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Networking erythropoiesis

Kerenyi, Marc A., Orkin, Stuart H.·2010·Journal of Experimental Medicine

Abstract

A relatively small cadre of lineage-restricted transcription factors largely orchestrates erythropoiesis, but how these nuclear factors interact to regulate this complex biology is still largely unknown. However, recent technological advances, such as chromatin immunoprecipitation (ChIP) paired with massively parallel sequencing (ChIP-seq), gene expression profiling, and comprehensive bioinformatic analyses, offer new insights into the intricacies of red cell molecular circuits.

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Metadata

Authors
Kerenyi, M. A., & Orkin, S. H.
Affiliations
M.A.K. and S.H.O. are at the Division of Hematology/Oncology, Children’s Hospital Boston and the Dana Farber Cancer Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115
Venue
Journal of Experimental Medicine
Published
2010-11-22
Volume
207
Issue
12
Pages
2537-2541
ISSN
  • 1540-9538
  • 0022-1007
Cited by
88
References
5
Language
en

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