Cited by 21Thyroid Disorders and TreatmentsDrug Solubulity and Delivery SystemsThyroid and Parathyroid Surgery

Tablet formulation of levothyroxine is absorbed less well than powdered levothyroxine

Yamamoto, Toshihide·2003·Thyroid

Abstract

The comparative bioavailability of oral doses of levothyroxine (LT(4)) formulation taken as tablets, after being crushed, or chewed before swallowing has not been well studied. Three patients with hypothyroidism who showed persistent elevation of serum thyrotropin (TSH) despite taking 200, 150, and 125 microg of LT(4) tablets per day are presented. They did not show signs and symptoms of gastrointestinal illness that could interfere with the absorption of LT(4) nor history of such a condition. They did not concurrently take medications known to affect the absorption of LT(4) from the gut. Their serum TSH levels normalized when the tablets were taken after being pulverized. The difference appeared attributable to the slow dissolution of the tablets in the gut of these patients.

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Registry

Crossref · 10.1089/10507250360731596

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23 of 23 references verified0 citation errors · 0 not checkable

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Authors
Yamamoto, T.
Affiliations
Yamamoto Naika, Chuo-ku, Osaka, Japan.
Corresponding author
Yamamoto, Toshihide
Venue
Thyroid
Published
2003-12
Volume
13
Issue
12
Pages
1177-1181
ISSN
  • 1050-7256 (ISSN-L)
  • 1557-9077
OpenAlex
W2118213544
Cited by
21
References
22
Citations by year
2025: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 3 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
  • Thyroid (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Abbott Laboratories
  • Abbott Japan
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords
levothyroxine, tablet formulation, drug absorption, bioavailability, hypothyroidism, thyroid-stimulating hormone, tablet dissolution, crushed tablets, antithyroid drug therapy
MeSH terms
Adult, Biological Availability, Congenital Hypothyroidism, Dose-Response Relationship, Drug, Female, Humans, Hypothyroidism, Intestinal Absorption, Male, Middle Aged, Powders, Tablets, Thyrotropin, Thyroxine

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