Lethal Synergism between Influenza Virus and Streptococcus pneumoniae: Characterization of a Mouse Model and the Role of Platelet‐Activating Factor Receptor

Principles and Practice of Infectious Diseases.

(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-818_5 · Cited by 12,045

Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor

Cundell, D. R., Gerard, N. P., Gerard, C. J., Idänpään‐Heikkilä, I., & TUOMANEN, E. I. (1995) · Nature · doi:10.1038/377435a0 · Cited by 741

The impact of influenza epidemics on mortality: introducing a severity index.

Simonsen, L., Clarke, M. J., Williamson, G. D., Stroup, D. F., Arden, N. H., & Schonberger, L. B. (1997) · American Journal of Public Health · doi:10.2105/ajph.87.12.1944 · Cited by 587

Options for the control of influenza III

Ada, G., Tannock, G. A., & Hampson, A. W. (1997) · Vaccine · doi:10.1016/s0264-410x(96)00191-0 · Cited by 587

STUDIES ON INFLUENZA IN THE PANDEMIC OF 1957-1958. II. PULMONARY COMPLICATIONS OF INFLUENZA*†

Louria, D. B., Blumenfeld, H. L., Ellis, J. T., Kilbourne, E. D., & Rogers, D. E. (1959) · Journal of Clinical Investigation · doi:10.1172/jci103791 · Cited by 479

The Impact of Influenza Epidemics on Hospitalizations

Simonsen, L., Fukuda, K., Schonberger, L. B., & Cox, N. J. (2000) · The Journal of Infectious Diseases · doi:10.1086/315320 · Cited by 476

Apoptosis: a mechanism of cell killing by influenza A and B viruses

Hinshaw, V. S., Olsen, C. W., Dybdahl-Sissoko, N., & Evans, D. T. (1994) · Journal of Virology · doi:10.1128/jvi.68.6.3667-3673.1994 · Cited by 424

The Polymeric Immunoglobulin Receptor Translocates Pneumococci across Human Nasopharyngeal Epithelial Cells

Zhang, J., Mostov, K. E., Lamm, M. E., Nanno, M., Shimida, S.-I., Ohwaki, M., & TUOMANEN, E. I. (2000) · Cell · doi:10.1016/s0092-8674(00)00071-4 · Cited by 418

Pathogenesis of Pneumococcal Infection

TUOMANEN, E. I., AUSTRIAN, R. C., & Masure, H. R. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505113321907 · Cited by 381

Respiratory viral infection predisposing for bacterial disease: a concise review.

Hament, J.-M., Kimpen, J. L. L., Fleer, A., & Wolfs, T. F. W. (1999) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1999.tb01389.x · Cited by 306

Platelet Activating Factor (PAF): A Mediator of Inflammation

Upton, J. E. M., Grunebaum, E., Sussman, G., & Vadas, P. (2022) · BioFactors · doi:10.1002/biof.1883 · Cited by 79

Platelet-Activating Factor Receptor Plays a Role in Lung Injury and Death Caused by Influenza A in Mice

Garcia, C. C., Russo, R. C., Guabiraba, R., Fagundes, C. T., Polidoro, R. B., Tavares, L. P., Salgado, A. P. C., Cassali, G. D., Sousa, L. P., Machado, A. V., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001171 · Cited by 79

The Association of Respiratory Viruses, Temperature, and Other Climatic Parameters with the Incidence of Invasive Pneumococcal Disease in Sydney, Australia

Watson, M., Gilmour, R. E., Menzies, R., Ferson, M. J., McIntyre, P. B., & New South Wales Pneumococcal Network (2005) · Clinical Infectious Diseases · doi:10.1086/498897 · Cited by 79

The role of influenza in the severity and transmission of respiratory bacterial disease

Mina, M. J., & Klugman, K. P. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70131-6 · Cited by 84

Enhancement of immune responses to influenza vaccine (H3N2) by ginsenoside Re

Song, X., Chen, J., Sakwiwatkul, K., Li, R., & Hu, S. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.12.009 · Cited by 72

Viral–bacterial interactions in the respiratory tract

Bellinghausen, C., Rohde, G. G. U., Savelkoul, P. H. M., Wouters, E. F. �., & Stassen, F. R. M. (2016) · Journal of General Virology · doi:10.1099/jgv.0.000627 · Cited by 77

Viral Coinfections in Children With Invasive Pneumococcal Disease

Techasaensiri, B., Techasaensiri, C., Mejías, A., McCracken, G. H., & Ramilo, O. (2010) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3181cdafc2 · Cited by 70

A Mouse Model of Lethal Synergism Between Influenza Virus and Haemophilus influenzae

Lee, L. N., Dias, P. B., Han, D., Yoon, S., Shea, A., Zakharov, V., Parham, D. M., & Sarawar, S. R. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090596 · Cited by 73

Dynamic Virus-Bacterium Interactions in a Porcine Precision-Cut Lung Slice Coinfection Model: Swine Influenza Virus Paves the Way for Streptococcus suis Infection in a Two-Step Process

Meng, F., Wu, N., Nerlich, A. G., Herrler, G., Valentin‐Weigand, P., & Seitz, M. (2015) · Infection and Immunity · doi:10.1128/iai.00171-15 · Cited by 71

The role of respiratory viruses in the etiology of bacterial pneumonia

Lee, K. H., Gordon, A., & Foxman, B. (2016) · Evolution Medicine and Public Health · doi:10.1093/emph/eow007 · Cited by 73

Maternal Influenza Immunization and Prevention of Severe Clinical Pneumonia in Young Infants

Omer, S. B., Clark, D. R., Aqil, A. R., Tapia, M. D., Nunes, M. C., Kozuki, N., Steinhoff, M. C., Madhi, S. A., & Wairagkar, N. S. (2018) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000001914 · Cited by 67

Host‐pathogen kinetics during influenza infection and coinfection: insights from predictive modeling

Smith, A. M. (2018) · Immunological Reviews · doi:10.1111/imr.12692 · Cited by 71

Influenza vaccination is associated with reduced severity of community-acquired pneumonia

Tessmer, A., Welte, T., Schmidt-Ott, R., Eberle, S., Barten, G., Suttorp, N., & Schaberg, T. (2011) · European Respiratory Journal · doi:10.1183/09031936.00133510 · Cited by 65

Influenza-Induced Inflammation Drives Pneumococcal Otitis Media

Short, K. R., Reading, P. C., Brown, L. E., Pedersen, J., Gilbertson, B. P., Job, E. R., Edenborough, K. M., Habets, M. N., Zomer, A., Hermans, P. W. M., et al. (2013) · Infection and Immunity · doi:10.1128/iai.01278-12 · Cited by 65

Postviral Complications

Prasso, J. E., & Deng, J. C. (2016) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2016.11.006 · Cited by 67

Inflammation as a Modulator of Host Susceptibility to Pulmonary Influenza, Pneumococcal, and Co-Infections

Aguilera, E. R., & Lenz, L. L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00105 · Cited by 65

Preventing and Treating Secondary Bacterial Infections with Antiviral Agents

McCullers, J. A. (2011) · Antiviral Therapy · doi:10.3851/imp1730 · Cited by 65

Defects in T-cell–mediated immunity to influenza virus in murine Wiskott-Aldrich syndrome are corrected by oncoretroviral vector–mediated gene transfer into repopulating hematopoietic cells

Strom, T. S., Turner, S. J., Andreansky, S. S., Liu, H., Doherty, P. C., Srivastava, D. K., Cunningham, J. M., & Nienhuis, A. W. (2003) · Blood · doi:10.1182/blood-2002-11-3489 · Cited by 64

Influenza Viruses, Including Avian Influenza and Swine Influenza

Treanor, J. J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-443-06839-3.00165-x · Cited by 63

The Innate Immune Response of Atlantic Salmon (Salmo salar) Is Not Negatively Affected by High Temperature and Moderate Hypoxia

Zanuzzo, F. S., Beemelmanns, A., Hall, J. R., Rise, M. L., & Gamperl, A. K. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01009 · Cited by 62

MicroRNA-155 regulates host immune response to postviral bacterial pneumonia via IL-23/IL-17 pathway

Podsiad, A. B., Standiford, T. J., Ballinger, M. N., Eakin, R., Park, P. K., Kunkel, S. L., Moore, B. B., & Bhan, U. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00224.2015 · Cited by 63

Potential role for alternatively activated macrophages in the secondary bacterial infection during recovery from influenza

Chen, W. H., Toapanta, F. R., Shirey, K. A., Zhang, L., Giannelou, A., Page, C., Frieman, M. B., Vogel, S. N., & Cross, A. S. (2011) · Immunology Letters · doi:10.1016/j.imlet.2011.10.009 · Cited by 64

Influenza A Virus Neuraminidase Enhances Meningococcal Adhesion to Epithelial Cells through Interaction with Sialic Acid-Containing Meningococcal Capsules

Rameix‐Welti, M., Zarantonelli, L., Giorgini, D., Ruckly, C., Marasescu, M., van der Werf, S., Alonso, J., Naffakh, N., & Taha, M. (2009) · Infection and Immunity · doi:10.1128/iai.00155-09 · Cited by 61

The complex link between influenza and severe sepsis

Florescu, D. F., & Kalil, A. C. (2013) · Virulence · doi:10.4161/viru.27103 · Cited by 64

Induction and Role of Indoleamine 2,3 Dioxygenase in Mouse Models of Influenza A Virus Infection

Huang, L., Li, L., Klonowski, K., Tompkins, S. M., Tripp, R. A., & Mellor, A. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066546 · Cited by 59

Influenza and tuberculosis co‐infection: A systematic review

Walaza, S., Cohen, C., Tempia, S., Moyes, J., Nguweneza, A., Madhi, S. A., McMorrow, M., & Cohen, A. L. (2019) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12670 · Cited by 58

Disease Severity in Patients with Simultaneous Influenza and Bacterial Pneumonia

Seki, M., Kosai, K., Yanagihara, K., Higashiyama, Y., Kurihara, S., Izumikawa, K., Miyazaki, Y., Hirakata, Y., Tashiro, T., & Kohno, S. (2007) · Internal Medicine · doi:10.2169/internalmedicine.46.6364 · Cited by 57

Severe Pneumonia Caused by Coinfection With Influenza Virus Followed by Methicillin-Resistant Staphylococcus aureus Induces Higher Mortality in Mice

Jia, L., Zhao, J., Yang, C., Liang, Y., Long, P., Liu, X., Qiu, S., Wang, L., Xie, J., Li, H., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03189 · Cited by 55

Protecting Against Post-influenza Bacterial Pneumonia by Increasing Phagocyte Recruitment and ROS Production

Subramaniam, R., Barnes, P. F., Fletcher, K., Boggaram, V., Hillberry, Z., Neuenschwander, P. F., & Shams, H. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit830 · Cited by 55

Interferon Lambda Inhibits Bacterial Uptake during Influenza Superinfection

Rich, H. E. A., McCourt, C. C., Zheng, W. Q., McHugh, K. J., Robinson, K. M., Wang, J., & Alcorn, J. F. (2019) · Infection and Immunity · doi:10.1128/iai.00114-19 · Cited by 55

Coinfection with Staphylococcus aureus increases risk of severe coagulopathy in critically ill children with influenza A (H1N1) virus infection.

Nguyen, T., Kyle, U. G., Jaimon, N., Tcharmtchi, M. H., Coss-Bu, J. A., Lam, F., Teruya, J., & Loftis, L. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e318260c7f8 · Cited by 54

Contribution of Vaccine-Induced Immunity toward either the HA or the NA Component of Influenza Viruses Limits Secondary Bacterial Complications

Huber, V. C., Peltola, V. T., Iverson, A., & McCullers, J. A. (2010) · Journal of Virology · doi:10.1128/jvi.02621-09 · Cited by 54

Influenza Suppresses Neutrophil Recruitment to the Lung and Exacerbates Secondary Invasive Pulmonary Aspergillosis

Tobin, J. M., Nickolich, K. L., Ramanan, K., Pilewski, M. J., Lamens, K. D., Alcorn, J. F., & Robinson, K. M. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000067 · Cited by 55

Social contexts, syndemics, and infectious disease in northern Aboriginal populations

Herring, D. A., & Sattenspiel, L. (2007) · American Journal of Human Biology · doi:10.1002/ajhb.20618 · Cited by 54

TheStreptococcus pyogenesCapsule Is Required for Adhesion of Bacteria to Virus-Infected Alveolar Epithelial Cells and Lethal Bacterial-Viral Superinfection

Okamoto, S., Kawabata, S., Terao, Y., Fujitaka, H., Okuno, Y., & Hamada, S. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.6068-6075.2004 · Cited by 54

Co-infection of influenza B and Streptococci causing severe pneumonia and septic shock in healthy women.

Aebi, T., Weisser, M., Bucher, E., Hirsch, H. H., Marsch, S., & Siegemund, M. (2010) · BMC Infectious Diseases · doi:10.1186/1471-2334-10-308 · Cited by 51

The role of influenza in the epidemiology of pneumonia

Shrestha, S., Foxman, B., Berus, J. M., van Panhuis, W. G., Steiner, C., Viboud, C. G., & Rohani, P. (2015) · Scientific Reports · doi:10.1038/srep15314 · Cited by 55

Novel protective mechanism for interleukin-33 at the mucosal barrier during influenza-associated bacterial superinfection

Robinson, K. M., Ramanan, K., Clay, M. E., McHugh, K. J., Rich, H. E. A., & Alcorn, J. F. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.32 · Cited by 51

Prevention of influenza-related illness in young infants by maternal vaccination during pregnancy

Nunes, M. C., & Madhi, S. A. (2018) · F1000Research · doi:10.12688/f1000research.12473.1 · Cited by 52

Viral strategies predisposing to respiratory bacterial superinfections

Rossi, G. A., Fanous, H., & Colin, A. A. (2020) · Pediatric Pulmonology · doi:10.1002/ppul.24699 · Cited by 54

Inactivated and live, attenuated influenza vaccines protect mice against influenza:Streptococcus pyogenes super-infections

Chaussee, M. S., Sandbulte, H. R., Schuneman, M. J., DePaula, F. P., Addengast, L. A., Schlenker, E. H., & Huber, V. C. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.03.031 · Cited by 49

The Novel Parainfluenza Virus Hemagglutinin-Neuraminidase Inhibitor BCX 2798 Prevents Lethal Synergism between a Paramyxovirus and Streptococcus pneumoniae

Alymova, I. V., Portner, A., Takimoto, T., Boyd, K. L., Babu, Y. S., & McCullers, J. A. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.1.398-405.2005 · Cited by 49

Infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells

Gołda, A., Małek, N., Dudek, B., Żegleń, S., Wojarski, J., Ochman, M., Kucewicz-Czech, E. M., Zembala, M., Potempa, J., & Pyrć, K. (2011) · Journal of General Virology · doi:10.1099/vir.0.028381-0 · Cited by 50

The Role of Streptococcus pneumoniae in Community-Acquired Pneumonia

Anderson, R., & Feldman, C. H. (2016) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0036-1592074 · Cited by 48

A Critical, Nonlinear Threshold Dictates Bacterial Invasion and Initial Kinetics During Influenza

Smith, A. M., & Smith, A. P. (2016) · Scientific Reports · doi:10.1038/srep38703 · Cited by 48

Rhinoviruses promote internalisation of Staphylococcus aureus into non-fully permissive cultured pneumocytes

Passariello, C., Schippa, S., Conti, C., Russo, P., Poggiali, F., Garaci, E., & Palamara, A. T. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2005.09.013 · Cited by 47

Respiratory syncytial virus infection facilitates acute colonization of Pseudomonas aeruginosa in mice

de Vrankrijker, A. M. M., Wolfs, T. F. W., Ciofu, O., Høiby, N., van der Ent, C. K., Poulsen, S. S., & Johansen, H. K. (2009) · Journal of Medical Virology · doi:10.1002/jmv.21623 · Cited by 46

Population-based surveillance for invasive pneumococcal disease and pneumonia in infants and young children in Bogotá, Colombia

Benavides, J. A., Ovalle, O., Salvador, G. R., Gray, S., Isaacman, D. J., & Rodgers, G. L. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.03.054 · Cited by 46

Vaccine efficacy and T helper cell differentiation change with aging

Lefebvre, J. S., Lorenzo, E. C., Masters, A. R., Hopkins, J. W., Eaton, S. M., Smiley, S. T., & Haynes, L. (2016) · Oncotarget · doi:10.18632/oncotarget.9254 · Cited by 46

Hierarchical effects of pro-inflammatory cytokines on the post-influenza susceptibility to pneumococcal coinfection

Duvigneau, S., Sharma-Chawla, N., Boianelli, A., Stegemann‐Koniszewski, S., Nguyễn, V. K., Bruder, D., & Hernandez-Vargas, E. A. (2016) · Scientific Reports · doi:10.1038/srep37045 · Cited by 46

Influenza hemagglutinin vaccine with poly(γ-glutamic acid) nanoparticles enhances the protection against influenza virus infection through both humoral and cell-mediated immunity

Okamoto, S., Yoshii, H., Akagi, T., Akashi, M., Ishikawa, T., Okuno, Y., Takahashi, M., Yamanishi, K., & Mori, Y. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.09.051 · Cited by 46

Signalling or binding: the role of the platelet-activating factor receptor in invasive pneumococcal disease

Iovino, F., Brouwer, M. C., van de Beek, D., Molema, G., & Bijlsma, J. J. E. (2013) · Cellular Microbiology · doi:10.1111/cmi.12129 · Cited by 45

Sialidase and Sialyltransferase Inhibitors: Targeting Pathogenicity and Disease

Bowles, W., & Gloster, T. M. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.705133 · Cited by 45

Neuraminidase Inhibitors and their Role in Avian and Pandemic Influenza

Crusat, M., & de Jong, M. D. (2007) · Antiviral Therapy · doi:10.1177/135965350701200s07.1 · Cited by 45

A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media

McGillivary, G., Ray, W. C., Bevins, C. L., Munson, R. S., & Bakaletz, L. O. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.10.008 · Cited by 45

Acute infection with influenza virus enhances susceptibility to fatal pneumonia following Streptococcus pneumoniae infection in mice with chronic pulmonary colonization with Pseudomonas aeruginosa

Seki, M., Higashiyama, Y., Tomono, K., Yanagihara, K., Ohno, H., Kaneko, Y., Izumikawa, K., Miyazaki, Y., Hirakata, Y., Mizuta, Y., et al. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02481.x · Cited by 47

Coinfection with Streptococcus pneumoniae Negatively Modulates the Size and Composition of the Ongoing Influenza-Specific CD8+ T Cell Response

Blevins, L. K., Wren, J. T., Holbrook, B. C., Hayward, S. L., Swords, W. E., Parks, G. D., & Alexander‐Miller, M. A. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400529 · Cited by 44

Within‐Host Evolution for the Invasiveness of Commensal Bacteria: an Experimental Study of Bacteremias Resulting fromHaemophilus influenzaeNasal Carriage

Margolis, E. B., & Levin, B. R. (2007) · The Journal of Infectious Diseases · doi:10.1086/520934 · Cited by 44

Dual Acting Neuraminidase Inhibitors Open New Opportunities to Disrupt the Lethal Synergism between Streptococcus pneumoniae and Influenza Virus

Walther, E., Xu, Z., Richter, M., Kirchmair, J., Grienke, U., Rollinger, J. M., Krumbholz, A., Saluz, H. P., Pfister, W., Sauerbrei, A., et al. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00357 · Cited by 44

Two Randomized Trials of the Effect of Live Attenuated Influenza Vaccine on Pneumococcal Colonization

Rylance, J., Piters, W. A. A. D. S., Pojar, S., Nikolaou, E., German, E. L., Mitsi, E., Jochems, S. P., Carniel, B. F., Solórzano, C., Reiné, J., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201811-2081le · Cited by 45

Do specific virus–bacteria pairings drive clinical outcomes of pneumonia?

McCullers, J. A. (2012) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12093 · Cited by 47

Filamentous Influenza A Virus Infection Predisposes Mice to Fatal Septicemia following Superinfection with Streptococcus pneumoniae Serotype 3

Speshock, J. L., Doyon‐Reale, N., Rabah, R. M., Neely, M. N., & Roberts, P. C. (2007) · Infection and Immunity · doi:10.1128/iai.01943-06 · Cited by 44

Influenza virus infection causes neutrophil dysfunction through reduced G-CSF production and an increased risk of secondary bacteria infection in the lung

Ishikawa, H., Fukui, T., Ino, S., Sasaki, H., Awano, N., Kohda, C., & Tanaka, K. (2016) · Virology · doi:10.1016/j.virol.2016.08.025 · Cited by 43

Lethal Synergism between Influenza and Streptococcus pneumoniae

Rudd, J. M. (2016) · Journal of Infectious Pulmonary Diseases · doi:10.16966/2470-3176.114 · Cited by 43

An NFκB Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NFκB via Distinct Mechanisms

Mitchell, S. A., Mercado, E. L., Adelaja, A., Ho, J. Q., Cheng, Q. J., Ghosh, G., & Hoffmann, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01425 · Cited by 44

Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial Toxin-Mediated Necroptosis

González-Juarbe, N., Riegler, A. N., Jureka, A. S., Gilley, R. P., Brand, J. D., Trombley, J. E., Scott, N. R., Platt, M. P., Dube, P. H., Petit, C. M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108062 · Cited by 43

The Prevalence and Impact of Coinfection and Superinfection on the Severity and Outcome of COVID-19 Infection: An Updated Literature Review

Omoush, S. A., & Alzyoud, J. A. M. (2022) · Pathogens · doi:10.3390/pathogens11040445 · Cited by 44

Sialidase‐Based Anti–Influenza Virus Therapy Protects against Secondary Pneumococcal Infection

Hedlund, M., Aschenbrenner, L. M., Jensen, K. A., Larson, J. L., & Fang, F. (2010) · The Journal of Infectious Diseases · doi:10.1086/651170 · Cited by 44

Trends in U.S. hospitalizations and inpatient deaths from pneumonia and influenza, 1996–2011

Chang, D. H., Bednarczyk, R. A., Becker, E. R., Hockenberry, J. M., Weiss, P., Orenstein, W. A., & Omer, S. B. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.12.003 · Cited by 42

An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens

Meliopoulos, V., de Velde, L.-A. V., van de Velde, N. C., Karlsson, E. A., Neale, G. A. M., Vogel, P., Guy, C. S., Sharma, S., Duan, S., Surman, S. L., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005804 · Cited by 43

Naturally Occurring Swine Influenza A Virus PB1-F2 Phenotypes That Contribute to Superinfection with Gram-Positive Respiratory Pathogens

Weeks, J. N., Hurtig, H. R., Iverson, A., Schuneman, M. J., Webby, R. J., McCullers, J. A., & Huber, V. C. (2012) · Journal of Virology · doi:10.1128/jvi.00369-12 · Cited by 42

A cooperativity between virus and bacteria during respiratory infections

Lalbiaktluangi, C., Yadav, M., Singh, P. K., Singh, A., Iyer, M., Vellingiri, B., Zomuansangi, R., Zothanpuia, Z., & Ram, H. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1279159 · Cited by 43

Bordetella pertussis Infection Exacerbates Influenza Virus Infection through Pertussis Toxin-Mediated Suppression of Innate Immunity

Ayala, V. I., Teijaro, J. R., Färber, D. L., Dorsey, S. G., & Carbonetti, N. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019016 · Cited by 41

Assessment of efficacy of Oseltamivir-Azithromycin combination therapy in prevention of Influenza-A (H1N1)pdm09 infection complications and rapidity of symptoms relief

Ishaqui, A. A., Khan, A. H., Sulaiman, S. A. S., Alsultan, M. T., Khan, I., & Naqvi, A. A. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2020.1730180 · Cited by 41

Increased Susceptibility for Superinfection with Streptococcus pneumoniae during Influenza Virus Infection Is Not Caused by TLR7-Mediated Lymphopenia

Stegemann‐Koniszewski, S., Dahlberg, S., Kröger, A., Gereke, M., Bruder, D., Henriques‐Normark, B., & Gunzer, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004840 · Cited by 42

Respiratory Syncytial Virus Promotes Moraxella catarrhalis-Induced Ascending Experimental Otitis Media

Brockson, M. E., Novotny, L. A., Jurcisek, J. A., McGillivary, G., Bowers, M. R., & Bakaletz, L. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040088 · Cited by 40

A live‐attenuated pneumococcal vaccine elicits CD4+ T‐cell dependent class switching and provides serotype independent protection against acute otitis media

Rosch, J. W., Iverson, A., Humann, J., Mann, B., Gao, G., Vogel, P., Mina, M. J., Murrah, K. A., Perez, A. C., Swords, W. E., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202150 · Cited by 40

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Wu, M., Gibbons, J. G., DeLoid, G. M., Bedugnis, A. S., Thimmulappa, R. K., Biswal, S. S., & Kobzik, L. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00075.2017 · Cited by 42

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Rowe, H. M., Livingston, B., Margolis, E. B., Davis, A., Meliopoulos, V., Echlin, H., Schultz‐Cherry, S., & Rosch, J. W. (2020) · mSystems · doi:10.1128/msystems.00762-20 · Cited by 40

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Yildiz, S., Bonifacio, J. P. P., Bergé, M., González‐Ruiz, V., Baud, D., Kloehn, J., Boal‐Carvalho, I., Schären, O. P., Schotsaert, M., Hathaway, L. J., et al. (2020) · eLife · doi:10.7554/elife.53581 · Cited by 41

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McCullers, J. A., & English, B. K. (2008) · Future Microbiology · doi:10.2217/17460913.3.4.397 · Cited by 41

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Wang, S.-M., Tsai, M.-H., Lei, H.-Y., Wang, J., & Liu, C. (2012) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.21117 · Cited by 39

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Respiratory tract barrier dysfunction in viral-bacterial co-infection cases

Sumitomo, T., & Kawabata, S. (2024) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2023.12.006 · Cited by 37

Cost-effectiveness of pneumococcal vaccination strategies for the elderly in Korea

Heo, J. Y., Seo, Y. B., Choi, W. S., Lee, J., Noh, J. Y., Jeong, H. W., Kim, W. J., Kim, M. J., Lee, H., & Song, J. Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177342 · Cited by 39

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Ortigoza, M. B., Blaser, S. B., Zafar, M. A., Hammond, A. J., & Weiser, J. N. (2018) · mBio · doi:10.1128/mbio.02359-18 · Cited by 37

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Deng, J. C. (2013) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12174 · Cited by 39

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Mccullers, J. A., Iverson, A. R., Mckeon, R., & Murray, P. J. (2008) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540701477568 · Cited by 36

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de Paus, R. A., van Crevel, R., van Beek, R., Sahiratmadja, E., Alisjahbana, B., Marzuki, S., Rimmelzwaan, G. F., van Dissel, J. T., Ottenhoff, T. H. M., & van de Vosse, E. (2013) · Tuberculosis · doi:10.1016/j.tube.2013.02.006 · Cited by 36

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Wolter, N., Cohen, C., Tempia, S., Madhi, S. A., Venter, M., Moyes, J., Walaza, S., Kgokong, B. M., Groome, M. J., du Plessis, M., et al. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit427 · Cited by 36

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Khan, M. N., & Pichichero, M. E. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/21645515.2014.979631 · Cited by 38

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Boianelli, A., Sharma-Chawla, N., Bruder, D., & Hernandez-Vargas, E. A. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00060 · Cited by 37

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Trained immunity and host‐pathogen interactions

Peignier, A., & Parker, D. (2020) · Cellular Microbiology · doi:10.1111/cmi.13261 · Cited by 36

Macrophage adaptation in airway inflammatory resolution

Kaur, M., Bell, T., Salek‐Ardakani, S., & Hussell, T. (2015) · European Respiratory Review · doi:10.1183/16000617.0030-2015 · Cited by 38

Comparison of methods of temperature measurement in swine

HANNEMAN, S. K. G., Jesurum-Urbaitis, J. T., & Bickel, D. R. (2004) · Laboratory Animals · doi:10.1258/002367704323133682 · Cited by 36

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Popovsky, E. Y., & Florin, T. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-102723-3.00013-5 · Cited by 36

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Wu, Y., Tu, W., Lam, K.-T., Chow, K., Ho, P., Guan, Y., Peiris, J. S. M., & Lau, Y. (2014) · Journal of Virology · doi:10.1128/jvi.02455-14 · Cited by 37

GP96 Drives Exacerbation of Secondary Bacterial Pneumonia following Influenza A Virus Infection

Sumitomo, T., Nakata, M., Nagase, S., Takahara, Y., Honda-Ogawa, M., Mori, Y., Akamatsu, Y., Yamaguchi, M., Okamoto, S., & Kawabata, S. (2021) · mBio · doi:10.1128/mbio.03269-20 · Cited by 35

Cooperation and cheating orchestrate Vibrio assemblages and polymicrobial synergy in oysters infected with OsHV-1 virus

Oyanedel, D., Lagorce, A., Bruto, M., Haffner, P., Morot, A., Labreuche, Y., Dorant, Y., Divonne, S. D. L. F., Delavat, F., Inguimbert, N., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2305195120 · Cited by 34

Lethal Synergism between Influenza Virus andStreptococcus pneumoniae

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