The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Protection against Experimental Staphylococcus aureus Arthritis by Vaccination with Clumping Factor A, a Novel Virulence Determinant
Abstract
The importance of the fibrinogen-binding adhesin clumping factor A (ClfA) in the pathogenesis of Staphylococcus aureus septic arthritis was examined in an animal model. The protective effect of active and passive immunization with ClfA also was investigated in S. aureus infection models. The severity of arthritis was markedly reduced in mice challenged intravenously with a clfA mutant, compared with mice infected with the wild-type strain. Mice immunized with recombinant ClfA and challenged with S. aureus developed less-severe arthritis than did mice immunized with a control antigen. Passive immunization of mice with rat and rabbit anti-ClfA antibodies protected against S. aureus arthritis and sepsis-induced death, indicating that the protection by active immunization is antibody mediated. Taken together, these data strongly suggest that ClfA is a crucial virulence determinant for septic arthritis and an excellent target for the generation of immune therapies directed against S. aureus.
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Cites
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Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus
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Self-citationBroadly Protective Vaccine for Staphylococcus aureus Based on an in Vivo-Expressed Antigen
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Cited by
Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
Foster, T. J., Geoghegan, J. A., Ganesh, V. K., & Höök, M. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3161 · Cited by 1,533
Self-citationMolecular Basis of In Vivo Biofilm Formation by Bacterial Pathogens
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The Role of Macrophages in Staphylococcus aureus Infection
Pidwill, G. R., Gibson, J. F., Cole, J., Renshaw, S. A., & Foster, S. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.620339 · Cited by 341
Vaccine assembly from surface proteins of Staphylococcus aureus
Stranger-Jones, Y. K., Bae, T., & Schneewind, O. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606863103 · Cited by 309
Surface Adhesins of Staphylococcus aureus
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Metadata
- Authors
- Josefsson, E., Hartford, O., O'Brien, L., Patti, J. M., & Foster, T.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-12-15
- Volume
- 184
- Issue
- 12
- Pages
- 1572-1580
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2119011878
- Cited by
- 287
- References
- 26
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Josefsson, E., Hartford, O., O'Brien, L., Patti, J. M., & Foster, T. (2001). Protection against Experimental Staphylococcus aureus Arthritis by Vaccination with Clumping Factor A, a Novel Virulence Determinant. The Journal of Infectious Diseases. https://doi.org/10.1086/324430
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
