The Pursuit of Chronically Reliable Neural Interfaces: A Materials Perspective
Open accessAbstract
Brain-computer interfaces represent one of the most astonishing technologies in our era. However, the grand challenge of chronic instability and limited throughput of the electrode-tissue interface has significantly hindered the further development and ultimate deployment of such exciting technologies. A multidisciplinary research workforce has been called upon to respond to this engineering need. In this paper, I briefly review this multidisciplinary pursuit of chronically reliable neural interfaces from a materials perspective by analyzing the problem, abstracting the engineering principles, and summarizing the corresponding engineering strategies. I further draw my future perspectives by extending the proposed engineering principles.
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Implant materials are assessed based on their chemical and mechanical similarity to the target tissue to prevent an undesirable immune response.
“These materials will also be assessed based on their chemical and mechanical similarity to the target tissue to prevent an undesirable immune response to these alien materials (Guo 2016).”
From Peripheral nerve bionic interface: a review of electrodes (2019) · cites this paper as Guo 2016
For some electrode coatings, particularly conducting polymers, there is an additional technological challenge of delamination of films from underlying conductors.
“However, for some of these coatings, in particular conducting polymers, there is an additional technological challenge of delamination of these films from the underlying conductors (Guo 2016).”
From Peripheral nerve bionic interface: a review of electrodes (2019) · cites this paper as Guo 2016
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Peripheral nerve bionic interface: a review of electrodes
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- Authors
- Guo, L.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Guo, Liang
- ORCID
- Guo, Liang
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2016-12-27
- Volume
- 10
- Pages
- 599-599
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC5186773
- OpenAlex
- W2561617906
- Cited by
- 19
- References
- 51
- Citations by year
- 2026: 2 · 2025: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 2
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Ohio State University
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
- Keywords
- brain-computer interface, neural interfaces, electrode materials, chronic instability
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