Biomineralization guided by polydopamine-modifed poly(L-lactide) fibrous membrane for promoted osteoconductive activity
Open accessAbstract
A method to mediate biomineralization of electrospinning poly(L-lactide) (PLLA) fibrous membrane assisted by polydopamine (PDA) coating was developed to obtain enhanced osteoconductive activity. The biomineralization mechanism, surface composition, morphology and hydrophilicity of the original and modified PLLA fibrous membranes were characterized. Results revealed that the PDA coating effectively accelerated the formation of hydroxyapatite (HA) on PLLA fibrous membrane and resulted a great increase in hydrophilicity. Moreover, the tensile property of PLLA fibrous membrane was enhanced by the PDA coating while almost kept unchanged by further immobilized with HA. Cells culture results indicated that the successive introduction of PDA and HA contributed to an obvious improvement in the adhesion and proliferation, as well as up-regulated alkaline phosphatase (ALP) activity and promoted osteogenic-related genes and proteins expression of MC3T3-E1 cells. Overall, the as-prepared PLLA-PDA-HA fibrous membrane can be expected as a favorable scaffold for bone tissue repair.
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After pHAF modification, an apatite structure was obtained on the surface of electrospun PLLA fibrous membranes.
“After the modification, the apatite structure was obtained on the surface of the electrospun PLLA fibrous membranes [67]”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [67]
The Introduction and section 3.2 report that hydroxyapatite minerals formed on the surface of electrospun PLLA fibrous membranes after polydopamine (PDA) modification and biomineralization. They do not identify the modification as pHAF; that specific part of the supplied claim is unsupported, although the verbatim citing sentence does not name pHAF. (LLM, conf=0.85)
Experimental — accuracy not yet measuredImproved bioactivity for bone generation was observed on modified PLLA fibrous membranes.
“Improved bioactivity for bone generation was also observed here.”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [67]
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Cites
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Kaushik, N., Nhat Nguyen, L., Kim, J. H., Choi, E. H., & Kumar Kaushik, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186544 · Cited by 76 · see citing works
“After the modification, the apatite structure was obtained on the surface of the electrospun PLLA fibrous membranes [67] Improved bioactivity for bone generation was also observed here.”
MethodAdler, C., Monavari, M., Abraham, G. A., Boccaccini, A. R., & Ghorbani, F. (2023) · RSC Advances · doi:10.1039/d3ra01311a · Cited by 20 · see citing works
- Authors
- Chen, X., Zhu, L., Liu, H., Wen, W., Li, H., Zhou, C., & Luo, B.
- Affiliations
- Jinan University (CN)
- Corresponding author
- Luo, Binghong
- Venue
- Biomedical Materials
- Publisher
- IOP Publishing
- Published
- 2019-07-19
- Volume
- 14
- Issue
- 5
- Pages
- 055005
- ISSN
- 1748-6041 (ISSN-L)
- 1748-605X
- OpenAlex
- W2953889853
- Cited by
- 21
- References
- 2
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 4
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biomedical Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science and Technology Planning Project of Guangdong, China (2017A010103042)
- Guangdong Provincial Natural Science Foundation of China (2016A030313086)
- National Natural Science Foundation of China (31570981)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- biomineralization, polydopamine coating, poly(L-lactic acid), fibrous membranes, hydroxyapatite, osteoconduction, bone scaffolds, hydrophilicity, tensile properties, MC3T3-E1 cells, alkaline phosphatase activity, osteogenic differentiation, electrospinning
- MeSH terms
- Biomineralization, Alkaline Phosphatase, Animals, Bone Regeneration, Cell Adhesion, Indoles, Materials Testing, Osteogenesis, Polyesters, Polymers, Surface Properties, Tensile Strength, Thermogravimetry, X-Ray Diffraction, 3T3 Cells, Spectroscopy, Fourier Transform Infrared, Durapatite, Bone Substitutes, Gene Expression Profiling, Cell Proliferation, Mice, Tissue Scaffolds
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