The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia
Open accessAbstract
A better understanding of the role of CD4+CD25+ regulatory T cells in disease pathogenesis should follow from the discovery of reliable markers capable of discriminating regulatory from activated T cells. We report that the CD4+CD25+ population in synovial fluid of juvenile idiopathic arthritis (JIA) patients comprises both regulatory and effector T cells that can be distinguished by expression of CD27. CD4+CD25+CD27+ cells expressed high amounts of FoxP3 (43% of them being FoxP3+), did not produce interleukin (IL)-2, interferon-γ, or tumor necrosis factor, and suppressed T cell proliferation in vitro, being, on a per cell basis, fourfold more potent than the corresponding peripheral blood population. In contrast, CD4+CD25+CD27− cells expressed low amounts of FoxP3, produced effector cytokines and did not suppress T cell proliferation. After in vitro activation and expansion, regulatory but not conventional T cells maintained high expression of CD27. IL-7 and IL-15 were found to be present in synovial fluid of JIA patients and, when added in vitro, abrogated the suppressive activity of regulatory T cells. Together, these results demonstrate that, when used in conjunction with CD25, CD27 is a useful marker to distinguish regulatory from effector T cells in inflamed tissues and suggest that at these sites IL-7 and IL-15 may interfere with regulatory T cell function.
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Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
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CD4+CD25+ Immunoregulatory T Cells
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Cited by
Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S. I., Nanan, R., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060468 · Cited by 1,512
Transient expression of FOXP3 in human activated nonregulatory CD4 + T cells
Wang, J., Ioan‐Facsinay, A., van der Voort, E. I. H., Huizinga, T. W. J., & Toes, R. E. M. (2007) · European Journal of Immunology · doi:10.1002/eji.200636435 · Cited by 1,011
Prakken, B., Albani, S., & Martini, A. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60244-4 · Cited by 771
Self-citationRibot, J. C., deBarros, A., Pang, D. J., Neves, J. F., Peperzak, V., Roberts, S. J., Girardi, M., Borst, J., Hayday, A. C., Pennington, D. J., et al. (2009) · Nature Immunology · doi:10.1038/ni.1717 · Cited by 628
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Lages, C. S., Suffia, I., Velilla, P. A., Huang, B., Warshaw, G., Hildeman, D. A., Belkaid, Y., & Chougnet, C. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.1835 · Cited by 399
IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction
Jabri, B., & Abadie, V. (2015) · Nature Reviews Immunology · doi:10.1038/nri3919 · Cited by 315
Persistence of naive CD45RA+ regulatory T cells in adult life
Seddiki, N., Santner-Nanan, B., Tangye, S. G., Alexander, S. I., Solomon, M., Lee, S., Nanan, R., & de Saint Groth, B. F. (2006) · Blood · doi:10.1182/blood-2005-06-2403 · Cited by 284
Coenen, J. J. A., Koenen, H. J. P. M., van Rijssen, E., Hilbrands, L. B., & Joosten, I. (2006) · Blood · doi:10.1182/blood-2005-07-3032 · Cited by 252
Lubberts, E. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-009-0189-9 · Cited by 173
Niedbala, W., Cai, B., Liu, H., Pitman, N., Chang, L., & Liew, F. Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703725104 · Cited by 156
Vukmanovic-Stejic, M., Agius, E., Booth, N., Dunne, P. J., Lacy, K. E., Reed, J. R., Sobande, T. O., Kissane, S., Salmon, M., Rustin, M. H., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35834 · Cited by 131
T Regulatory Cells in Bone Remodelling
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Metadata
- Authors
- Ruprecht, C. R., Gattorno, M., Ferlito, F., Gregorio, A., Martini, A., Lanzavecchia, A., & Sallusto, F.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2005-06-06
- Volume
- 201
- Issue
- 11
- Pages
- 1793-1803
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2161152348
- Cited by
- 361
- References
- 4
- FWCI
- 14.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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