RBP4: a controversial adipokine
Abstract
Adipose tissue is an endocrine organ secreting biologically active factors called adipokines that act on both local and distant tissues. Adipokines have an important role in the development of obesity-related comorbidities not only in adults but also in children and adolescents. Retinol binding protein 4 (RBP4) is a recently identified adipokine suggested to link obesity with its comorbidities, especially insulin resistance, type 2 diabetes (T2D), and certain components of the metabolic syndrome. However, data, especially resulting from the clinical studies, are conflicting. In this review, we summarize up-to-date knowledge on RBP4's role in obesity, development of insulin resistance, and T2D. Special attention is given to studies on children and adolescents. We also discuss the role of possible confounding factors that should be taken into account when critically evaluating published studies or planning new studies on this exciting adipokine.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some LCN family members, including major urinary protein 1, retinol-binding protein 4, LCN2, and LCN13, regulate energy metabolism.
“Some LCN family members, including major urinary protein 1, retinol-binding protein 4, LCN2, and LCN13, have been shown to regulate energy metabolism [[254], [255], [256]].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [256]
Cites
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522 · see citing works
A decade of molecular biology of retinoic acid receptors
Chambon, P. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801176 · Cited by 2,889 · see citing works
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L., & Kahn, B. B. (2005) · Nature · doi:10.1038/nature03711 · Cited by 2,086 · see citing works
The lipocalin protein family: structure and function
FLOWER, D. R. (1996) · Biochemical Journal · doi:10.1042/bj3180001 · Cited by 1,679 · see citing works
Adipose Tissue as an Endocrine Organ
Ahima, R. S., & Flier, J. S. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00301-5 · Cited by 1,608 · see citing works
Adipose tissue as an endocrine organ
Galić, S., Oakhill, J. S., & Steinberg, G. R. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.018 · Cited by 1,597 · see citing works
Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic Subjects
Graham, T. E., Yang, Q., Blüher, M., Hammarstedt, A., Ciaraldi, T. P., Henry, R. R., Wason, C. J., Oberbach, A., Jansson, P.-A., Smith, U., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054862 · Cited by 1,319 · see citing works
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
Abel, E. D., Peroni, O. D., Kim, J. K., Kim, Y., Boss, O., Hadro, E., Minnemann, T., Shulman, G. I., & Kahn, B. B. (2001) · Nature · doi:10.1038/35055575 · Cited by 1,253 · see citing works
Klöting, N., Fasshauer, M., Dietrich, A., Kovacs, P., Schön, M. R., Kern, M., Stumvoll, M., & Blüher, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00586.2009 · Cited by 856 · see citing works
Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein
Nishizawa, H., Shimomura, I., Kishida, K., Maeda, N., Kuriyama, H., Nagaretani, H., Matsuda, M., Kondo, H., Furuyama, N., Kihara, S., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2734 · Cited by 837 · see citing works
A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A
Kawaguchi, R., Yu, J., Honda, J., Hu, J., Whitelegge, J., Ping, P., Wiita, P., Bok, D., & Sun, H. (2007) · Science · doi:10.1126/science.1136244 · Cited by 836 · see citing works
Adipose Tissue as an Endocrine Organ
Ahima, R. S. (2006) · Obesity · doi:10.1038/oby.2006.317 · Cited by 636 · see citing works
Klöting, N., Graham, T. E., Berndt, J., Kralisch, S., Kovacs, P. L., Wason, C. J., Faßhauer, M., Schön, M. R., Stümvoll, M., Blüher, M., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.002 · Cited by 404 · see citing works
Cho, Y. M., Youn, B., Lee, H., Lee, N., Min, S.-S., Kwak, S. H., Lee, H. K., & Park, K. S. (2006) · Diabetes Care · doi:10.2337/dc06-0360 · Cited by 401 · see citing works
Wabitsch, M., Blum, W. F. P., Muche, R., Braun, M., Hube, F., Rascher, W., Heinze, E., Teller, W. M., & Hauner, H. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119595 · Cited by 360 · see citing works
Retinol-Binding Protein 4 in Human Obesity
Janke, J., Engeli, S., Boschmann, M., Adams, F., Böhnke, J., Luft, F. C., Sharma, A. M., & Jordan, J. (2006) · Diabetes · doi:10.2337/db06-0616 · Cited by 351 · see citing works
Duggirala, R., Blangero, J., Almasy, L., Dyer, T. D., Williams, K. L., Leach, R. J., O'Connell, P., & Stern, M. P. (1999) · The American Journal of Human Genetics · doi:10.1086/302316 · Cited by 337 · see citing works
Retinoids and retinoid-binding protein expression in rat adipocytes.
Tsutsumi, C., Okuno, M., Tannous, L., Piantedosi, R., Allan, M., Goodman, D. S., & Blaner, W. S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46017-6 · Cited by 317 · see citing works
Balagopal, P., Graham, T. E., Kahn, B. B., Altomare, A., Funanage, V. L., & George, D. E. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2712 · Cited by 234 · see citing works
Serum Retinol-Binding Protein 4 Is Reduced after Weight Loss in Morbidly Obese Subjects
Haider, D. G., Schindler, K., Prager, G., Bohdjalian, A., Luger, A., Wolzt, M., & Ludvik, B. H. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1839 · Cited by 216 · see citing works
Yao‐Borengasser, A., Varma, V., Bodles, A. M., Rasouli, N., Phanavanh, B., Lee, M., Starks, T., Kern, L. M., Spencer, H. J., Rashidi, A. A., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0816 · Cited by 215 · see citing works
Stefan, N., Hennige, A. M., Staiger, H., Machann, J., Schick, F., Schleicher, E. D., Fritsche, A., & Häring, H. (2007) · Diabetes Care · doi:10.2337/dc06-2342 · Cited by 212 · see citing works
Elevated Retinol-Binding Protein 4 Levels Are Associated with Metabolic Syndrome in Chinese People
Qi, Q., Yu, Z., Ye, X., Zhao, F., Huang, P., Hu, F. B., Franco, O. H., Wang, J., Li, H., Liu, Y., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1219 · Cited by 209 · see citing works
Endocrinology of Adipose Tissue - An Update
Fischer‐Posovszky, P., Wabitsch, M., & Hochberg, Z. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-976539 · Cited by 200 · see citing works
Retinol Binding Protein-4 Levels and Clinical Features of Type 2 Diabetes Patients
Takebayashi, K., Suetsugu, M., Wakabayashi, S., Aso, Y., & Inukai, T. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1249 · Cited by 198 · see citing works
Meigs, J. B., Panhuysen, C. I. M., Myers, R. H., Wilson, P. W. F., & Cupples, L. A. (2002) · Diabetes · doi:10.2337/diabetes.51.3.833 · Cited by 185 · see citing works
Adipocytokines and Insulin Resistance
Esteve, E., Ricart, W., & Fernández‐Real, J. M. (2009) · Diabetes Care · doi:10.2337/dc09-s340 · Cited by 182 · see citing works
Plasma retinol binding protein: structure and function of the prototypic lipocalin
Newcomer, M. E., & Ong, D. E. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00150-3 · Cited by 172 · see citing works
von Eynatten, M., Lepper, P. M., Liu, D., Lang, K., Baumann, M., Nawroth, P. P., Bierhaus, A., Dugi, K. A., Heemann, U. W., Allolio, B., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0743-8 · Cited by 171 · see citing works
Gavi, S., Stuart, L. M., Kelly, P., Meléndez, M. M., Mynarcik, D. C., Gelato, M. C., & McNurlan, M. A. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1815 · Cited by 167 · see citing works
Herter‐Aeberli, I., Biebinger, R., Lehmann, R., l’Allemand, D., Spinas, G. A., & Zimmermann, M. B. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0468 · Cited by 149 · see citing works
Broch, M., Vendrell, J. J., Ricart, W., Richart, C., & Fernández‐Real, J. M. (2007) · Diabetes Care · doi:10.2337/dc06-2034 · Cited by 149 · see citing works
Şen, Y., Kandemir, N., Alikaşifoğlu, A., Gonc, N. E., & Özön, A. (2008) · European Journal of Pediatrics · doi:10.1007/s00431-007-0658-x · Cited by 145 · see citing works
Goodman, A. B. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20784 · Cited by 137 · see citing works
Jia, W., Wu, H., Bao, Y., Wang, C., Lu, J., Zhu, J., & Xiang, K. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0209 · Cited by 132 · see citing works
Lee, D., Lee, J., & Im, J. (2007) · Metabolism · doi:10.1016/j.metabol.2006.10.011 · Cited by 128 · see citing works
Öst, A., Danielsson, A., Lidén, M., Eriksson, U., Nyström, F. H., & Strålfors, P. (2007) · The FASEB Journal · doi:10.1096/fj.07-8173com · Cited by 126 · see citing works
Hermsdorff, H. H. M., Zulet, M. Á., Puchau, B., & Martínez, J. A. (2010) · Inflammation · doi:10.1007/s10753-010-9219-y · Cited by 124 · see citing works
Retinol, α-tocopherol and carotenoids in diabetes
Abahusain, M., Wright, J. L., Dickerson, J., & Vol, E. B. D. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600825 · Cited by 122 · see citing works
The interaction of retinol-binding protein with its plasma-membrane receptor.
Sivaprasadarao, A., & Findlay, J. B. C. (1988) · PubMed Central · Cited by 118 · see citing works
Ingelsson, E., Sundström, J., Melhus, H., Michaëlsson, K., Berne, C., Vasan, R. S., Risérus, U., Blomhoff, R., Lind, L., & Ärnlöv, J. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.02.029 · Cited by 114 · see citing works
Munkhtulga, L., Nakayama, K., Utsumi, N., Yanagisawa, Y., Gotoh, T., Omi, T., Kumada, M., Erdenebulgan, B., Zolzaya, K., Lkhagvasuren, T., et al. (2006) · Human Genetics · doi:10.1007/s00439-006-0264-4 · Cited by 109 · see citing works
Henze, A., Frey, S. K., Raila, J., Tepel, M., Scholze, A., Pfeiffer, A. F. H., Weickert, M. O., Spranger, J., & Schweigert�, F. J. (2008) · Diabetes · doi:10.2337/db08-0866 · Cited by 109 · see citing works
Cloning and sequencing of a full length cDNA coding for human retinol-binding protein
Colantuoni, V., Romano, V., Bensi, G., Santoro, C., Costanzo, F. S., Raugei, G., & Cortese, R. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.22.7769 · Cited by 104 · see citing works
Ku, Y., Han, K. D., Ahn, H., Kwon, H.-R., Koo, B., Kim, H. C., & Min, K. (2010) · Journal of International Medical Research · doi:10.1177/147323001003800305 · Cited by 102 · see citing works
RBP‐to‐retinol ratio, but not total RBP, is elevated in patients with type 2 diabetes
Erikstrup, C., Mortensen, O. H., Nielsen, A. R., Fischer, C. P., Plomgaard, P., Petersen, A. M., Krogh‐Madsen, R., Lindegaard, B., Erhardt, J. G., Ullum, H., et al. (2008) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00901.x · Cited by 99 · see citing works
Bobbert, T., Raila, J., Schwarz, F., Mai, K., Henze, A., Pfeiffer, A. F. H., Schweigert�, F. J., & Spranger, J. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.07.063 · Cited by 98 · see citing works
Šiklová, M., Klimčáková, E., Kováčiková, M., Valle, C., Moro, C., Polak, J., Hanáček, J., Capel, F., Viguerie, N., Richterova, B., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2668 · Cited by 97 · see citing works
Mody, N., Graham, T. E., Tsuji, Y., Yang, Q., & Kahn, B. B. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00521.2007 · Cited by 94 · see citing works
Kovacs, P. L., Geyer, M., Berndt, J., Klöting, N., Graham, T. E., Böttcher, Y., Enigk, B., Tönjes, A., Schleinitz, D., Schön, M. R., et al. (2007) · Diabetes · doi:10.2337/db06-1647 · Cited by 93 · see citing works
Tan, B. K., Chen, J., Lehnert, H., Kennedy, R., & Randeva, H. S. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0091 · Cited by 90 · see citing works
Insulin Resistance Is Unrelated to Circulating Retinol Binding Protein and Protein C Inhibitor
Promintzer, M., Krebs, M., Todoric, J., Luger, A., Bischof, M. G., Nowotny, P., Wagner, O. F., Esterbauer, H., & Anderwald, C. H. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2522 · Cited by 90 · see citing works
Craig, R. L., Chu, W. S., & Elbein, S. C. (2006) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2006.11.003 · Cited by 89 · see citing works
Reinehr, T., Stoffel‐Wagner, B., & Roth, C. L. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2745 · Cited by 87 · see citing works
Visceral Adiposity Is Associated with Serum Retinol Binding Protein‐4 Levels in Healthy Women
Lee, J., Im, J., Lee, H. C., Shim, J., Youn, B., & Lee, D. (2007) · Obesity · doi:10.1038/oby.2007.264 · Cited by 86 · see citing works
Serum Levels of Adipokine Retinol-Binding Protein-4 in Relation to Renal Function
Ziegelmeier, M., Bachmann, A., Seeger, J., Lössner, U., Kratzsch, J., Blüher, M., Stümvoll, M., & Faßhauer, M. (2007) · Diabetes Care · doi:10.2337/dc07-0275 · Cited by 80 · see citing works
Vitamin A (retinol) status of first nation adults with non-insulin-dependent diabetes mellitus.
Basualdo, C., Wein, E. E., & Basu, T. K. (1997) · Journal of the American College of Nutrition · doi:10.1080/07315724.1997.10718647 · Cited by 79 · see citing works
Differentiation-dependent expression of retinoid-binding proteins in BFC-1 beta adipocytes.
Zovich, D., Orologa, A., Okuno, M., Kong, L. W., Talmage, D. A., Piantedosi, R., Goodman, D. S., & Blaner, W. S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49651-8 · Cited by 76 · see citing works
Jaconi, S., Rose, K., Hughes, G. J., Saurat, J. ‐., & Siegenthaler, G. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41132-0 · Cited by 65 · see citing works
Retinol-Binding Protein 4 and Prediction of Incident Coronary Events in Healthy Men and Women
Mallat, Z., Simon, T., Bénessiano, J., Clément, K., Taleb, S., Wareham, N. J., Luben, R., Khaw, K., Tedgui, A., & Boekholdt, S. M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0253 · Cited by 64 · see citing works
Elevated serum RBP4 is associated with insulin resistance in women with polycystic ovary syndrome
Weiping, L., Cheng, Q., Ma, S., Xiurong, L., Hua, Q., Xiaoshu, B., Suhua, Z., & Qifu, L. (2006) · Endocrine · doi:10.1007/s12020-006-0006-3 · Cited by 63 · see citing works
Retinol-Binding Protein 4 in Twins
Ribel‐Madsen, R., Friedrichsen, M. H., Vaag, A. A., & Poulsen, P. (2008) · Diabetes · doi:10.2337/db08-1019 · Cited by 62 · see citing works
Kanaka‐Gantenbein, C., Margeli, A., Pervanidou, P., Sakka, S. D., Mastorakos, G. P., Chrousos, G. P., & Papassotiriou, I. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.099002 · Cited by 61 · see citing works
Ülgen, F., Herder, C., Kühn, M. C., Willenberg, H. S., Schott, M., Scherbaum, W. A., & Schinner, S. (2010) · Archives of Physiology and Biochemistry · doi:10.3109/13813451003631421 · Cited by 58 · see citing works
Nair, A. K., Sugunan, D., Kumar, H., & Gopalakrishnapillai, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011444 · Cited by 58 · see citing works
Regulatory SNP in the RBP4 Gene Modified the Expression in Adipocytes and Associated With BMI
Munkhtulga, L., Nagashima, S., Nakayama, K., Utsumi, N., Yanagisawa, Y., Gotoh, T., Omi, T., Kumada, M., Zolzaya, K., Lkhagvasuren, T., et al. (2009) · Obesity · doi:10.1038/oby.2009.358 · Cited by 56 · see citing works
Choi, K. M., Yannakoulia, M., Park, M. S., Cho, G. J., Kim, J. H., Lee, S. H., Hwang, T. G., Yang, S. J., Kim, T. N., Yoo, H. J., et al. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29667 · Cited by 54 · see citing works
Retinol binding protein 4 (RBP4) is primarily associated with adipose tissue mass in children
Friebe, D., Neef, M., Erbs, S., Dittrich, K., Kratzsch, J., Kovacs, P. L., Blüher, M., Kiess, W., & Körner, A. (2010) · International Journal of Pediatric Obesity · doi:10.3109/17477166.2010.491228 · Cited by 54 · see citing works
Lim, S. K., Yoon, J. W., Choi, S. H., Park, Y. J., Lee, J. J., Park, J. H., Lee, S. B., Kim, K. W., Lim, J., Kim, Y., et al. (2009) · Obesity · doi:10.1038/oby.2009.232 · Cited by 51 · see citing works
Kelly, K. R., Kashyap, S. R., O’Leary, V. B., Major, J. A., Schauer, P. R., & Kirwan, J. P. (2009) · Obesity · doi:10.1038/oby.2009.328 · Cited by 51 · see citing works
Retinol-binding protein 4 expression in visceral and subcutaneous fat in human obesity
Bajzová, M., Kováčiková, M., Vítková, M., Klimčáková, E., Polak, J., Kováčová, Z., Viguerie, N., Vedral, T., Mikulášek, L., Šrámková, P., et al. (2008) · Physiological Research · doi:10.33549/physiolres.931379 · Cited by 49 · see citing works
Metabolic Syndrome in Pediatrics: Old Concepts Revised, New Concepts Discussed
D’Adamo, E., Santoro, N., & Caprio, S. (2009) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2009.06.002 · Cited by 48 · see citing works
Lee, J., Lee, H.-R., Shim, J., Im, J., & Lee, D. (2008) · Endocrine Journal · doi:10.1507/endocrj.k08e-030 · Cited by 46 · see citing works
Aigner, E. S., Bachofner, N., Klein, K., Geyter, C. D., Hohla, F., Patsch, W., & Datz, C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2156 · Cited by 44 · see citing works
Chávez, A. O., Coletta, D. K., Kamath, S., Cromack, D. T., Monroy, A., Folli, F. B., DeFronzo, R. A., & Tripathy, D. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90737.2008 · Cited by 44 · see citing works
Fernández‐Real, J. M., Moreno‐Navarrete, J. M., & Ricart, W. (2008) · Diabetes · doi:10.2337/db08-0041 · Cited by 44 · see citing works
Wu, Y., Li, H., Loos, R. J. F., Qi, Q., Hu, F. B., Liu, Y., & Lin, X. (2009) · Journal of Lipid Research · doi:10.1194/jlr.p900014-jlr200 · Cited by 42 · see citing works
Serum retinol binding protein 4 level is related with renal functions in Type 2 diabetes
Akbay, E., Muşlu, N., Nayır, E., Ozhan, O., & KIYKIM, A. A. (2010) · Journal of Endocrinological Investigation · doi:10.1007/bf03346678 · Cited by 41 · see citing works
Sasaki, M., Otani, T., Kawakami, M., & Ishikawa, S. (2009) · Metabolism · doi:10.1016/j.metabol.2009.08.015 · Cited by 37 · see citing works
Gnudi, L., Shepherd, P. R., & Kahn, B. B. (1996) · Proceedings of The Nutrition Society · doi:10.1079/pns19960020 · Cited by 37 · see citing works
Sell, H., & Eckel, J. (2007) · Diabetologia · doi:10.1007/s00125-007-0764-3 · Cited by 36 · see citing works
Goodman, E., Graham, T. E., Dolan, L. M., Daniels, S. R., Goodman, E. R., & Kahn, B. B. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2008.07.018 · Cited by 34 · see citing works
Elevated serum retinol-binding protein 4 is associated with insulin resistance in older women
Suh, J.-B., Kim, S. M., Cho, G.-J., Choi, K. M., Han, J. H., & Hwang, T. G. (2009) · Metabolism · doi:10.1016/j.metabol.2009.06.025 · Cited by 34 · see citing works
Makino, S., FUJIWARA, M. T., Suzukawa, K., Handa, H., Fujie, T., Ohtaka, Y., Komatsu, Y., Aoki, Y., Maruyama, H., Terada, Y., et al. (2008) · Hormone and Metabolic Research · doi:10.1055/s-0028-1100411 · Cited by 33 · see citing works
Human RBP4 adipose tissue expression is gender specific and influenced by leptin
Kos, K., Wong, S., Tan, B. K., Kerrigan, D. D., Randeva, H. S., Pinkney, J. H., & Wilding, J. P. H. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03892.x · Cited by 33 · see citing works
An, C., Wang, H., Liu, X.-M., Li, Y., Su, Y., Gao, X., & JIANG, W. (2009) · Endocrine Journal · doi:10.1507/endocrj.k09e-096 · Cited by 29 · see citing works
An Increase in Serum Retinol-Binding Protein 4 in the Type 2 Diabetic Subjects with Nephropathy
MURATA, M., Saito, T., Otani, T., SASAKI, M., Ikoma, A., Toyoshima, H., Kawakami, M., & Ishikawa, S. (2009) · Endocrine Journal · doi:10.1507/endocrj.k08e-242 · Cited by 28 · see citing works
Specific uptake of retinol-binding protein by variant F9 cell lines.
Matarese, V., & Lodish, H. F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46706-8 · Cited by 24 · see citing works
Frey, S. K., Spranger, J., Henze, A., Pfeiffer, A. F. H., Schweigert�, F. J., & Raila, J. (2009) · Metabolism · doi:10.1016/j.metabol.2009.05.003 · Cited by 23 · see citing works
Santoro, N., Perrone, L., Cirillo, G., Brienza, C., Grandone, A., Cresta, N., & del Giudice, E. M. (2009) · Journal of Endocrinological Investigation · doi:10.1007/bf03346477 · Cited by 19 · see citing works
Retinol-Binding Protein 4 Levels in Obese Children and Adolescents with Glucose Intolerance
Yeste, D., Vendrell, J. J., Tomasini, R., Gallart, L., Clemente, M., Simón, I., Albisu, M., Gussinyé, M., Audı́, L., & Carrascosa, A. (2010) · Hormone Research in Paediatrics · doi:10.1159/000308165 · Cited by 18 · see citing works
Kim, I. K., Lee, H.-J., Kang, J., & Song, J. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.251 · Cited by 17 · see citing works
Aust, G., Uptaite-Patapoviene, M., Scholz, M. R., Richter, O., Rohm, S., & Blüher, M. (2011) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.03.008 · Cited by 16 · see citing works
Retinol-binding protein 4 in neonates born small for gestational age
Giacomozzi, C., Ghirri, P., Lapolla, R., Bartoli, A., Scirè, G., Serino, L., Germani, D., Boldrini, A., & Cianfarani, S. (2010) · Journal of Endocrinological Investigation · doi:10.1007/bf03345782 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028 · see citing works
Adipocytokines in Obesity and Metabolic Disease
Cao, H. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0339 · Cited by 705 · see citing works
Hepatokines: Linking nonalcoholic fatty liver disease and insulin resistance
Meex, R. C. R., & Watt, M. J. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.56 · Cited by 631 · see citing works
Berger, M. M., Shenkin, A., Schweinlin, A., Amrein, K., Augsburger, M., Biesalski, H.-K., Bischoff, S. C., Casaer, M. P., Gundogan, K., Lepp, H.-L., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.02.015 · Cited by 615 · see citing works
Immune Regulation of Metabolic Homeostasis in Health and Disease
Brestoff, J. R., & Artis, D. (2015) · Cell · doi:10.1016/j.cell.2015.02.022 · Cited by 498 · see citing works
Biomarkers of Nutrition for Development (BOND)-Vitamin A Review
Tanumihardjo, S. A., Russell, R. M., Stephensen, C. B., Gannon, B. M., Craft, N. E., Haskell, M. J., Lietz, G., Schulze, K., & Raiten, D. J. (2016) · The Journal of Nutrition · doi:10.3945/jn.115.229708 · Cited by 451 · see citing works
Retinol and retinyl esters: biochemistry and physiology
O'Byrne, S. M., & Blaner, W. S. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r037648 · Cited by 378 · see citing works
Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication
Funcke, J., & Scherer, P. E. (2019) · Journal of Lipid Research · doi:10.1194/jlr.r094060 · Cited by 337 · see citing works
Inter-organ cross-talk in metabolic syndrome
Priest, C., & Tontonoz, P. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0145-5 · Cited by 279 · see citing works
Adipose tissue and its role in organ crosstalk
Romacho, T., Elsen, M., Röhrborn, D., & Eckel, J. (2014) · Acta Physiologica · doi:10.1111/apha.12246 · Cited by 278 · see citing works
HOCKING, S. L., Samocha‐Bonet, D., Milner, K., Greenfield, J. R., & Chisholm, D. J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1041 · Cited by 281 · see citing works
Norseen, J., Hosooka, T., Hammarstedt, A., Yore, M. M., Kant, S., Aryal, P., Kiernan, U. A., Phillips, D. A., Maruyama, H., Kraus, B. J., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06193-11 · Cited by 272 · see citing works
Hepatokines and metabolism: Deciphering communication from the liver
Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252 · see citing works
Adipokines in gestational diabetes
Fasshauer, M., Blüher, M., & Stumvoll, M. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70176-1 · Cited by 230 · see citing works
Besse-Patin, A., Montastier, E., Vinel, C., Castan-Laurell, I., Louche, K., Dray, C., Daviaud, D., Mir, L., Marques, M.-A., Thalamas, C., et al. (2014) · International Journal of Obesity · doi:10.1038/ijo.2013.158 · Cited by 227 · see citing works
Neale, E. P., Batterham, M. J., & Tapsell, L. C. (2016) · Nutrition Research · doi:10.1016/j.nutres.2016.02.009 · Cited by 220 · see citing works
Biomarkers of insulin sensitivity and insulin resistance: Past, present and future
Park, S. E., Park, C., & Sweeney, G. (2015) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2015.1023429 · Cited by 209 · see citing works
Vitamins and Type 2 Diabetes Mellitus
Valdés‐Ramos, R., Laura, G., Elina, M.-C., & Donaji, B.-A. (2014) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530314666141111103217 · Cited by 187 · see citing works
Recent advances in biosensor technology in assessment of early diabetes biomarkers
Salek-Maghsoudi, A., Vakhshiteh, F., Torabi, R., Hassani, S., Ganjali, M. R., Norouzi, P., Hosseini, M., & Abdollahi, M. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2017.07.047 · Cited by 174 · see citing works
RNA-targeting and gene editing therapies for transthyretin amyloidosis
Aimo, A., Castiglione, V., Rapezzi, C., Franzini, M., Panichella, G., Vergaro, G., Gillmore, J. D., Fontana, M., Passino, C., & Emdin, M. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00683-z · Cited by 170 · see citing works
GRUBB, A. O., Lindström, V., Jonsson, M., Bäck, S.-E., Åhlund, T., Rippe, B., & Christensson, A. G. (2015) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2015.1025427 · Cited by 139 · see citing works
Lipophilic Micronutrients and Adipose Tissue Biology
Landrier, J., Marcotorchino, J., & Tourniaire, F. (2012) · Nutrients · doi:10.3390/nu4111622 · Cited by 129 · see citing works
Retinol Binding Protein 4 in Relation to Diet, Inflammation, Immunity, and Cardiovascular Diseases
Zabetian‐Targhi, F., Mahmoudi, M. J., Rezaei, N., & Mahmoudi, M. (2015) · Advances in Nutrition · doi:10.3945/an.115.008292 · Cited by 129 · see citing works
The multifaceted nature of retinoid transport and metabolism
(2014) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2304-3881.2014.05.04 · Cited by 125 · see citing works
Plasma Retinol-Binding Protein 4 (RBP4) Levels and Risk of Coronary Heart Disease
Sun, Q., Kiernan, U. A., Shi, L., Phillips, D. A., Kahn, B. B., Hu, F. B., Manson, J. E., Albert, C. M., & Rexrode, K. M. (2013) · Circulation · doi:10.1161/circulationaha.113.002073 · Cited by 118 · see citing works
Hepatokines and adipokines in NASH-related hepatocellular carcinoma
Kücükoglu, Ö., Sowa, J., Mazzolini, G. D., Syn, W., & Canbay, A. E. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.10.030 · Cited by 114 · see citing works
Wang, X., Hasegawa, J., Kitamura, Y., Wang, Z., Matsuda, A., Shinoda, W., Miura, N., & Kimura, K. (2011) · Journal of Pharmacological Sciences · doi:10.1254/jphs.11097fp · Cited by 115 · see citing works
Inflammatory Signaling and Brown Fat Activity
Omran, F., & Christian, M. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00156 · Cited by 107 · see citing works
Adipocyte‐specific overexpression of retinol‐binding protein 4 causes hepatic steatosis in mice
Lee, S., Yuen, J. J., Jiang, H., Kahn, B. B., & Blaner, W. S. (2016) · Hepatology · doi:10.1002/hep.28659 · Cited by 100 · see citing works
Desmet, K. L. J., Hoeck, V. V., Gagné, D., Fournier, E., Thakur, A., O’Doherty, A., Walsh, C. P., Sirard, M., Bols, P. E. J., & Leroy, J. (2016) · BMC Genomics · doi:10.1186/s12864-016-3366-y · Cited by 98 · see citing works
Bergmann, K., & Sypniewska, G. (2012) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2012-0490 · Cited by 96 · see citing works
The Roles of Vitamin A in the Regulation of Carbohydrate, Lipid, and Protein Metabolism
Chen, W., & Chen, G. (2014) · Journal of Clinical Medicine · doi:10.3390/jcm3020453 · Cited by 93 · see citing works
Retinol-binding protein 4 in obesity and metabolic dysfunctions
Nankam, P. A. N., & Blüher, M. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111312 · Cited by 91 · see citing works
RNA Targeting and Gene Editing Strategies for Transthyretin Amyloidosis
Ioannou, A., Fontana, M., & Gillmore, J. D. (2023) · BioDrugs · doi:10.1007/s40259-023-00577-7 · Cited by 90 · see citing works
Frye, M. A., Nassan, M. M., Jenkins, G. D., Kung, S., Veldić, M., Palmer, B. A., Feeder, S. E., Tye, S. J., Choi, D., & Biernacka, J. M. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.185 · Cited by 87 · see citing works
Retinoids: Potent regulators of metabolism
Brun, P., Yang, K. J. Z., Lee, S., Yuen, J. J., & Blaner, W. S. (2012) · BioFactors · doi:10.1002/biof.1056 · Cited by 84 · see citing works
Ong, K. L., Rye, K., O'Connell, R. L., Jenkins, A. J., Brown, C. S. B., Xu, A., SULLIVAN, D. R., Barter, P. J., KEECH, A. C., & on behalf of the FIELD study investigators (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2267 · Cited by 82 · see citing works
Bonet, M. L., Ribot, J., Galmés, S., Serra, F. A., & Palou, A. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158676 · Cited by 80 · see citing works
Wong, Y., & Tse, H. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.713191 · Cited by 82 · see citing works
Venojärvi, M., Wasenius, N., Manderoos, S., Heinonen, O. J., Hernelahti, M., Lindholm, H. J., Surakka, J., Lindström, J., Aunola, S., Atalay, M., et al. (2012) · Annals of Medicine · doi:10.3109/07853890.2012.727020 · Cited by 78 · see citing works
Oluwagbemigun, K., Buyken, A. E., Alexy, U., Schmid, M. C., Herder, C., & Nöthlings, U. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0813-5 · Cited by 77 · see citing works
Retinoid Metabolism and Diabetes Mellitus
Rhee, E., & Plutzky, J. (2012) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2012.36.3.167 · Cited by 73 · see citing works
Spyrou, N., Avgerinos, K. I., Mantzoros, C. S., & Dalamaga, Μ. (2018) · Current Obesity Reports · doi:10.1007/s13679-018-0318-7 · Cited by 75 · see citing works
den Hartigh, L. D., May, K. S., Zhang, X.-S., Chait, A., & Blaser, M. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1197432 · Cited by 75 · see citing works
Urine Retinol-Binding Protein 4
Norden, A. G. W., Lapsley, M., & Unwin, R. J. (2013) · Advances in clinical chemistry · doi:10.1016/b978-0-12-800094-6.00003-0 · Cited by 73 · see citing works
Kiliçarslan, M., de Weijer, B. A., Sjödin, K. S., Aryal, P., ter Horst, K. W., Cakir, H., Romijn, J. A., Ackermans, M. T., Janssen, I. M. C., Berends, F. J., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201901979rr · Cited by 65 · see citing works
Chen, D., Zhang, Y., Yidilisi, A., Xu, Y., Dong, Q., & Jiang, J. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac048 · Cited by 66 · see citing works
The molecular aspects of absorption and metabolism of carotenoids and retinoids in vertebrates
Widjaja‐Adhi, M. A. K., & Golczak, M. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.158571 · Cited by 65 · see citing works
Vaishya, S., Sarwade, R. D., & Seshadri, V. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00180 · Cited by 64 · see citing works
Llombart, V., García‐Berrocoso, T., Bustamante, A., Giralt, D., Rodríguez‐Luna, D., Muchada, M., Peñalba, A., Boada, C., Hernández‐Guillamón, M., & Montaner, J. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13419 · Cited by 62 · see citing works
Transthyretin amyloid cardiomyopathy: a paradigm for advancing precision medicine
González-López, E., Maurer, M. S., & García‐Pavía, P. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae811 · Cited by 60 · see citing works
Mody, N., & Mcilroy, G. D. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.07.012 · Cited by 55 · see citing works
Liu, Y., Wang, D., Li, D., Sun, R., & Xia, M. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-25 · Cited by 56 · see citing works
Cioffi, C. L., Dobri, N., Freeman, E. E., Conlon, M. P., Chen, P., Stafford, D. G., Schwarz, D. M. C., Golden, K. C., Zhu, L., Kitchen, D. B., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm5010013 · Cited by 56 · see citing works
Proinflammatory and lipid biomarkers mediate metabolically healthy obesity: A proteomics study
Doumatey, A. P., Zhou, J., Zhou, M., Prieto, D. A., Rotimi, C. N., & Adeyemo, A. (2016) · Obesity · doi:10.1002/oby.21482 · Cited by 52 · see citing works
Rosell, M., Hondares, E., Iwamoto, S., Gonzalez, F. J., Wabitsch, M., Staels, B., Olmos, Y., Monsalve, M., Giralt, M., Iglesias, R., et al. (2012) · Endocrinology · doi:10.1210/en.2011-1367 · Cited by 52 · see citing works
Terra, X., Auguet, T., Broch, M., Sabench, F., Hernández, M., Pastor, R. M., Quesada, I., Luna, A. M., Aguilar, C., Déjardin, D. D. C., et al. (2013) · Obesity · doi:10.1002/oby.20233 · Cited by 50 · see citing works
Ma, X., Zhou, Z., Chen, Y., Wu, Y., & Liu, Y. (2015) · Diabetologia · doi:10.1007/s00125-015-3807-1 · Cited by 51 · see citing works
Chen, Y., Azman, S. N., Kerishnan, J. P., Zain, R. B., Chen, Y. N., Wong, Y.-L., & Gopinath, S. C. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109012 · Cited by 47 · see citing works
Long-Term High-Fat High-Fructose Diet Induces Type 2 Diabetes in Rats through Oxidative Stress
Zhao, Y., Wang, Q., Zeng, L.-T., Wang, J.-J., Liu, Z., Fan, G., Li, J., & Cai, J. (2022) · Nutrients · doi:10.3390/nu14112181 · Cited by 45 · see citing works
Retinol-Binding Protein 4 Induces Hepatic Mitochondrial Dysfunction and Promotes Hepatic Steatosis
Liu, Y., Mu, D., Chen, H., Li, D., Song, J., Yuan, Ž., & Xia, M. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1320 · Cited by 44 · see citing works
A discovery-phase urine proteomics investigation in type 1 diabetes
Soggiù, A., Piras, C., Bonizzi, L., Hussein, H. A., Pisanu, S., & Roncada, P. (2012) · Acta Diabetologica · doi:10.1007/s00592-012-0407-0 · Cited by 41 · see citing works
Pullakhandam, R., Palika, R., Ghosh, S., & Reddy, G. B. (2012) · IUBMB Life · doi:10.1002/iub.1096 · Cited by 41 · see citing works
Proteomic and genomic studies of non-alcoholic fatty liver disease - clues in the pathogenesis
Lim, J. W. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i26.8325 · Cited by 40 · see citing works
Mohamad, N. E., Yeap, S. K., Kỳ, H., Ho, W. Y., Boo, S. Y., Chua, J. Y. H., Beh, B., Sharifuddin, S. A., Long, K., & Alitheen, N. B. (2017) · Food & Nutrition Research · doi:10.1080/16546628.2017.1368322 · Cited by 40 · see citing works
Rácz, B., Váradi, A., Kong, J., Allikmets, R. L., Pearson, P. G., Johnson, G., Cioffi, C. L., & Petrukhin, K. E. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002062 · Cited by 40 · see citing works
Jiao, C., Cui, L., Ma, A., Li, N., & Si, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167498 · Cited by 38 · see citing works
Lachine, N. A., Elnekeidy, A., Megallaa, M. H. Z., Khalil, G. I., Sadaka, M. A., Rohoma, K. H., & Kassab, H. S. (2016) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018816637312 · Cited by 38 · see citing works
Nanda, S., Nikoletakis, G., Markova, D. M., Poon, L. C., & Nicolaides, K. H. (2013) · Metabolism · doi:10.1016/j.metabol.2012.12.011 · Cited by 37 · see citing works
Biomarkers of Metabolic Syndrome: Biochemical Background and Clinical Significance
Robberecht, H. J., & Hermans, N. (2016) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2015.0113 · Cited by 37 · see citing works
Vendrame, S., Zhao, A. S., Merrow, T., & Klimis‐Zacas, D. J. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2014.0065 · Cited by 37 · see citing works
Association of RBP4 genetic variants with childhood obesity and cardiovascular risk factors
Codoñer‐Franch, P., Carrasco‐Luna, J., Allepuz, P., Codoñer‐Alejos, A., & Guillem, V. M. (2015) · Pediatric Diabetes · doi:10.1111/pedi.12339 · Cited by 34 · see citing works
Personalizing Nutrition Strategies: Bridging Research and Public Health
Clemente‐Suárez, V. J., Peris-Ramos, H. C., Redondo-Flórez, L., Beltrán-Velasco, A. I., Martín-Rodríguez, A., David-Fernandez, S., Sepulveda, R. A. Y., & Tornero-Aguilera, J. F. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14030305 · Cited by 35 · see citing works
Xiao, J., Liu, H., Yao, J., Yang, S., Shen, F., Bu, K., Wang, Z., Liu, F., Xia, N., Yuan, Q., et al. (2024) · Open Research (University of Surrey) · doi:10.1002/viw.20240031 · Cited by 35 · see citing works
Chielle, E. O., de Souza, W. M., da Silva, T. P., Moresco, R. N., & Moretto, M. B. (2016) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2016.01.003 · Cited by 34 · see citing works
Are adipokines associated with gestational diabetes mellitus?
Görkem, Ü., Küçükler, F. K., Toğrul, C., & Gungor, T. (2016) · Journal of the Turkish-German Gynecological Association · doi:10.5152/jtgga.2016.16112 · Cited by 34 · see citing works
Karadağ, A. S., Ertuğrul, D. T., Kalkan, G., Bilgili, S. G., Çelik, H. T., Takçı, Z., Balahoroğlu, R., & Çalka, Ö. (2013) · Dermatology · doi:10.1159/000351769 · Cited by 34 · see citing works
Retinol binding protein 4 and type 2 diabetes: from insulin resistance to pancreatic β-cell function
Fan, J., & Hu, J. (2024) · Endocrine · doi:10.1007/s12020-024-03777-5 · Cited by 36 · see citing works
Vergès, B. L., Guiu, B., Cercueil, J., Duvillard, L., Robin, I., Buffier, P., Bouillet, B., Aho, S., Brindisi, M., & Petit, J. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.255190 · Cited by 33 · see citing works
Retinol and Retinol Binding Protein 4 Levels and Cardiometabolic Disease Risk
Schiborn, C., Weber, D., Grune, T., Biemann, R., Jäger, S., Neu, N., von Blumencron, M. M., Fritsche, A., Weikert, C., Schulze, M. B., et al. (2022) · Circulation Research · doi:10.1161/circresaha.122.321295 · Cited by 34 · see citing works
Retinol‐binding protein 4 levels and susceptibility to ischaemic events in men
Cubedo, J., Padró, T., Cinca, J., Mata, P., Rodrigo Alonso, K., & Badimón, L. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12229 · Cited by 31 · see citing works
Umeno, A., Yoshino, K., Hashimoto, Y. K., Shichiri, M., Kataoka, M., & Yoshida, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130971 · Cited by 32 · see citing works
Neirynck, N., Eloot, S., Glorieux, G., Barreto, D. V., Barreto, F. C., Liabeuf, S., Lenglet, A., Lemke, H. ‐., Massy, Z. A., & Vanholder, R. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044201 · Cited by 32 · see citing works
Pandey, G. K., Balasubramanyam, J., Balakumar, M., Deepa, M., Anjana, R. M., Shiny, A., Anand, K., Velmurugan, K., Miranda, P., Balasubramanyam, M., et al. (2015) · Endocrine Practice · doi:10.4158/ep14558.or · Cited by 30 · see citing works
Ross, A., & Harrison, E. H. (2013) · CRC Press eBooks · doi:10.1201/b15413-2 · Cited by 30 · see citing works
Ooi, D. J., Adamu, H. A., Imam, M. U., Ithnin, H., & Ismail, M. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.12.002 · Cited by 31 · see citing works
Association of retinol binding protein 4 with risk of gestational diabetes
Abetew, D. F., Qiu, C., Fida, N., Dishi, M., Hevner, K., Williams, M. A., & Enquobahrie, D. A. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.10.023 · Cited by 29 · see citing works
Dessein, P. H., Tsang, L., Norton, G. R., Woodiwiss, A. J., & Solomon, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092739 · Cited by 29 · see citing works
Manicam, C., Perumal, N., Wasielica‐Poslednik, J., Ngongkole, Y. C., Tschäbunin, A., Sievers, M., Lisch, W., Pfeiffer, N., Grus, F. H., & Gericke, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-30032-5 · Cited by 28 · see citing works
Lipocalin 13 regulation of glucose and lipid metabolism in obesity
Zhou, Y., & Rui, L. (2013) · Vitamins & Hormones · doi:10.1016/b978-0-12-407766-9.00015-8 · Cited by 28 · see citing works
Wang, P., Menheere, P. P. C. A., Astrup, A. V., Andersen, M. R., van Baak, M. A., Larsen, T. M., Jebb, S. A., Kafatos, A., Pfeiffer, A. F. H., Martínez, J. A., et al. (2013) · Obesity · doi:10.1002/oby.20311 · Cited by 28 · see citing works
Adipokines, Vascular Wall, and Cardiovascular Disease
Maresca, F., Palma, V. D., Bevilacqua, M., Uccello, G., Taglialatela, V., Giaquinto, A., Esposito, G., Trimarco, B., & Cirillo, P. L. (2014) · Angiology · doi:10.1177/0003319713520463 · Cited by 27 · see citing works
Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis
Fenzl, A., Kulterer, O. C., Spirk, K., Mitulović, G., Marculescu, R., Bilban, M., Baumgartner-Parzer, S. M., Kautzky‐Willer, A., Kenner, L., Plutzky, J., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101088 · Cited by 29 · see citing works
Li, M., Wang, Z., Zhu, L., Shui, Y., Zhang, S., & Guo, W. (2021) · Bioscience Reports · doi:10.1042/bsr20210328 · Cited by 28 · see citing works
Cioffi, C. L., Rácz, B., Váradi, A., Freeman, E. E., Conlon, M. P., Chen, P., Zhu, L., Kitchen, D. B., Barnes, K. D., Martin, W. H., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00352 · Cited by 29 · see citing works
Dietary vitamin A impacts DNA methylation patterns of adipogenesis-related genes in suckling rats
Arreguín, A., Ribot, J., Mušinović, H., Lintig, J. V., Palou, A., & Bonet, M. L. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.05.009 · Cited by 27 · see citing works
Proteomic Analysis of RBP4/Vitamin A in Children with Cleft Lip and/or Palate
Zhang, J., Zhou, S., Zhang, Q., Feng, S., Chen, Y., Zheng, H., Wang, X., Zhao, W., Zhang, T., Zhou, Y., et al. (2014) · Journal of Dental Research · doi:10.1177/0022034514530397 · Cited by 26 · see citing works
Mansouri, M., Nikooie, R., Keshtkar, A., Larijani, B. A., & Omidfar, K. (2014) · Journal of Diabetes Investigation · doi:10.1111/jdi.12186 · Cited by 26 · see citing works
Alterations in vitamin A/retinoic acid homeostasis in diet-induced obesity and insulin resistance
Mody, N. (2017) · Proceedings of The Nutrition Society · doi:10.1017/s0029665117001069 · Cited by 26 · see citing works
Lipocalin-2 plasmatic levels are reduced in patients with long-term type 2 diabetes mellitus.
de la Chesnaye, E., Manuel‐Apolinar, L., Zárate, A., Damasio, L., Espino, N., Revilla-Monsalve, M. C., & Islas‐Andrade, S. (2015) · PubMed Central · Cited by 26 · see citing works
- Authors
- Kotnik, P., Fischer-Posovszky, P., & Wabitsch, M.
- Affiliations
- Universität Ulm (DE)
- Corresponding author
- Wabitsch, Martin
- ORCID
- Wabitsch, Martin
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-11
- Volume
- 165
- Issue
- 5
- Pages
- 703-711
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2133792826
- Cited by
- 233
- References
- 94
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 8 · 2023: 11 · 2022: 13 · 2021: 10 · 2020: 17 · 2019: 15 · 2018: 16 · 2017: 11 · 2016: 23 · 2015: 28 · 2014: 28 · 2013: 26 · 2012: 19
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- retinol-binding protein 4, adipokines, obesity, insulin resistance, type 2 diabetes, metabolic syndrome, childhood obesity, adolescent obesity, obesity-related comorbidities, confounding factors
- MeSH terms
- Adipose Tissue, Animals, Clinical Trials as Topic, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Obesity, Adipokines, Retinol-Binding Proteins, Plasma
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review