Differential impact of mammalian target of rapamycin inhibition on CD4 +CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells

N aturally A rising CD4+R egulatory T C ells for I mmunologic S elf -T olerance and N egative C ontrol of I mmune R esponses

Sakaguchi, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141122 · Cited by 3,293 · see citing works

Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

Shimizu, J., Yamazaki, S., Takahashi, T., Ishida, Y., & Sakaguchi, S. (2002) · Nature Immunology · doi:10.1038/ni759 · Cited by 1,729 · see citing works

Causal Protein-Signaling Networks Derived from Multiparameter Single-Cell Data

Sachs, K., Perez, O. D., Pe’er, D., Lauffenburger, D. A., & Nolan, G. P. (2005) · Science · doi:10.1126/science.1105809 · Cited by 1,724 · see citing works

CD4+CD25+ Immunoregulatory T Cells

McHugh, R. S., Whitters, M. J., Piccirillo, C. A., Young, D. A., Shevach, E. M., Collins, M., & Byrne, M. C. (2002) · Immunity · doi:10.1016/s1074-7613(02)00280-7 · Cited by 1,395 · see citing works

CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation

Edinger, M., Hoffmann, P., Ermann, J., Drago, K., Fathman, C. G., Strober, S., & Negrin, R. S. (2003) · Nature Medicine · doi:10.1038/nm915 · Cited by 1,286 · see citing works

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.

Battaglia, M., Stabilini, A., & Roncarolo, M. (2005) · Blood · doi:10.1182/blood-2004-10-3932 · Cited by 1,203 · see citing works

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

Wu, Y., Borde, M., Heissmeyer, V., Feuerer, M., Lapan, A. D., Stroud, J. C., Bates, D. L., Guo, L., Han, A., Ziegler, S. F., et al. (2006) · Cell · doi:10.1016/j.cell.2006.05.042 · Cited by 1,188 · see citing works

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells

Burchill, M. A., Yang, J., Vogtenhuber, C., Blazar, B. R., & Farrar, M. A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.1.280 · Cited by 836 · see citing works

CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses

Kingsley, C. I., Karim, M., Bushell, A., & Wood, K. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.3.1080 · Cited by 742 · see citing works

Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients

Battaglia, M., Stabilini, A., Migliavacca, B., Horejs‐Hoeck, J., Kaupper, T., & Roncarolo, M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.12.8338 · Cited by 731 · see citing works

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

Suzuki, A., Tsukio, M., Ohteki, T., Sasaki, T., Kaisho, T., Kimura, Y., Yoshida, R., Wakeham, A. C., Higuchi, T., Fukumoto, M., et al. (2001) · Immunity · doi:10.1016/s1074-7613(01)00134-0 · Cited by 589 · see citing works

Nonredundant roles for Stat5a/b in directly regulating Foxp3

Yao, Z., Kanno, Y., Kerenyi, M. A., Stephens, G. L., Durant, L. R., Watford, W. T., Laurence, A. D. J., Robinson, G. W., Shevach, E. M., Moriggl, R., et al. (2007) · Blood · doi:10.1182/blood-2006-11-055756 · Cited by 575 · see citing works

Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production

Zeiser, R., Nguyen, V. H., Beilhack, A., Buess, M., Schulz, S., Baker, J. B., Contag, C. H., & Negrin, R. S. (2006) · Blood · doi:10.1182/blood-2006-01-0329 · Cited by 499 · see citing works

Histopathology of graft-vs.-host reaction (GvHR) in human recipients of marrow from HL-A-matched sibling donors.

Lerner, K. G., Kao, G. F., Storb, R. F., Buckner, C. D., Ra, C., & Thomas, E. D. (1974) · PubMed · Cited by 454 · see citing works

Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD

Ermann, J., Hoffmann, P., Edinger, M., Dutt, S., Blankenberg, F. G., Higgins, J., Negrin, R. S., Fathman, C. G., & Strober, S. (2004) · Blood · doi:10.1182/blood-2004-05-2044 · Cited by 418 · see citing works

PTEN: The down side of PI 3-kinase signalling

Leslie, N. R., & Downes, C. P. (2002) · Cellular Signalling · doi:10.1016/s0898-6568(01)00234-0 · Cited by 415 · see citing works

Distinct roles of CTLA‐4 and TGF‐β in CD4+CD25+ regulatory T cell function

Tang, Q., Boden, E. K., Henriksen, K., Bour‐Jordan, H., Bi, M., & Bluestone, J. A. (2004) · European Journal of Immunology · doi:10.1002/eji.200425143 · Cited by 377 · see citing works

In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro

Klein, L., Khazaie, K., & von Boehmer, H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1533365100 · Cited by 375 · see citing works

Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia

Ruprecht, C. R., Gattorno, M., Ferlito, F., Gregorio, A., Martini, A., Lanzavecchia, A., & Sallusto, F. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050085 · Cited by 360 · see citing works

In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets

Beilhack, A., Schulz, S., Baker, J. B., Beilhack, G. F., Wieland, C. B., Herman, E. I., Baker, E. M., Cao, Y., Contag, C. H., & Negrin, R. S. (2005) · Blood · doi:10.1182/blood-2005-02-0509 · Cited by 352 · see citing works

L-Selectinhi but not the L-selectinlo CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection

Taylor, P. A., Panoskaltsis‐Mortari, A., Swedin, J. M., Lucas, P. J., Gress, R. E., Levine, B. L., June, C. H., Serody, J. S., & Blazar, B. R. (2004) · Blood · doi:10.1182/blood-2004-05-1850 · Cited by 350 · see citing works

Shifting foci of hematopoiesis during reconstitution from single stem cells

Cao, Y., Wagers, A. J., Beilhack, A., Dusich, J., Bachmann, M. H., Negrin, R. S., Weissman, I. L., & Contag, C. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2637010100 · Cited by 337 · see citing works

Selective Survival of Naturally Occurring Human CD4+CD25+Foxp3+ Regulatory T Cells Cultured with Rapamycin

Strauss, L., Whiteside, T. L., Knights, A. J., Bergmann, C., Knuth, A. K., & Zippelius, A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.1.320 · Cited by 335 · see citing works

Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation

Powell, J. D., Lerner, C. G., & Schwartz, R. H. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.5.2775 · Cited by 290 · see citing works

Distinct IL-2 Receptor Signaling Pattern in CD4+CD25+ Regulatory T Cells

Bensinger, S. J., Walsh, P. T., Zhang, J., Carroll, M. P., Parsons, R. E., Rathmell, J. C., Thompson, C. B., Burchill, M. A., Farrar, M. A., & Turka, L. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.9.5287 · Cited by 289 · see citing works

Calcineurin Inhibitors, but not Rapamycin, Reduce Percentages of CD4+CD25+FOXP3+ Regulatory T Cells in Renal Transplant Recipients

Segundo, D. S., Ruiz, J. C., Izquierdo, M., Fernández‐Fresnedo, G., Gómez-Alamillo, C., Merino, R., Benito, M. J., Cacho, E., Rodrigo, E., Palomar, R., et al. (2006) · Transplantation · doi:10.1097/01.tp.0000229473.95202.50 · Cited by 249 · see citing works

Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease

Wysocki, C., Jiang, Q., Panoskaltsis‐Mortari, A., Taylor, P. A., McKinnon, K. P., Su, L., Blazar, B. R., & Serody, J. S. (2005) · Blood · doi:10.1182/blood-2005-04-1632 · Cited by 243 · see citing works

Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells

Crellin, N. K., García, R., & Levings, M. K. (2006) · Blood · doi:10.1182/blood-2006-07-035279 · Cited by 234 · see citing works

Regulatory T Cells and T Cell Depletion

Noris, M., Casiraghi, F., Todeschini, M., Cravedi, P., Cugini, D., Monteferrante, G., Aiello, S., Cassis, L., Gotti, E., Gaspari, F., et al. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006101143 · Cited by 230 · see citing works

RAPAMYCIN: CLINICAL RESULTS AND FUTURE OPPORTUNITIES1

Kahan, B. D., & Camardo, J. S. (2001) · Transplantation · doi:10.1097/00007890-200110150-00001 · Cited by 225 · see citing works

Essential Role for STAT5 Signaling in CD25+CD4+ Regulatory T Cell Homeostasis and the Maintenance of Self-Tolerance

Antov, A., Yang, L., Vig, M., Baltimore, D., & Parijs, L. V. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3435 · Cited by 204 · see citing works

The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade

Blaha, P., Bigenzahn, S., Koporc, Z., Schmid, M. P., Langer, F. B., Selzer, E., Bergmeister, H., Wrba, F., Kurtz, J. M., Kiss, C., et al. (2003) · Blood · doi:10.1182/blood-2002-10-3014 · Cited by 175 · see citing works

Regulation of Trafficking Receptor Expression in Human Forkhead Box P3+ Regulatory T Cells

Lim, H. W., Broxmeyer, H. E., & Kim, C. H. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.2.840 · Cited by 164 · see citing works

PTEN inhibits IL-2 receptor-mediated expansion of CD4+CD25+ Tregs

Walsh, P. T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28057 · Cited by 164 · see citing works

Rapamycin, not cyclosporine, permits thymic generation and peripheral preservation of CD4+CD25+FoxP3+ T cells

Coenen, J. J. A., Koenen, H. J. P. M., van Rijssen, E., Kasran, A., Boon, L., Hilbrands, L. B., & Joosten, I. (2007) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705628 · Cited by 164 · see citing works

Selective Expression of the Cre Recombinase in Late-Stage Thymocytes Using the Distal Promoter of the Lck Gene

Zhang, D. J., Wang, Q., Wei, J., Baimukanova, G., Buchholz, F., Stewart, A. F., Mao, X., & Killeen, N. P. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.6725 · Cited by 132 · see citing works

Coordinate Analysis of Murine Immune Cell Surface Markers and Intracellular Phosphoproteins by Flow Cytometry

Krutzik, P. O., Clutter, M. R., & Nolan, G. P. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2357 · Cited by 132 · see citing works

Protein kinase B (Akt) regulation and function in T lymphocytes

Cantrell, D. A. (2002) · Seminars in Immunology · doi:10.1006/smim.2001.0338 · Cited by 127 · see citing works

Interleukin 2 signaling involves the phosphorylation of Stat proteins.

Frank, D. A., Robertson, M. J., Bonni, A., Ritz, J., & Greenberg, M. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7779 · Cited by 113 · see citing works

CD27/CFSE-Based Ex Vivo Selection of Highly Suppressive Alloantigen-Specific Human Regulatory T Cells

Koenen, H. J. P. M., Fasse, E., & Joosten, I. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.7573 · Cited by 104 · see citing works

A Potential Side Effect of Cyclosporin A: Inhibition of CD4+CD25+ Regulatory T Cells in Mice

Wang, H., Zhao, L., Sun, Z., Sun, L., Zhang, B., & Zhao, Y. X. (2006) · Transplantation · doi:10.1097/01.tp.0000246312.89689.17 · Cited by 101 · see citing works

Determinants of Sensitivity and Resistance to Rapamycin-Chemotherapy Drug Combinations In vivo

Wendel, H., Malina, A., Zhao, Z., Zender, L., Kogan, S. C., Cordon‐Cardo, C., Pelletier, J., & Lowe, S. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0419 · Cited by 96 · see citing works

Cutting Edge: T Cell Requirement for CD28 Costimulation Is Due to Negative Regulation of TCR Signals by PTEN

Buckler, J. L., Walsh, P. T., Porrett, P. M., Choi, Y., & Turka, L. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4262 · Cited by 79 · see citing works

Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease

Zeiser, R., Nguyen, V. H., Hou, J., Beilhack, A., Zambricki, E. A., Buess, M., Contag, C. H., & Negrin, R. S. (2006) · Blood · doi:10.1182/blood-2006-07-038455 · Cited by 78 · see citing works

Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes

Terada, N., Takase, K., Papst, P. J., Nairn, A. C., & Gelfand, E. W. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.7.3418 · Cited by 75 · see citing works

The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases.

Horwitz, D. A., Gray, J. D., & Zheng, S. G. (2002) · Arthritis Research · doi:10.1186/ar414 · Cited by 66 · see citing works

Endothelial Akt Signaling Is Rate-Limiting for Rapamycin Inhibition of Mouse Mammary Tumor Progression

Phung, T. L., Eyiah-Mensah, G., O’Donnell, R. K., Bieniek, R., Shechter, S., Walsh, K., Kuperwasser, C., & Benjamin, L. E. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3341 · Cited by 55 · see citing works

Uncoupling p70s6 Kinase Activation and Proliferation: Rapamycin-Resistant Proliferation of Human CD8+ T Lymphocytes1

Slavik, J. M., Lim, D., Burakoff, S., & Hafler, D. (2001) · Journal of Immunology · doi:10.4049/jimmunol.166.5.3201 · Cited by 38 · see citing works

Overcoming T cell–mediated rejection of bone marrow allografts by T-regulatory cells: Synergism with veto cells and rapamycin

Steiner, D., Brunicki, N., Bachar-Lustig, E., Taylor, P. A., Blazar, B. R., & Reisner, Y. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2006.02.017 · Cited by 29 · see citing works

Prevention of lethal acute GVHD with an agonistic CD28 antibody and rapamycin

Albert, M. H., Yu, X., Martin, P. J., & Anasetti, C. (2005) · Blood · doi:10.1182/blood-2004-08-3305 · Cited by 28 · see citing works

A Foxy tango with NFAT

Ho, L., & Crabtree, G. (2006) · Nature Immunology · doi:10.1038/ni0906-906 · Cited by 8 · see citing works

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

Park, J., Kim, M., Kang, S. G., Jannasch, A. H., Cooper, B., Patterson, J., & Kim, C. H. (2015) · Mucosal Immunology · doi:10.1038/mi.2014.44 · Cited by 1,307 · see citing works

Acute Graft-versus-Host Disease — Biologic Process, Prevention, and Therapy

Zeiser, R., & Blazar, B. R. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1609337 · Cited by 1,316 · see citing works

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

Brunstein, C. G., Miller, J. S., Cao, Q., McKenna, D. H., Hippen, K. L., Curtsinger, J., DeFor, T. E., Levine, B. L., June, C. H., Rubinstein, P., et al. (2010) · Blood · doi:10.1182/blood-2010-07-293795 · Cited by 1,052 · see citing works

Regulation and function of mTOR signalling in T cell fate decisions

Chi, H. (2012) · Nature Reviews Immunology · doi:10.1038/nri3198 · Cited by 1,035 · see citing works

Signaling and Function of Interleukin-2 in T Lymphocytes

Ross, S. H., & Cantrell, D. A. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053352 · Cited by 979 · see citing works

Immunoregulatory functions of mTOR inhibition

Thomson, A. W., Turnquist, H. R., & Raimondi, G. (2009) · Nature reviews. Immunology · doi:10.1038/nri2546 · Cited by 849 · see citing works

Regulation of Immune Responses by mTOR

Powell, J. D., Pollizzi, K. N., Heikamp, E. B., & Horton, M. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075024 · Cited by 836 · see citing works

T cell receptor signalling in the control of regulatory T cell differentiation and function

Li, M. O., & Rudensky, A. Y. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.26 · Cited by 493 · see citing works

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

Powell, J. D., & Delgoffe, G. M. (2010) · Immunity · doi:10.1016/j.immuni.2010.09.002 · Cited by 487 · see citing works

The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease

Cooke, K. R., Luznik, L., Sarantopoulos, S., Hakim, F. T., Jagasia, M., Fowler, D. H., van den Brink, M. R. M., Hansen, J. A., Parkman, R., Miklos, D. B., et al. (2016) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2016.09.023 · Cited by 472 · see citing works

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R

Wilhelm, K., Ganesan, J., Müller, T., Dürr, C., Grimm, M., Beilhack, A., Krempl, C. D., Sorichter, S., Gerlach, U. V., Jüttner, E., et al. (2010) · Nature Medicine · doi:10.1038/nm.2242 · Cited by 435 · see citing works

<scp>mTOR</scp> , metabolism, and the regulation of T‐cell differentiation and function

Waickman, A. T., & Powell, J. D. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01152.x · Cited by 420 · see citing works

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

Huynh, A., DuPage, M. J. P., Priyadharshini, B., Sage, P. T., Quiros, J., Borges, C. M., Townamchai, N., Gerriets, V. A., Rathmell, J. C., Sharpe, A. H., et al. (2015) · Nature Immunology · doi:10.1038/ni.3077 · Cited by 412 · see citing works

Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease

Spoerl, S., Mathew, N. R., Bscheider, M., Schmitt-Graeff, A. H., Chen, S., Mueller, T., Verbeek, M., Fischer, J. C., Otten, V., Schmickl, M., et al. (2014) · Blood · doi:10.1182/blood-2013-12-543736 · Cited by 404 · see citing works

NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects

Olson, J. A., Leveson-Gower, D. B., Gill, S. I., Baker, J. B., Beilhack, A., & Negrin, R. S. (2010) · Blood · doi:10.1182/blood-2009-05-222190 · Cited by 387 · see citing works

Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

Brusko, T. M., Putnam, A. L., & Bluestone, J. A. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00637.x · Cited by 374 · see citing works

Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes

Putnam, A. L., Brusko, T. M., Lee, M. R., Liu, W., Szot, G. L., Ghosh, T., Atkinson, M. A., & Bluestone, J. A. (2008) · Diabetes · doi:10.2337/db08-1168 · Cited by 357 · see citing works

Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage

Schwab, L., Goroncy, L., Palaniyandi, S., Gautam, S., Triantafyllopoulou, A., Mócsai, A., Reichardt, W., Karlsson, F. J., Radhakrishnan, S. V., Hanke, K., et al. (2014) · Nature Medicine · doi:10.1038/nm.3517 · Cited by 302 · see citing works

Acute graft-versus-host disease: from the bench to the bedside

Socié, G., & Blazar, B. R. (2009) · Blood · doi:10.1182/blood-2009-06-204669 · Cited by 262 · see citing works

TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy

Li, L., Liu, X., Sanders, K. L., Edwards, J. L., Ye, J., Si, F., Gao, A., Huang, L., Hsueh, E. C., Ford, D. A., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.09.020 · Cited by 247 · see citing works

Treg Enhancing Therapies to Treat Autoimmune Diseases

Eggenhuizen, P. J., Ng, B. H., & Ooi, J. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197015 · Cited by 248 · see citing works

The Nlrp3 inflammasome regulates acute graft-versus-host disease

Jankovic, D. L., Ganesan, J., Bscheider, M., Stickel, N., Weber, F. C., Guarda, G., Follo, M., Pfeifer, D., Tardivel, A., Ludigs, K., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130084 · Cited by 236 · see citing works

Regulatory T-Cell Therapy in Transplantation: Moving to the ClinicPreprint

Tang, Q., & Bluestone, J. A. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015552 · Cited by 233 · see citing works

Metabolic control of the Treg/Th17 axis

Barbi, J. J., Pardoll, D. M., & Pan, F. (2013) · Immunological Reviews · doi:10.1111/imr.12029 · Cited by 215 · see citing works

Regulation of T cells by mTOR: the known knowns and the known unknowns

Pollizzi, K. N., & Powell, J. D. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.11.005 · Cited by 202 · see citing works

Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells

Laidlaw, B. J., Cui, W., Amezquita, R. A., Gray, S. M., Guan, T., Lu, Y., Kobayashi, Y., Flavell, R. A., Kleinstein, S. H., Craft, J. E., et al. (2015) · Nature Immunology · doi:10.1038/ni.3224 · Cited by 194 · see citing works

Cutting Edge: Foxp3-Mediated Induction of Pim 2 Allows Human T Regulatory Cells to Preferentially Expand in Rapamycin

Basu, S., Golovina, T. N., Mikheeva, T., June, C. H., & Riley, J. L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.5794 · Cited by 183 · see citing works

Regulatory T Cells as Immunotherapy

Singer, B. D., King, L. S., & D’Alessio, F. R. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00046 · Cited by 183 · see citing works

Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance

Headen, D. M., Woodward, K. B., Coronel, M. M., Shrestha, P., Weaver, J. D., Zhao, H., Tan, M., Hunckler, M. D., Bowen, W. S., Johnson, C. T., et al. (2018) · Nature Materials · doi:10.1038/s41563-018-0099-0 · Cited by 175 · see citing works

Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches

Diehl, R., Ferrara, F., Müller, C., Dreyer, A. Y., McLeod, D. D., Fricke, S., & Boltze, J. (2016) · Cellular and Molecular Immunology · doi:10.1038/cmi.2016.39 · Cited by 175 · see citing works

Differential Responses of Human Regulatory T Cells (Treg) and Effector T Cells to Rapamycin

Strauss, L., Czystowska, M., Szajnik, M. E., Mandapathil, M., & Whiteside, T. L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005994 · Cited by 170 · see citing works

Regulatory T cells in stem cell transplantation: strategies and first clinical experiences

Edinger, M., & Hoffmann, P. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.06.006 · Cited by 166 · see citing works

CD4+Foxp3+ regulatory T cell therapy in transplantation

Tang, Q., Bluestone, J. A., & Kang, S. (2011) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjr047 · Cited by 159 · see citing works

CHAI and LATAIE: new genetic diseases of CTLA-4 checkpoint insufficiency

Lo, B., Fritz, J. M., Su, H. C., Uzel, G., Jordan, M. B., & Lenardo, M. J. (2016) · Blood · doi:10.1182/blood-2016-04-712612 · Cited by 155 · see citing works

Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells.

Shin, H., Baker, J., Leveson-Gower, D., Smith, A. T., Sega, E. I., & Negrin, R. (2011) · Blood · doi:10.1182/blood-2010-10-313684 · Cited by 160 · see citing works

mTOR Signaling, Tregs and Immune Modulation

Chapman, N. M., & Chi, H. (2014) · Immunotherapy · doi:10.2217/imt.14.84 · Cited by 148 · see citing works

mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T Cells

Sun, I., Oh, M. H., Zhao, L., Patel, C. H., Arwood, M. L., Xu, W., Tam, A. J., Blosser, R. L., Wen, J., & Powell, J. D. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701477 · Cited by 146 · see citing works

Frequency of CD4+CD25hiFOXP3+ Regulatory T Cells Has Diagnostic and Prognostic Value as a Biomarker for Acute Graft-versus-Host-Disease

Magenau, J. M., Qin, X., Tawara, I., Rogers, C. E., Kitko, C. L., Schlough, M., Bickley, D., Braun, T., Jang, P., Lowler, K. P., et al. (2010) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2010.02.026 · Cited by 143 · see citing works

A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials

Fraser, H., Safinia, N., Grageda, N., Thirkell, S., Lowe, K., Fry, L., Scottà, C., Hope, A. J., Fisher, C., Hilton, R. M., et al. (2018) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2018.01.006 · Cited by 143 · see citing works

Immunosuppression for liver transplantation

Geissler, E. K., & Schlitt, H. J. (2008) · Gut · doi:10.1136/gut.2008.163527 · Cited by 139 · see citing works

Treg-Therapy Allows Mixed Chimerism and Transplantation Tolerance Without Cytoreductive Conditioning

Pilat, N., Baranyi, U., Klaus, C., Jaeckel, E., Mpofu, N., Wrba, F., Golshayan, D., Muehlbacher, F., & Wekerle, T. (2010) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2010.03018.x · Cited by 137 · see citing works

Identification and expansion of highly suppressive CD8+FoxP3+ regulatory T cells after experimental allogeneic bone marrow transplantation

Robb, R. J., Lineburg, K. E., Kuns, R. D., Wilson, Y. A., Raffelt, N. C., Olver, S. D., Varelias, A., Alexander, K. A., Teal, B. E., Sparwasser, T. D., et al. (2012) · Blood · doi:10.1182/blood-2011-12-396119 · Cited by 136 · see citing works

Alpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation

Tawara, I., Sun, Y., Lewis, E. C., Toubai, T., Evers, R., Nieves, E. C., Azam, T., Dinarello, C. A., & Reddy, P. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117665109 · Cited by 134 · see citing works

Allogeneic CAR Cell Therapy—More Than a Pipe Dream

Caldwell, K. J., Gottschalk, S. M., & Talleur, A. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.618427 · Cited by 133 · see citing works

The STAT5b Pathway Defect and Autoimmunity

Kanai, T., Jenks, J. A., & Nadeau, K. C. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00234 · Cited by 130 · see citing works

STAT5b Deficiency: An Unsuspected Cause of Growth Failure, Immunodeficiency, and Severe Pulmonary Disease

Nadeau, K. C., Hwa, V., & Rosenfeld, R. G. (2011) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.12.042 · Cited by 128 · see citing works

Impact of Immune-Modulatory Drugs on Regulatory T Cell

Furukawa, A., Wisel, S. A., & Tang, Q. (2016) · Transplantation · doi:10.1097/tp.0000000000001379 · Cited by 127 · see citing works

De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR

Kang, J., Huddleston, S. J., Fraser, J. M., & Khoruts, A. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1207851 · Cited by 124 · see citing works

Gene editing to induce FOXP3 expression in human CD4 + T cells leads to a stable regulatory phenotype and function

Honaker, Y., Hubbard, N., Xiang, Y., Fisher, L., Hagin, D., Sommer, K., Song, Y., Yang, S. J., Lopez, C., Tappen, T., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay6422 · Cited by 123 · see citing works

mTOR, Cancer and Transplantation

Geissler, E. K., Schlitt, H. J., & Thomas, G. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2008.02391.x · Cited by 122 · see citing works

Role of T cells in graft rejection and transplantation tolerance

Issa, F., Șchiopu, A., & Wood, K. J. (2009) · Expert Review of Clinical Immunology · doi:10.1586/eci.09.64 · Cited by 122 · see citing works

Induced Regulatory T Cells Promote Tolerance When Stabilized by Rapamycin and IL-2 In Vivo

Zhang, P., Tey, S.-K., Koyama, M., Kuns, R. D., Olver, S., Lineburg, K., Lor, M., Teal, B. E., Raffelt, N. C., Raju, J., et al. (2013) · Journal of Immunology · doi:10.4049/jimmunol.1301181 · Cited by 110 · see citing works

Regulatory T Cells: Serious Contenders in the Promise for Immunological Tolerance in Transplantation

Safinia, N., Scottà, C., Vaikunthanathan, T., Lechler, R. I., & Lombardi, G. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00438 · Cited by 119 · see citing works

Progesterone suppresses the mTOR pathway and promotes generation of induced regulatory T cells with increased stability

Lee, J., Lydon, J., & Kim, C. H. (2012) · European Journal of Immunology · doi:10.1002/eji.201142317 · Cited by 129 · see citing works

Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4–dependent mechanism

Leveson-Gower, D. B., Olson, J. A., Sega, E. I., Luong, R. H., Baker, J. B., Zeiser, R., & Negrin, R. S. (2011) · Blood · doi:10.1182/blood-2010-08-303008 · Cited by 119 · see citing works

Immunogenicity assessment of AAV-based gene therapies: An IQ consortium industry white paper

Yang, T., Braun, M., Lembke, W., McBlane, F., Kamerud, J., DeWall, S. L., Tarcsa, E., Fang, X., Hofer, L., Kavita, U., et al. (2022) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2022.07.018 · Cited by 118 · see citing works

CD4+ invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4+CD25+FoxP3+ regulatory T cells

Schneidawind, D., Pierini, A., Álvarez, M., Pan, Y., Baker, J. B., Buechele, C., Luong, R. H., Meyer, E. H., & Negrin, R. S. (2014) · Blood · doi:10.1182/blood-2014-05-576017 · Cited by 115 · see citing works

Mechanistic approaches for the prevention and treatment of chronic GVHD

Cutler, C. S., Koreth, J., & Ritz, J. (2016) · Blood · doi:10.1182/blood-2016-08-686659 · Cited by 115 · see citing works

Sirolimus as Primary Immunosuppression Attenuates Allograft Vasculopathy With Improved Late Survival and Decreased Cardiac Events After Cardiac Transplantation

Topilsky, Y., Hasin, T., Raichlin, E., Boilson, B. A., Schirger, J. A., Pereira, N. L., Edwards, B. S., Clavell, A. L., Rodeheffer, R. J., Frantz, R. P., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.040360 · Cited by 114 · see citing works

Pathogenesis of acute graft‐versus‐host disease: from intestinal microbiota alterations to donor T cell activation

Zeiser, R., Socié, G., & Blazar, B. R. (2016) · British Journal of Haematology · doi:10.1111/bjh.14295 · Cited by 113 · see citing works

AKT isoforms modulate Th1‐like Treg generation and function in human autoimmune disease

Kitz, A., de Marcken, M., Gautron, A.-S., Mitrovič, M., Hafler, D. A., & Dominguez‐Villar, M. (2016) · EMBO Reports · doi:10.15252/embr.201541905 · Cited by 112 · see citing works

Impact of age on T cell signaling: A general defect or specific alterations?

Larbi, A., Pawelec, G., Wong, S. C., Goldeck, D., Tai, J. J.-Y., & Fulop, T. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.09.008 · Cited by 108 · see citing works

Ex Vivo–Expanded but Not In Vitro–Induced Human Regulatory T Cells Are Candidates for Cell Therapy in Autoimmune Diseases Thanks to Stable Demethylation of the FOXP3 Regulatory T Cell–Specific Demethylated Region

Rossetti, M. M., Spreafico, R., Saidin, S., Chua, C. J. H., Moshref, M., Leong, J. Y., Tan, Y. K., Thumboo, J., van Loosdregt, J., & Albani, S. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401145 · Cited by 106 · see citing works

New Insights on OX40 in the Control of T Cell Immunity and Immune Tolerance In Vivo

Xiao, X., Gong, W., Demirci, G., Liu, W., Spoerl, S., Chu, X., Bishop, D. K., Turka, L. A., & Li, X. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101373 · Cited by 102 · see citing works

Methods to manufacture regulatory T cells for cell therapy

MacDonald, K. N., Piret, J. M., & Levings, M. K. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13297 · Cited by 99 · see citing works

The emerging role of anti‐ CD 25 directed therapies as both immune modulators and targeted agents in cancer

Flynn, M. J., & Hartley, J. A. (2017) · British Journal of Haematology · doi:10.1111/bjh.14770 · Cited by 98 · see citing works

A randomized phase II study to evaluate tacrolimus in combination with sirolimus or methotrexate after allogeneic hematopoietic cell transplantation

Pidala, J., Kim, J., Jim, H., Kharfan‐Dabaja, M. A., Nishihori, T., Fernandez, H. F., Tomblyn, M. R., Perez, L. E., Perkins, J. B., Xu, M., et al. (2012) · Haematologica · doi:10.3324/haematol.2012.067140 · Cited by 98 · see citing works

Multiparameter Flow Cytometry: Advances in High Resolution Analysis

O'Donnell, E. A., Ernst, D. N., & Hingorani, R. (2013) · Immune Network · doi:10.4110/in.2013.13.2.43 · Cited by 95 · see citing works

Mammalian Target of Rapamycin Inhibition and Alloantigen-Specific Regulatory T Cells Synergize To Promote Long-Term Graft Survival in Immunocompetent Recipients

Raimondi, G., Sumpter, T. L., Matta, B. M., Pillai, M., Corbitt, N., Yoram Vodovotz, B., Wang, Z., & Thomson, A. W. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900936 · Cited by 96 · see citing works

Regulatory T cells for tolerance

Kawai, K., Uchiyama, M., Hester, J., Wood, K. J., & Issa, F. (2017) · Human Immunology · doi:10.1016/j.humimm.2017.12.013 · Cited by 95 · see citing works

Future prospects for CD8+ regulatory T cells in immune tolerance

Flippe, L., Bézie, S., Anegón, I., & Guillonneau, C. (2019) · Immunological Reviews · doi:10.1111/imr.12812 · Cited by 94 · see citing works

Graft-versus-host disease prophylaxis: Pathophysiology-based review on current approaches and future directions

Martínez‐Cibrián, N., Zeiser, R., & Pérez‐Simón, J. A. (2020) · Blood Reviews · doi:10.1016/j.blre.2020.100792 · Cited by 93 · see citing works

The Role of Mechanistic Target of Rapamycin (mTOR) Complexes Signaling in the Immune Responses

Soliman, G. A. (2013) · Nutrients · doi:10.3390/nu5062231 · Cited by 93 · see citing works

Low-Dose Rapamycin Treatment Increases the Ability of Human Regulatory T Cells to Inhibit Transplant Arteriosclerosis In Vivo

Hester, J., Șchiopu, A., Nadig, S. N., & Wood, K. J. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2012.04065.x · Cited by 92 · see citing works

The therapeutic potential of regulatory T cells for the treatment of autoimmune disease

Bluestone, J. A., Trotta, E., & Xu, D. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1037282 · Cited by 92 · see citing works

Advances in understanding the pathogenesis of graft‐versus‐host disease

Zeiser, R. (2019) · British Journal of Haematology · doi:10.1111/bjh.16190 · Cited by 91 · see citing works

Induction of tolerance to factor VIII by transient co‐administration with rapamycin

Moghimi, B., Sack, B. K., Nayak, S., Markusic, D. M., Mah, C. S., & Herzog, R. W. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04351.x · Cited by 91 · see citing works

Deficiency of CD73/ecto-5′-nucleotidase in mice enhances acute graft-versus-host disease

Tsukamoto, H., Chernogorova, P., Ayata, C. K., Gerlach, U. V., Rughani, A., Ritchey, J. W., Ganesan, J., Follo, M., Zeiser, R., Thompson, L. F., et al. (2012) · Blood · doi:10.1182/blood-2011-09-375899 · Cited by 91 · see citing works

Third-party CD4+ invariant natural killer T cells protect from murine GVHD lethality

Schneidawind, D., Baker, J. B., Pierini, A., Buechele, C., Luong, R. H., Meyer, E. H., & Negrin, R. S. (2015) · Blood · doi:10.1182/blood-2014-11-612762 · Cited by 91 · see citing works

Induced regulatory T cells in inhibitory microenvironments created by cancer

Whiteside, T. L. (2014) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2014.927432 · Cited by 91 · see citing works

Regulatory T cells and natural killer T cells for modulation of GVHD following allogeneic hematopoietic cell transplantation

Schneidawind, D., Pierini, A., & Negrin, R. S. (2013) · Blood · doi:10.1182/blood-2013-08-453126 · Cited by 88 · see citing works

Pharmacotherapy for uveitis: current management and emerging therapy

Denniston, A. K., Barry, R. J., Nguyen, Q. D., Lee, R., & Murray, P. I. (2014) · Clinical ophthalmology · doi:10.2147/opth.s47778 · Cited by 86 · see citing works

Impact of Mammalian Target of Rapamycin Inhibition on Lymphoid Homing and Tolerogenic Function of Nanoparticle-Labeled Dendritic Cells following Allogeneic Hematopoietic Cell Transplantation

Reichardt, W., Dürr, C., von Elverfeldt, D., Jüttner, E., Gerlach, U. V., Yamada, M., Smith, B., Negrin, R. S., & Zeiser, R. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4770 · Cited by 88 · see citing works

Preclinical models of acute and chronic graft-versus-host disease: how predictive are they for a successful clinical translation?

Zeiser, R., & Blazar, B. R. (2016) · Blood · doi:10.1182/blood-2016-02-699082 · Cited by 84 · see citing works

TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway

Nguyen, K. D., Vanichsarn, C. T., & Nadeau, K. C. (2010) · Allergy Asthma and Clinical Immunology · doi:10.1186/1710-1492-6-4 · Cited by 84 · see citing works

Immune Regulatory Cells in Umbilical Cord Blood and Their Potential Roles in Transplantation Tolerance

Kim, Y.-J., & Broxmeyer, H. (2010) · Critical reviews in oncology/hematology · doi:10.1016/j.critrevonc.2010.07.009 · Cited by 71 · see citing works

Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells

Chen, H. H., Händel, N., Ngeow, J. Y. Y., Muller, J., Hühn, M. H., Yang, H.-T., Heindl, M., Berbers, R.-M., Hegazy, A. N., Kionke, J., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.03.059 · Cited by 75 · see citing works

Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T‐regulatory cells

Ai, W. Z., Hou, J., Zeiser, R., Czerwinski, D. K., Negrin, R. S., & Levy, R. (2008) · International Journal of Cancer · doi:10.1002/ijc.23881 · Cited by 75 · see citing works

Lactic acid bacteria-specific induction of CD4+Foxp3+T cells ameliorates shrimp tropomyosin-induced allergic response in mice via suppression of mTOR signaling

Fu, L., Peng, J., Zhao, S., Zhang, Y., Su, X., & Wang, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-02260-8 · Cited by 75 · see citing works

Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance

Hirai, T., Ramos, T. L., Lin, P., Simonetta, F., Su, L., Picton, L. K., Baker, J. B., Lin, J., Li, P., Seo, K., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci139991 · Cited by 72 · see citing works

Regulatory T Cells (Tregs) and COVID-19: Unveiling the Mechanisms, and Therapeutic Potentialities with a Special Focus on Long COVID

Dhawan, M. K., Rabaan, A. A., Alwarthan, S. M., Alhajri, M. M., Halwani, M. A., Alshengeti, A., Najim, M. A., Alwashmi, A. S. S., Alshehri, A. A., Alshamrani, S., et al. (2023) · Vaccines · doi:10.3390/vaccines11030699 · Cited by 78 · see citing works

Subsets of human CD4 + regulatory T cells express the peripheral homing receptor CXCR3

Hoerning, A., Koss, K. E., Datta, D. B., Boneschansker, L., Jones, C. N., Wong, I. Y., Irimia, D., Calzadilla, K., Benítez, F., Hoyer, P. F., et al. (2011) · European Journal of Immunology · doi:10.1002/eji.201041095 · Cited by 73 · see citing works

Superiority of Rapamycin Over Tacrolimus in Preserving Nonhuman Primate Treg Half-Life and Phenotype After Adoptive Transfer

Singh, K., Stempora, L., Harvey, R. D., Kirk, A. D., Larsen, C. P., Blazar, B. R., & Kean, L. S. (2014) · American Journal of Transplantation · doi:10.1111/ajt.12934 · Cited by 71 · see citing works

Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell-dependent induction of CD4+CD25+FoxP3+ Treg

Biswas, M., Sarkar, D., Kumar, S. R. P., Nayak, S., Rogers, G. L., Markusic, D. M., Liao, G., Terhorst, C., & Herzog, R. W. (2015) · Blood · doi:10.1182/blood-2014-09-599266 · Cited by 70 · see citing works

A TNFR2-Agonist Facilitates High Purity Expansion of Human Low Purity Treg Cells

He, X., Landman, S., Bauland, S. C. G., van den Dolder, J., Koenen, H. J. P. M., & Joosten, I. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156311 · Cited by 69 · see citing works

Stable human regulatory T cells switch to glycolysis following TNF receptor 2 costimulation

de Kivit, S., Mensink, M., Hoekstra, A. T., Berlin, I., Derks, R. J. E., Both, D., Aslam, M. A., Amsen, D., Berkers, C. R., & Borst, J. G. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00271-w · Cited by 68 · see citing works

Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T cells

NAYAK, S., CAO, O., HOFFMAN, B. E., COOPER, M., ZHOU, S., ATKINSON, M. A., & HERZOG, R. W. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03548.x · Cited by 66 · see citing works

Intracellular metabolic pathways control immune tolerance

Procaccini, C., Galgani, M., Rosa, V. D., & Matarese, G. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.09.002 · Cited by 66 · see citing works

A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells

Volta, V., Pérez-Baos, S., de la Parra, C., Katsara, O., Ernlund, A. W., Dornbaum, S., & Schneider, R. J. (2021) · Nature Communications · doi:10.1038/s41467-021-27087-w · Cited by 64 · see citing works

Regulatory T cells: tolerance induction in solid organ transplantation

Vaikunthanathan, T., Safinia, N., Boardman, D. A., Lechler, R. I., & Lombardi, G. (2017) · Clinical & Experimental Immunology · doi:10.1111/cei.12978 · Cited by 64 · see citing works

Impact of mTOR Inhibition on FoxP3+ Regulatory T Cells as Compared to Conventional T Cells after Allogeneic Bone Marrow Transplantation.

Zeiser, R., Leveson-Gower, D. B., Zambricki, E. A., Hou, J., & Negrin, R. S. (2006) · Blood · doi:10.1182/blood.v108.11.448.448 · Cited by 2 · see citing works

39: Differential impact of mTOR inhibition on FoxP3+ regulatory T cells as compared to conventional T cells after allogeneic bone marrow transplantation

Zeiser, R., Leveson-Gower, D. B., Zambricki, E. A., Hou, J., & Negrin, R. S. (2007) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2006.12.042

Differential Responses of Human Regulatory T Cells (Treg) and Effector T Cells to Rapamycin

Strauss, L., Czystowska, M., Szajnik, M. E., Mandapathil, M., & Whiteside, T. L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005994 · Cited by 170 · see citing works

Regulatory T Cells Require Mammalian Target of Rapamycin Signaling To Maintain Both Homeostasis and Alloantigen-Driven Proliferation in Lymphocyte-Replete Mice

Wang, Y., Camirand, G., Lin, Y., Froicu, M., Deng, S.-Y., Shlomchik, W. D., Lakkis, F. G., & Rothstein, D. (2011) · Journal of Immunology · doi:10.4049/jimmunol.0903805 · Cited by 64 · see citing works

Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells.

Shin, H., Baker, J., Leveson-Gower, D., Smith, A. T., Sega, E. I., & Negrin, R. (2011) · Blood · doi:10.1182/blood-2010-10-313684 · Cited by 160 · see citing works