The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Enteroaggregative Escherichia coli Produce Intestinal Inflammation and Growth Impairment and Cause Interleukin‐8 Release from Intestinal Epithelial Cells
Abstract
Enteroaggregative E. coli (EAggEC) are emerging as an important cause of persistent diarrhea, especially in children in the developing world, yet the pathogenesis of EAggEC infection is poorly understood. In an ongoing prospective study of childhood diarrhea in an urban Brazilian slum, EAggEC are the leading cause of persistent diarrhea. Children from this study with EAggEC and persistent diarrhea had significant elevations in fecal lactoferrin, interleukin (IL)-8, and IL-1beta. Moreover, children with EAggEC without diarrhea had elevated fecal lactoferrin and IL-1beta concentrations. The children with EAggEC in their stool had significant growth impairment after their positive culture, regardless of the presence or absence of diarrhea. Finally, 2 EAggEC strains were shown to cause IL-8 release from Caco-2 cells, apparently via a novel heat-stable, high-molecular-weight protein. These findings suggest that EAggEC may contribute to childhood malnutrition, trigger intestinal inflammation in vivo, and induce IL-8 secretion in vitro.
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Cites
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Heterogeneity of Enteroaggregative Escherichia Coli Virulence Demonstrated
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Cited by
The impoverished gut—a triple burden of diarrhoea, stunting and chronic disease
Guerrant, R. L., DeBoer, M. D., Moore, S. R., Scharf, R. J., & Lima, A. A. M. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.239 · Cited by 604
Buie, T., Fuchs, G. J., Furuta, G. T., Kooros, K., Levy, J., Lewis, J. D., Wershil, B. K., & Winter, H. (2010) · Pediatrics · doi:10.1542/peds.2009-1878d · Cited by 228
Environmental enteric dysfunction and child stunting
Budge, S., Parker, A. H., Hutchings, P. T., & Garbutt, C. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuy068 · Cited by 201
Updating the DALYs for diarrhoeal disease
Guerrant, R. L., Kosek, M., Lima, A. A. M., Lorntz, B., & Guyatt, H. L. (2002) · Trends in Parasitology · doi:10.1016/s1471-4922(02)02253-5 · Cited by 126
Self-citationOkhuysen, P. C., & DuPont, H. L. (2010) · The Journal of Infectious Diseases · doi:10.1086/654895 · Cited by 112
Metadata
- Authors
- Steiner, T. S., Lima, A. A. M., Nataro, J. P., & Guerrant, R. L.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-01
- Volume
- 177
- Issue
- 1
- Pages
- 88-96
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2048214746
- Cited by
- 288
- References
- 26
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Enteroaggregative Escherichia coli Produce Intestinal Inflammation and Growth Impairment and Cause Interleukin‐8 Release from Intestinal Epithelial Cells. https://app.cochat.ai/papers/10.1086/513809
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- Steiner, T. S., Lima, A. A. M., Nataro, J. P., & Guerrant, R. L. (1998). Enteroaggregative Escherichia coli Produce Intestinal Inflammation and Growth Impairment and Cause Interleukin‐8 Release from Intestinal Epithelial Cells. The Journal of Infectious Diseases. https://doi.org/10.1086/513809
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
