Cited by 234Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

RBP4: a controversial adipokine

Kotnik, Primoz, Fischer-Posovszky, Pamela, Wabitsch, Martin·2011·European Journal of Endocrinology

Abstract

Adipose tissue is an endocrine organ secreting biologically active factors called adipokines that act on both local and distant tissues. Adipokines have an important role in the development of obesity-related comorbidities not only in adults but also in children and adolescents. Retinol binding protein 4 (RBP4) is a recently identified adipokine suggested to link obesity with its comorbidities, especially insulin resistance, type 2 diabetes (T2D), and certain components of the metabolic syndrome. However, data, especially resulting from the clinical studies, are conflicting. In this review, we summarize up-to-date knowledge on RBP4's role in obesity, development of insulin resistance, and T2D. Special attention is given to studies on children and adolescents. We also discuss the role of possible confounding factors that should be taken into account when critically evaluating published studies or planning new studies on this exciting adipokine.

Integrity signals

Registry

Crossref · 10.1530/eje-11-0431

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94 of 94 references verified0 citation errors · 0 not checkable

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  • Some LCN family members, including major urinary protein 1, retinol-binding protein 4, LCN2, and LCN13, regulate energy metabolism.

    “Some LCN family members, including major urinary protein 1, retinol-binding protein 4, LCN2, and LCN13, have been shown to regulate energy metabolism [[254], [255], [256]].”

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Authors
Kotnik, P., Fischer-Posovszky, P., & Wabitsch, M.
Affiliations
Universität Ulm (DE)
Corresponding author
Wabitsch, Martin
Venue
European Journal of Endocrinology
Published
2011-11
Volume
165
Issue
5
Pages
703-711
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
OpenAlex
W2133792826
Cited by
233
References
94
Citations by year
2026: 3 · 2025: 4 · 2024: 8 · 2023: 11 · 2022: 13 · 2021: 10 · 2020: 17 · 2019: 15 · 2018: 16 · 2017: 11 · 2016: 23 · 2015: 28 · 2014: 28 · 2013: 26 · 2012: 19
FWCI
2.77
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
retinol-binding protein 4, adipokines, obesity, insulin resistance, type 2 diabetes, metabolic syndrome, childhood obesity, adolescent obesity, obesity-related comorbidities, confounding factors
MeSH terms
Adipose Tissue, Animals, Clinical Trials as Topic, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Obesity, Adipokines, Retinol-Binding Proteins, Plasma

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