu, M., & Huang, Y. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119925 · Cited by 284
Direct exosome stimulation of peripheral humanT cells detected by ELISPOT
Admyre, C., Johansson, S. M., Paulie, S., & Gabrielsson, S. (2006) · European Journal of Immunology · doi:10.1002/eji.200535615 · Cited by 281
Maio, A. D. (2010) · Cell Stress and Chaperones · doi:10.1007/s12192-010-0236-4 · Cited by 291
Tetraspanins, More than Markers of Extracellular Vesicles in Reproduction
Jankovičová, J., Sečová, P., Michalková, K., & Antalíková, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207568 · Cited by 295
Isolation of extracellular vesicles: Determining the correct approach (Review)
Szatanek, R., Baran, J., Siedlar, M., & Baj‐Krzyworzeka, M. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2194 · Cited by 297
Intracellular trafficking of lysosomal membrane proteins
Hunziker, W., & Geuze, H. J. (1996) · BioEssays · doi:10.1002/bies.950180508 · Cited by 280
Self-citationStem cells as drug delivery methods: Application of stem cell secretome for regeneration
Tran, C., & Damaser, M. S. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.10.007 · Cited by 281
Exosomes as Biomarker Treasure Chests for Prostate Cancer
Duijvesz, D., Luider, T. M., Bangma, C. H., & Jenster, G. W. (2010) · European Urology · doi:10.1016/j.eururo.2010.12.031 · Cited by 282
T cell‐induced secretion of MHC class II–peptide complexes on B cell exosomes
Muntasell, A., Berger, A. C., & Roche, P. A. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601842 · Cited by 278
Trichomonas vaginalis Exosomes Deliver Cargo to Host Cells and Mediate Host∶Parasite Interactions
Twu, O., de Miguel, N., Lustig, G., Stevens, G. C., Vashisht, A. A., Wohlschlegel, J. A., & Johnson, P. J. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003482 · Cited by 282
Identifying mRNA, MicroRNA and Protein Profiles of Melanoma Exosomes
Xiao, D., Ohlendorf, J. M., Chen, Y., Taylor, D. D., Rai, S. N., Waigel, S. J., Zacharias, W., Hao, H., & McMasters, K. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046874 · Cited by 287
Exosomes as nucleic acid nanocarriers
van den Boorn, J. G., Daßler, J., Coch, C., Schlee, M., & Hartmann, G. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.06.011 · Cited by 285
Buschow, S. I., van Balkom, B. W. M., Aalberts, M., Heck, A. J. R., Wauben, M. H. M., & Stoorvogel, W. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.64 · Cited by 278
Self-citationParacrine induction of endothelium by tumor exosomes
Hood, J. L., Pan, H., Lanza, G. M., & Wickline, S. A. (2009) · Laboratory Investigation · doi:10.1038/labinvest.2009.94 · Cited by 273
Benchtop isolation and characterization of functional exosomes by sequential filtration
Heinemann, M. L., Ilmer, M., Silva, L. P., Hawke, D. H., Boiles, A. R., Vorontsova, M. A., Alt, E., & Vykoukal, J. V. (2014) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.10.026 · Cited by 286
Chowdhury, R., Webber, J. P., Gurney, M., Mason, M. D., Tabi, Z., & Clayton, A. (2014) · Oncotarget · doi:10.18632/oncotarget.2711 · Cited by 285
Iraci, N., Leonardi, T., Gessler, F., Vega, B., & Pluchino, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020171 · Cited by 301
Mallegol, J., van Niel, G., Lebreton, C., Lepelletier, Y., Candalh, C., Dugave, C., Heath, J. K., Raposo, G., Cerf–Bensussan, N., & Heyman, M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.043 · Cited by 271
Self-citationExosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein
Tamai, K., Tanaka, N., Nakano, T., Kakazu, E., Kondo, Y., Inoue, J., Shiina, M., Fukushima, K., Hoshino, T., Sano, K., et al. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.083 · Cited by 269
Exosomes-loaded thermosensitive hydrogels for corneal epithelium and stroma regeneration
Tang, Q., Lu, B., He, J., Chen, X., Fu, Q., Han, H., Luo, C., Yin, H., Qin, Z., Lyu, D., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121320 · Cited by 270
Li, X. J., Ren, Z. J., Tang, J. H., & Yu, Q. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485780 · Cited by 271
Intestinal epithelial exosomes carry MHC class II/peptides able to inform the immune system in mice
van Niel, G., Mallegol, J., Bevilacqua, C., Candalh, C., Brugière, S., Tomaskovic-Crook, E., Heath, J. K., Cerf–Bensussan, N., & Heyman, M. (2003) · Gut · doi:10.1136/gut.52.12.1690 · Cited by 274
Chaput, N., Schartz, N. E. C., André, F., Taı̈eb, J., Novault, S., Bonnaventure, P., Aubert, N., Bernard, J., Lemonnier, F. A., Mérad, M., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2137 · Cited by 272
Maumus, M., Jørgensen, C., & Noël, D. (2013) · Biochimie · doi:10.1016/j.biochi.2013.04.017 · Cited by 279
Proinflammatory role of epithelial cell–derived exosomes in allergic airway inflammation
Kulshreshtha, A., Ahmad, T., Agrawal, A., & Ghosh, B. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.1565 · Cited by 268
New evidence that a large proportion of human blood plasma cell-free DNA is localized in exosomes
Fernando, M. R., Jiang, C. Y., Krzyzanowski, G. D., & Ryan, W. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183915 · Cited by 286
Montecalvo, A., Shufesky, W. J., Stolz, D. B., Sullivan, M., Wang, Z., Divito, S. J., Papworth, G. D., Watkins, S. C., Robbins, P. D., Larregina, A. T., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3081 · Cited by 279
Immunological self/nonself discrimination
Mannie, M. D. (1999) · Immunologic Research · doi:10.1007/bf02786477 · Cited by 265
Sprague, D. L., Elzey, B. D., Crist, S. A., Waldschmidt, T. J., Jensen, R. J., & Ratliff, T. L. (2008) · Blood · doi:10.1182/blood-2007-06-097410 · Cited by 264
Zhou, H., Zhu, L., Song, J. H., Wang, G., Li, P., Li, W., Luo, P., Sun, X., Wu, J., Liu, Y., et al. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01556-2 · Cited by 273
Current Knowledge on Exosome Biogenesis, Cargo-Sorting Mechanism and Therapeutic Implications
Xie, S., Zhang, Q., & Jiang, L. (2022) · Membranes · doi:10.3390/membranes12050498 · Cited by 262
Proteomic Analysis of Two Types of Exosomes in Human Whole Saliva
Ogawa, Y., Miura, Y., Harazono, A., Kanai‐Azuma, M., Akimoto, Y., Kawakami, H., Yamaguchi, T., Toda, T., Endo, T., Tsubuki, M., et al. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.13 · Cited by 267
Regulation of chronic inflammatory and immune processes by extracellular vesicles
Robbins, P. D., Dorronsoro, A., & Booker, C. N. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81131 · Cited by 266
Glycosylation of extracellular vesicles: current knowledge, tools and clinical perspectives
Williams, C., Royo, F., Aizpurua‐Olaizola, O., Pazos, R., Boons, G., Reichardt, N., & Falcón‐Pérez, J. M. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1442985 · Cited by 269
Presentation of Phagocytosed Antigens by MHC Class I and II
Mantegazza, A. R., Magalhaes, J. G., Amigorena, S., & Marks, M. S. (2012) · Traffic · doi:10.1111/tra.12026 · Cited by 289
Exosome-Like Vesicles with Dipeptidyl Peptidase IV in Human Saliva
Ogawa, Y., Kanai‐Azuma, M., Akimoto, Y., Kawakami, H., & Yanoshita, R. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.1059 · Cited by 273
Association of citrullinated proteins with synovial exosomes
Skriner, K., Adolph, K., Jungblut, P. R., & Burmester, G. R. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22276 · Cited by 271
Metadata
- Authors
- Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J.
- Affiliations
- Utrecht University (NL)
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1996-03-01
- Volume
- 183
- Issue
- 3
- Pages
- 1161-1172
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2192324
- OpenAlex
- W2155366992
- Cited by
- 3,546
- References
- 54
- Citations by year
- 2026: 103 · 2025: 189 · 2024: 247 · 2023: 242 · 2022: 242 · 2021: 274 · 2020: 280 · 2019: 210 · 2018: 214 · 2017: 206 · 2016: 177 · 2015: 159 · 2014: 144 · 2013: 107 · 2012: 99
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Universiteit Utrecht
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (AI 35726, R01AI035726)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- exosomes, MHC class II, B cells, vesicle secretion, membrane fusion, antigen presentation, T cell response
- MeSH terms
- Animals, Antigen-Presenting Cells, Histocompatibility Antigens Class II, B-Lymphocytes, Bacterial Proteins, Biotin, Cell Fractionation, Cell Line, Cell Line, Transformed, Cell Membrane, Cytoplasmic Granules, Endocytosis, Herpesvirus 4, Human, Exocytosis, HLA-DR Antigens, Humans, Lymphocyte Activation, Membrane Fusion, Protein Conformation, Chaperonins, Chaperonin 60, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
