The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Activation phenotype, rather than central– or effector–memory phenotype, predicts the recall efficacy of memory CD8+ T cells
Open accessAbstract
The contributions of different subsets of memory CD8+ T cells to recall responses at mucosal sites of infection are poorly understood. Here, we analyzed the CD8+ T cell recall responses to respiratory virus infection in mice and demonstrate that activation markers, such as CD27 and CD43, define three distinct subpopulations of memory CD8+ T cells that differ in their capacities to mount recall responses. These subpopulations are distinct from effector– and central–memory subsets, coordinately express other markers associated with activation status, including CXCR3, CD127, and killer cell lectin-like receptor G1, and are superior to CD62L in predicting the capacity of memory T cells to mediate recall responses. Furthermore, the capacity of vaccines to elicit these memory T cell subpopulations predicted the efficacy of the recall response. These findings extend our understanding of how recall responses are generated and suggest that activation and migration markers define distinct, and unrelated, characteristics of memory T cells.
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Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846
Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function
Zajac, A. J., Blattman, J. N., Murali-Krishna, K., Sourdive, D. J. D., Suresh, M., Altman, J. D., & Ahmed, R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2205 · Cited by 1,978
Lineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni1009 · Cited by 1,830
Visualizing the generation of memory CD4 T cells in the whole body
Reinhardt, R. L., Khoruts, A., Merica, R., Zell, T., & Jenkins, M. K. (2001) · Nature · doi:10.1038/35065111 · Cited by 1,026
Duration of antiviral immunity after smallpox vaccination
Hammarlund, E., Lewis, M. W., Hansen, S. G., Strelow, L. I., Nelson, J. A., Sexton, G. J., Hanifin, J. M., & Slifka, M. K. (2003) · Nature Medicine · doi:10.1038/nm917 · Cited by 946
Cited by
Gerlach, C., Moseman, E. A., Loughhead, S. M., Alvarez, D., Zwijnenburg, A. J., Waanders, L., Garg, R., de la Torre, J. C., & von Andrian, U. H. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.018 · Cited by 567
Contributions of humoral and cellular immunity to vaccine-induced protection in humans
Amanna, I. J., & Slifka, M. K. (2011) · Virology · doi:10.1016/j.virol.2010.12.016 · Cited by 263
The Loss of TET2 Promotes CD8+ T Cell Memory Differentiation
Carty, S. A., Gohil, M., Banks, L. B., Cotton, R. M., Johnson, M. E., Stelekati, E., Wells, A. D., Wherry, E. J., Koretzky, G. A., & Jordan, M. S. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700559 · Cited by 172
Ng, T. P., Camous, X., Nyunt, M. S. Z., Vasudev, A., Tan, C. T. Y., Feng, L., Fulop, T., Yap, K. B., & Larbi, A. (2015) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2015.5 · Cited by 58
Metadata
- Authors
- Hikono, H., Kohlmeier, J. E., Takamura, S., Wittmer, S. T., Roberts, A. D., & Woodland, D. L.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2007-07-02
- Volume
- 204
- Issue
- 7
- Pages
- 1625-1636
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2165684303
- Cited by
- 316
- References
- 6
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hikono, H., Kohlmeier, J. E., Takamura, S., Wittmer, S. T., Roberts, A. D., & Woodland, D. L. (2007). Activation phenotype, rather than central– or effector–memory phenotype, predicts the recall efficacy of memory CD8+ T cells. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20070322
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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