Replicative senescence in the immune system: impact of the Hayflick limit on T-cell function in the elderly
Open accessIntegrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Senescent T cells are characterized by telomere shortening, loss of CD28 expression, and cell cycle arrest.
“Senescent T cells are characterized by telomere shortenings, phenotypic change (loss of CD28 expression), and cell cycle arrest [46,47] (Fig. 1).”
From T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment (2013) · cites this paper as [47]
Cites
The limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876 · see citing works
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975 · see citing works
Immunobiology: the immune system in health and disease
(1995) · Choice Reviews Online · doi:10.5860/choice.32-3876 · Cited by 4,110 · see citing works
The B7 and CD28 receptor families
June, C. H., Bluestone, J. A., Nadler, L. M., & Thompson, C. B. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90080-9 · Cited by 1,296 · see citing works
Handbook of the Biology of Aging
Finch, C. E., & Schneider, E. L. (1990) · DigitalGeorgetown (Georgetown University Library) · Cited by 1,210 · see citing works
Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo
Tough, D. F., Borrow, P., & Sprent, J. (1996) · Science · doi:10.1126/science.272.5270.1947 · Cited by 1,081 · see citing works
Posnett, D. N., Sinha, R., Kabak, S., & Russo, C. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.2.609 · Cited by 761 · see citing works
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.
Vaziri, H., Schächter, F., Uchida, I. A., Wei, L., Zhu, X., Effros, R. B., Cohen, D., & Harley, C. (1993) · PubMed · Cited by 734 · see citing works
Self-citationReplicative Senescence: Implications for in Vivo Aging and Tumor Suppression
Smith, J. R., & Pereira-Smith, O. M. (1996) · Science · doi:10.1126/science.273.5271.63 · Cited by 547 · see citing works
Effros, R. B., Allsopp, R., Chiu, C.-P., Hausner, M. A., Hirji, K., Wang, L., Harley, C. B., Villeponteau, B., West, M. D., & Giorgi, J. V. (1996) · AIDS · doi:10.1097/00002030-199607000-00001 · Cited by 457 · see citing works
Self-citationTelomerase activity in human cancer
Shay, J. W., & Wright, W. E. (1996) · Current Opinion in Oncology · doi:10.1097/00001622-199601000-00012 · Cited by 404 · see citing works
Regulated expression of telomerase activity in human T lymphocyte development and activation.
Weng, N., Levine, B. L., June, C. H., & Hodes, R. J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2471 · Cited by 403 · see citing works
CD28- T lymphocytes. Antigenic and functional properties
Azuma, M., Phillips, J. H., & Lanier, L. L. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.4.1147 · Cited by 392 · see citing works
Effros, R. B., Boucher, N., Porter, V., Zhu, X., Spaulding, C., Walford, R. L., Kronenberg, M., Cohen, D., & Schächter, F. (1994) · Experimental Gerontology · doi:10.1016/0531-5565(94)90073-6 · Cited by 377 · cited 9× · see citing works
“To determine the proliferative potential of the putatively senescent lymphocytes, sorted populations of CD281 and CD282 T cells were stimulated with mitogens.”
BackgroundInfluentialSelf-citationMonteiro, J., Batliwalla, F., Ostrer, H., & Gregersen, P. K. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.10.3587 · Cited by 376 · see citing works
Rocha, B., Dautigny, N., & Pereira, P. (1989) · European Journal of Immunology · doi:10.1002/eji.1830190518 · Cited by 343 · see citing works
Levine, B. L., Bernstein, W. B., Connors, M., Craighead, N., Lindsten, T., Thompson, C. B., & June, C. H. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.12.5921 · Cited by 340 · see citing works
Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?
Effros, R. B., & Pawelec, G. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01079-7 · Cited by 336 · see citing works
Self-citationMechanism of Telomerase Induction during T Cell Activation
Bodnar, A. G., Kim, N. W., Effros, R. B., & Chiu, C. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0299 · Cited by 285 · see citing works
Self-citationEffros, R. B., Doherty, P. C., Gerhard, W., & Bennink, J. R. (1977) · The Journal of Experimental Medicine · doi:10.1084/jem.145.3.557 · Cited by 280 · see citing works
Self-citationWALDENSTRÖM, J. G. (1984) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1984.tb05032.x · Cited by 248 · see citing works
Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion.
Shimizu, Y., van Seventer, G. A., Ennis, E. A., Newman, W., Horgan, K. J., & Shaw, S. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.2.577 · Cited by 190 · see citing works
Cuadrado, E., & Barrena, M. (1996) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1996.0031 · Cited by 128 · see citing works
Recruitment and proliferation of CD8+ T cells in respiratory virus infections.
Tripp, R. A., Hou, S., McMickle, A., Houston, J., & Doherty, P. C. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.11.6013 · Cited by 127 · see citing works
Pawelec, G., Adibzadeh, M., Solana, R., & Beckman, I. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01812-x · Cited by 109 · see citing works
Handbook of the Biology of Aging
(2021) · Elsevier eBooks · doi:10.1016/c2017-0-03906-x · Cited by 86 · see citing works
Stress Response of Senescent T Lymphocytes Reduced hsp70 Is Independent of the Proliferative Block
Effros, R. B., Zhu, X., & Walford, R. L. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.2.b65 · Cited by 72 · see citing works
Self-citationAging and immune function: Cellular and biochemical analyses
MILLER, R. (1994) · Experimental Gerontology · doi:10.1016/0531-5565(94)90060-4 · Cited by 66 · see citing works
Grubeck‐Loebenstein, B., Lechner, H., & Trieb, K. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000236671 · Cited by 58 · see citing works
The Genetics of Cellular Senescence
Bérubé, N. G., Smith, J. R., & Pereira‐Smith, O. M. (1998) · The American Journal of Human Genetics · doi:10.1086/301848 · Cited by 39 · see citing works
Adibzadeh, M., Mariani, E., Bartoloni, C., Beckman, I., Ligthart, G. J., Remarque, E. J., Shall, S., Solana, R., Taylor, G. M., Barnett, Y., et al. (1996) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(96)01783-6 · Cited by 35 · see citing works
Characterization of cloned murine cytolytic T cell lines.
Engers, H. D., Collavo, D., North, M., von Boehmer, H., Haas, W., Hengartner, H., & Nabholz, M. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.125.4.1481 · Cited by 28 · see citing works
Flagged first, then by citations
1 of the 34 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Johnson, F. B., Sinclair, D. A., & Guarente, L. (1999) · Cell · doi:10.1016/s0092-8674(00)80567-x · Cited by 840 · see citing works
T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
Crespo, J., Sun, H., Welling, T. H., Tian, Z., & Zou, W. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.12.003 · Cited by 752 · see citing works
A synopsis on aging—Theories, mechanisms and future prospects
da Costa, J. P., Vitorino, R. M. P., Silva, G. M., Vogel, C., Duarte, A. C., & Rocha‐Santos, T. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.06.005 · Cited by 486 · see citing works
Telomere shortening in T cells correlates with Alzheimer's disease status
Panossian, L. A. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00043-x · Cited by 409 · see citing works
Cellular senescence, cancer and aging: the telomere connection
Campisi, J., Kim, S.-H., Lim, C.-S., & Rubio, M. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00160-7 · Cited by 400 · see citing works
T cells and aging january 2002 update
Pawelec, G. (2002) · Frontiers in bioscience · doi:10.2741/a831 · Cited by 368 · see citing works
Do telomere dynamics link lifestyle and lifespan?
Monaghan, P., & Haussmann, M. F. (2005) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2005.11.007 · Cited by 364 · see citing works
Telomere Length Inversely Correlates With Pulse Pressure and Is Highly Familial
Jeanclos, E. M., Schork, N. J., Kyvik, K. O., Kimura, M., Skurnick, J., & Aviv, A. (2000) · Hypertension · doi:10.1161/01.hyp.36.2.195 · Cited by 352 · see citing works
The role of CD8<sup>+</sup> T‐cell replicative senescence in human aging
Effros, R. B., Dagarag, M., Spaulding, C., & Man, J. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00259.x · Cited by 336 · see citing works
Self-citationT Cell Replicative Senescence in Human Aging
P. Chou, J., & B. Effros, R. (2013) · Current Pharmaceutical Design · doi:10.2174/138161213805219711 · Cited by 323 · see citing works
Self-citationMarkers of T Cell Senescence in Humans
Xu, W., & Larbi, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081742 · Cited by 261 · see citing works
From cells to organisms: can we learn about aging from cells in culture?
Campisi, J. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00230-8 · Cited by 263 · see citing works
The aging of lympho-hematopoietic stem cells
Geiger, H., & Van Zant, G. (2002) · Nature Immunology · doi:10.1038/ni0402-329 · Cited by 233 · see citing works
Telomeres, aging and cancer: In search of a happy ending
Kim, S.-H., Kaminker, P. G., & Campisi, J. (2002) · Oncogene · doi:10.1038/sj.onc.1205077 · Cited by 227 · see citing works
Vaccination in the elderly: an immunological perspective
Chen, W. H., Kozlovsky, B. F., Effros, R. B., Grubeck‐Loebenstein, B., Edelman, R., & Sztein, M. B. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.05.002 · Cited by 228 · see citing works
Self-citationRegulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition
Liu, X., Mo, W., Ye, J., Li, L., Zhang, Y., Hsueh, E. C., Hoft, D. F., & Peng, G. (2018) · Nature Communications · doi:10.1038/s41467-017-02689-5 · Cited by 224 · see citing works
Homeostasis of the naive CD4+ T cell compartment during aging
Kilpatrick, R. D., Rickabaugh, T., Hultin, L. E., Hultin, P., Hausner, M. A., Detels, R., Phair, J., & Jamieson, B. D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1499 · Cited by 213 · see citing works
Allsopp, R., Cheshier, S. H., & Weissman, I. L. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.8.917 · Cited by 194 · see citing works
Immunosenescence: Role and measurement in influenza vaccine response among the elderly
Targonski, P. V., Jacobson, R. M., & Poland, G. A. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.01.025 · Cited by 186 · see citing works
Lombardi, V., Garcı́a, M., Rey, L., & Cacabelos, R. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00046-6 · Cited by 182 · see citing works
Senescent T cells: a potential biomarker and target for cancer therapy
Zhang, J., He, T., Xue, L., & Guo, H. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103409 · Cited by 171 · see citing works
Telomerase in cancer and aging
Granger, M. P., Wright, W. E., & Shay, J. W. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00188-3 · Cited by 159 · see citing works
Role of T lymphocyte replicative senescence in vaccine efficacy
Effros, R. B. (2007) · Vaccine · doi:10.1016/j.vaccine.2006.08.032 · Cited by 152 · see citing works
Self-citationExhaustion of T lymphocytes in the tumor microenvironment: Significance and effective mechanisms
Gholami, M. D., Kardar, G. A., Saeedi, Y., Heidari, S., Garssen, J., & Falak, R. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.10.002 · Cited by 140 · see citing works
T cells and aging (update February 1999)
Pawelec, G. (1999) · Frontiers in bioscience · doi:10.2741/pawelec · Cited by 138 · see citing works
Role of CD8 T Cell Replicative Senescence in Human Aging and in HIV-mediated Immunosenescence.
Dock, J., & Effros, R. B. (2011) · Europe PMC (PubMed Central) · Cited by 137 · see citing works
Self-citationCancer and aging: the importance of telomeres in genome maintenance
Rodier, F., Kim, S.-H., Nijjar, T., Yaswen, P., & Campisi, J. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.10.012 · Cited by 132 · see citing works
Trzonkowski, P., Zilvetti, M., Chapman, S. J., Więckiewicz, J., Sutherland, A., Friend, P. J., & Wood, K. J. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.02078.x · Cited by 127 · see citing works
Replicative senescence of CD8 T cells: Effect on human ageing
Effros, R. B. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.09.024 · Cited by 127 · see citing works
Self-citationImmune Regulatory Processes of the Tumor Microenvironment under Malignant Conditions
Pansy, K., Uhl, B., Krstić, J., Szmyra, M., Fechter, K., Santiso, A., Thüminger, L., Greinix, H., Kargl, J., Prochazka, K. T., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413311 · Cited by 110 · see citing works
CHANGES IN IMMUNE FUNCTION WITH AGE
Yung, R. L. (2000) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70151-4 · Cited by 96 · see citing works
The 3 I’s of immunity and aging: immunosenescence, inflammaging, and immune resilience
Wrona, M. V., Ghosh, R. B., Coll, K., Chun, C., & Yousefzadeh, M. J. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1490302 · Cited by 102 · see citing works
Decline of immune responsiveness: A pathogenetic factor in Alzheimer’s disease?
Richartz, E., Stransky, E., Batra, A., Simon, P. D., Lewczuk, P., Buchkremer, G., BARTELS, M., & Schott, K. J. (2005) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2004.12.005 · Cited by 95 · see citing works
Costimulatory mechanisms in the elderly
Effros, R. B. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00503-4 · Cited by 79 · see citing works
Self-citationWu, Z., Uhl, B., Gires, O., & Reichel, C. A. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00915-5 · Cited by 78 · see citing works
CD8+CD28– T cells: Certainties and uncertainties of a prevalent human T‐cell subset
Arosa, F. A. (2002) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2002.01057.x · Cited by 73 · see citing works
Bryl, E., & Witkowski, J. M. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.10.029 · Cited by 73 · see citing works
Age related changes in population of peripheral T cells: towards a model of immunosenescence
Romanyukha, A. A., & Yashin, A. I. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00019-8 · Cited by 73 · see citing works
Allsopp, R., & Weissman, I. L. (2002) · Oncogene · doi:10.1038/sj.onc.1205314 · Cited by 71 · see citing works
Genetic alterations in the ageing immune system: impact on infection and cancer
Effros, R. B. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00171-9 · Cited by 67 · see citing works
Self-citationThe silent war of CMV in aging and HIV infection
Effros, R. B. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.09.003 · Cited by 63 · see citing works
Self-citationSenescent stromal cells: roles in the tumor microenvironment
Gabai, Y., Assouline, B., & Ben‐Porath, I. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.09.002 · Cited by 63 · see citing works
Altered apoptotic profiles in irradiated patients with increased toxicity
Crompton, N. E. A., Miralbell, R., Rutz, H.-P., Ersoy, F., Sanal, Ö., Wellmann, D., Bieri, S., Coucke, P. A., Emery, G. C., Shi, Y., et al. (1999) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(99)00256-4 · Cited by 61 · see citing works
Telomere Attrition in White Blood Cell Correlating with Cardiovascular Damage
NAKASHIMA, H., Ozono, R., SUYAMA, C., Sueda, T., Kambe, M., & Oshima, T. (2004) · Hypertension Research · doi:10.1291/hypres.27.319 · Cited by 58 · see citing works
Causes, Effects, and Constraints in the Genetics of Human Longevity
Schächter, F. (1998) · The American Journal of Human Genetics · doi:10.1086/301849 · Cited by 54 · see citing works
Effros, R. B. (2004) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-004-0508-x · Cited by 48 · see citing works
Self-citationJanelle, V., & Delisle, J. (2021) · Cancers · doi:10.3390/cancers13040598 · Cited by 47 · see citing works
Onyema, O. O., Njemini, R., Forti, L. N., Bautmans, I., Aerts, J. L., Waele, M. D., & Mets, T. F. (2015) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2015.08.007 · Cited by 45 · see citing works
Long-term immunological memory against viruses
Effros, R. B. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00207-4 · Cited by 45 · see citing works
Self-citationMariani, E. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00058-5 · Cited by 43 · see citing works
Moreno‐Villanueva, M., Morath, J., Vanhooren, V., Elbert, T. R., Kolassa, S., Libert, C., Bürkle, A., & Kolassa, I. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.93 · Cited by 43 · see citing works
The Genetics of Cellular Senescence
Bérubé, N. G., Smith, J. R., & Pereira‐Smith, O. M. (1998) · The American Journal of Human Genetics · doi:10.1086/301848 · Cited by 39 · see citing works
Contribution of viral and bacterial infections to senescence and immunosenescence
Reyes, A., Ortiz, G., Duarte, L. F., Fernández, C., Hernández‐Armengol, R., Palacios, P. A., Prado, Y., Andrade, C. A., Rodríguez‐Guilarte, L., Kalergis, A. M., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1229098 · Cited by 36 · see citing works
Lahav, M., Uziel, O., Kestenbaum, M., Fraser, A., Shapiro, H., Radnay, J., Szyper‐Kravitz, M., Shimoni, A., Hardan, I., Shem‐Tov, N., et al. (2005) · Transplantation · doi:10.1097/01.tp.0000173649.99261.df · Cited by 31 · see citing works
Ye, B., Pei, Y., Wang, L., Meng, D., Zhang, Y., Zou, S., Li, H., Liu, J., Xie, Z., Tian, C., et al. (2024) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30522 · Cited by 32 · see citing works
Cellular Senescence in Hepatocellular Carcinoma: The Passenger or the Driver?
Cai, X., Guillot, A., & Liu, H. (2022) · Cells · doi:10.3390/cells12010132 · Cited by 30 · see citing works
Problems and solutions to the development of vaccines in the elderly
Effros, R. B. (2003) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(02)00055-3 · Cited by 27 · see citing works
Self-citationImpact of the Hayflick Limit on T cell responses to infection: lessons from aging and HIV disease
Effros, R. B. (2003) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2003.11.003 · Cited by 25 · see citing works
Self-citationTelomeres and Essential Hypertension
Aviv, A. (1999) · American Journal of Hypertension · doi:10.1016/s0895-7061(98)00202-7 · Cited by 24 · see citing works
Brain Aging and Regeneration after Injuries: an Organismal approach.
Buga, A.-M., Vintilescu, R., Pop, O. T., & Popa‐Wagner, A. (2011) · Europe PMC (PubMed Central) · Cited by 20 · see citing works
Saretzki, G. C., & von Zglinicki, T. (1999) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s003910050086 · Cited by 20 · see citing works
Antioxidants Improve the Proliferation and Efficacy of hUC-MSCs against H2O2-Induced Senescence
Zheng, Z., Wang, X., Ouyang, L., Chen, W., Zhang, L., & Cao, Y. (2023) · Antioxidants · doi:10.3390/antiox12071334 · Cited by 19 · see citing works
Neuber, K., Schmidt, S., & Mensch, A. (2003) · Immunology · doi:10.1046/j.1365-2567.2003.01640.x · Cited by 19 · see citing works
Telomerization as a Method of Obtaining Immortal Human Cells Preserving Normal Properties
Yegorov, Y. E., Terekhov, S. M., Vishnyakova, K. S., Karachentsev, D. N., Kazimirchuk, E. V., Tg, T., Nn, V., Td, S., As, M., El'darov, M. A., et al. (2003) · Russian Journal of Developmental Biology · doi:10.1023/a:1024068606285 · Cited by 18 · see citing works
Kahl, V. F. S., Simon, D., de Souza, M. R., da Rosa, V. H., Nicolau, C. C., da Silva, F. R., Kvitko, K., Peres, A., Dorneles, G. P., de Souza, C. T., et al. (2018) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2018.04.001 · Cited by 18 · see citing works
Brzezińska, A., Magalska, A., & Sikora, E. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00012-5 · Cited by 18 · see citing works
Current and potential roles of immuno-PET/-SPECT in CAR T-cell therapy
Mulgaonkar, A., Udayakumar, D., Yang, Y., Harris, S. F., Öz, O. K., Geethakumari, P. R., & Sun, X. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1199146 · Cited by 18 · see citing works
Neoadjuvant chemotherapy modulates exhaustion of T cells in breast cancer patients
Rodríguez, I. J., Bernal-Estévez, D. A., Llano-León, M., Bonilla, C., & Parra-López, C. (2023) · PLoS ONE · doi:10.1371/journal.pone.0280851 · Cited by 16 · see citing works
Franzin, R., Stasi, A., Castellano, G., & Gesualdo, L. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1507-2_6 · Cited by 14 · see citing works
Senescent T Cells in Age-Related Diseases
Yu, P.-J., Zhou, M. L., Liu, Y., & Du, J. (2024) · Aging and Disease · doi:10.14336/ad.2024.0219 · Cited by 15 · see citing works
Stromal senescence contributes to age-related increases in cancer
Ye, J., Melam, A., & Stewart, S. A. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00840-9 · Cited by 14 · see citing works
Stem Cells and Genetics in the Study of Development, Aging, and Longevity
Zant, G. E. V. (2000) · Results and problems in cell differentiation · doi:10.1007/978-3-540-48003-7_11 · Cited by 12 · see citing works
Chen, Y., Yim, W. Y., Li, C., Wang, Z., Hou, J., Peng, Y., Liu, F., Liu, Z., Dong, N., & Wang, Y. (2026) · Molecular Therapy · doi:10.1016/j.ymthe.2026.02.015 · Cited by 11 · see citing works
The Hayflick Limit May Determine the Effective Clonal Diversity of Naive T Cells
Ndifon, W. O., & Dushoff, J. G. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502343 · Cited by 11 · see citing works
The evaluation of hTERT mRNA expression in acute leukemia children and 2 years follow-up of 40 cases
Çoğulu, Ö., Kosova, B., Gündüz, C., Karaca, E., Aksoylar, S., Erbay, A., Karapınar, D. Y., Vergin, C. R., Vural, F., Tombuloğlu, M., et al. (2008) · International Journal of Hematology · doi:10.1007/s12185-008-0054-y · Cited by 9 · see citing works
Immune system aging may be affected by HIV infection: the mathematical model of immunosenescence
Sannikova, T. E., Rudnev, S. G., Romanyukha, A. A., & YASHIN, A. I. (2004) · Russian Journal of Numerical Analysis and Mathematical Modelling · doi:10.1515/1569398041974897 · Cited by 7 · see citing works
Immune system aging may be affected by HIV infection: the mathematical model of immunosenescence
Sannikova, T. E., Rudnev, S. G., Romanyukha, A. A., & YASHIN, A. I. (2004) · Russian Journal of Numerical Analysis and Mathematical Modelling · doi:10.1515/rnam.2004.19.4.315 · Cited by 6 · see citing works
A road to ruins: an insight into immunosenescence
(2002) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(02)13010-0 · Cited by 6 · see citing works
Centenarian Offspring as a Model of Successful Ageing
Aiello, A., Ligotti, M. E., & Cossarizza, A. (2019) · Springer eBooks · doi:10.1007/978-3-030-20762-5_3 · Cited by 7 · see citing works
Long-term persistence of IL-2-unresponsive allogeneic T cells in sublethally irradiated SCID mice
Spaner, D., Sheng-Tanner, X., Raju, K., Rabinovich, B. A., Messner, H. A., & Miller, R. G. (1999) · International Immunology · doi:10.1093/intimm/11.10.1601 · Cited by 5 · see citing works
At a crossroads of cancer risk and aging: the role of telomeres.
Gerashchenko, B. I. (2010) · PubMed · Cited by 5 · see citing works
Vorzeitige Immunalterung: ein pathogenetischer Faktor bei Alzheimer-Demenz?
Richartz-Salzburger, E., Stransky, E., Laske, C., & Köhler, N. (2010) · Der Nervenarzt · doi:10.1007/s00115-009-2918-7 · Cited by 4 · see citing works
Thymocytes maintain immune activity through telomere elongation in rats under hypoxic conditions
Wang, Y., Zhao, Z., Yang, Y., Zhao, Y.-X., & Ge, R. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2754 · Cited by 2 · see citing works
Decline of Immune Responsiveness: A Pathogenetic Factor in Alzheimer’s Disease?
Richartz-Salzburger, E., & Koehler, N. K. U. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_61 · Cited by 2 · see citing works
When wrinkles appear on the immune system can it be reversed?
Sibaii, H., El-Zayat, S. R., & Khalil, M. (2020) · European Cytokine Network · doi:10.1684/ecn.2020.0441 · Cited by 3 · see citing works
Campisi, J. (2003) · CRC Press eBooks · doi:10.1201/9780203911709.pt1 · Cited by 2 · see citing works
Hematopoietic stem cells and aging
Zant, G. E. V., Manning, E., & Geiger, H. (2002) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(02)09042-9 · Cited by 2 · see citing works
Senescencia celular y envejecimiento
Andréu, G. P., & Delgado, R. (2003) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 2 · see citing works
Telomeres, Senescence and Longevity: The Role of Oxidative Stress and Antioxidants
Saretzki, G. C. (2005) · Current Pharmacogenomics · doi:10.2174/1570160054022926 · Cited by 1 · see citing works
MATHEMATICAL AND COMPUTER MODELLING ORGANISM'S CELLULAR COMMUNITIES REGULATORIKA AT ANOMALIES
Saidalieva, M. (2008) · Scientiae mathematicae Japonicae · doi:10.32219/isms.67.2_161 · Cited by 1 · see citing works
Morath, J. (2013) · KOPS (University of Konstanz) · Cited by 1 · see citing works
Anti-Aging Medicine LiteratureWatch
Pawelec, G. (1998) · Rejuvenation Research · doi:10.1089/rej.1.1998.1.275
T Cell Fate in the Tumor Microenvironment
Crespo, J., Kryczek, I., Welling, T. H., Wei, S., & Zou, W. (2015) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-21167-1_3
Somatic Cells: Growth and Expansion Potential of T Lymphocytes
Effros, R. B. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-381422-7.10025-2
Self-citationImpfen älterer Personen: Immunologische Besonderheiten beachten
Leischker, A. H. (2019) · Deutsches Ärzteblatt · doi:10.3238/persinfek.2019.07.22.04
Rodríguez, R., & Johanna, I. (2021)
Fauce, S. R., & Effros, R. B. (2008) · Springer eBooks · doi:10.1007/978-0-387-76842-7_4
Self-citation(2007) · Steinkopff eBooks · doi:10.1007/978-3-7985-1787-5_7
Somatic Cells: Growth and Expansion Potential of T Lymphocytes
Effros, R. B. (2008) · Elsevier eBooks · doi:10.1016/b978-012369410-2.50028-0
Self-citationT cell exhaustion and aging: is replicative senescence relevant?
Effros, R. B. (2002) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(02)13016-1
Self-citation
- Authors
- Effros, R. B.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Effros, Rita B.
- ORCID
- Effros, Rita B.
- Venue
- The American Journal of Human Genetics
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 62
- Issue
- 5
- Pages
- 1003-1007
- ISSN
- 0002-9297 (ISSN-L)
- PMC
- PMC1377102
- OpenAlex
- W2036284362
- Cited by
- 105
- References
- 34
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 4 · 2013: 4
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The American Journal of Human Genetics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG-10415, P60AG010415)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- replicative senescence, Hayflick limit, T cell function, immunosenescence, cellular senescence, growth arrest, older adults
- MeSH terms
- Aged, Aging, Animals, Cell Division, Humans, T-Lymphocytes, Cellular Senescence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review