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Use of Unlinked Genetic Markers to Detect Population Stratification in Association Studies
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We examine the issue of population stratification in association-mapping studies. In case-control studies of association, population subdivision or recent admixture of populations can lead to spurious associations between a phenotype and unlinked candidate loci. Using a model of sampling from a structured population, we show that if population stratification exists, it can be detected by use of unlinked marker loci. We show that the case-control-study design, using unrelated control individuals, is a valid approach for association mapping, provided that marker loci unlinked to the candidate locus are included in the study, to test for stratification. We suggest guidelines as to the number of unlinked marker loci to use.
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“Methods were developed to detect and adjust for such biases (67–69) as well as unexpected relatedness between subjects.”
From Genetic Mapping in Human Disease (2008) · cites this paper as [68]
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“Under the null (one-cluster) model of no population structure, for which the L and H groups are assumed to be well matched, we observed a large excess of small P values in x 2 tests for association with skin color (table 2), and a global test for population stratification based on the sum of x 2 statistics 46 was highly statistically significant”
From A Genomewide Association Study of Skin Pigmentation in a South Asian Population (2007) · cites this paper as [46]
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Cites
THE GENETICAL STRUCTURE OF POPULATIONS
Wright, S. (1949) · Annals of Eugenics · doi:10.1111/j.1469-1809.1949.tb02451.x · Cited by 6,729
The Future of Genetic Studies of Complex Human Diseases
Risch, N., & Merikangas, K. (1996) · Science · doi:10.1126/science.273.5281.1516 · Cited by 5,355
Spielman, R. S., McGinnis, R. E., & Ewens, W. J. (1993) · PubMed · Cited by 3,679
Genetic Dissection of Complex Traits
Lander, E. S., & Schork, N. J. (1994) · Science · doi:10.1126/science.8091226 · Cited by 3,425
The History and Geography of Human Genes
Cavalli-Sforza, L. L., Menozzi, P., & Piazza, A. (2018) · Princeton University Press eBooks · doi:10.2307/j.ctv301gjp · Cited by 3,175
Wang, D. G., Fan, J., Siao, C.-J., Berno, A. J., Young, P. R., Sapolsky, R., Ghandour, G., Perkins, N., Winchester, E., Spencer, J. B., et al. (1998) · Science · doi:10.1126/science.280.5366.1077 · Cited by 2,162
Genetic dissection of complex traits
Witte, J., Elston, R., & Schork, N. (1996) · Nature Genetics · doi:10.1038/ng0496-355 · Cited by 1,883
Gene genealogies and the coalescent process.
Hudson, R. R. (1990) · Medical Entomology and Zoology · Cited by 1,838
Evaluating loci for use in the genetic analysis of population structure
(1996) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1996.0237 · Cited by 1,768
OXFORD SURVEYS IN EVOLUTIONARY BIOLOGY
Allendorf, F. W., Dawkins, R., & Ridley, M. (1989) · Evolution · doi:10.2307/2409372 · Cited by 1,462
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- Jorde, 1995, Origins and affinities of modern humans: a comparison of mitochondrial and nuclear genetic data, Am J Hum Genet, 57, 523
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Pritchard, J. K., Stephens, M., & Donnelly, P. (2000) · Genetics · doi:10.1093/genetics/155.2.945 · Cited by 33,871
Self-citationGenome-wide association studies for common diseases and complex traits
Hirschhorn, J. N., & Daly, M. J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1521 · Cited by 2,923
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,416
Association mapping in structured populations.
Pritchard, J. K., Stephens, M., Rosenberg, N., & Donnelly, P. (2000) · American Journal of Human Genetics · doi:10.1086/302959 · Cited by 2,066
Self-citationSearching for genetic determinants in the new millennium
Risch, N. J. (2000) · Nature · doi:10.1038/35015718 · Cited by 1,839
Structure of Linkage Disequilibrium in Plants
Flint-Garcia, S. A., Thornsberry, J. M., & Buckler, E. S. (2003) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.54.031902.134907 · Cited by 1,752
A comprehensive review of genetic association studies
Hirschhorn, J. N., Lohmueller, K., Byrne, E., & Hirschhorn, K. (2002) · Genetics in Medicine · doi:10.1097/00125817-200203000-00002 · Cited by 1,674
Genetic Mapping in Human Disease
Altshuler, D., Daly, M. J., & Lander, E. S. (2008) · Science · doi:10.1126/science.1156409 · Cited by 1,452
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Holsinger, K. E., & Weir, B. S. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2611 · Cited by 1,480
Association study designs for complex diseases
Cardon, L. R., & Bell, J. I. (2001) · Nature Reviews Genetics · doi:10.1038/35052543 · Cited by 1,395
Status and Prospects of Association Mapping in Plants
Zhu, C., Gore, M. A., Buckler, E. S., & Yu, J. (2008) · The Plant Genome · doi:10.3835/plantgenome2008.02.0089 · Cited by 1,395
Linkage Disequilibrium in Humans: Models and Data
Pritchard, J. K., & Przeworski, M. (2001) · The American Journal of Human Genetics · doi:10.1086/321275 · Cited by 1,285
Self-citationPopulation stratification and spurious allelic association
Cardon, L. R., & Palmer, L. J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12520-2 · Cited by 1,189
New approaches to population stratification in genome-wide association studies
Price, A. L., Zaitlen, N., Reich, D., & Patterson, N. J. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2813 · Cited by 1,226
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Genome-wide association studies: theoretical and practical concerns
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Hunter, D. J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1578 · Cited by 1,132
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Flint-Garcia, S. A., Thuillet, A., Yu, J., Pressoir, G., Romero, S. M., Mitchell, S. E., Doebley, J., Kresovich, S., Goodman, M. M., & Buckler, E. S. (2005) · The Plant Journal · doi:10.1111/j.1365-313x.2005.02591.x · Cited by 916
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Marchini, J., Cardon, L. R., Phillips, M. S., & Donnelly, P. (2004) · Nature Genetics · doi:10.1038/ng1337 · Cited by 869
Chumakov, I. M., BLUMENFELD, M. L., Guerassimenko, O., Cavarec, L., Palicio, M., Abderrahim, H., Bougueleret, L., Barry, C., Tanaka, H., Rosa, P. L., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182412499 · Cited by 834
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Kaufman, J., Yang, B., Douglas-Palumberi, H., Houshyar, S., Lipschitz, D. S., Krystal, J. H., & Gelernter, J. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404376101 · Cited by 819
Assessing the impact of population stratification on genetic association studies
Freedman, M. L., Reich, D., Penney, K. L., McDonald, G. J., Mignault, A. A., Patterson, N. J., Gabriel, S., Topol, E. J., Smoller, J. W., Pato, C. N., et al. (2004) · Nature Genetics · doi:10.1038/ng1333 · Cited by 807
Informativeness of Genetic Markers for Inference of Ancestry*
Rosenberg, N. A., Li, L. M., Ward, R. H., & Pritchard, J. K. (2003) · The American Journal of Human Genetics · doi:10.1086/380416 · Cited by 710
Self-citationKaufman, J., Yang, B.-Z., Douglas-Palumberi, H., Grasso, D., Lipschitz, D., Houshyar, S., Krystal, J. H., & Gelernter, J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.026 · Cited by 692
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Novembre, J., & Stephens, M. (2008) · Nature Genetics · doi:10.1038/ng.139 · Cited by 685
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Liu, Y., Helms, C., Liao, W. J., Zaba, L. C., Duan, S., Gardner, J. M., Wise, C. A., Miner, A. G., Malloy, M. J., Pullinger, C. R., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000041 · Cited by 674
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Thakkinstian, A., McElduff, P., D’Este, C. A., Duffy, D. L., & Attia, J. (2004) · Statistics in Medicine · doi:10.1002/sim.2010 · Cited by 615
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Malhotra, A. K., Kestler, L. J., Mazzanti, C. M., Bates, J. A., Goldberg, T. E., & Goldman, D. A. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.652 · Cited by 623
Cordell, H. J., & Clayton, D. G. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67424-7 · Cited by 587
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Revealing the architecture of gene regulation: the promise of eQTL studies
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Hu, X., Oroszi, G., Chun, J., Smith, T. L., Goldman, D. A., & Schuckit, M. A. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000150008.68473.62 · Cited by 478
Peacock, M., Turner, C. H., Econs, M. J., & Foroud, T. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.3.0464 · Cited by 464
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Smith, M. W., Patterson, N., Lautenberger, J. A., Truelove, A. L., McDonald, G. J., Waliszewska, A., Kessing, B. D., Malasky, M. J., Scafe, C., Le, E., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/420856 · Cited by 459
Association studies for finding cancer-susceptibility genetic variants
Pharoah, P. D. P., Dunning, A. M., Ponder, B. A. J., & Easton, D. F. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1476 · Cited by 460
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Astle, W. J., & Balding, D. J. (2009) · Statistical Science · doi:10.1214/09-sts307 · Cited by 477
Comparison of FST outlier tests for SNP loci under selection
Narum, S. R., & Hess, J. E. (2011) · Molecular Ecology Resources · doi:10.1111/j.1755-0998.2011.02987.x · Cited by 468
Demonstrating stratification in a European American population
Campbell, C. D., Ogburn, E. L., Lunetta, K. L., Lyon, H. N., Freedman, M. L., Groop, L. C., Altshuler, D., Ardlie, K. G., & Hirschhorn, J. N. (2005) · Nature Genetics · doi:10.1038/ng1607 · Cited by 444
Influence of mode of delivery on gut microbiota composition in seven year old children: Table 1
Salminen, S., Gibson, G. R., McCartney, A. L., & Isolauri, E. (2004) · Gut · doi:10.1136/gut.2004.041640 · Cited by 435
Haplotypes vs single marker linkage disequilibrium tests: what do we gain?
Akey, J. M., Li, J., & Xiong, M. (2001) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200619 · Cited by 435
Fallin, M. D., Cohen, A., Essioux, L., Chumakov, I. M., BLUMENFELD, M. L., Cohen, D., & Schork, N. J. (2001) · Genome Research · doi:10.1101/gr.148401 · Cited by 417
Kilpatrick, D. G., Koenen, K. C., Ruggiero, K. J., Acierno, R. E., Galea, S., Resnick, H. S., Roitzsch, J. C., Boyle, J. M., & Gelernter, J. E. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06122007 · Cited by 405
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Kochi, Y., Yamada, R., Suzuki, A., Harley, J. B., Shirasawa, S., Sawada, T., Bae, S., Tokuhiro, S., Chang, X., Sekine, A., et al. (2005) · Nature Genetics · doi:10.1038/ng1540 · Cited by 394
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Stolk, L., Perry, J. R. B., Chasman, D. I., He, C., Mangino, M., Sulem, P., Barbalić, M., Broer, L., Byrne, E. M., Ernst, F. D., et al. (2012) · Nature Genetics · doi:10.1038/ng.1051 · Cited by 373
Bellizzi, D., Rose, G., Cavalcante, P., Covello, G., Dato, S., De Rango, F., Greco, V., Maggiolini, M., Feraco, E., Mari, V., et al. (2005) · Genomics · doi:10.1016/j.ygeno.2004.11.003 · Cited by 367
Burchard, E. G., Borrell, L., Choudhry, S., Naqvi, M., Tsai, H.-J., Rodriguez-Santana, J., Chapela, R., Rogers, S. D., Mei, R., Rodriguez-Cintron, W., et al. (2005) · American Journal of Public Health · doi:10.2105/ajph.2005.068668 · Cited by 385
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Leek, J. T., & Storey, J. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808709105 · Cited by 376
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Reliability of Genomic Predictions Across Multiple Populations
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Sen, S., Nesse, R. M., Stoltenberg, S. F., Li, S., Gleiberman, L., Chakravarti, A., Weder, A. B., & Burmeister, M. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300053 · Cited by 331
Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder
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Chen, Y., Lin, S., Lin, M., Tsai, H.-L., Kuo, S.-S., Chen, J., Charng, M., Wu, T.-C., Chen, L.-C., Ding, P. Y. A., et al. (2002) · Human Genetics · doi:10.1007/s00439-002-0769-4 · Cited by 309
Genetics of Crohn disease, an archetypal inflammatory barrier disease
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Leschziner, G. D., Andrew, T., Pirmohamed, M., & Johnson, M. R. (2006) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500413 · Cited by 306
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Galanter, J., Fernández-López, J. C., Gignoux, C. R., Barnholtz‐Sloan, J. S., Fernández–Rozadilla, C., Vía, M., Hidalgo‐Miranda, A., Contreras, A. V., Uribe-Figueroa, L., Raska, P., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002554 · Cited by 305
Lekman, M., Laje, G., Charney, D., Rush, A. J., Wilson, A. F., Sorant, A. J. M., Lipsky, R., Wisniewski, S. R., Manji, H., McMahon, F. J., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.026 · Cited by 284
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Newton‐Cheh, C., & Hirschhorn, J. N. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.01.006 · Cited by 285
Topol, E. J., McCarthy, J. J., Gabriel, S., Moliterno, D. J., Rogers, W. J., Newby, L. K., Freedman, M., Metivier, J., Cannata, R., O’Donnell, C. J., et al. (2001) · Circulation · doi:10.1161/hc4701.100910 · Cited by 282
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Pfaff, C., Parra, E., Bonilla, C., Hiester, K., McKeigue, P., Kamboh, M., Hutchinson, R., Ferrell, R., Boerwinkle, E., & Shriver, M. (2001) · American Journal of Human Genetics · doi:10.1086/316935 · Cited by 271
Xie, P., Kranzler, H. R., Poling, J., Stein, M. B., Anton, R. F., Brady, K., Weiss, R. D., Farrer, L., & Gelernter, J. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.153 · Cited by 264
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Raby, B. A., Lazarus, R. M., Silverman, E. K., Lake, S., Lange, C., Wjst, M., & Weiss, S. T. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200404-447oc · Cited by 263
Sookoian, S. C., Gemma, C., Gianotti, T. F., Burgueño, A. L., Castaño, G. O., & Pirola, C. J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1606 · Cited by 262
Haplotype Block Structure and Its Applications to Association Studies: Power and Study Designs
Zhang, K., Calabrese, P. P., Nordborg, M., & Sun, F. (2002) · The American Journal of Human Genetics · doi:10.1086/344780 · Cited by 262
Kabbaj, H., Sall, A. T., Al-Abdallat, A. M., Geleta, M., Amri, A., Filali‐Maltouf, A., Belkadi, B., Ortiz, R. O., & Bassi, F. M. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01277 · Cited by 257
Population structure and long-range linkage disequilibrium in a durum wheat elite collection
Maccaferri, M., Sanguineti, M. C., Noli, E., & Tuberosa, R. (2005) · Molecular Breeding · doi:10.1007/s11032-004-7012-z · Cited by 256
Wacholder, S., Rothman, N., & Caporaso, N. E. (2002) · PubMed · Cited by 255
Stein, M. B., Schork, N. J., & Gelernter, J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301422 · Cited by 247
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Metadata
- Authors
- Pritchard, J. K., & Rosenberg, N. A.
- Affiliations
- University of Oxford (GB)
- Stanford University (US)
- Corresponding author
- Pritchard, Jonathan K.
- Venue
- The American Journal of Human Genetics
- Publisher
- Elsevier BV
- Published
- 1999-07
- Volume
- 65
- Issue
- 1
- Pages
- 220-228
- ISSN
- 0002-9297 (ISSN-L)
- PMC
- PMC1378093
- OpenAlex
- W2116329478
- Cited by
- 1,198
- References
- 27
- Citations by year
- 2026: 9 · 2025: 3 · 2024: 9 · 2023: 6 · 2022: 3 · 2021: 9 · 2020: 13 · 2019: 49 · 2018: 21 · 2017: 12 · 2016: 22 · 2015: 27 · 2014: 28 · 2013: 42 · 2012: 46
- FWCI
- 27.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The American Journal of Human Genetics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Defense Science and Engineering Graduate
- National Institute of General Medical Sciences (GM19634, GM 28428, F32GM019634, P01GM028428)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- population stratification, association mapping, case-control study, spurious association, admixture, population structure
- MeSH terms
- Alleles, Genetic Markers, Genotype, Humans, Genetic Linkage, Models, Genetic, Research Design, Case-Control Studies
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