Cited by 337Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and AnimalsDiabetes and associated disorders

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Linkage of Type 2 Diabetes Mellitus and of Age at Onset to a Genetic Location on Chromosome 10q in Mexican Americans

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Duggirala, Ravindranath, Blangero, John, Almasy, Laura, Dyer, Thomas D., Williams, Kenneth L., Leach, Robin J., O'Connell, Peter, Stern, Michael P.·1999·The American Journal of Human Genetics

DOI 10.1086/302316PMC PMC1377837

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Abstract

Since little is known about chromosomal locations harboring type 2 diabetes-susceptibility genes, we conducted a genomewide scan for such genes in a Mexican American population. We used data from 27 low-income extended Mexican American pedigrees consisting of 440 individuals for whom genotypic data are available for 379 markers. We used a variance-components technique to conduct multipoint linkage analyses for two phenotypes: type 2 diabetes (a discrete trait) and age at onset of diabetes (a truncated quantitative trait). For the multipoint analyses, a subset of 295 markers was selected on the basis of optimal spacing and informativeness. We found significant evidence that a susceptibility locus near the marker D10S587 on chromosome 10q influences age at onset of diabetes (LOD score 3.75) and is also linked with type 2 diabetes itself (LOD score 2.88). This susceptibility locus explains 63.8%+/-9.9% (P=. 000016) of the total phenotypic variation in age at onset of diabetes and 65.7%+/-10.9% (P=.000135) of the total variation in liability to type 2 diabetes. Weaker evidence was found for linkage of diabetes and of age at onset to regions on chromosomes 3p, 4q, and 9p. In conclusion, our strongest evidence for linkage to both age at onset of diabetes and type 2 diabetes itself in the Mexican American population was for a region on chromosome 10q.

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Authors: Duggirala, R., Blangero, J., Almasy, L., Dyer, T. D., Williams, K. L., Leach, R. J., O'Connell, P., & Stern, M. P.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
Texas Biomedical Research Institute (US)
Corresponding author: Duggirala, Ravindranath
ORCID: Duggirala, Ravindranath
Blangero, John
Almasy, Laura
Dyer, Thomas D.
Leach, Robin J.
O'Connell, Peter
Venue: The American Journal of Human Genetics
Publisher: Elsevier BV
Published: 1999-04
Volume: 64
Issue: 4
Pages: 1127-1140
ISSN: 0002-9297 (ISSN-L)
DOI: 10.1086/302316
PMC: PMC1377837
OpenAlex: W2058805992
Cited by: 337
References: 70
Citations by year: 2026: 1 · 2025: 2 · 2024: 8 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 12 · 2019: 8 · 2018: 9 · 2017: 4 · 2016: 11 · 2015: 17 · 2014: 14 · 2013: 11 · 2012: 7
FWCI: 11.66
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5223 d)
Locations: The American Journal of Human Genetics (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: World Health Organization
National Institutes of Health (5r29dk044297-04)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-44297, R01DK042273, R01DK047482, DK47482, DK42273)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords: type 2 diabetes, age at onset of diabetes, genetic susceptibility, chromosome 10q, genetic linkage, Mexican Americans, extended pedigrees, multipoint linkage analysis
MeSH terms: Age Factors, Chromosome Mapping, Chromosomes, Human, Pair 10, Diabetes Mellitus, Type 2, Female, Genotype, Hispanic or Latino, Humans, Lod Score, Male, Mexico, Pedigree, Sex Factors, United States, Age of Onset, Disease-Free Survival, Microsatellite Repeats, Quantitative Trait, Heritable, Penetrance, Genetic Predisposition to Disease

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Linkage of Type 2 Diabetes Mellitus and of Age at Onset to a Genetic Location on Chromosome 10q in Mexican Americans

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