Markers of t-cell senescence and physical frailty: Insights from singapore longitudinal ageing studies
Open accessAbstract
Abstract Background: Elderly individuals have an eroded immune system but whether immune senescence is implicated with the development of frailty is unknown. The underlying immune mechanisms and the link between markers of senescence and physical frailty is not well established. Methods: We explored the association of specific T-cell subset markers of immune differentiation and senescence on CD4+ and CD8+ cells (CD28−, CD27− and CD57+) and the immune risk profile (inverted CD4/CD8 ratio <1) with physical frailty among 421 participants who were frail (N=32), prefrail (N=187) and robust (N=202) in the Singapore Longitudinal Ageing Study cohort. Results: In ordinal logistic regression models relating tertile category rank scores of immune biomarker with frailty status (robust, prefrail and frail), CD8+CD28−CD27+ (odds ratio (OR)=1.35, P=0.013), CD4+CD28−CD27+ (OR=1.29, P=0.025), CD8+CD28− (OR=1.31, P=0.022), and CD4/CD8 ratio (OR=1.27, P=0.026) were positively associated with frailty, controlling for age, sex and multimorbidity. CD4/CD8 ratio less than one was not associated with frailty (OR=0.84, P=0.64). In stepwise multinomial logistic regression controlling for age, sex and comorbidity, only CD8+CD28−CD27+ was the independent predictor of prefrailty: highest tertile of the immune marker significantly predicted prefrailty (versus low tertile, OR=1.72, P=0.037) and frailty (OR=2.56, P=0.06). Conclusion: The study supports the hypothetical role of immune senescence in physical frailty, particularly in regard to the observed loss of CD28 expression from both CD8+ cells and CD4+ cells, but not for CD27 or CD4/CD8 ratio as a marker of senescence. The potential of CD8+CD28−CD27+ as a biological marker of frailty should be further investigated in prospective studies.
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T-cell senescence is profoundly associated with physical frailty.
“T-cell senescence is profoundly associated with physical frailty [46].”
From Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases (2020) · cites this paper as [46]
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Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases
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“T cells Abnormal glucose homeostasis, insulin resistance, physical frailty [46,89]”
Background
- Authors
- Ng, T. P., Camous, X., Nyunt, M. S. Z., Vasudev, A., Tan, C. T. Y., Feng, L., Fulop, T., Yap, K. B., & Larbi, A.
- Affiliations
- National University of Singapore (SG)
- Agency for Science, Technology and Research (SG)
- Ministry of Health (SG)
- Corresponding author
- Ng, Tze Pin
- ORCID
- Venue
- npj Aging and Mechanisms of Disease
- Published
- 2015-09-28
- Volume
- 1
- Issue
- 1
- Pages
- 15005-15005
- ISSN
- 2056-3973 (ISSN-L)
- PMC
- PMC5514983
- OpenAlex
- W2594837771
- Cited by
- 58
- References
- 39
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 11 · 2023: 2 · 2022: 5 · 2021: 11 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 1 · 2016: 3
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- npj Aging and Mechanisms of Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion, cc-by)
- Funders
- Agency for Science, Technology and Research
- Biomedical Research Council
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- immunosenescence, physical frailty, pre-frailty, T cell senescence, CD28, CD27, CD57, CD4/CD8 ratio, CD4+ T cells, CD8+ T cells, immunological markers, older adults
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