Cited by 138Spaceflight effects on biologyStress Responses and CortisolImmunotoxicology and immune responses

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Altered Cytokine Production by Specific Human Peripheral Blood Cell Subsets Immediately Following Space Flight

Open access

Crucian, Brian E., Cubbage, Michael L., Sams, Clarence F.·2000·Journal of Interferon & Cytokine Research

Open this paper in CoChat — free account Open PDF

Abstract

In this study, flow cytometry was used to positively identify the specific lymphocyte subsets exhibiting space flight-induced alterations in cytokine production. Whole blood samples were collected from 27 astronauts at three points (one preflight, two postflight) surrounding four space shuttle missions. Assays performed included serum/urine stress hormones, white blood cell (WBC) phenotyping, and intracellular cytokine production following mitogenic stimulation. Absolute levels of peripheral granulocytes were significantly elevated following space flight, but the levels of circulating lymphocytes and monocytes were unchanged. Lymphocyte subset analysis demonstrated a decreased percentage of T cells, whereas percentages of B cells and natural killer (NK) cells remained unchanged after flight. Nearly all the astronauts exhibited an increased CD4/CD8 T cell ratio. Assessment of naive (CD45RA+) vs. memory (CD45RO+) CD4+ T cell subsets was ambiguous, and subjects tended to group within specific missions. Although no significant trend was seen in absolute monocyte levels, a significant decrease in the percentage of the CD14+ CD16+ monocytes was seen following space flight in all subjects tested. T cell (CD3+) production of interleukin-2 (IL-2) was significantly decreased after space flight, as was IL-2 production by both CD4+ and CD8+ T cell subsets. Production of interferon-gamma (IFN-gamma) was not altered by space flight for the CD8+ cell subset, but there was a significant decrease in IFN-gamma production for the CD4+ T cell subset. Serum and urine stress hormone analysis indicated significant physiologic stresses in astronauts following space flight. Altered peripheral leukocyte subsets, altered serum and urine stress hormone levels, and altered T cell cytokine secretion profiles were all observed postflight. In addition, there appeared to be differential susceptibility to space flight regarding cytokine secretion by T cell subsets. These alterations may be the result of either microgravity exposure or the physiologic stresses of landing and readaptation to unit gravity. Future studies, including in-flight analysis or sampling, will be necessary to determine the cause of these alterations.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1089/10799900050044741

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Aviat space environ med
(1992) · Applied Ergonomics · doi:10.1016/0003-6870(92)90338-v · Cited by 7,153
Detection of intracellular cytokines by flow cytometry
Jung, T., Schauer, U., Heusser, C., Neumann, C. R., & Rieger, C. (1993) · Journal of Immunological Methods · doi:10.1016/0022-1759(93)90158-4 · Cited by 976
Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry
Picker, L. J., Singh, M. K., Zdraveski, Z. Z., Treer, J., Waldrop, S. L., Bergstresser, P., & Maino, V. C. (1995) · Blood · doi:10.1182/blood.v86.4.1408.bloodjournal8641408 · Cited by 551
The novel subset of CD14+/CD16+ blood monocytes is expanded in sepsis patients
Fingerle, G., Pforte, A., Passlick, B., Blumenstein, M., Ströbel, M., & Ziegler-Heitbrock, H. W. L. (1993) · Blood · doi:10.1182/blood.v82.10.3170.3170 · Cited by 497
Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies
Prussin, C., & Metcalfe, D. D. (1995) · Journal of Immunological Methods · doi:10.1016/0022-1759(95)00209-x · Cited by 466
Assessment of Cytokines by Immunofluorescence and the Paraformaldehyde‐Saponin Procedure
Sander, B., Andersson, J., & Andersson, U. (1991) · Immunological Reviews · doi:10.1111/j.1600-065x.1991.tb00578.x · Cited by 456
Heterogeneity of human blood monocytes: the CD14+CD16+ subpopulation
Ziegler-Heitbrock, H. W. L. (1996) · Immunology Today · doi:10.1016/0167-5699(96)10029-3 · Cited by 312
Flow cytometric analysis for cytokine production identifies T helper 1, T helper 2, and T helper 0 cells within the human CD4+CD27- lymphocyte subpopulation.
Elson, L. H., Nutman, T. B., Metcalfe, D. D., & Prussin, C. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.9.4294 · Cited by 165
Immune changes during long-duration missions
Konstantinova, I., Петровна, Р. М., Lesnyak, A. T., & Antropova, E. A. (1993) · Journal of Leukocyte Biology · doi:10.1002/jlb.54.3.189 · Cited by 160
Leukocyte subsets and neutrophil function after short-term spaceflight
Stowe, R. P., Sams, C. F., Mehta, S. K., Kaur, I., Jones, M. L., Feeback, D. L., & Pierson, D. L. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.2.179 · Cited by 152
Self-citation

Show all 30 references

Research works printed but not linked: 8

SONNENFELD G., 1998, In. J. Sports Med., 19, S195
UCHAKIN P.H., 1998, J. Gravitat. Physiol., 5, 171
COGOLI A., 1980, Aviat. Space Environ. Med., 51, 29
NASH P.V., 1992, J. Appl. Physiol., 73, 286S
SONNENFELD G., 1988, Acta Microbiol. Hung., 35, 411
MEEHAN R.T., 1992, Immunology, 76, 491
TAYLOR G.R., 1986, Aviat. Space Environ. Med., 57, 213
CRUCIAN B., 1999, J. Gravitat. Physiol., 6, 33

Sorted by citations

Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond earth's orbit?
Guéguinou, N., Huin-Schohn, C., Bascove, M., Bueb, J.-L., Tschirhart, E., Legrand-Frossi, C., & Frippiat, J.-P. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0309167 · Cited by 280
Alterations in adaptive immunity persist during long-duration spaceflight
Crucian, B. E., Stowe, R. P., Mehta, S. K., Quiriarte, H. D., Pierson, D. L., & Sams, C. F. (2015) · npj Microgravity · doi:10.1038/npjmgrav.2015.13 · Cited by 255
Self-citation
Incidence of clinical symptoms during long-duration orbital spaceflight
Crucian, B., Babiak-Vazquez, A., Johnston, S., Pierson, D., Ott, C. M., & Sams, C. (2016) · International Journal of General Medicine · doi:10.2147/ijgm.s114188 · Cited by 223
Self-citation
Immune System Dysregulation Occurs During Short Duration Spaceflight On Board the Space Shuttle
Crucian, B., Stowe, R., Mehta, S., Uchakin, P., Quiriarte, H., Pierson, D., & Sams, C. (2013) · Journal of Clinical Immunology · doi:10.1007/s10875-012-9824-7 · Cited by 196
Self-citation
Biological effects of space radiation and development of effective countermeasures
Kennedy, A. R. (2014) · Life Sciences in Space Research · doi:10.1016/j.lssr.2014.02.004 · Cited by 188
Interplay of space radiation and microgravity in DNA damage and DNA damage response
Moreno-Villanueva, M., Wong, M., Lu, T., Zhang, Y., & Wu, H. (2017) · npj Microgravity · doi:10.1038/s41526-017-0019-7 · Cited by 181
Effects of spaceflight on innate immune function and antioxidant gene expression
Baqai, F. P., Gridley, D. S., Slater, J. M., Luo‐Owen, X., Stodieck, L., Ferguson, V. L., Chapes, S. K., & Pecaut, M. J. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91361.2008 · Cited by 182
Infection Prevention and Control During Prolonged Human Space Travel
Mermel, L. A. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis861 · Cited by 159
Immune function during space flight
Sonnenfeld, G., & Shearer, W. T. (2002) · Nutrition · doi:10.1016/s0899-9007(02)00903-6 · Cited by 155
Spaceflight effects on T lymphocyte distribution, function and gene expression
Gridley, D. S., Slater, J. M., Luo‐Owen, X., Rizvi, A., Chapes, S. K., Stodieck, L., Ferguson, V. L., & Pecaut, M. J. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91126.2008 · Cited by 152
How does spaceflight affect the acquired immune system?
Akiyama, T., Horie, K., Hinoi, E., Hiraiwa, M., Kato, A., Maekawa, Y., Takahashi, A., & Furukawa, S. (2020) · npj Microgravity · doi:10.1038/s41526-020-0104-1 · Cited by 132
Impact of modeled microgravity on migration, differentiation, and cell cycle control of primitive human hematopoietic progenitor cells
Plett, P. A., Abonour, R., Frankovitz, S. M., & Orschell, C. M. (2004) · Experimental Hematology · doi:10.1016/j.exphem.2004.03.014 · Cited by 126
Microgravity and immune responsiveness
Borchers, A. T., Keen, C. L., & Gershwin, M. E. (2002) · Nutrition · doi:10.1016/s0899-9007(02)00913-9 · Cited by 125
Gut Microbiome and Space Travelers’ Health: State of the Art and Possible Pro/Prebiotic Strategies for Long-Term Space Missions
Turroni, S., Magnani, M., Pukar, K. C., Lesnik, P., Vidal, H., & Heer, M. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.553929 · Cited by 132
Stress Related Shift Toward Inflammaging in Cosmonauts After Long-Duration Space Flight
Buchheim, J., Matzel, S., Петровна, Р. М., Vassilieva, G. Y., Ponomarev, S. A., Ничипорук, И. А., Hoerl, M., Moser, D., Biere, K., Feuerecker, M., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00085 · Cited by 119
Effects of the Space Flight Environment on the Immune System
Sonnenfeld, G., Butel, J. S., & Shearer, W. T. (2003) · Reviews on Environmental Health · doi:10.1515/reveh.2003.18.1.1 · Cited by 113
Towards human exploration of space: The THESEUS review series on immunology research priorities
Frippiat, J.-P., Crucian, B. E., de Quervain, D. J.-F., Grimm, D., Montano, N., Praun, S., Roozendaal, B., Schelling, G., Thiel, M., Ullrich, O., et al. (2016) · npj Microgravity · doi:10.1038/npjmgrav.2016.40 · Cited by 100
Self-citation
The immune system in space and microgravity
Sonnenfeld, G. (2002) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200212000-00024 · Cited by 89
Effect of Spaceflight on Ability of Monocytes To Respond to Endotoxins of Gram-Negative Bacteria
Kaur, I., Simons, E. R., Kapadia, A. S., Ott, C. M., & Pierson, D. L. (2008) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00065-08 · Cited by 85
Humoral and cellular immunity in cosmonauts after the ISS missions
Петровна, Р. М., Николаевна, А. Е., Larina, I. M., & Morukov, B. V. (2008) · Acta Astronautica · doi:10.1016/j.actaastro.2008.03.016 · Cited by 79
Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Missions
Tesei, D., Jewczynko, A., Lynch, A., & Urbaniak, C. (2022) · Life · doi:10.3390/life12040495 · Cited by 78
Spaceflight and simulated microgravity conditions increase virulence of Serratia marcescens in the Drosophila melanogaster infection model
Gilbert, R., Torres, M. L., Clemens, R., Hateley, S. L., Hosamani, R., Wade, W. F., & Bhattacharya, S. (2020) · npj Microgravity · doi:10.1038/s41526-019-0091-2 · Cited by 78
Three Weeks of Murine Hindlimb Unloading Induces Shifts from B to T and from Th to Tc Splenic Lymphocytes in Absence of Stress and Differentially Reduces Cell-Specific Mitogenic Responses
Gaignier, F., Schenten, V., Bittencourt, M. D. C., Gauquelin‐Koch, G., Frippiat, J., & Legrand-Frossi, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092664 · Cited by 71
Proteomics and genomics of microgravity
Nichols, H. L., Zhang, N., & Wen, X. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00323.2005 · Cited by 69
Stress response and humoral immune system alterations related to chronic hypergravity in mice
Guéguinou, N., Bojados, M., Jamon, M., Derradji, H., Baatout, S., Tschirhart, E. J., Frippiat, J., & Legrand-Frossi, C. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.05.015 · Cited by 69
Protective effect of polysaccharides on simulated microgravity-induced functional inhibition of human NK cells
Huyan, T., Li, Q., Yang, H., Jin, M., Zhang, M.-J., Ye, L.-J., Ji, L., Huang, Q., & Yin, D. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.10.021 · Cited by 62
Effect of Solar Particle Event Radiation and Hindlimb Suspension on Gastrointestinal Tract Bacterial Translocation and Immune Activation
Zhou, Y., Ni, H., Li, M., Sanzari, J. K., Diffenderfer, E. S., Lin, L., Kennedy, A. R., & Weissman, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044329 · Cited by 60
Spaceflight alters expression of microRNA during T‐cell activation
Hughes‐Fulford, M., Chang, T. T., Martinez, E. M., & Li, C. (2015) · The FASEB Journal · doi:10.1096/fj.15-277392 · Cited by 56
IL-6 and the dysregulation of immune, bone, muscle, and metabolic homeostasis during spaceflight
Smith, J. K. (2018) · npj Microgravity · doi:10.1038/s41526-018-0057-9 · Cited by 56
Effects of Simulated Microgravity on Primary Human NK Cells
Li, Q., Mei, Q., Huyan, T., Xie, L., Che, S., Yang, H., Zhang, M., & Huang, Q. (2013) · Astrobiology · doi:10.1089/ast.2013.0981 · Cited by 52
Decreases in thymopoiesis of astronauts returning from space flight
Benjamin, C. L., Stowe, R. P., John, L. S. S., Sams, C. F., Mehta, S. K., Crucian, B. E., Pierson, D. L., & Komanduri, K. V. (2016) · JCI Insight · doi:10.1172/jci.insight.88787 · Cited by 56
Self-citation
Considerations for non-invasive in-flight monitoring of astronaut immune status with potential use of MEMS and NEMS devices
Aponte, V. M., Finch, D. S., & Klaus, D. M. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.04.007 · Cited by 51
Optical Scanner for Immunoassays With Up-Converting Phosphorescent Labels
Li, J. J., Ouellette, A. L., Giovangrandi, L., Cooper, D. E., Ricco, A. J., & Kovacs, G. T. A. (2008) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2007.914674 · Cited by 51
T cell regulation in microgravity – The current knowledge from in vitro experiments conducted in space, parabolic flights and ground-based facilities
Hauschild, S., Tauber, S., Lauber, B. A., Thiel, C. S., Layer, L. E., & Ullrich, O. (2014) · Acta Astronautica · doi:10.1016/j.actaastro.2014.05.019 · Cited by 50
Changes in immune cell signalling, apoptosis and stress response functions in mice returned from the BION-M1 mission in space
Novoselova, E. G., Lunin, S. M., Khrenov, M. O., Parfenyuk, S. B., Novoselova, T. V., Shenkman, B. S., & Fesenko, E. E. (2014) · Immunobiology · doi:10.1016/j.imbio.2014.10.021 · Cited by 52
The Cytoskeleton, apoptosis, and gene expression in T lymphocytes and other mammalian cells exposed to altered gravity
Lewis, M. L. (2002) · Advances in space biology and medicine · doi:10.1016/s1569-2574(02)08016-4 · Cited by 49
Effects of a long-term spaceflight on immunoglobulin heavy chains of the urodele amphibian Pleurodeles waltl
Boxio, R., Dournon, C., & Frippiat, J. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00957.2004 · Cited by 47
Innate Immune Responses of Drosophila melanogaster Are Altered by Spaceflight
Marcu, O., Lera, M. P., Sanchez, M. E., Levic, E., Higgins, L. A., Shmygelska, A., Fahlen, T. F., Nichol, H., & Bhattacharya, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015361 · Cited by 51
Decrease in antibody somatic hypermutation frequency under extreme, extended spaceflight conditions
Bascove, M., Guéguinou, N., Schaerlinger, B., Gauquelin‐Koch, G., & Frippiat, J. (2011) · The FASEB Journal · doi:10.1096/fj.11-185215 · Cited by 45
Hindlimb suspension and spe-like radiation impairs clearance of bacterial infections
Li, M., Holmes, V., Zhou, Y., Ni, H., Sanzari, J. K., Kennedy, A. R., & Weissman, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085665 · Cited by 43
Altered cytokine expression in tissues of mice subjected to simulated microgravity
Felix, K., WISE, K. C., Manna, S. K., Yamauchi, K., Wilson, B. L., THOMAS, R. L., Kulkarni, A. D., Pellis, N. R., & Ramesh, G. T. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000049136.55611.dd · Cited by 43
Contribution of the urodele amphibian Pleurodeles waltl to the analysis of spaceflight-associated immune system deregulation
Frippiat, J. (2013) · Molecular Immunology · doi:10.1016/j.molimm.2013.06.011 · Cited by 42
Microgravity Inhibits Resting T Cell Immunity in an Exposure Time-Dependent Manner
Luo, H., Wang, C., Feng, M., & Zhao, Y. X. (2014) · International Journal of Medical Sciences · doi:10.7150/ijms.7651 · Cited by 43
The Emerging Role of Macrophages in Immune System Dysfunction under Real and Simulated Microgravity Conditions
Sun, Y., Kuang, Y., & Zuo, Z. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052333 · Cited by 41
T-cell immunity and cytokine production in cosmonauts after long-duration space flights
Morukov, B. V., Петровна, Р. М., Николаевна, А. Е., Берендеева, Т. А., Пономарев, С. А., & Ларина, И. М. (2010) · Acta Astronautica · doi:10.1016/j.actaastro.2010.08.036 · Cited by 38
Synergistic interplay between radiation and microgravity in spaceflight-related immunological health risks
Wadhwa, A., Moreno‐Villanueva, M., Crucian, B. E., & Wu, H. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00449-w · Cited by 38
Self-citation
21 Days head-down bed rest induces weakening of cell-mediated immunity – Some spaceflight findings confirmed in a ground-based analog
Kelsen, J., Bartels, L. E., Dige, A. K., Hvas, C. L., Frings‐Meuthen, P., Boehme, G., Thomsen, M. K., Fenger‐Grøn, M., & Dahlerup, J. F. (2012) · Cytokine · doi:10.1016/j.cyto.2012.04.032 · Cited by 36
Hematopoietic stem cells and lineage cells undergo dynamic alterations under microgravity and recovery conditions
Cao, D., Song, J., Ling, S., Niu, S., Lu, L., Cui, Z., Li, Y., Hao, S., Zhong, G., Qi, Z., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802421rr · Cited by 36
Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells
Ott, C. M., Pellis, N. R., & Nickerson, C. A. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3277-1 · Cited by 35
Changes of Cytokines during a Spaceflight Analog - a 45-Day Head-Down Bed Rest
Xu, X., Tan, C., Li, P., Zhang, S., Pang, X., Liu, H., Li, L., Sun, X., Zhang, Y., Wu, H., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077401 · Cited by 33
Different Sequences of Fractionated Low-Dose Proton and Single Iron-Radiation-Induced Divergent Biological Responses in the Heart
Sasi, S. P., Yan, X., Zuriaga-Herrero, M., Gee, H., Lee, J., Mehrzad, R., Song, J., Onufrak, J., Morgan, J., Enderling, H., et al. (2017) · Radiation Research · doi:10.1667/rr14667.1 · Cited by 32
Salivary antimicrobial proteins and stress biomarkers are elevated during a 6-month mission to the International Space Station
Agha, N. H., Baker, F. L., Kunz, H., Spielmann, G., Mylabathula, P. L., Rooney, B. V., Mehta, S. K., Pierson, D. L., Laughlin, M. S., Markofski, M. M., et al. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00560.2019 · Cited by 32
Self-citation
Microgravity Impairs DNA Damage Repair in Human Hematopoietic Stem/Progenitor Cells and Inhibits Their Differentiation into Dendritic Cells
Low, E. K., Brudvik, E., Kuhlman, B. M., Wilson, P. F., Almeida-Porada, G. D., & Porada, C. D. (2018) · Stem Cells and Development · doi:10.1089/scd.2018.0052 · Cited by 31
Effects of 10-day confinement on the immune system and psychological aspects in humans
Shimamiya, T., Terada, N., Hiejima, Y., Wakabayashi, S., Kasai, H., & Mohri, M. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00043.2004 · Cited by 30
Exposure of the Bone Marrow Microenvironment to Simulated Solar and Galactic Cosmic Radiation Induces Biological Bystander Effects on Human Hematopoiesis
Almeida-Porada, G. D., Rodman, C., Kuhlman, B. M., Brudvik, E., Moon, J. H., George, S. K., Guida, P. M., Sajuthi, S. P., Langefeld, C. D., Walker, S. J., et al. (2018) · Stem Cells and Development · doi:10.1089/scd.2018.0005 · Cited by 30
Effects of Spaceflight on Cells of Bone Marrow Origin
Özçivici, E. (2013) · Turkish Journal of Hematology · doi:10.4274/tjh.2012.0127 · Cited by 28
Reactivation of Latent Herpes Viruses in Astronauts
Pierson, D. L., Mehta, S. K., & Stowe, R. P. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50047-2 · Cited by 28
Counterbalancing immunosuppression-induced infections during long-term stay of humans in space
Mortazavi, S. M. J., Motamedifar, M., Namdari, G., Taheri‬, M., & Mortazavi, A. (2012) · Journal of Medical Hypotheses and Ideas · doi:10.1016/j.jmhi.2012.12.001 · Cited by 26
Immune system changes during simulated planetary exploration on Devon Island, high arctic
Crucian, B. E., Lee, P., Stowe, R., Jones, J., Effenhauser, R., Widen, R. E., & Sams, C. F. (2007) · BMC Immunology · doi:10.1186/1471-2172-8-7 · Cited by 26
Self-citation
T cell resistance to activation by dendritic cells requires long-term culture in simulated microgravity
Bradley, J. H., Stein, R., Randolph, B., Molina, E., Arnold, J. P., & Gregg, R. K. (2017) · Life Sciences in Space Research · doi:10.1016/j.lssr.2017.08.002 · Cited by 26
Down-regulation of GATA1-dependent erythrocyte-related genes in the spleens of mice exposed to a space travel
Horie, K., Sasanuma, H., Kudo, T., Fujita, S.-I., Miyauchi, M., Miyao, T., Seki, T., Akiyama, N., Takakura, Y., Shimbo, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-44067-9 · Cited by 25
Functional changes in neutrophils and psychoneuroendocrine responses during 105 days of confinement
Strewe, C., Muckenthaler, F., Feuerecker, M., Yi, B., Рыкова, М. П., Kaufmann, I., Ничипорук, И. А., Vassilieva, G. Y., Hoerl, M., Matzel, S., et al. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00755.2014 · Cited by 24
Cellular and Molecular Effects of Microgravity on the Immune System: A Focus on Bioactive Lipids
Fava, M., Dominicis, N. D., Forte, G., Bari, M., Leuti, A., & Maccarrone, M. (2024) · Biomolecules · doi:10.3390/biom14040446 · Cited by 24
Low-dose Gamma-rays and Simulated Solar Particle Event Protons Modify Splenocyte Gene and Cytokine Expression Patterns
Rizvi, A., Pecaut, M. J., & Gridley, D. S. (2011) · Journal of Radiation Research · doi:10.1269/jrr.10107 · Cited by 22
Time course of cellular and molecular regulation in the immune system in altered gravity: Progressive damage or adaptation ?
Thiel, C. S., Lauber, B. A., Polzer, J., & Ullrich, O. (2017) · REACH · doi:10.1016/j.reach.2017.03.003 · Cited by 21
Functional recovery of peripheral blood mononuclear cells in modeled microgravity
Ritz, B. W., Lelkes, P. I., & Gardner, E. M. (2005) · The FASEB Journal · doi:10.1096/fj.04-3122fje · Cited by 21
Modelled microgravity does not modify the yield of chromosome aberrations induced by high-energy protons in human lymphocytes
Manti, L., Durante, M., Cirrone, G. A. P., Grossi, G., Lattuada, M., Pugliese, M., SABINI, M. G., Scampoli, P., Valastro, L. M., & Gialanella, G. (2005) · International Journal of Radiation Biology · doi:10.1080/09553000500091188 · Cited by 21
3D microenvironment attenuates simulated microgravity-mediated changes in T cell transcriptome
ElGindi, M., Sapudom, J., Laws, P., Garcia‐Sabaté, A., Daqaq, M. F., & Teo, J. C. M. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04531-8 · Cited by 20
Post-Spaceflight (STS-135) Mouse Splenocytes Demonstrate Altered Activation Properties and Surface Molecule Expression
Hwang, S., Crucian, B. E., Sams, C. F., & Actor, J. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124380 · Cited by 18
Self-citation
Gravity-Related Immunological Changes in Human Whole Blood Cultured Under Simulated Microgravity Using an In Vitro Cytokine Release Assay
Walleghem, M. V., Tabury, K., Fernandez‐Gonzalo, R., Janssen, A., Buchheim, J., Choukèr, A., Baatout, S., & Moreels, M. (2017) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2017.0065 · Cited by 18
Navigating mental health in space: gut–brain axis and microbiome dynamics
Yang, J., Kim, H.-D., Barrila, J., Lee, S. M., Nickerson, C. A., Ott, C. M., Israel, S., Choukèr, A., & Yang, J. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01488-z · Cited by 18
Intact T cell receptor signaling by CD4+ T cells cultured in the rotating wall‐vessel bioreactor
Simons, D. M., Gardner, E. M., & Lelkes, P. I. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22502 · Cited by 17
Human neural network activity reacts to gravity changes in vitro
Striebel, J., Kalinski, L., Sturm, M., Drouvé, N., Peters, S., Lichterfeld, Y., Habibey, R., Hauslage, J., Sheikh, S. E., Busskamp, V., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1085282 · Cited by 16
Risk of Crew Adverse Health Event Due to Altered Immune Response
Crucian, B. E., Kunz, H., & Sams, C. F. (2015) · NASA Technical Reports Server (NASA) · Cited by 16
Self-citation
Mechano-Immunomodulation in Space: Mechanisms Involving Microgravity-Induced Changes in T Cells
Dhar, S., Kaeley, D. K., Kanan, M. J., & Yildirim-Ayan, E. D. (2021) · Life · doi:10.3390/life11101043 · Cited by 17
Broad-Spectrum Antibiotic or G-CSF as Potential Countermeasures for Impaired Control of Bacterial Infection Associated with an SPE Exposure during Spaceflight
Li, M., Holmes, V. M., Ni, H., Sanzari, J. K., Romero-Weaver, A. L., Lin, L., Cárabe, A., Diffenderfer, E. S., Kennedy, A. R., & Weissman, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120126 · Cited by 15
Design and surface modification of a microfluidic chip for intercellular interactions research during space flight
Chen, Y., Pei, S., Yan, L., Qiu, X., Li, R., Yu, S., Lodhi, A. F., Li, B., Manzoor, R., Zhang, P., et al. (2019) · Acta Astronautica · doi:10.1016/j.actaastro.2019.02.002 · Cited by 15
Single drop cytometry onboard the International Space Station
Rea, D. J., Miller, R. S., Crucian, B. E., Valentine, R. W., Cristoforetti, S., Bearg, S. B., Sipic, Z., Cheng, J., Yu, R., Calaway, K. M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46483-6 · Cited by 14
Self-citation
Space radiobiology and the new era of induced radioresistance: Should traditional concepts be moved to science history museums?
Mortazavi, S. M. J. (2013) · Technology and Health Care · doi:10.3233/thc-130732 · Cited by 14
Dynamic culture in a rotating-wall vessel bioreactor differentially inhibits murine T-lymphocyte activation by mitogenic stimuli upon return to static conditions in a time-dependent manner
Simons, D. M., Gardner, E. M., & Lelkes, P. I. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00887.2005 · Cited by 14
Reduced gravity evaluation of potential spaceflight‐compatible flow cytometer technology
Crucian, B. E., & Sams, C. F. (2005) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.20057 · Cited by 13
Self-citation
Putative Receptors for Gravity Sensing in Mammalian Cells: The Effects of Microgravity
Aventaggiato, M., Barreca, F., Vernucci, E., Bizzarri, M., Ferretti, E., Russo, M. A., & Tafani, M. (2020) · Applied Sciences · doi:10.3390/app10062028 · Cited by 12
Spaceflight Influences both Mucosal and Peripheral Cytokine Production in PTN-Tg and Wild Type Mice
McCarville, J. L., Clarke, S. T., Shastri, P., Liu, Y., Kalmokoff, M. L., Brooks, S. P. J., & Green-Johnson, J. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068961 · Cited by 11
Sub‐mitogenic phorbol myristate acetate co‐stimulation rescues the PHA‐induced activation of both naïve and memory T cells cultured in the rotating‐wall vessel bioreactor
Simons, D. M., Gardner, E. M., & Lelkes, P. I. (2009) · Cell Biology International · doi:10.1016/j.cellbi.2009.04.024 · Cited by 9
Lost in Space? Unmasking the T Cell Reaction to Simulated Space Stressors
Miranda, S., Vermeesen, R., Radstake, W. E., Parisi, A., Ivanova, A., Baatout, S., Tabury, K., & Baselet, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316943 · Cited by 8
Immune System in Space: General Introduction and Observations on Stress-Sensitive Regulations
Crucian, B. E., & Choukèr, A. (2011) · Springer eBooks · doi:10.1007/978-3-642-22272-6_9 · Cited by 8
Self-citation
Differential effects of Rhodiola rosea on regulatory T cell differentiation and interferon-γ production in vitro and in vivo
Xu, X., Li, P., Zhang, P., Chu, M., Liu, H., Chen, X., & Ge, Q. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5278 · Cited by 8
Particle Radiation-Induced Nontargeted Effects in Bone-Marrow-Derived Endothelial Progenitor Cells
Sasi, S. P., Park, D. S., Muralidharan, S., Wage, J., Kiladjian, A., Onufrak, J., Enderling, H., Yan, X., & Goukassian, D. A. (2015) · Stem Cells International · doi:10.1155/2015/496512 · Cited by 8
Immune Dysfunction in Spaceflight: An Integrative View
Yi, B., Crucian, B. E., Tauber, S., Ullrich, O., & Choukèr, A. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3277-1_3 · Cited by 7
Self-citation
Longitudinal transcriptomic and epigenetic analysis of the blood in two astronauts
Ao, X., Parisien, M., Cata, J. P., Montagna, F., Vigouroux, M., de Araujo, L. O. F., Karaky, M., Ingelmo, P. M., & Diatchenko, L. B. (2025) · Scientific Reports · doi:10.1038/s41598-025-13383-8 · Cited by 7
Immunological Changes During Space Travel: A Ground-Based Evaluation of the Impact of Neutron Dose Rate on Plasma Cytokine Levels in Human Whole Blood Cultures
Fisher, R., Baselet, B., Vermeesen, R., Moreels, M., Baatout, S., Rahiman, F., Miles, X., Nair, S., du Plessis, P., Engelbrecht, M., et al. (2020) · Frontiers in Physics · doi:10.3389/fphy.2020.568124 · Cited by 6
Aging and Altered Gravity: A Cellular Perspective
van Rijthoven, S., & van Loon, J. J. W. A. (2025) · The FASEB Journal · doi:10.1096/fj.202402989r · Cited by 5
Mechano-immunology in microgravity
Murali, A., & Sarkar, R. R. (2023) · Life Sciences in Space Research · doi:10.1016/j.lssr.2023.03.001 · Cited by 5
The Distinctive Sensitivity to Microgravity of Immune Cell Subpopulations
Chen, H., Luo, H., Liu, J., Wang, P., Dong, D., Shang, P., & Zhao, Y. X. (2015) · Microgravity Science and Technology · doi:10.1007/s12217-015-9441-1 · Cited by 5
Modeled Microgravity Suppressed Expansion of the MBP-specific T Lymphocytes of Rats with Experimental Autoimmune Encephalomyelitis
Bai, S., Li, Y., Wang, J., Zhai, D., Kong, Q., Liu, Y., Liu, X., Sun, B., Xu, J., Wang, D., et al. (2011) · Immunological Investigations · doi:10.3109/08820139.2011.568032 · Cited by 4
Lipid Signalling in Human Immune Response and Bone Remodelling under Microgravity
Fava, M., Leuti, A., & Maccarrone, M. (2020) · Applied Sciences · doi:10.3390/app10124309 · Cited by 4
16S rRNA beacons for bacterial monitoring during human space missions.
Larios‐Sanz, M., Kourentzi, K. D., Warmflash, D. M., Jones, J. A., Pierson, D. L., Willson, R. C., & Fox, G. E. (2007) · PubMed · Cited by 4
Medicinal Plants in the Space Exploration Era: Opportunities and Challenges for Mitigating Spaceflight-Induced Health Hazards
Pettinau, F., & Orrù, A. (2026) · Applied Sciences · doi:10.3390/app16041860 · Cited by 3
Immunologic Concerns
Sams, C. F., & Pierson, D. L. (2008) · Springer eBooks · doi:10.1007/978-0-387-68164-1_15 · Cited by 3
Self-citation
Adaptive Immunity and Spaceflight
Crucian, B. E., & Sams, C. F. (2011) · Springer eBooks · doi:10.1007/978-3-642-22272-6_12 · Cited by 3
Self-citation

Authors: Crucian, B. E., Cubbage, M. L., & Sams, C. F.
Affiliations: Wyle (United States) (US)
Baylor College of Medicine (US)
Johnson Space Center (US)
Venue: Journal of Interferon & Cytokine Research
Publisher: SAGE Publications
Published: 2000-06
Volume: 20
Issue: 6
Pages: 547-556
ISSN: 1079-9907 (ISSN-L)
1557-7465
DOI: 10.1089/10799900050044741
OpenAlex: W2014660126
Cited by: 137
References: 30
Citations by year: 2026: 2 · 2025: 8 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 11 · 2018: 5 · 2017: 6 · 2016: 11 · 2015: 10 · 2014: 6 · 2013: 9 · 2012: 7
FWCI: 1.22
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations: Journal of Interferon & Cytokine Research (publishedVersion)
PubMed (publishedVersion)
NASA STI Repository (National Aeronautics and Space Administration) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Spaceflight effects on biology
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords: spaceflight, astronauts, cytokine production, T cell subsets, CD4/CD8 ratio, interleukin-2, interferon-gamma, CD14+CD16+ monocytes, stress hormones, microgravity, lymphocyte subsets, granulocytes
MeSH terms: Hormones, Humans, Interferon-gamma, Interleukin-2, Leukocyte Count, Lymphocyte Activation, Space Flight, Stress, Physiological, Time Factors, Weightlessness, CD4-Positive T-Lymphocytes, Lymphocyte Subsets, Cytokines, CD8-Positive T-Lymphocytes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Altered Cytokine Production by Specific Human Peripheral Blood Cell Subsets Immediately Following Space Flight

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks