Cited by 384Neuroscience and Neural EngineeringConducting polymers and applicationsAnalog and Mixed-Signal Circuit Design

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Progress towards biocompatible intracortical microelectrodes for neural interfacing applications

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Jorfi, Mehdi, Skousen, John L, Weder, Christoph, Capadona, Jeffrey R·2015·Journal of Neural Engineering

DOI 10.1088/1741-2560/12/1/011001PMC PMC4428498

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Abstract

To ensure long-term consistent neural recordings, next-generation intracortical microelectrodes are being developed with an increased emphasis on reducing the neuro-inflammatory response. The increased emphasis stems from the improved understanding of the multifaceted role that inflammation may play in disrupting both biologic and abiologic components of the overall neural interface circuit. To combat neuro-inflammation and improve recording quality, the field is actively progressing from traditional inorganic materials towards approaches that either minimizes the microelectrode footprint or that incorporate compliant materials, bioactive molecules, conducting polymers or nanomaterials. However, the immune-privileged cortical tissue introduces an added complexity compared to other biomedical applications that remains to be fully understood. This review provides a comprehensive reflection on the current understanding of the key failure modes that may impact intracortical microelectrode performance. In addition, a detailed overview of the current status of various materials-based approaches that have gained interest for neural interfacing applications is presented, and key challenges that remain to be overcome are discussed. Finally, we present our vision on the future directions of materials-based treatments to improve intracortical microelectrodes for neural interfacing.

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Authors: Jorfi, M., Skousen, J. L., Weder, C., & Capadona, J. R.
Affiliations: University of Fribourg (CH)
University of Utah (US)
Louis Stokes Cleveland VA Medical Center (US)
Corresponding author: Capadona, Jeffrey R
ORCID: Jorfi, Mehdi
Skousen, John L
Weder, Christoph
Capadona, Jeffrey R
Venue: Journal of Neural Engineering
Publisher: IOP Publishing
Published: 2014-12-02
Volume: 12
Issue: 1
Pages: 011001
ISSN: 1741-2552 (ISSN-L)
1741-2560
DOI: 10.1088/1741-2560/12/1/011001
PMC: PMC4428498
OpenAlex: W2056731994
Cited by: 384
References: 376
Citations by year: 2026: 12 · 2025: 26 · 2024: 20 · 2023: 29 · 2022: 31 · 2021: 36 · 2020: 39 · 2019: 33 · 2018: 43 · 2017: 51 · 2016: 27 · 2015: 20 · 2014: 11
FWCI: 4.15
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: iopscience.iop.org/info/page/text-and-data-mining (tdm)
iopscience.iop.org/page/copyright (vor)
Locations: Journal of Neural Engineering (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs (B1495-R, PECASE, B7122R)
National Institute of Neurological Disorders and Stroke (1R01NS082404-01A1)
Swiss National Science Foundation (NRP 62: Smart Materials, Nr. 406240_126046)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
Physical Sciences › Engineering › Electrical and Electronic Engineering › Analog and Mixed-Signal Circuit Design
Keywords: intracortical microelectrodes, neural interfaces, neuroinflammation, biocompatibility, long-term neural recording, compliant materials, conducting polymers, nanomaterials, bioactive compounds, electrode materials
MeSH terms: Action Potentials, Brain, Electrodes, Implanted, Electroencephalography, Equipment Design, Microelectrodes, Neurons, Equipment Failure Analysis, Coated Materials, Biocompatible, Brain-Computer Interfaces

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Progress towards biocompatible intracortical microelectrodes for neural interfacing applications

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