Elderly Humans Show Prolonged In Vivo Inflammatory Activity during Pneumococcal Infections
Abstract
Levels of circulating cytokines were measured in 22 hospitalized patients with pneumococcal infections during the first week after admission, to test for age-associated differences. Twenty-two healthy age- and sex-matched subjects were included as controls. Concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, IL-1 receptor antagonist, soluble TNF receptor I (sTNFR-I), and IL-10 were increased on admission (P<.05), but macrophage inflammatory protein (MIP)-1beta was not. Whereas levels of cytokines were similar on admission, levels of TNF-alpha and sTNFR-I after 1 week were higher (P<.05) in elderly (68-91 years) than in young (37-55 years) patients. Furthermore, plasma levels of IL-10 and sTNFR-I after 1 week were positively correlated with age, and the declines in sTNFR-I and in the TNFalpha/IL-10 ratio from day 0 to day 7 were correlated with age. Thus, aging was associated with prolonged inflammatory activity. This may reflect decreased ability to control the infection or a dysregulated cytokine response.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Elderly patients exhibit reduced tolerance to systemic inflammation, with increased mortality when compared with younger septic individuals.
“Further, elderly patients exhibit reduced tolerance to systemic inflammation, with increased mortality when compared with younger septic individuals (146–148).”
From Aging and Lung Disease (2020) · cites this paper as [148]
Cites
The aging immune system: primer and prospectus
Miller, R. A. (1996) · Science · doi:10.1126/science.273.5271.70 · Cited by 1,165 · cited 1× · see citing works
“Decreased ability to clear bacterial infections may be related to immunosenescence [12], as described in rodent models [13].”
BackgroundIncreased cytokine production in mononuclear cells of healthy elderly people
Fagiolo, U., Cossarizza, A., Scala, E., Fanales‐Belasio, E., Ortolani, C., Cozzi, E., Monti, D., Franceschi, C., & Paganelli, R. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230950 · Cited by 665 · see citing works
Anti-inflammatory cytokine profile and mortality in febrile patients
van Dissel, J. T., van Langevelde, P., Westendorp, R. G., Kwappenberg, K. M. C., & Frölich, M. (1998) · The Lancet · doi:10.1016/s0140-6736(05)60606-x · Cited by 481 · see citing works
Interieukin-10 Impairs Host Defense in Murine Pneumococcal Pneumonia
van der Poll, T., Marchant, A., Keogh, C. V., Goldman, M., & Lowry, S. F. (1996) · The Journal of Infectious Diseases · doi:10.1093/infdis/174.5.994 · Cited by 254 · see citing works
Lipopolysaccharide-induced lethality and cytokine production in aged mice
Tateda, K., Matsumoto, T., Miyazaki, S., & Yamaguchi, K. (1996) · Infection and Immunity · doi:10.1128/iai.64.3.769-774.1996 · Cited by 235 · see citing works
Afebrile bacteremia. A phenomenon in geriatric patients
Gleckman, R. A. (1982) · JAMA · doi:10.1001/jama.248.12.1478 · Cited by 205 · see citing works
van der Poll, T., Keogh, C. V., Buurman, W. A., & Lowry, S. F. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.2.9032201 · Cited by 199 · see citing works
Role of tumor necrosis factor alpha in pathogenesis of pneumococcal pneumonia in mice
Takashima, K., Tateda, K., Matsumoto, T., Iizawa, Y., Nakao, M., & Yamaguchi, K. (1997) · Infection and Immunity · doi:10.1128/iai.65.1.257-260.1997 · Cited by 178 · see citing works
O’Mahony, L., Holland, J., Jackson, J., Feighery, C., Hennessy, T. P. J., & Mealy, K. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00641.x · Cited by 173 · see citing works
Gon, Y., Hashimoto, S., Hayashi, S., Koura, T., Matsumoto, K., & Horie, T. (1996) · PubMed · Cited by 127 · see citing works
Nielsen, S. V., & Henrichsen, J. (1996) · Epidemiology and Infection · doi:10.1017/s0950268800059057 · Cited by 91 · see citing works
Streptococcus pneumoniae Bacteremia in a Community Hospital
Torres, J. M., Cardenas, O., Vasquez, A., & Schlossberg, D. (1998) · CHEST Journal · doi:10.1378/chest.113.2.387 · Cited by 79 · see citing works
Aging and the response to salmonella infection
Bradley, S. F., & Kauffman, C. A. (1990) · Experimental Gerontology · doi:10.1016/0531-5565(90)90012-q · Cited by 35 · see citing works
Role of Cytokines in the Acute Phase Response
Kluger, M. J. (1994) · Defense Technical Information Center (DTIC) · Cited by 31 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Steensberg, A., van Hall, G., Osada, T., Sacchetti, M., Saltin, B., & Pedersen, B. K. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00237.x · Cited by 1,095 · see citing works
Self-citationGavazzi, G., & Krause, K.-H. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00437-1 · Cited by 990 · see citing works
Inflammatory mediators in the elderly
Krabbe, K. S., Pedersen, M., & Bruunsgaard, H. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.01.009 · Cited by 928 · see citing works
Self-citationMuscle‐derived interleukin‐6: mechanisms for activation and possible biological roles
FEBBRAIO, M. A., & PEDERSEN, B. K. (2002) · The FASEB Journal · doi:10.1096/fj.01-0876rev · Cited by 875 · see citing works
Self-citationFerrucci, L., Penninx, B. W. J. H., Volpato, S., Harris, T. B., Bandeen‐Roche, K., Balfour, J., Leveille, S. G., Fried, L. P., & Md, J. M. G. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50605.x · Cited by 618 · see citing works
Age-related inflammatory cytokines and disease
Brüünsgaard, H., & Pedersen, B. K. (2003) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(02)00056-5 · Cited by 608 · see citing works
Self-citationCho, S. J., & Stout-Delgado, H. W. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034610 · Cited by 458 · see citing works
Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity
Minciullo, P. L., Catalano, A., Mandraffino, G., Casciaro, M., Crucitti, A., Maltese, G., Morabito, N., Lasco, A., Gangemi, S., & Basile, G. (2016) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-015-0377-3 · Cited by 433 · see citing works
Taaffe, D. R., Harris, T. B., Ferrucci, L., Rowe, J., & Seeman, T. E. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.12.m709 · Cited by 438 · see citing works
Inflammaging as a prodrome to Alzheimer's disease
Giunta, B., Fernandez, F., Nikolic, W. V., Obregon, D., Rrapo, E., Town, T., & Tan, J. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-51 · Cited by 327 · see citing works
Innate immune responses in the ageing lung.
Boe, D. M., Boule, L. A., & Kovacs, E. J. (2016) · Clinical and Experimental Immunology · doi:10.1111/cei.12881 · Cited by 156 · see citing works
Immunosenescence and pneumococcal disease: an imbalance in host-pathogen interactions.
Krone, C. L., van de Groep, K., Trzciński, K., Sanders, E. A. M., & Bogaert, D. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70165-6 · Cited by 134 · see citing works
- Authors
- Bruunsgaard, H., Skinhøj, P., Qvist, J., & Pedersen, B. K.
- Affiliations
- University of Copenhagen (DK)
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-08
- Volume
- 180
- Issue
- 2
- Pages
- 551-554
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2119524953
- Cited by
- 167
- References
- 14
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 7 · 2020: 7 · 2019: 10 · 2018: 8 · 2017: 4 · 2016: 5 · 2015: 6 · 2014: 11 · 2013: 3 · 2012: 3
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- pneumococcal infection, Streptococcus pneumoniae, aging, elderly patients, inflammatory cytokines, TNF-α, soluble TNF receptor 1, IL-10, interleukin-6, IL-1β, macrophage inflammatory protein-1β, cytokine response, dysregulated inflammation
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Female, Humans, Male, Meningitis, Pneumococcal, Middle Aged, Pneumococcal Infections, Pneumonia, Pneumococcal, Streptococcus pneumoniae, Case-Control Studies, Cytokines, Matched-Pair Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
