Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand

Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2

Serbina, N. V., & Pamer, E. G. (2006) · Nature Immunology · doi:10.1038/ni1309 · Cited by 1,658

Characterization of the reconstructed 1918 Spanish influenza pandemic virus

Tumpey, T. M., Basler, C. F., Aguilar, P. V., Zeng, H., Solórzano, A., Swayne, D. E., Cox, N. J., Katz, J. M., Taubenberger, J. K., Palese, P., et al. (2005) · Science · doi:10.1126/science.1119392 · Cited by 1,327

Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites

Tsou, C.-L., Peters, W., Si, Y., Slaymaker, S., Aslanian, A. M., Weisberg, S. P., Mack, M., & Charo, I. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29919 · Cited by 1,152

A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells

Fogg, D. K., Sibon, C., Miled, C., Jung, S., Aucouturier, P., Littman, D. R., Cumano, A., & Geissmann, F. (2005) · Science · doi:10.1126/science.1117729 · Cited by 1,050

Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?

Cheung, C., Poon, L., Lau, A., Luk, W., Lau, Y., Shortridge, K., Gordon, S., Guan, Y., & Peiris, J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11772-7 · Cited by 889

Avian Influenza A (H5N1) in 10 Patients in Vietnam

Hien, T. T., Liem, N. T., Dung, N. T., Luong, S. T., Mai, P. P., Châu, N. V. V., Suu, P. T., Dong, V. C., Mai, L. T. Q., Thi, N. T., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040419 · Cited by 854

Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2

Kuziel, W. A., Morgan, S. J., Dawson, T. C., Griffin, S., Smithies, O., Ley, K. F., & Maeda, N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.12053 · Cited by 707

Increased Susceptibility to Tumor Initiation and Metastasis in TNF-Related Apoptosis-Inducing Ligand-Deficient Mice

Cretney, E., Takeda, K., Yagita∥, H., Glaccum, M. B., Peschon, J. J., & Smyth, M. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.3.1356 · Cited by 615

Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus

Kash, J. C., Tumpey, T. M., Proll, S. C., Carter, V., Perwitasari, O., Thomas, M. J., Basler, C. F., Palese, P., Taubenberger, J. K., García-Sastre, A., et al. (2006) · Nature · doi:10.1038/nature05181 · Cited by 551

Migratory fate and differentiation of blood monocyte subsets

Tacke, F., & Randolph, G. J. (2006) · Immunobiology · doi:10.1016/j.imbio.2006.05.025 · Cited by 528

Type I interferons in infectious disease

McNab, F., Mayer-Barber, K., Sher, A., Wack, A., & O'Garra, A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3787 · Cited by 2,780

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

Ye, Q., Wang, B., & Mao, J. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.03.037 · Cited by 2,761

Pathogenic human coronavirus infections: Causes and consequences of cytokine storm and immunopathology

Channappanavar, R., & Perlman, S. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0629-x · Cited by 2,524

Alveolar macrophages: plasticity in a tissue-specific context

Hussell, T., & Bell, T. J. (2014) · Nature Reviews Immunology · doi:10.1038/nri3600 · Cited by 1,377

Influenza A viruses: new research developments

Medina, R., & García‐Sastre, A. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2613 · Cited by 699

Macrophages: Their role, activation and polarization in pulmonary diseases

Arora, S., Dev, K., Agarwal, B., Das, P., & Syed, M. A. (2017) · Immunobiology · doi:10.1016/j.imbio.2017.11.001 · Cited by 653

Pathogenesis of influenza-induced acute respiratory distress syndrome

Short, K. R., Kroeze, E. J. B. V., Fouchier, R. A. M., & Kuiken, T. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70286-x · Cited by 556

Influenza virus-induced lung injury: pathogenesis and implications for treatment

Herold, S., Becker, C., Ridge, K. M., & Budinger, G. R. S. (2015) · European Respiratory Journal · doi:10.1183/09031936.00186214 · Cited by 517

TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection

Aldridge, J. R., Moseley, C. E., Boltz, D. A., Negovetich, N. J., Reynolds, C., Franks, J., Brown, S. A., Doherty, P. C., Webster, R. G., & Thomas, P. G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900655106 · Cited by 436

Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections

Ghoneim, H. E., Thomas, P. G., & McCullers, J. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300014 · Cited by 394

Pathogenic potential of interferon αβ in acute influenza infection

Davidson, S., Crotta, S., McCabe, T. M., & Wack, A. (2014) · Nature Communications · doi:10.1038/ncomms4864 · Cited by 386

A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues

Yu, Y.-R., O’Koren, E. G., Hotten, D. F., Kan, M. J., Kopin, D., Nelson, E. R., Que, L., & Gunn, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150606 · Cited by 343

Regulating the adaptive immune response to respiratory virus infection

Braciale, T. J., Sun, J., & Kim, T. S. (2012) · Nature reviews. Immunology · doi:10.1038/nri3166 · Cited by 374

Critical Role of IL-17RA in Immunopathology of Influenza Infection

Crowe, C. R., Chen, K., Pociask, D. A., Alcorn, J. F., Krivich, C., Enelow, R. I., Ross, T. M., Witztum, J. L., & Kolls, J. K. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900995 · Cited by 353

Acute Lung Injury: How Macrophages Orchestrate Resolution of Inflammation and Tissue Repair

Herold, S., Mayer, K., & Lohmeyer, J. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00065 · Cited by 344

Pulmonary Macrophage Subpopulations in the Induction and Resolution of Acute Lung Injury

Johnston, L. K., Rims, C. R., Gill, S. E., McGuire, J. K., & Manicone, A. M. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0090oc · Cited by 329

Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12

Teng, Y., Xu, F., Zhang, X., Mu, J., Sayed, M. E., Hu, X., Lei, C., Sriwastva, M. K., Kumar, A., Sundaram, K., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.05.005 · Cited by 290

Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report

Kulkarni, H. S., Lee, J. S., Bastarache, J. A., Kuebler, W. M., Downey, G. P., Albaiceta, G. M., Altemeier, W. A., Artigas, A., Bates, J. H. T., Calfee, C. S., et al. (2022) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2021-0531st · Cited by 289

The pathogenesis of influenza virus infections: the contributions of virus and host factors

Fukuyama, S., & Kawaoka, Y. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.07.016 · Cited by 295

Alveolar macrophage–derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes

Goritzka, M., Makris, S., Kausar, F., Durant, L. R., Pereira, C., Kumagai, Y., Culley, F. J., Mack, M., Akira, S., & Johansson, C. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20140825 · Cited by 288

Host-Directed Antiviral Therapy

Kumar, N., Sharma, S., Kumar, R., Tripathi, B. N., Barua, S., Ly, H., & Rouse, B. T. (2020) · Clinical Microbiology Reviews · doi:10.1128/cmr.00168-19 · Cited by 289

Human Influenza Virus Infections

Peteranderl, C., Schmoldt, C., & Herold, S. (2016) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0036-1584801 · Cited by 277

Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions

Short, K. R., Kasper, J. Y., van der Aa, S., Andeweg, A. C., Zaaraoui‐Boutahar, F., Goeijenbier, M., Richard, M., Herold, S., Becker, C., Scott, D. P., et al. (2016) · European Respiratory Journal · doi:10.1183/13993003.01282-2015 · Cited by 272

Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy

Lechner, A. J., Driver, I. H., Lee, J., Conroy, C., Nagle, A., Locksley, R. M., & Rock, J. R. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.03.024 · Cited by 261

Modeling Within-Host Dynamics of Influenza Virus Infection Including Immune Responses

Pawelek, K. A., Huynh, G. T., Quinlivan, M., Cullinane, A., Rong, L., & Perelson, A. S. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002588 · Cited by 240

Protective and Harmful Immunity to RSV Infection

Openshaw, P., Chiu, C., Culley, F. J., & Johansson, C. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052206 · Cited by 252

New insights into the mechanisms of pulmonary edema in acute lung injury

Herrero, R., Sánchez, G., & Lorente, J. A. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2017.12.18 · Cited by 244

Inhibition of Nox2 Oxidase Activity Ameliorates Influenza A Virus-Induced Lung Inflammation

Vlahos, R., Stambas, J., Bozinovski, S., Broughton, B. R. S., Drummond, G. R., & Selemidis, S. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001271 · Cited by 240

The Mechanism behind Influenza Virus Cytokine Storm

Gu, Y., Zuo, X., Zhang, S., Ouyang, Z., Jiang, S., Wang, F., & Wang, G. (2021) · Viruses · doi:10.3390/v13071362 · Cited by 241

Macrophage-expressed IFN-β Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia

Högner, K., Wolff, T., Pleschka, S., Plog, S., Gruber, A. D., Kalinke, U., Walmrath, H., Bodner, J., Gattenlöhner, S., Lewe-Schlosser, P., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003188 · Cited by 237

Critical Role of Airway Macrophages in Modulating Disease Severity during Influenza Virus Infection of Mice

Tate, M. D., Pickett, D. L., van Rooijen, N., Brööks, A. G., & Reading, P. C. (2010) · Journal of Virology · doi:10.1128/jvi.00291-10 · Cited by 240

Diversity of Macrophages in Lung Homeostasis and Diseases

Hou, F., Xiao, K., Tang, L., & Xie, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.753940 · Cited by 226

Type I Interferon Signaling Regulates Ly6Chi Monocytes and Neutrophils during Acute Viral Pneumonia in Mice

Seo, S., Kwon, H.-J., Ko, H.-J., Byun, Y.-H., Seong, B. L., Uematsu, S., Akira, S., & Kweon, M. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001304 · Cited by 213

Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting

Malainou, C., Abdin, S. M., Lachmann, N., Matt, U., & Herold, S. (2023) · Journal of Clinical Investigation · doi:10.1172/jci170501 · Cited by 215

Disease-Promoting Effects of Type I Interferons in Viral, Bacterial, and Coinfections

Davidson, S., Maini, M. K., & Wack, A. (2015) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2014.0227 · Cited by 201

DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway

Tsai, S.-Y., Segovia, J. A., Chang, T.-H., Morris, I. R., Berton, M. T., Tessier, P. A., Tardif, M. R., Césaro, A., & Bose, S. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003848 · Cited by 198

ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death

Kesavardhana, S., Kuriakose, T., Guy, C. S., Samir, P., Malireddi, R. K. S., Mishra, A., & Kanneganti, T. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170550 · Cited by 195

Therapeutic targeting of acute lung injury and acute respiratory distress syndrome

Standiford, T. J., & Ward, P. A. (2015) · Translational research · doi:10.1016/j.trsl.2015.04.015 · Cited by 184

Comparative Immunology, Microbiology and Infectious Diseases

Soloff, A. C., Weirback, H. K., Ross, T. M., & Barratt‐Boyes, S. M. (2012) · Cited by 176

Innate immune control and regulation of influenza virus infections

McGill, J. L., Heusel, J. W., & Legge, K. L. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0509368 · Cited by 171

Interleukin‐6 limits influenza‐induced inflammation and protects against fatal lung pathology

Lauder, S. N., Jones, E., Smart, K., Bloom, A. C., Williams, A. S., Hindley, J. P., Ondondo, B., Taylor, P. R., Clement, M., Fielding, C. A., et al. (2013) · European Journal of Immunology · doi:10.1002/eji.201243018 · Cited by 175

Cellular Inhibitor of Apoptosis Protein cIAP2 Protects against Pulmonary Tissue Necrosis during Influenza Virus Infection to Promote Host Survival

Rodrigue‐Gervais, I. G., Labbè, K., Dagenais, M., Dupaul-Chicoine, J., Champagne, C., Morizot, A., Skeldon, A. M., Brincks, E. L., Vidal, S. M., Griffith, T. S., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2013.12.003 · Cited by 161

The Pathology and Pathogenesis of Experimental Severe Acute Respiratory Syndrome and Influenza in Animal Models

van den Brand, J. M. A., Haagmans, B. L., van Riel, D. A. J., Osterhaus, A. D. M. E., & Kuiken, T. (2014) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2014.01.004 · Cited by 161

Airway macrophages as the guardians of tissue repair in the lung

Puttur, F. K., Gregory, L. G., & Lloyd, C. M. (2019) · Immunology and Cell Biology · doi:10.1111/imcb.12235 · Cited by 167

Type I Interferons as Regulators of Lung Inflammation

Makris, S., Paulsen, M. T., & Johansson, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00259 · Cited by 166

STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury

Paris, A. J., Hayer, K. E., Oved, J. H., Avgousti, D. C., Toulmin, S. A., Zepp, J. A., Zacharias, W. J., Katzen, J. B., Basil, M. C., Kremp, M. M., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0569-x · Cited by 149

PB1-F2 Expression by the 2009 Pandemic H1N1 Influenza Virus Has Minimal Impact on Virulence in Animal Models

Hai, R., Schmolke, M., Varga, Z. T., Manicassamy, B., Wang, T. T., Belser, J. A., Pearce, M. B., García‐Sastre, A., Tumpey, T. M., & Palese, P. (2010) · Journal of Virology · doi:10.1128/jvi.02717-09 · Cited by 144

Mechanisms of ATII-to-ATI Cell Differentiation during Lung Regeneration

Aspal, M., & Zemans, R. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093188 · Cited by 147

Inhibition of influenza virus-induced NF-kappaB and Raf/MEK/ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo

Pinto, R., Herold, S., Cakarova, L., Högner, K., Lohmeyer, J., Planz, O., & Pleschka, S. (2011) · Antiviral Research · doi:10.1016/j.antiviral.2011.05.009 · Cited by 140

Eicosanoids

Hammock, B. D., Wang, W., Gilligan, M. M., & Panigrahy, D. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.06.010 · Cited by 144

The induction and consequences of Influenza A virus-induced cell death

Atkin‐Smith, G. K., Duan, M., Chen, W., & Poon, I. K. H. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1035-6 · Cited by 141

Distinct Macrophage Subpopulations Characterize Acute Infection and Chronic Inflammatory Lung Disease

Duan, M., Li, W. C., Vlahos, R., Maxwell, M. J., Anderson, G. P., & Hibbs, M. L. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200660 · Cited by 133

Macrophage Tumor Necrosis Factor-α Induces Epithelial Expression of Granulocyte–Macrophage Colony-stimulating Factor: Impact on Alveolar Epithelial Repair

Cakarova, L., Marsh, L. M., Wilhelm, J., Mayer, K., Grimminger, F., Seeger, W., Lohmeyer, J., & Herold, S. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200812-1837oc · Cited by 140

Antiviral CD8+ T cell effector activities in situ are regulated by target cell type

Hufford, M. M., Kim, T. S., Sun, J., & Braciale, T. J. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101850 · Cited by 133

Specification of the NF-κB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKKε

Moreno, R., Sobotzik, J.-M., Schultz, C., & Schmitz, M. L. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq439 · Cited by 133

Immunopathology in influenza virus infection: Uncoupling the friend from foe

Damjanovic, D., Small, C.-L. N., Jeyananthan, M., McCormick, S. M., & Xing, Z. (2012) · Clinical Immunology · doi:10.1016/j.clim.2012.05.005 · Cited by 134

Critical Role of Natural Killer Cells in Lung Immunopathology During Influenza Infection in Mice

Abdul-Careem, M. F., Mian, M. F., Yue, G., Gillgrass, A. E., Chenoweth, M. J., Barra, N. G., Chew, M. V., Chan, T., Al-Garawi, A. A., Jordana, M., et al. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis340 · Cited by 127

Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies

Fukuyama, S., Katsura, H., Zhao, D., Ozawa, M., Ando, T., Shoemaker, J. E., Ishikawa, I., Yamada, S., Neumann, G., Watanabe, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms7600 · Cited by 125

Cytokine Storm in COVID-19: “When You Come Out of the Storm, You Won’t Be the Same Person Who Walked in”

Castelli, V., Cimini, A., & Ferri, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02132 · Cited by 129

Treating the host response to emerging virus diseases: lessons learned from sepsis, pneumonia, influenza and Ebola

Fedson, D. S. (2016) · Annals of Translational Medicine · doi:10.21037/atm.2016.11.03 · Cited by 124

The cytokines HGF and CXCL13 predict the severity and the mortality in COVID-19 patients

Perreau, M., Suffiotti, M., Marques-Vidal, P. M., Wiedemann, A., Lévy, Y., Laouenan, C., Ghosn, J., Fenwick, C. W., Comte, D., Roger, T., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25191-5 · Cited by 123

Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair

Quantius, J., Schmoldt, C., Vazquez‐Armendariz, A. I., Becker, C., Agha, E. E., Wilhelm, J., Morty, R. E., Vadász, I., Mayer, K., Gattenloehner, S., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005544 · Cited by 121

Cytokine-Dependent Induction of CD4+T cells with Cytotoxic Potential during Influenza Virus Infection

Hua, L., Yao, S., Pham, D., Jiang, L., Wright, J., Sawant, D. V., Dent, A. L., Braciale, T. J., Kaplan, M. H., & Sun, J. (2013) · Journal of Virology · doi:10.1128/jvi.01461-13 · Cited by 122

PPAR-γ in Macrophages Limits Pulmonary Inflammation and Promotes Host Recovery following Respiratory Viral Infection

Huang, S., Zhu, B., Cheon, I. S., Goplen, N. P., Jiang, L., Zhang, R., Peebles, R. S., Mack, M., Kaplan, M. H., LIMPER, A. H., et al. (2019) · Journal of Virology · doi:10.1128/jvi.00030-19 · Cited by 119

Respiratory syncytial virus vaccine development

Hurwitz, J. L. (2011) · Expert Review of Vaccines · doi:10.1586/erv.11.120 · Cited by 118

Innate Immune Sensing and Response to Influenza

Pulendran, B., & Maddur, M. S. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_405 · Cited by 127

Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury

Herold, S., Ludwig, S., Pleschka, S., & Wolff, T. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.1011530 · Cited by 114

Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection

Peteranderl, C., Morales‐Nebreda, L., Selvakumar, B., Lecuona, E., Vadász, I., Morty, R. E., Schmoldt, C., Bespalowa, J., Wolff, T., Pleschka, S., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83931 · Cited by 113

Viral Infection Augments Nod1/2 Signaling to Potentiate Lethality Associated with Secondary Bacterial Infections

Kim, Y., Park, J., Reimer, T., Baker, D. P., Kawai, T., Kumar, H., Akira, S., Wobus, C. E., & Núñez, G. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.05.006 · Cited by 113

Inflammatory Monocytes Drive Influenza A Virus–Mediated Lung Injury in Juvenile Mice

Coates, B. M., Staricha, K. L., Koch, C. M., Cheng, Y., Shumaker, D. K., Budinger, G. R. S., Perlman, H., Misharin, A. V., & Ridge, K. M. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701543 · Cited by 112

Alveolar epithelial cells orchestrate DC function in murine viral pneumonia

Unkel, B., Högner, K., Clausen, B. E., Lewe-Schlosser, P., Bodner, J., Gattenloehner, S., Janßen, H., Seeger, W., Lohmeyer, J., & Herold, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62139 · Cited by 111

Exudate Macrophages Attenuate Lung Injury by the Release of IL-1 Receptor Antagonist in Gram-negative Pneumonia

Herold, S., Tabar, T. S., Janßen, H., Högner, K., Cabanski, M., Lewe-Schlosser, P., Albrecht, J., Driever, F., Vadász, I., Seeger, W., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201009-1431oc · Cited by 117

Myeloid Cells during Viral Infections and Inflammation

Stegelmeier, A. A., van Vloten, J. P., Mould, R. C., Klafuric, E. M., Minott, J. A., Wootton, S. K., Bridle, B. W., & Karimi, K. (2019) · Viruses · doi:10.3390/v11020168 · Cited by 117

Lowering the Threshold of Lung Innate Immune Cell Activation Alters Susceptibility to Secondary Bacterial Superinfection

Goulding, J., Godlee, A., Vekaria, S., Hilty, M., Snelgrove, R. J., & Hussell, T. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir467 · Cited by 115

Targeting the host or the virus: Current and novel concepts for antiviral approaches against influenza virus infection

Lee, S. M.-Y., & Yen, H. (2012) · Antiviral Research · doi:10.1016/j.antiviral.2012.09.013 · Cited by 108

Postinfluenza bacterial pneumonia: Host defenses gone awry

Ballinger, M. N., & Standiford, T. J. (2010) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0049 · Cited by 103

TRAIL+ monocytes and monocyte‐related cells cause lung damage and thereby increase susceptibility to influenza–Streptococcus pneumoniae coinfection

Ellis, G. T., Davidson, S., Crotta, S., Branzk, N., Papayannopoulos, V., & Wack, A. (2015) · EMBO Reports · doi:10.15252/embr.201540473 · Cited by 102

Signaling pathways and potential therapeutic targets in acute respiratory distress syndrome (ARDS)

Huang, Q., Le, Y., Li, S., & Bian, Y. (2024) · Respiratory Research · doi:10.1186/s12931-024-02678-5 · Cited by 119

The Comparative Immunological Characteristics of SARS-CoV, MERS-CoV, and SARS-CoV-2 Coronavirus Infections

Zhang, Y.-Y., Li, B.-R., & Ning, B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02033 · Cited by 103

Pathogenicity of different PR8 influenza A virus variants in mice is determined by both viral and host factors

Błażejewska, P., Kościński, Ł., Viegas, N., Anhlan, D., Ludwig, S., & Schughart, K. (2011) · Virology · doi:10.1016/j.virol.2010.12.047 · Cited by 98

Radix isatidis Polysaccharides Inhibit Influenza a Virus and Influenza A Virus-Induced Inflammation via Suppression of Host TLR3 Signaling In Vitro

Li, Z., Li, L., Zhou, H., Zeng, L., Chen, T., Chen, Q., Zhou, B., Wang, Y., Chen, Q., Hu, P., et al. (2017) · Molecules · doi:10.3390/molecules22010116 · Cited by 97

MCP-1 Antibody Treatment Enhances Damage and Impedes Repair of the Alveolar Epithelium in Influenza Pneumonitis

Narasaraju, T., Ng, H. H., Phoon, M. C., & Chow, V. T. K. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0423oc · Cited by 96

Treating Influenza Infection, From Now and Into the Future

Davidson, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01946 · Cited by 98

CCR2-Antagonist Prophylaxis Reduces Pulmonary Immune Pathology and Markedly Improves Survival during Influenza Infection

Lin, K. L., Sweeney, S., Kang, B. D., Ramsburg, E. A., & Gunn, M. D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001002 · Cited by 92

A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection

Maelfait, J., Roose, K., Bogaert, P., Sze, M., Saelens, X., Pasparakis, M., Carpentier, I., Loo, G., & Beyaert, R. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002570 · Cited by 91

Influenza Virus A Infection of Human Monocyte and Macrophage Subpopulations Reveals Increased Susceptibility Associated with Cell Differentiation

Hoeve, M. A., Nash, A. A., Jackson, D., Randall, R. E., & Dransfield, I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029443 · Cited by 90

The Effector T Cell Response to Influenza Infection

Hufford, M. M., Kim, T. S., Sun, J., & Braciale, T. J. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_397 · Cited by 89

The role of Nrf2 transcription factor in viral infection

Ramezani, A., Parsanahad, M., & Faghihloo, E. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26897 · Cited by 92

Mechanisms of Bacterial Superinfection Post-influenza: A Role for Unconventional T Cells

Paget, C., & Trottein, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00336 · Cited by 91

Respiratory Barrier as a Safeguard and Regulator of Defense Against Influenza A Virus and Streptococcus pneumoniae

LeMessurier, K. S., Tiwary, M., Morin, N. P., & Samarasinghe, A. E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00003 · Cited by 91

Host Defense and the Airway Epithelium: Frontline Responses That Protect against Bacterial Invasion and Pneumonia

Eisele, N. A., & Anderson, D. M. (2011) · Journal of Pathogens · doi:10.4061/2011/249802 · Cited by 91

Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity

Chu, H., Shuai, H., Hou, Y., Zhang, X., Wen, L., Huang, X., Hu, B., Yang, D., Wang, Y., Yoon, C., et al. (2021) · Science Advances · doi:10.1126/sciadv.abf8577 · Cited by 89

T Cells Are Not Required for Pathogenesis in the Syrian Hamster Model of Hantavirus Pulmonary Syndrome

Hammerbeck, C. D., & Hooper, J. W. (2011) · Journal of Virology · doi:10.1128/jvi.05356-11 · Cited by 88

In vitro and in vivo mechanism of immunomodulatory and antiviral activity of Edible Bird's Nest (EBN) against influenza A virus (IAV) infection

Haghani, A., Mehrbod, P., Safi, N., Aminuddin, N. A., Bahadoran, A., Omar, A. R., & Ideris, A. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.03.020 · Cited by 91

Aging and Interferons: Impacts on Inflammation and Viral Disease Outcomes

Feng, E., Balint, E., Poznanski, S. M., Ashkar, A. A., & Loeb, M. B. (2021) · Cells · doi:10.3390/cells10030708 · Cited by 95

Distinctive features of severe SARS-CoV-2 pneumonia

Budinger, G. R. S., Misharin, A. V., Ridge, K. M., Singer, B. D., & Wunderink, R. G. (2021) · Journal of Clinical Investigation · doi:10.1172/jci149412 · Cited by 87

The NF-κB inhibitor SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistance

Ehrhardt, C., Rückle, A., Hrincius, E. R., Haasbach, E., Anhlan, D., Ahmann, K., Banning, C., Reiling, S. J., Kühn, J., Strobl, S., et al. (2013) · Cellular Microbiology · doi:10.1111/cmi.12108 · Cited by 84

Macrophage-Mediated Inflammation and Disease: A Focus on the Lung

Findlay, E. G., & Hussell, T. (2012) · Mediators of Inflammation · doi:10.1155/2012/140937 · Cited by 84

PPAR-γ Activation As an Anti-inflammatory Therapy for Respiratory Virus Infections

Bassaganya-Riera, J., Song, R., Roberts, P. C., & Hontecillas, R. (2010) · Viral Immunology · doi:10.1089/vim.2010.0016 · Cited by 83

The NS Segment of an H5N1 Highly Pathogenic Avian Influenza Virus (HPAIV) Is Sufficient To Alter Replication Efficiency, Cell Tropism, and Host Range of an H7N1 HPAIV

Ma, W., Brenner, D., Wang, Z., Dauber, B., Ehrhardt, C., Högner, K., Herold, S., Ludwig, S., Wolff, T., Yu, K., et al. (2009) · Journal of Virology · doi:10.1128/jvi.01668-09 · Cited by 82

Macrophage TRAIL expression is IFN- β-dependent and mediates alveolar epithelial apoptosis and barrier dysfunction in influenza virus pneumonia

Högner, K., Janßen, H., Pleschka, S., Albrecht, J., Driever, F., Seeger, W., Lohmeyer, J., & Herold, S. (2010) · German Medical Science (German Research Foundation) · doi:10.3205/10kit025

Macrophage-epithelial interactions during influenza virus pneumonia : Alveolar recruitment pathways and impact on epithelial barrier integrity

Herold, S., & Justus Liebig University Giessen (2008) · University writing server of the Justus Liebig University Giessen (Justus-Liebig-Universität Gießen) · doi:10.22029/jlupub-13351

Macrophage-expressed IFN-β Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia

Högner, K., Wolff, T., Pleschka, S., Plog, S., Gruber, A. D., Kalinke, U., Walmrath, H., Bodner, J., Gattenlöhner, S., Lewe-Schlosser, P., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003188 · Cited by 237

Macrophage-expressed IFN-b Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia

Wolff, T., Pleschka, S., Plog, S., Gruber, A. D., Kalinke, U., Walmrath, H.-D., Bodner, J., Lewe-Schlosser, P., Matrosovich, M. N., Seeger, W., et al. (2016)

Macrophage TRAIL Expression Is IFN-ß-dependent And Mediates Alveolar Epithelial Apoptosis And Barrier Dysfunction In Influenza Virus Pneumonia

Högner, K., Pleschka, S., Albrecht, J., Driever, F., Seeger, W., Lohmeyer, J., & Herold, S. (2010) · doi:10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2313