The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Pediatric Psychotropic Medication Compliance: A Literature Review and Research-Based Suggestions for Improving Treatment Compliance
Abstract
Without good compliance the best psychiatric treatment is ineffective. This article reviews what is known or can be inferred about compliance with psychiatric medications in the pediatric population. The review includes discussions of assessment techniques, risk and protective factors, the relevant research literature, and research-based practical techniques to improve compliance. A Medline search surveying the years from 1966 to August 2000 yielded only seven peer-reviewed papers reporting on compliance with pediatric psychopharmacology. All seven studies looked at stimulant compliance among children with attention deficit hyperactivity disorder. Reported levels of compliance range from 56% to 75%. These rates, although low, are likely to be overestimates of actual compliance. We review two related areas of research for which there are small but significant bodies of knowledge: pharmacological compliance studies among adult psychiatric populations and pediatric medical populations. This literature supports the idea that medication compliance is a significant obstacle to the effective treatment of patients. Because compliance rates are lower for children as compared to adults and psychiatric patients as compared to medical patients, we suspect that children with psychiatric illness may be at great risk for poor medication compliance. Fortunately, the research literature demonstrates several simple techniques that clinicians can use to improve medication compliance among their patients. The treatment alliance; education; and medication duration, dosing, palatability, and cost can all be tailored to improve medication compliance.
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In the citing paper
“estimated adherence rates in children with ADHD only range from 56% to 75%, 16 and more than 50% of patients with ADHD discontinue treatment regardless of its efficacy or symptom severity.17,18”
From Medication Adherence in the MTA: Saliva Methylphenidate Samples Versus Parent Report and Mediating Effect of Concomitant Behavioral Treatment (2009) · cites this paper as [16]
In the citing paper
“Despite our high reported adherence rates, our physiological adherence findings are consistent with studies 1, 16,18,29 that have linked poor adherence to adverse outcomes.”
From Medication Adherence in the MTA: Saliva Methylphenidate Samples Versus Parent Report and Mediating Effect of Concomitant Behavioral Treatment (2009) · cites this paper as [16]
In the citing paper
“However, unlike some previous studies, we found no associations between adherence and demographic factors such as age, sex, 17,22 family income, and single-parent status 1, 16,18,29,30”
From Medication Adherence in the MTA: Saliva Methylphenidate Samples Versus Parent Report and Mediating Effect of Concomitant Behavioral Treatment (2009) · cites this paper as [16]
Citations
Cites
Compliance With Medication Regimens for Mental and Physical Disorders
Cramer, J. A., & Rosenheck, R. (1998) · Psychiatric Services · doi:10.1176/ps.49.2.196 · Cited by 725
Blackwell, B. (1973) · New England Journal of Medicine · doi:10.1056/nejm197308022890506 · Cited by 510
HOW WELL DO PATIENTS TAKE ORAL PENICILLIN? A COLLABORATIVE STUDY IN PRIVATE PRACTICE
Charney, E., BYNUM, R. S., Eldredge, D., Frank, D., MacWhinney, J. B., McNabb, N., Scheiner, A. P., Sumpter, E. A., & Iker, H. P. (1967) · PEDIATRICS · doi:10.1542/peds.40.2.188 · Cited by 343
Psychological Factors Associated with Medication Nonadherence in Asthmatic Children
Bender, B., Milgrom, H., Rand, C. S., & Ackerson, L. (1998) · Journal of Asthma · doi:10.3109/02770909809075667 · Cited by 209
Factors associated with children's adherence to stimulant medication
Firestone, P. (1982) · American Journal of Orthopsychiatry · doi:10.1111/j.1939-0025.1982.tb01431.x · Cited by 143
Locus of Control, Social Support, and Adherence to the Diabetes Regimen
Tillotson, L. M., & Smith, M. S. (1996) · The Science of Diabetes Self-Management and Care · doi:10.1177/014572179602200206 · Cited by 142
Matsui, D. M. (1997) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(05)70459-4 · Cited by 129
Compliance with Medical Regimens During Adolescence
Litt, I. F., & Cuskey, W. R. (1980) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(16)33815-9 · Cited by 128
Beck, D. E., Fennell, R. S., Yost, R. L., Robinson, J. D., Geary, D., & Richards, G. A. (1980) · The Journal of Pediatrics · doi:10.1016/s0022-3476(80)80653-6 · Cited by 128
(1981) · Patient Counselling and Health Education · doi:10.1016/s0738-3991(81)80067-5 · Cited by 108
Research works printed but not linked: 2
- Brown RT, 1985, Psychopharmacol Bull, 21, 28
- Lansky S, 1983, Am J Pediatr Hematol Oncol, 5, 87
Cited by
Sorted by citations
3-year follow-up of the NIMH MTA study
JENSEN, P. S., ARNOLD, L. E., SWANSON, J. M., VITIELLO, B., ABIKOFF, H. B., GREENHILL, L. L., HECHTMAN, L., HINSHAW, S. P., PELHAM, W. E., WELLS, K. C., et al. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3180686d48 · Cited by 643
“For example, one literature review from 1966 to 2000 found widely varying rates of adherence (35%Y100%), with adherence rates decreasing over time (Hack and Chow, 2001).”
BackgroundEvidence-based pharmacological treatment options for ADHD in children and adolescents
Mechler, K., Banaschewski, T., Hohmann, S., & Häge, A. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107940 · Cited by 293
Satisfaction with Medication: An Overview of Conceptual, Methodologic, and Regulatory Issues
Shikiar, R., & Rentz, A. M. (2004) · Value in Health · doi:10.1111/j.1524-4733.2004.72252.x · Cited by 245
Literature Review: ADHD in Adults
Davidson, M. A. (2007) · Journal of Attention Disorders · doi:10.1177/1087054707310878 · Cited by 206
“In children, varied medication adherence rates have been noted, with rates ranging from 35% to 100% (Hack & Chow, 2001).”
Swanson, J. (2003) · CNS Drugs · doi:10.2165/00023210-200317020-00004 · Cited by 162
Metadata
- Authors
- Hack, S., & Chow, B.
- Affiliations
- New York University (US)
- University of California San Diego (US)
- Venue
- Journal of Child and Adolescent Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2001-03
- Volume
- 11
- Issue
- 1
- Pages
- 59-67
- ISSN
- 1044-5463 (ISSN-L)
- 1557-8992
- OpenAlex
- W1967979227
- Cited by
- 120
- References
- 29
- Citations by year
- 2024: 5 · 2023: 5 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 1 · 2014: 7 · 2013: 4 · 2012: 5
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Child and Adolescent Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Keywords
- medication adherence, pediatric psychopharmacology, attention deficit hyperactivity disorder, stimulant medication, treatment alliance, patient education, drug costs, risk and protective factors
- MeSH terms
- Adult, Child, Humans, Patient Compliance, Patient Education as Topic, Psychotropic Drugs
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