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Cited by 132Malaria Research and ControlBird parasitology and diseasesHemoglobinopathies and Related Disorders

MALARIA IN PREGNANT CAMEROONIAN WOMEN: THE EFFECT OF AGE AND GRAVIDITY ON SUBMICROSCOPIC AND MIXED-SPECIES INFECTIONS AND MULTIPLE PARASITE GENOTYPES

WALKER-ABBEY, ANNIE, DJOKAM, ROSINE R. T., ENO, ANNA, LEKE, ROSE F. G., TITANJI, VINCENT P. K., FOGAKO, JOSEPHINE, SAMA, GRACE, THUITA, LUCY H. +4 more·2005·The American Journal of Tropical Medicine and Hygiene
DOI 10.4269/ajtmh.2005.72.229
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Abstract

Polymerase chain reaction (PCR)–based methods were used to investigate malaria in pregnant women residing in Yaoundé, Cameroon. Microscopy and species-specific PCR-based diagnosis show that at delivery 82.4% of the women were infected with Plasmodium falciparum (27.5% blood-smear positive and 54.9% submicroscopic infections). The prevalence of P. malariae and P. ovale was 7.6% and 2.5%, respectively, with 9.4% infected with more than one species. Based on genotyping of the merozoite surface protein 1 (msp-1) and msp-2 alleles, the mean number of genetically different P. falciparum parasites in peripheral blood was 3.4 (range = 1–9) and 3.5 (range 1–8) in the placenta. Plasmodium falciparum detected by microscopy and PCR as well as mixed-species infections were significantly higher in women ≤ 20 years old and paucigravidae, but maternal anemia was associated only with microscopic detection of parasites. Neither submicroscopic infections nor number of parasite genotypes decreased significantly with age or gravidity. Thus, pregnancy-associated immunity helps reduce malaria to submicroscopic levels, but does not reduce the number of circulating parasite genotypes.

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Crossref · 10.4269/ajtmh.2005.72.229

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  • Younger women, particularly adolescents, are at higher risk of malaria infection than older women, independent of parity.

    “It is well established that younger women (primigravidae and multigravidae), particularly adolescents, are at higher risk of malaria infection than older women,18–20 and this is independent of parity.20–22”

    From Malaria in pregnancy. (2013) · cites this paper as [22]

  • An earlier study reported higher rates of submicroscopic infection with increasing parity, whereas other studies reported similar rates among women of different parities.

    “An earlier study also reported higher rates of submicroscopic infection with increasing parity [47], whereas other studies have reported similar rates of sub microscopic infections among women of different parities [16,38,40].”

    From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [40]

  • Whether applied to peripheral blood or placental blood samples, PCR methods yield positivity rates 20% or more above those of blood smear microscopy.

    “Whether applied to peripheral blood or placental blood samples, PCR methods yield positivity rates 20% or more above those of BS microscopy (Tables 3 & 4) [10,14–16,38–46].”

    From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [40]

  • The association of maternal anemia to submicroscopic infection is inconsistent, with some studies finding a relationship and other studies not.

    “However, the association of maternal anemia to submicroscopic infection (defined by PCR, qPCR or HRP2 methods) is inconsistent, with some studies finding a relationship [16,47,53] while other studies did not [38,40,47].”

    From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [40]

  • Submicroscopic infections were linked with maternal anemia in some studies but not all.

    “Submicroscopic infections were linked with maternal anemia in some 17,18,20,23 but not all 12,13,15,21 studies.”

    From What is the burden of submicroscopic malaria in pregnancy in central India? (2015) · cites this paper as [15]

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Authors
WALKER-ABBEY, A., DJOKAM, R. R. T., ENO, A., LEKE, R. F. G., TITANJI, V. P. K., FOGAKO, J., SAMA, G., THUITA, L. H., BEARDSLEE, E., SNOUNOU, G., ZHOU, A., & TAYLOR, D. W.
Affiliations
Université de Yaoundé I (CM)
ORCID
Venue
The American Journal of Tropical Medicine and Hygiene
Publisher
American Society of Tropical Medicine and Hygiene
Published
2005-03
Volume
72
Issue
3
Pages
229-235
ISSN
0002-9637 (ISSN-L)
DOI
10.4269/ajtmh.2005.72.229
OpenAlex
W2153783038
Cited by
132
References
23
Citations by year
2026: 3 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 15 · 2021: 11 · 2020: 4 · 2019: 7 · 2018: 6 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 10 · 2013: 3 · 2012: 8
FWCI
2.80
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Tropical Medicine and Hygiene (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Allergy and Infectious Diseases (U01 AI43888, UO1-AI-135839, U01AI043888)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Life Sciences › Immunology and Microbiology › Parasitology › Bird parasitology and diseases
  • Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
Keywords
malaria in pregnancy, Plasmodium falciparum, submicroscopic malaria infection, Plasmodium malariae, Plasmodium ovale, merozoite surface protein 1, merozoite surface protein 2, parasite genotypes, maternal age, gravidity, anemia in pregnancy, placental malaria, Yaoundé
MeSH terms
Adult, Age Factors, Anemia, Animals, Antimalarials, Cameroon, Female, Genotype, Humans, Malaria, Plasmodium, Plasmodium falciparum, Pregnancy, Pregnancy Complications, Parasitic, Polymerase Chain Reaction, Malaria, Falciparum

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