-D-Glucan Assay for the Diagnosis of Invasive Fungal Infections: A Meta-analysis
Abstract
We aimed to assess the accuracy of measuring serum or plasma (1→3)-β-D-glucan (BDG) for the diagnosis of invasive fungal infections (IFIs) by means of a meta-analysis of relevant studies. We searched in bibliographic databases for relevant cohort or case-control studies. We primarily compared BDG between patients with proven or probable IFIs (excluding Pneumocystis jirovecii infections), according to the criteria of the European Organization for Research and Treatment of Cancer/Mycoses Study Group or similar criteria, and patients without IFIs (excluding healthy individuals as controls). A total of 2979 patients (594 with proven or probable IFIs), included in 16 studies, were analyzed. The pooled sensitivity of BDG was 76.8% (95% confidence interval [CI], 67.1%-84.3%), and the specificity was 85.3% (95% CI, 79.6%-89.7%). The area under the summary receiver operating characteristic curve was 0.89. Marked statistical heterogeneity was noted. BDG has good diagnostic accuracy for distinguishing proven or probable IFIs from no IFIs. It can be useful in clinical practice, if implemented in the proper setting and interpreted after consideration of its limitations.
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A meta-analysis of 16 trials found a pooled sensitivity of 76% and specificity of 85% for (1,3)-β-d-glucan.
“A meta-analysis of 16 trials found a pooled sensitivity of 76% and specificity of 85% [80]; false positive results are attributed to the ubiquity of glucans in the environment.”
From Treatment of Invasive Candidiasis: A Narrative Review (2018) · cites this paper as [80]
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- Authors
- Karageorgopoulos, D. E., Vouloumanou, E. K., Ntziora, F., Michalopoulos, A., Rafailidis, P. I., & Falagas, M. E.
- Affiliations
- Laiko General Hospital of Athens (GR)
- Alfa Institute of Biomedical Sciences (GR)
- Henry Dunant Hospital (GR)
- Tufts University (US)
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-03-01
- Volume
- 52
- Issue
- 6
- Pages
- 750-770
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2056588441
- Cited by
- 538
- References
- 55
- Citations by year
- 2026: 18 · 2025: 19 · 2024: 27 · 2023: 33 · 2022: 25 · 2021: 30 · 2020: 38 · 2019: 39 · 2018: 41 · 2017: 41 · 2016: 54 · 2015: 42 · 2014: 54 · 2013: 29 · 2012: 31
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Keywords
- β-1,3-glucan, invasive fungal infections, diagnostic accuracy, serum biomarkers, sensitivity and specificity, fungal infection diagnosis, EORTC/MSG criteria
- MeSH terms
- Humans, Mycoses, Plasma, Proteoglycans, ROC Curve, Sensitivity and Specificity, Biomarkers, Clinical Laboratory Techniques, Serum, beta-Glucans
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