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Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells
Open accessAbstract
Immunostimulatory properties of dendritic cells (DCs) are linked to their maturation state. Injection of mature DCs rapidly enhances antigen-specific CD4+ and CD8+ T cell immunity in humans. Here we describe the immune response to a single injection of immature DCs pulsed with influenza matrix peptide (MP) and keyhole limpet hemocyanin (KLH) in two healthy subjects. In contrast to prior findings using mature DCs, injection of immature DCs in both subjects led to the specific inhibition of MP-specific CD8+ T cell effector function in freshly isolated T cells and the appearance of MP-specific interleukin 10–producing cells. When pre- and postimmunization T cells were boosted in culture, there were greater numbers of MP-specific major histocompatibility complex tetramer-binding cells after immunization, but these had reduced interferon γ production and lacked killer activity. These data demonstrate the feasibility of antigen-specific inhibition of effector T cell function in vivo in humans and urge caution with the use of immature DCs when trying to enhance tumor or microbial immunity.
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Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function
Zajac, A. J., Blattman, J. N., Murali-Krishna, K., Sourdive, D. J. D., Suresh, M., Altman, J. D., & Ahmed, R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2205 · Cited by 1,978
HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function
Appay, V., Nixon, D. F., Donahoe, S. M., Gillespie, G. M. A., Dong, T., King, A., Ogg, G. S., Spiegel, H. M. L., Conlon, C., Spina, C. A., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.1.63 · Cited by 871
Bell, D., Chomarat, P., Broyles, D., Netto, G., Harb, G. M., Lebecque, S., Valladeau, J., Davoust, J., Palucka, K. A., & Banchereau, J. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.10.1417 · Cited by 544
Are dendritic cells the key to liver transplant tolerance?
Thomson, A. W., & Lu, L. (1999) · Immunology Today · doi:10.1016/s0167-5699(98)01378-4 · Cited by 174
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Immunosuppressive networks in the tumour environment and their therapeutic relevance
Zou, W. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1586 · Cited by 2,057
Brown, J. A., Dorfman, D. M., Ma, F.-R., Sullivan, E. L., Munoz, O., Wood, C. R., Greenfield, E. A., & Freeman, G. J. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1257 · Cited by 968
Heiser, A., Coleman, D., Dannull, J., Yancey, D., Maurice, M. A., Lallas, C. D., Dahm, P., Niedzwiecki, D., Gilboa, E., & Vieweg, J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214364 · Cited by 562
IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation
Park, S.-J., Nakagawa, T., Kitamura, H., Atsumi, T., Kamon, H., Sawa, S.-I., Kamimura, D., Ueda, N., Iwakura, Y., Ishihara, K., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.3844 · Cited by 519
(2003) · PubMed · Cited by 477
Su, Z., Dannull, J., Yang, B. K., Dahm, P., Coleman, D., Yancey, D., Sichi, S., Niedzwiecki, D., Boczkowski, D., Gilboa, E., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3798 · Cited by 359
Vicari, A. P., & Caux, C. (2002) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(01)00033-8 · Cited by 351
Vicari, A. P., Chiodoni, C., Vaure, C., Aït-Yahia, S., Dercamp, C., Matsos, F., Reynard, O., Taverne, C., Merle, P., Colombo, M. P., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020732 · Cited by 343
The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients
Osada, T., Chong, G., Tansik, R., Hong, T., Spector, N., Kumar, R., Hurwitz, H. I., Dev, I., Nixon, A. B., Lyerly, H. K., et al. (2008) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-007-0441-x · Cited by 311
Suhoski, M. M., Golovina, T. N., Aqui, N. A., Tai, V. C., Varela-Rohena, A., Milone, M. C., Carroll, R. G., Riley, J. L., & June, C. H. (2007) · Molecular Therapy · doi:10.1038/mt.sj.6300134 · Cited by 266
Tumor microenvironment in ovarian cancer: function and therapeutic strategy
Yang, Y., Yang, Y., Yang, J., Zhao, X., & Wei, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00758 · Cited by 218
Jahnsen, F. L., Strickland, D. H., Thomas, J. A., Tobagus, I. T., Napoli, S., Zosky, G. R., Turner, D. J., Sly, P. D., Stumbles, P. A., & Holt, P. G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.5861 · Cited by 213
Induction of potent antitumor immunity by in situ targeting of intratumoral DCs
Furumoto, K., Soares, L., Engleman, E. G., & Merad, M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419762 · Cited by 180
Regulatory T cells and tolerogenic dendritic cells: from basic biology to clinical applications
Rutella, S., & Lemoli, R. M. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.04.015 · Cited by 147
Hamdi, H., Godot, V., Maillot, M.-C., Prejean, M. V., Cohen, N., Krzysiek, R., Lemoine, F. M., Zou, W., & Emilie, D. (2007) · Blood · doi:10.1182/blood-2006-10-052506 · Cited by 126
Targeting dendritic cell signaling to regulate the response to immunization
Escors, D., Lopes, L., Lin, R., Hiscott, J., Akira, S., Davis, R. J., & Collins, M. K. (2008) · Blood · doi:10.1182/blood-2007-11-122408 · Cited by 116
Xiao, Y., Zou, Q., Xie, X., Liu, T., Li, H. S., Jie, Z., Jin, J., Hu, H., Manyam, G., Zhang, L., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20161524 · Cited by 87
Long-lived immature dendritic cells mediated by TRANCE-RANK interaction
Cremer, I., Dieu-Nosjean, M.-C., Maréchal, S., Dezutter-Dambuyant, C., Goddard, S., Adams, D., Winter, N., Menetrier-Caux, C., Sautès-Fridman, C., Fridman, W. H., et al. (2002) · Blood · doi:10.1182/blood-2002-01-0312 · Cited by 85
CD4+ CD25+ regulatory T cells inhibit immune-mediated transgene rejection
Gross, D.-A., Leboeuf, M., Gjata, B., Danos, O., & Davoust, J. (2003) · Blood · doi:10.1182/blood-2003-05-1454 · Cited by 45
O'Garra, A., & Barrat, F. J. (2003) · Immunology Letters · doi:10.1016/s0165-2478(02)00239-0 · Cited by 42
Yang, S., Li, W., Liu, W., Gao, C., Zhou, B., Li, S., Li, Y., & Kong, Y. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.06.009 · Cited by 40
Metadata
- Authors
- Dhodapkar, M. V., Steinman, R. M., Krasovsky, J., Munz, C., & Bhardwaj, N.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2001-01-15
- Volume
- 193
- Issue
- 2
- Pages
- 233-238
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2102689053
- Cited by
- 1,359
- References
- 4
- FWCI
- 45.87
- Type
- journal article
- Language
- en
- Open access
- green
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