The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Redox Considerations in Female Reproductive Function and Assisted Reproduction: From Molecular Mechanisms to Health Implications
Abstract
Physiological levels of reactive oxygen species (ROS) play an important regulatory role through various signaling transduction pathways in folliculogenesis, oocyte maturation, endometrial cycle, luteolysis, implantation, embryogenesis, and pregnancy. Persistent and elevated generation of ROS leads to a disturbance of redox potential that in turn causes oxidative stress (OS). Our literature review captures the role of ROS in modulating a range of physiological functions and pathological processes affecting the female reproductive life span and even thereafter (i.e., menopause). The role of OS in female reproduction is becoming increasingly important, as recent evidence suggest that it plays a part in conditions such as polycystic ovarian disease, endometriosis, spontaneous abortions, preeclampsia, hydatidiform mole, embryopathies, preterm labor, and intrauterine growth retardation. OS has been implicated in different reproductive scenarios and is detrimental to both natural and assisted fertility. Many extrinsic and intrinsic conditions exist in assisted reproduction settings that can be tailored to reduce the toxic effects of ROS. Laboratory personnel should avoid procedures that are known to be deleterious, especially when safer procedures that can prevent OS are available. Although antioxidants such as folate, zinc, and thiols may help enhance fertility, the available data are contentious and must be evaluated in controlled studies with larger populations.
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Cites
[1] Role of free radicals and catalytic metal ions in human disease: An overview
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Role of oxidative stress in female reproduction
Agarwal, A., Gupta, S., & Sharma, R. K. (2005) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-3-28 · Cited by 1,729
Self-citationMitochondrial damage induced by conditions of oxidative stress
Kowaltowski, A. J., & Vercesi, A. E. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00216-0 · Cited by 866
Caniggia, I., Mostachfi, H., Winter, J., Gassmann, M., Lye, S. J., Kuliszewski, M., & Post, M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8316 · Cited by 644
Hanukoglu, I. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600570040 · Cited by 293
Oxidative stress may be a piece in the endometriosis puzzle.
Szczepańska, M., Koźlik, J., Skrzypczak, J., & Mikołajczyk, M. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00266-8 · Cited by 269
Role of oxidative stress in endometriosis
Gupta, S., Agarwal, A., Krajcir, N., & Alvarez, J. G. (2006) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)62026-3 · Cited by 240
Self-citationTranscriptional characterizations of differences between eutopic and ectopic endometrium
Wu, Y., Kajdacsy-Balla, A., Strawn, E., Basir, Z., Halverson, G., Jailwala, P., Wang, Y., Wang, X., Ghosh, S., & Guo, S.-W. (2006) · Endocrinology · doi:10.1210/en.2005-0426 · Cited by 208 · cited 1×
“Cell proliferation and angiogenesis are cellular responses to OS that also may be determined by differential gene expression (246).”
The selenium status of women with a history of recurrent miscarriage
Al‐Kunani, A. S., Knight, R., Haswell, S. J., Thompson, J. W., & Lindow, S. W. (2001) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2001.00253.x · Cited by 103
Current Thinking on the Pathogenesis of Endometriosis
Donnez, J., van Langendonckt, A., Casanas-Roux, F., van Gossum, J.-P., Pirard, C., Jadoul, P., Squifflet, J., & Smets, M. (2002) · Gynecologic and Obstetric Investigation · doi:10.1159/000066295 · Cited by 100
Cited by
The effects of oxidative stress on female reproduction: a review
Agarwal, A., Aponte-Mellado, A., Premkumar, B. J., Shaman, A., & Gupta, S. (2012) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-10-49 · Cited by 1,637
Self-citationOxidative Stress and Endometriosis: A Systematic Review of the Literature
Scutiero, G., Iannone, P., Bernardi, G., Bonaccorsi, G., Spadaro, S., Volta, C. A., Greco, P., & Nappi, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7265238 · Cited by 436
Robker, R. L., Akison, L. K., Bennett, B. D., Thrupp, P. N., Chura, L. R., Russell, D. L., Lane, M., & Norman, R. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2648 · Cited by 384
Sanchez, A. M., Viganò, P., Somigliana, E., Panina-Bordignon, P., Vercellini, P., & Candiani, M. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt053 · Cited by 357
Preterm prelabor rupture of the membranes: A disease of the fetal membranes
Menon, R., & Richardson, L. S. (2017) · Seminars in Perinatology · doi:10.1053/j.semperi.2017.07.012 · Cited by 357
Metadata
- Authors
- Agarwal, A., Gupta, S., Sekhon, L., & Shah, R.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2008-08
- Volume
- 10
- Issue
- 8
- Pages
- 1375-1404
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2046380299
- Cited by
- 361
- References
- 13
- FWCI
- 12.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Agarwal, A., Gupta, S., Sekhon, L., & Shah, R. (2008). Redox Considerations in Female Reproductive Function and Assisted Reproduction: From Molecular Mechanisms to Health Implications. Antioxidants & Redox Signaling. https://doi.org/10.1089/ars.2007.1964
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