The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus
Open accessAbstract
Increased type I interferon (IFN-I) production and IFN-stimulated gene (ISG) expression are linked to the pathogenesis of systemic lupus erythematosus (SLE). Although the mechanisms responsible for dysregulated IFN-I production in SLE remain unclear, autoantibody-mediated uptake of endogenous nucleic acids is thought to play a role. 2,6,10,14-tetramethylpentadecane (TMPD; also known as pristane) induces a lupus-like disease in mice characterized by immune complex nephritis with autoantibodies to DNA and ribonucleoproteins. We recently reported that TMPD also causes increased ISG expression and that the development of the lupus is completely dependent on IFN-I signaling (Nacionales, D.C., K.M. Kelly-Scumpia, P.Y. Lee, J.S. Weinstein, R. Lyons, E. Sobel, M. Satoh, and W.H. Reeves. 2007. Arthritis Rheum. 56:3770–3783). We show that TMPD elicits IFN-I production, monocyte recruitment, and autoantibody production exclusively through a Toll-like receptor (TLR) 7– and myeloid differentiation factor 88 (MyD88)–dependent pathway. In vitro studies revealed that TMPD augments the effect of TLR7 ligands but does not directly activate TLR7 itself. The effects of TMPD were amplified by the Y-linked autoimmune acceleration cluster, which carries a duplication of the TLR7 gene. In contrast, deficiency of Fcγ receptors (FcγRs) did not affect the production of IFN-I. Collectively, the data demonstrate that TMPD-stimulated IFN-I production requires TLR7/MyD88 signaling and is independent of autoantibody-mediated uptake of ribonucleoproteins by FcγRs.
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Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., et al. (2006) · Nature · doi:10.1038/nature04734 · Cited by 3,888
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444
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Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S. (2005) · Nature Immunology · doi:10.1038/ni1243 · Cited by 2,562
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Metadata
- Authors
- Lee, P. Y., Kumagai, Y., Li, Y., Takeuchi, O., Yoshida, H., Weinstein, J., Kellner, E. S., Nacionales, D., Barker, T., Kelly-Scumpia, K., van Rooijen, N., Kumar, H., Kawai, T., Satoh, M., Akira, S., & Reeves, W. H.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2008-12-01
- Volume
- 205
- Issue
- 13
- Pages
- 2995-3006
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2088120033
- Cited by
- 223
- References
- 5
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus. https://app.cochat.ai/papers/10.1084/jem.20080462
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- Lee, P. Y., Kumagai, Y., Li, Y., Takeuchi, O., Yoshida, H., Weinstein, J., Kellner, E. S., Nacionales, D., Barker, T., Kelly-Scumpia, K., van Rooijen, N., Kumar, H., Kawai, T., Satoh, M., Akira, S., & Reeves, W. H. (2008). TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20080462
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