The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand
Open accessAbstract
Mononuclear phagocytes have been attributed a crucial role in the host defense toward influenza virus (IV), but their contribution to influenza-induced lung failure is incompletely understood. We demonstrate for the first time that lung-recruited "exudate" macrophages significantly contribute to alveolar epithelial cell (AEC) apoptosis by the release of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in a murine model of influenza-induced pneumonia. Using CC-chemokine receptor 2-deficient (CCR2(-/-)) mice characterized by defective inflammatory macrophage recruitment, and blocking anti-CCR2 antibodies, we show that exudate macrophage accumulation in the lungs of influenza-infected mice is associated with pronounced AEC apoptosis and increased lung leakage and mortality. Among several proapoptotic mediators analyzed, TRAIL messenger RNA was found to be markedly up-regulated in alveolar exudate macrophages as compared with peripheral blood monocytes. Moreover, among the different alveolar-recruited leukocyte subsets, TRAIL protein was predominantly expressed on macrophages. Finally, abrogation of TRAIL signaling in exudate macrophages resulted in significantly reduced AEC apoptosis, attenuated lung leakage, and increased survival upon IV infection. Collectively, these findings demonstrate a key role for exudate macrophages in the induction of alveolar leakage and mortality in IV pneumonia. Epithelial cell apoptosis induced by TRAIL-expressing macrophages is identified as a major underlying mechanism.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, the strategies for differentiation of resident macrophage subsets in the airways and lung tissues are insufficient to distinguish AMs from lung interstitial macrophages or inflammatory monocytic cells invading the lung in response to infections.”
From Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections (2013) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Serbina, N. V., & Pamer, E. G. (2006) · Nature Immunology · doi:10.1038/ni1309 · Cited by 1,658
Characterization of the reconstructed 1918 Spanish influenza pandemic virus
Tumpey, T. M., Basler, C. F., Aguilar, P. V., Zeng, H., Solórzano, A., Swayne, D. E., Cox, N. J., Katz, J. M., Taubenberger, J. K., Palese, P., et al. (2005) · Science · doi:10.1126/science.1119392 · Cited by 1,327
Tsou, C.-L., Peters, W., Si, Y., Slaymaker, S., Aslanian, A. M., Weisberg, S. P., Mack, M., & Charo, I. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29919 · Cited by 1,152
A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells
Fogg, D. K., Sibon, C., Miled, C., Jung, S., Aucouturier, P., Littman, D. R., Cumano, A., & Geissmann, F. (2005) · Science · doi:10.1126/science.1117729 · Cited by 1,050
Cheung, C., Poon, L., Lau, A., Luk, W., Lau, Y., Shortridge, K., Gordon, S., Guan, Y., & Peiris, J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11772-7 · Cited by 889
Avian Influenza A (H5N1) in 10 Patients in Vietnam
Hien, T. T., Liem, N. T., Dung, N. T., Luong, S. T., Mai, P. P., Châu, N. V. V., Suu, P. T., Dong, V. C., Mai, L. T. Q., Thi, N. T., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040419 · Cited by 854
Kuziel, W. A., Morgan, S. J., Dawson, T. C., Griffin, S., Smithies, O., Ley, K. F., & Maeda, N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.12053 · Cited by 707
Cretney, E., Takeda, K., Yagita∥, H., Glaccum, M. B., Peschon, J. J., & Smyth, M. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.3.1356 · Cited by 615
Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus
Kash, J. C., Tumpey, T. M., Proll, S. C., Carter, V., Perwitasari, O., Thomas, M. J., Basler, C. F., Palese, P., Taubenberger, J. K., García-Sastre, A., et al. (2006) · Nature · doi:10.1038/nature05181 · Cited by 551
Migratory fate and differentiation of blood monocyte subsets
Tacke, F., & Randolph, G. J. (2006) · Immunobiology · doi:10.1016/j.imbio.2006.05.025 · Cited by 528
Flagged first, then by citations
Research works printed but not linked: 3
- 2007, Am. J. Respir. Cell Mol. Biol., 38, 105
- 1997, Am. J. Pathol., 151, 999
- 2006, Nat. Immunol., 7, 311
Cited by
Sorted by citations
Items 201–300 of 377
Maier, B. B., Hladik, A., Lakovits, K., Korosec, A., Martins, R., Kral-Pointner, J. B., Mesteri, I., Strobl, B., Müller, M. M., Kalinke, U., et al. (2016) · European Journal of Immunology · doi:10.1002/eji.201546201 · Cited by 30
Kim, C.-U., Lim, D., Kim, Y. S., Ku, B., & Kim, D. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05749-5 · Cited by 29
Hrincius, E. R., Hennecke, A.-K., Gensler, L., Nordhoff, C., Anhlan, D., Vogel, P., McCullers, J. A., Ludwig, S., & Ehrhardt, C. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.02.029 · Cited by 27
Infection of mice with influenza A/WSN/33 (H1N1) virus alters alveolar type II cell phenotype
Hofer, C. C., Woods, P. S., & Davis, I. C. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00373.2014 · Cited by 28
Wang, J., Li, X., Wang, Y., Li, Y., Shi, F., & Diao, H. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00904-x · Cited by 27
Darvas, K., Rosenberger, S., Brenner, D., Fritsch, C., Gmelin, N., Krammer, P. H., & Rösl, F. (2010) · International Journal of Cancer · doi:10.1002/ijc.25170 · Cited by 27
Mgbemena, V. E., Segovia, J. A., Chang, T.-H., Tsai, S.-Y., Cole, G. T., Hung, C.-Y., & Bose, S. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102742 · Cited by 27
Severe Acute Respiratory Distress Syndrome Secondary to Coronavirus 2 (SARS-CoV-2)
Maveddat, A., Mallah, H., Rao, S., Ali, K., Sherali, S., & NUGENT, K. M. (2020) · The International Journal of Occupational and Environmental Medicine · doi:10.34172/ijoem.2020.2202 · Cited by 26
Mehrbod, P., Ebrahimi, S. N., Fotouhi, F., Eskandari, F., Eloff, J. N., McGaw, L. J., & Fasina, F. O. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2774-3 · Cited by 26
Shin, N., Pyo, C.-W., Jung, K. I., & Choi, S.-Y. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.03.010 · Cited by 26
Cheng, W., Zhao, Y., Wang, S., & Jiang, F. (2014) · Vascular Pharmacology · doi:10.1016/j.vph.2014.10.004 · Cited by 25
ZBP1/DAI-Dependent Cell Death Pathways in Influenza A Virus Immunity and Pathogenesis
Thomas, P. G., Shubina, M., & Balachandran, S. (2019) · Current topics in microbiology and immunology · doi:10.1007/82_2019_190 · Cited by 25
Miniaturized Bronchoscopy Enables Unilateral Investigation, Application, and Sampling in Mice
Dames, C., Akyüz, L., Reppe, K., Tabeling, C., Dietert, K., Kershaw, O., Gruber, A. D., Meisel, C., Meisel, A., Witzenrath, M., et al. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0052ma · Cited by 25
Brazee, P. L., Morales‐Nebreda, L., Magnani, N., Garcia, J. G. N., Misharin, A. V., Ridge, K. M., Budinger, G. R. S., Iwaï, K., Dada, L. A., & Sznajder, J. I. (2019) · Journal of Clinical Investigation · doi:10.1172/jci128368 · Cited by 22
Jia, S. H., Parodo, J. C., Charbonney, E., Tsang, J. L. Y., Jia, S. Y., Rotstein, O. D., Kapùs, A., & Marshall, J. C. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.12.031 · Cited by 23
Sundarasivarao, P. Y. K., Walker, J. M., Rodrı́guez, A. R., Spur, B. W., & Yin, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1011944 · Cited by 23
TRAIL signaling is proinflammatory and proviral in a murine model of rhinovirus 1B infection
Girkin, J. L. N., Hatchwell, L., Collison, A., Starkey, M. R., Hansbro, P. M., Yagita∥, H., Foster, P. S., & Mattes, J. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00200.2016 · Cited by 22
Wolf, A. I., Strauman, M. C., Mozdzanowska, K., Williams, K. L., Osborne, L. C., Shen, H., Liu, Q., Garlick, D., Artis, D., Hensley, S. E., et al. (2014) · Virology · doi:10.1016/j.virol.2014.06.019 · Cited by 22
Huang, N., Singh, N., Yoon, K. J., Loiacono, C. M., Kohut, M. L., & Birt, D. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076491 · Cited by 21
Inflammatory and pathological changes in Escherichia coli infected mice
Long, N.-N., Deng, J., Qiu, M., Zhang, Y., Wang, Y., Guo, W., Dai, M., & Lin, L. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e12533 · Cited by 23
Preuß, S., Scheiermann, J., Stadelmann, S., Omam, F. D., Winoto‐Morbach, S., Lex, D., von Bismarck, P., Adam‐Klages, S., Knerlich‐Lukoschus, F., Wesch, D., et al. (2013) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2013.10.002 · Cited by 21
Natural Killer Cells Regulate Murine Cytomegalovirus-Induced Sialadenitis and Salivary Gland Disease
Carroll, V., Lundgren, A., Wei, H., Sainz, S., Tung, K. S. K., & Brown, M. G. (2011) · Journal of Virology · doi:10.1128/jvi.06898-11 · Cited by 21
Ordija, C. M., Chiou, T. T.-Y., Yang, Z., DeLoid, G. M., Valdo, M. D. O., Wang, Z., Bedugnis, A. S., Noah, T. L., Jones, S., Koziel, H., et al. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00067.2017 · Cited by 24
Lipopolysaccharide‐induced expression of TRAIL promotes dendritic cell differentiation
Cho, Y. S., Challa, S., Clancy, L., & Chan, F. K. ‐. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03266.x · Cited by 23
Klonoski, J. M., Hurtig, H. R., Juber, B. A., Schuneman, M. J., Bickett, T. E., Svendsen, J. M., Burum, B., Penfound, T. A., Sereda, G. A., Dale, J. B., et al. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.06.093 · Cited by 20
Alveolar Macrophages in Viral Respiratory Infections: Sentinels and Saboteurs of Lung Defense
Pöpperl, P., Stoff, M., & Beineke, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26010407 · Cited by 21
Immune function and dysfunction are determined by lymphoid tissue efficacy
Makris, S., de Winde, C. M., Horsnell, H. L., Cantoral-Rebordinos, J. A., Finlay, R. E., & Acton, S. E. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049256 · Cited by 20
Alshammary, A. F., & Alsulaiman, A. M. (2021) · Virulence · doi:10.1080/21505594.2021.1929800 · Cited by 18
TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity
Jackson, W. D., Giacomassi, C., Ward, S., Owen, A., Luis, T. C., Spear, S., Woollard, K. J., Johansson, C., Strid, J., & Botto, M. (2023) · eLife · doi:10.7554/elife.85647 · Cited by 19
The role of alveolar macrophages in viral respiratory infections and their therapeutic implications
Javaherdehi, A. P., Ghanbari, S., Mahdavi, P., Zafarani, A., & Razizadeh, M. H. (2024) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2024.101826 · Cited by 18
TRAIL-Deficient Mice Exhibit Delayed Regression of Retinal Neovascularization
Hubert, K. E., Davies, M. H., Stempel, A. J., Griffith, T. S., & Powers, M. R. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090099 · Cited by 18
Response Modifiers: Tweaking the Immune Response Against Influenza A Virus
Elbahesh, H., Gerlach, T. H., Saletti, G., & Rimmelzwaan, G. F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00809 · Cited by 18
Lee, J. K., Kim, J.-A., Oh, S. J., Lee, E., & Shin, O. S. (2020) · Cells · doi:10.3390/cells9112487 · Cited by 19
Critical Role of Lkb1 in the Maintenance of Alveolar Macrophage Self-Renewal and Immune Homeostasis
Wang, Q., Chen, S., Li, T., Yang, Q., Liu, J., Yuan, T., Yuan, M., Chen, J., Feng, X., Han, Z., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.629281 · Cited by 17
CHARACTERISTICS AND ROLE OF MACROPHAGES IN PATHOGENESIS OF ACUTE AND CHRONIC LUNG DISEASES
Nikonova, A. A., Khaitov, M. R., & Khaitov, R. M. (2017) · Medical Immunology (Russia) · doi:10.15789/1563-0625-2017-6-657-672 · Cited by 17
Downey, J., Randolph, H. E., Pernet, E., Tran, K. A., Khader, S. A., King, I. L., Barreiro, L. B., & Divangahi, M. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110974 · Cited by 15
Wilder, C. L., Lefaudeux, D., Mathenge, R., Kishimoto, K., Munoz, A. Z., Nguyen, M. A., Meyer, A. S., Cheng, Q. J., & Hoffmann, A. (2023) · Molecular Systems Biology · doi:10.15252/msb.202211294 · Cited by 20
Cytokine storm and translating IL-6 biology into effective treatments for COVID-19
Li, T., Wang, D., Wei, H., & Xu, X. (2023) · Frontiers of Medicine · doi:10.1007/s11684-023-1044-4 · Cited by 16
Miyake, T., Soda, K., Itoh, Y., Sakoda, Y., Ishigaki, H., Nagata, T., Ishida, H., Nakayama, M., Ozaki, H., Tsuchiya, H., et al. (2009) · Journal of Medical Primatology · doi:10.1111/j.1600-0684.2009.00395.x · Cited by 16
Broadbent, A., Boonnak, K., & Subbarao, K. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-415847-4.00059-8 · Cited by 18
Chen, L., Chen, H., Dong, S., Huang, W., Chen, L., Wei, Y., Shi, L., Li, J., Zhu, F., Zhu, Z., et al. (2020) · Function · doi:10.1093/function/zqaa012 · Cited by 16
TRAIL protects the immature lung from hyperoxic injury
Shahzad, T., Chao, C., Hadžić, S., Behnke, J., Biebach, L., Böttcher‐Friebertshäuser, E., Wilhelm, J., Hilgendorff, A., Zimmer, K., Morty, R. E., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05072-5 · Cited by 15
EMAPII Monoclonal Antibody Ameliorates Influenza A Virus-Induced Lung Injury
Lu, H., Chelvanambi, S., Poirier, C., Saliba, J., March, K. L., Clauss, M. A., & Bogatcheva, N. V. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.05.017 · Cited by 15
RGS10 Reduces Lethal Influenza Infection and Associated Lung Inflammation in Mice
Almutairi, F., Sarr, D., Tucker, S. L., Fantone, K. M., Lee, J., & Rada, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.772288 · Cited by 14
The Interplay Between Innate Immunity and Nonimmune Cells in Lung Damage, Inflammation, and Repair
Iliakis, C. S., Crotta, S., & Wack, A. (2025) · Annual Review of Immunology · doi:10.1146/annurev-immunol-082323-031852 · Cited by 16
Huckestein, B. R., Zeng, K., Westcott, R., Alder, J. K., Antos, D., Kolls, J. K., & Alcorn, J. F. (2023) · American Journal Of Pathology · doi:10.1016/j.ajpath.2023.11.017 · Cited by 14
Hook, J. L., & Bhattacharya, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1328453 · Cited by 18
Kebaabetswe, L. P., Haick, A. K., & Miura, T. A. (2013) · Virus Research · doi:10.1016/j.virusres.2013.04.008 · Cited by 14
Influenza leaves a TRAIL to pulmonary edema
Brauer, R., & Chen, P. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86802 · Cited by 14
Thermostable Subunit Vaccines for Pulmonary Delivery: How Close Are We?
Foged, C. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160202141603 · Cited by 14
NMP4 regulates the innate immune response to influenza A virus infection
Yang, S., Adaway, M., Du, J., Huang, S., Sun, J., Bidwell, J. P., & Zhou, B. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0280-z · Cited by 14
Harpur, C. M., Page, M. A. L., & Tate, M. D. (2021) · Virulence · doi:10.1080/21505594.2021.1939608 · Cited by 16
Kulshrestha, R., Dhanda, H., Pandey, A., Singh, A. K., & Kumar, R. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2020.1776117 · Cited by 15
Apoptosis in Pneumovirus Infection
den Berg, E. V., van Woensel, J. B. M., & Reinout, A. (2013) · Viruses · doi:10.3390/v5010406 · Cited by 14
Osteopontin Exacerbates Pulmonary Damage in Influenza-Induced Lung Injury
Zhu, Y., Wei, Y., Chen, J., Cui, G., Ding, Y., Kohanawa, M., Xu, X., & Diao, H. (2015) · Japanese Journal of Infectious Diseases · doi:10.7883/yoken.jjid.2014.467 · Cited by 14
Influenza Virus in Community-Acquired Pneumonia: Current Understanding and Knowledge Gaps
Xu, J., Yu, J., Yang, L., Zhou, F., Li, H., & Cao, B. (2020) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0040-1710584 · Cited by 13
Role of Autophagy and Apoptosis in the Postinfluenza Bacterial Pneumonia
Qin, Z., Yang, Y., Wang, H., Luo, J., Huang, X., You, J., Wang, B., & Li, M. (2016) · BioMed Research International · doi:10.1155/2016/3801026 · Cited by 13
Using evasins to target the chemokine network in inflammation
Bhattacharya, S., & Kawamura, A. (2019) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2019.09.003 · Cited by 13
Lung cell fates during influenza
Jarboe, B., Shubina, M., Langlois, R. A., Boyd, D. F., & Balachandran, S. (2025) · Cell Research · doi:10.1038/s41422-025-01163-y · Cited by 15
Hua, D.-X., Ma, K.-S., Cheng, J., Liu, Y., Sun, J., He, Q.-Y., Deng, Y.-P., Yang, J., Fu, L., & Zhao, H. (2022) · Internal and Emergency Medicine · doi:10.1007/s11739-022-03086-7 · Cited by 12
Soloff, A. C., Weirback, H. K., Ross, T. M., & Barratt‐Boyes, S. M. (2012) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2012.01.012 · Cited by 12
Fischer, K. J., Yajjala, V. K., Bansal, S., Bauer, C. D., Chen, R., & Sun, K. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801471 · Cited by 12
Aromatic amino acid metabolites alter interferon signaling and influenza pathogenesis
Anand, G., Clark-Dinovo, C., Perry, A. M., Goodwin, V. M., Raymond, E. S., Sakleshpur, S., & Steed, A. L. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1232573 · Cited by 12
Lee, A. J., Feng, E., Chew, M. V., Balint, E., Poznanski, S. M., Giles, E. C., Zhang, A., Marzok, A., Revill, S. D., Vahedi, F., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010471 · Cited by 11
Wei, L., Wang, X., & Zhou, H. (2023) · Immunity Inflammation and Disease · doi:10.1002/iid3.997 · Cited by 11
TRAIL (CD253) Sensitizes Human Airway Epithelial Cells to Toxin-Induced Cell Death
Rong, Y., Doering, J., Ehrbar, D. J., LaRocca, T. J., & Mantis, N. J. (2018) · mSphere · doi:10.1128/msphere.00399-18 · Cited by 11
Lafferty, E. I., Flaczyk, A., Angers, I., Homer, R., d'Hennezel, E. B., Malo, D., Piccirillo, C. A., Vidal, S. M., & Qureshi, S. T. (2014) · Genes and Immunity · doi:10.1038/gene.2014.22 · Cited by 12
The caspase inhibitor zVAD increases lung inflammation in pneumovirus infection in mice
van den Berg, E., Bal, S. M., Kuipers, M. T., Matute‐Bello, G., Lutter, R., Bos, A. P., van Woensel, J. B. M., & Reinout, A. (2015) · Physiological Reports · doi:10.14814/phy2.12332 · Cited by 11
University of Veterinary Medicine Hannover
Komm, K. (2010) · Cited by 11
Closely Related Influenza Viruses Induce Contrasting Respiratory Tract Immunopathology
Le, V. L., Courtney, C. L., Steel, J., & Compans, R. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076708 · Cited by 9
Melnichuk, N., Kashuba, V. I., Рыбалко, С. Л., & Tkachuk, Z. Y. (2018) · Pharmaceuticals · doi:10.3390/ph11030073 · Cited by 10
Sagulkoo, P., Suratanee, A., & Plaimas, K. (2022) · Biomolecules · doi:10.3390/biom12050690 · Cited by 9
Chaemsaithong, P., Romero, R. J., Korzeniewski, S. J., Schwartz, A. G., Stampalija, T., Dong, Z., Yeo, L., Hernandez‐Andrade, E. A., Hassan, S. S., & Chaiworapongsa, T. (2013) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2013.783811 · Cited by 10
Correction: A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection
Maelfait, J., Roose, K., Bogaert, P., Sze, M., Saelens, X., Pasparakis, M., Carpentier, I., Loo, G., & Beyaert, R. (2012) · PLoS Pathogens · doi:10.1371/annotation/a2136b9a-3cbf-426f-9cfb-73e3c9c6396d · Cited by 10
Anti-CCL2 therapy reduces oxygen toxicity to the immature lung
Shahzad, T., Dong, Y., Behnke, N. K., Brandner, J., Hilgendorff, A., Chao, C., Behnke, J., Bellusci, S., & Ehrhardt, H. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02073-5 · Cited by 9
Owen, A., Farias, A., Levins, A.-M., Wang, Z., Higham, S. L., Mack, M., Tregoning, J. S., & Johansson, C. (2024) · Mucosal Immunology · doi:10.1016/j.mucimm.2024.08.002 · Cited by 9
The intersection of influenza infection and autoimmunity
Xie, S., Wei, J., & Wang, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1558386 · Cited by 10
Myeloid Protease-Activated Receptor-2 Contributes to Influenza A Virus Pathology in Mice
Gunther, R., Bharathi, V., Miles, S. D., Tumey, L., Schmedes, C. M., Tatsumi, K., Bridges, M. D., Martinez, D. R., Montgomery, S. A., Beck, M. A., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.791017 · Cited by 9
Paradoxical immunodeficiencies—When failures of innate immunity cause immunopathology
Kolter, J., Henneke, P., Groß, O., Kierdorf, K., Prinz, M., Graf, L., & Schwemmle, M. (2022) · European Journal of Immunology · doi:10.1002/eji.202149531 · Cited by 9
Complement Decay-Accelerating Factor is a modulator of influenza A virus lung immunopathology
Santos, N. B., da Silva, Z. E. V., Gomes, C., Reis, C. A., & Amorim, M. J. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009381 · Cited by 9
CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infectionPreprint
Vanderheiden, A., Thomas, J. K., Soung, A., Davis-Gardner, M. E., Floyd, K. A., Jin, F., Cowan, D. A., Pellegrini, K. L., Creanga, A., Pegu, A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.03.442538 · Cited by 9
In vitro anti-influenza assessment of anionic compounds ascorbate, acetate and citrate
Shokouhi, H., Mehrbod, P., Fotouhi, F., & Amininasab, M. (2022) · Virology Journal · doi:10.1186/s12985-022-01823-0 · Cited by 8
Coronary Implications of COVID-19
Triantafyllis, A. S., Sfantou, D., Karapedi, E., Peteinaki, K., Kotoulas, S. C., Saad, R., Fountoulakis, P. N., Tsamakis, K., Tsiptsios, D., Rallidis, L. S., et al. (2024) · Medical Principles and Practice · doi:10.1159/000541553 · Cited by 8
Differential ER stress as a driver of cell fate following ricin toxin exposure
Peterson‐Reynolds, C., & Mantis, N. J. (2021) · FASEB BioAdvances · doi:10.1096/fba.2021-00005 · Cited by 8
Vidaña, B., Martínez, J., Martorell, J., Montoya, M., Córdoba, L., Pérez, M., & Majó, N. (2016) · Veterinary Research · doi:10.1186/s13567-016-0395-0 · Cited by 9
Endothelial activation and dysfunction caused by influenza A virus (Alphainfluenzavirus influenzae)
Marchenko, V. A., & Zhilinskaya, I. N. (2024) · Problems of Virology · doi:10.36233/0507-4088-264 · Cited by 7
Kobayashi, K., Umezawa, K., & Yasui, M. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.087577 · Cited by 7
TRAIL-R3/R4 and Inhibition of TRAIL Signalling in Cancer
Danish, L., Stöhr, D., Scheurich, P., & Pollak, N. (2017) · Resistance to targeted anti-cancer therapeutics · doi:10.1007/978-3-319-56805-8_2 · Cited by 7
Wilkinson, J. M., Gunvaldsen, R. E., Detmer, S. E., Dyck, M. K., Dixon, W. T., Foxcroft, G. R., Plastow, G. S., & Harding, J. C. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138653 · Cited by 7
Xin, Y., Chen, S., Tang, K., Wu, Y., & Guo, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042372 · Cited by 8
Hao, Q., Kundu, S., Shetty, S., Tucker, T. A., Idell, S., & Tang, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1011922 · Cited by 6
Gu, Y., Hsu, A., Zuo, X., Guo, X., Zhou, Z., Jiang, S., Ouyang, Z., & Wang, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1119473 · Cited by 6
Surman, S. L., Brown, S. A., Jones, B. G., Woodland, D. L., & Hurwitz, J. L. (2010) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2009.0266 · Cited by 6
PR8 virus harbouring H5N1 NS gene contributed for THP-1 cell tropism
Lamichhane, P. P., & Puthavathana, P. (2018) · VirusDisease · doi:10.1007/s13337-018-0499-4 · Cited by 6
IRE1 Signaling As a Putative Therapeutic Target in Influenza Virus–induced Pneumonia
Schmoldt, C., Vazquez‐Armendariz, A. I., Shalashova, I., Selvakumar, B., Bremer, C. M., Peteranderl, C., Wasnick, R. M., Witte, B., Gattenlöhner, S., Fink, L., et al. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0123le · Cited by 6
Yang, H., Yang, D., Zhou, Y., & Li, H. (2021) · Acta Biochimica Polonica · doi:10.18388/abp.2020_5523 · Cited by 6
Acute Respiratory Distress Syndrome
Zemans, R. L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803809-3.00010-5 · Cited by 6
Taye, B., Chen, H., Myaing, M. Z., Tan, B. H., Maurer‐Stroh, S., & Sugrue, R. J. (2017) · BMC Genomics · doi:10.1186/s12864-017-3803-6 · Cited by 6
Malainou, C., Peteranderl, C., Ferrero, M. R., Vazquez‐Armendariz, A. I., Alexopoulos, I., Franz, K., Knippenberg, K., Better, J., Estiri, M., Wu, C., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci185390 · Cited by 5
Eicosanoids Signals in SARS-CoV-2 Infection: A Foe or Friend
Rahman, M. S., & Hossain, M. S. (2023) · Molecular Biotechnology · doi:10.1007/s12033-023-00919-4 · Cited by 5
Metadata
- Authors
- Herold, S., Steinmueller, M., von Wulffen, W., Cakarova, L., Pinto, R., Pleschka, S., Mack, M., Kuziel, W. A., Corazza, N., Brunner, T., Seeger, W., & Lohmeyer, J.
- Affiliations
- Justus-Liebig-Universität Gießen (DE)
- 1University of Giessen Lung Center, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Infectious Diseases,
- University of Regensburg (DE)
- 4PDL BioPharma Inc., Redwood City, CA 94063
- University of Bern (CH)
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2008-12-08
- Volume
- 205
- Issue
- 13
- Pages
- 3065-3077
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2605231
- OpenAlex
- W2105053798
- Cited by
- 376
- References
- 44
- Citations by year
- 2026: 3 · 2025: 19 · 2024: 16 · 2023: 17 · 2022: 26 · 2021: 32 · 2020: 32 · 2019: 16 · 2018: 21 · 2017: 21 · 2016: 23 · 2015: 20 · 2014: 21 · 2013: 21 · 2012: 22
- FWCI
- 15.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- KOPS (University of Konstanz) (submittedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- influenza virus pneumonia, alveolar epithelial cell apoptosis, TRAIL, tumor necrosis factor-related apoptosis-inducing ligand, CCR2, macrophage recruitment, respiratory failure, host defense
- MeSH terms
- Animals, Bronchoalveolar Lavage Fluid, Chimera, Humans, Influenza, Human, Leukocytes, Mononuclear, Lung, Macrophages, Mice, Inbred C57BL, Orthomyxoviridae, Phagocytes, Pneumonia, Apoptosis, Mice, Knockout, Respiratory Mucosa, Apoptosis Regulatory Proteins, Mice, TNF-Related Apoptosis-Inducing Ligand, Receptors, CCR2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review