Cited by 100Endometriosis Research and TreatmentGynecological conditions and treatmentsEctopic Pregnancy Diagnosis and Management

Current Thinking on the Pathogenesis of Endometriosis

Donnez, Jacques, van Langendonckt, Anne, Casanas-Roux, Françoise, van Gossum, Jean-Paul, Pirard, Céline, Jadoul, Pascale, Squifflet, Jean, Smets, Mireille·2002·Gynecologic and Obstetric Investigation

Abstract

This manuscript is a review of new ideas regarding the pathogenesis of peritoneal endometriosis, ovarian endometriosis, and retroperitoneal adenomyosis. Peritoneal endometriosis, the different aspects of which (black, red and white) represent distinctive steps in the evolutionary process, can be explained by the transplantation theory. Red lesions are the most active and most highly vascularized lesions and are considered to be the first stage of peritoneal endometriosis. The retroperitoneal nodule is an adenomyotic nodule whose histopathogenesis is not related to the implantation of regurgitated endometrial cells but to metaplasia of Müllerian remnants located in the rectovaginal septum. Metaplastic changes of Müllerian rests into adenomyotic glands involving the rectovaginal septum and the retroperitoneal space are responsible for the striking proliferation of the smooth muscle, creating an adenomyomatous appearance similar to that of adenomyosis in the endometrium.

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Crossref · 10.1159/000066295

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42 of 42 references verified0 citation errors · 0 not checkable

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Authors
Donnez, J., van Langendonckt, A., Casanas-Roux, F., van Gossum, J.-P., Pirard, C., Jadoul, P., Squifflet, J., & Smets, M.
Affiliations
Cliniques Universitaires Saint-Luc (BE)
Venue
Gynecologic and Obstetric Investigation
Publisher
S. Karger AG
Published
2002
Volume
54
Issue
Suppl. 1
Pages
52-62
ISSN
  • 0378-7346 (ISSN-L)
  • 1423-002X
OpenAlex
W2054034692
Cited by
100
References
42
Citations by year
2026: 1 · 2025: 2 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 9
FWCI
3.70
Type
journal article
Language
en
Open access
closed
Locations
  • Gynecologic and Obstetric Investigation (publishedVersion)
  • PubMed (publishedVersion)
  • DIAL (Catholic University of Leuven) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords
endometriosis pathogenesis, peritoneal endometriosis, endometrioma, Müllerian remnants, metaplasia, rectovaginal septum, adenomyosis, smooth muscle cell proliferation
MeSH terms
Uterine Cervical Diseases, Endometriosis, Female, Humans, Muscle, Smooth, Peritoneal Diseases, Rectal Diseases, Recurrence, Retroperitoneal Space, Vaginal Diseases, Treatment Outcome, Oxidative Stress

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