Transcriptional characterizations of differences between eutopic and ectopic endometrium

Wu, Yan; Kajdacsy-Balla, André; Strawn, Estil; Basir, Zainab; Halverson, Gloria; Jailwala, Parthav; Wang, Yuedong; Wang, Xujing; Ghosh, Soumitra; Guo, Sun-Wei

doi:10.1210/en.2005-0426

Cited by 209Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementEndometrial and Cervical Cancer Treatments

Transcriptional characterizations of differences between eutopic and ectopic endometrium

Wu, Yan, Kajdacsy-Balla, André, Strawn, Estil, Basir, Zainab, Halverson, Gloria, Jailwala, Parthav, Wang, Yuedong, Wang, Xujing +2 more·2006·Endocrinology

DOI 10.1210/en.2005-0426

Open this paper in CoChat — free account

Abstract

Endometriosis, defined as the presence of endometrial glandular and stromal cells outside the uterine cavity, is a common gynecological disease with poorly understood pathogenesis. Using laser capture microdissection and a cDNA microarray with 9600 genes/expressed sequence tags (ESTs), we have conducted a comprehensive profiling of gene expression differences between the ectopic and eutopic endometrium taken from 12 women with endometriosis adjusted for menstrual phase and the location of the lesions. With dye-swapping and replicated arrays, we found 904 genes/ESTs that are differentially expressed. We validated the gene expression using real-time RT-PCR. We found that the expression patterns of these genes/ESTs correctly classified the 12 patients into ovarian and nonovarian endometriosis. We identified gene clusters that are location-specific. In addition, we identified several biological themes using Expression Analysis Systematic Explorer. Finally, we identified 79 pathways with over 100 genes with known functions, which include oxidative stress, focal adhesion, Wnt signaling, and MAPK signaling. The identification of these genes and their associated pathways provides new insight. Our findings will stimulate future investigations on molecular genetic mechanisms underlying the pathogenesis of endometriosis.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1210/en.2005-0426

Cites

119 of 119 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Over 1000 genes are differentially expressed between adenomyotic lesions and eutopic endometrium, and close to 1000 genes are differentially expressed between ectopic and eutopic endometrium.
“In fact, over 1000 genes are documented to be differentially expressed between adenomyotic lesions and eutopic endometrium [65] and close to 1000 genes are differentially expressed between ectopic and eutopic endometrium [66].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [66]
Normal endometrial stromal cells are very different in behavior from endometriotic or adenomyotic stromal cells.
“Yet normal endometrial stromal cells are very different in behavior from endometriotic or even adenomyotic stromal cells.”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [66]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

KEGG: Kyoto Encyclopedia of Genes and Genomes
Kanehisa, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.27 · Cited by 37,077 · see citing works
KEGG: Kyoto Encyclopedia of Genes and Genomes
Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232 · see citing works
A Gene-Expression Signature as a Predictor of Survival in Breast Cancer
van de Vijver, M. J., He, Y. D., Veer, L. V. ‘., Dai, H. A., Hart, A. A. M., Voskuil, D. W., Schreiber, G. J., Peterse, J. L., Roberts, C., Marton, M. J., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021967 · Cited by 6,411 · see citing works
Mammalian MAP kinase signalling cascades
Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,118 · see citing works
Matrix Metalloproteinases
Nagase, H., & Woessner, J. F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21491 · Cited by 3,905 · see citing works
Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation.
Yang, Y., Dudoit, S., Luu, P., Lin, D., Peng, V., Ngai, J., & Speed, T. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.4.e15 · Cited by 3,722 · see citing works
Dating the Endometrial Biopsy
Rw, N., Hertig, A. T., & Rock, J. A. (1950) · Fertility and Sterility · doi:10.1016/s0015-0282(16)30062-0 · Cited by 2,854 · see citing works
Laser Capture Microdissection
Emmert‐Buck, M. R., Bonner, R. F., Smith, P. D., Chuaqui, R. F., Zhuang, Z., Goldstein, S. R., Weiss, R. A., & Liotta, L. A. (1996) · Science · doi:10.1126/science.274.5289.998 · Cited by 2,540 · see citing works
Exploring the new world of the genome with DNA microarrays
Brown, P. O., & Botstein, D. (1999) · Nature Genetics · doi:10.1038/4462 · Cited by 2,430 · see citing works
Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity
Sampson, J. A. (1927) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30003-x · Cited by 2,334 · see citing works
Interleukin-8 as a macrophage-derived mediator of angiogenesis
Koch, A. E., Polverini, P. J., Kunkel, S. L., Harlow, L. A., DiPietro, L. A., Elner, V. M., Elner, S. G., & Strieter, R. M. (1992) · Science · doi:10.1126/science.1281554 · Cited by 2,135 · see citing works
Identifying biological themes within lists of genes with EASE
Hosack, D. A., Dennis, G., Sherman, B. T., Lane, H. C., & Lempicki, R. A. (2003) · Genome biology · doi:10.1186/gb-2003-4-10-r70 · Cited by 1,950 · see citing works
Revised American Fertility Society Classification of Endometriosis: 1985
(1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48430-x · Cited by 1,803 · see citing works
EPIDEMIOLOGY OF ENDOMETRIOSIS
Eskenazi, B., & Warner, M. L. (1997) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(05)70302-8 · Cited by 1,617 · see citing works
Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
Ip, Y. T., & Davis, R. J. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80143-9 · Cited by 1,538 · see citing works
Mitogen-activated protein kinases in apoptosis regulation
Wada, T., & Penninger, J. M. (2004) · Oncogene · doi:10.1038/sj.onc.1207556 · Cited by 1,432 · see citing works
Analysis of Variance for Gene Expression Microarray Data
Kerr, K. F., Martin, M., & Churchill, G. A. (2000) · Journal of Computational Biology · doi:10.1089/10665270050514954 · Cited by 1,310 · see citing works
Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities
Nisolle, M., & Donnez, J. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00191-x · Cited by 1,279 · see citing works
Fundamentals of experimental design for cDNA microarrays
Churchill, G. A. (2002) · Nature Genetics · doi:10.1038/ng1031 · Cited by 1,049 · see citing works
Prediction of Survival in Diffuse Large-B-Cell Lymphoma Based on the Expression of Six Genes
Lossos, I. S., Czerwinski, D. K., Alizadeh, A. A., Wechser, M. A., Tibshirani, R. J., Botstein, D., & Levy, R. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032520 · Cited by 912 · see citing works
Laser Capture Microdissection: Molecular Analysis of Tissue
Bonner, R. F., Emmert‐Buck, M. R., Cole, K. A., Pohida, T. J., Chuaqui, R. F., Goldstein, S. R., & Liotta, L. A. (1997) · Science · doi:10.1126/science.278.5342.1481 · Cited by 877 · see citing works
Importance of replication in microarray gene expression studies: Statistical methods and evidence from repetitive cDNA hybridizations
Lee, M. T., Kuo, F. C., Whitmore, G. A., & Sklar, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.18.9834 · Cited by 861 · see citing works
Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals
Morrison, D. K., & Davis, R. J. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111401.091942 · Cited by 787 · see citing works
Expression Profiling of Endometrium from Women with Endometriosis Reveals Candidate Genes for Disease-Based Implantation Failure and Infertility
Kao, L. C., Germeyer, A., Tulac, S., Lobo, S., Yang, J. P., Taylor, R. N., Osteen, K., Lessey, B. A., & Giudice, L. C. (2003) · Endocrinology · doi:10.1210/en.2003-0043 · Cited by 696 · see citing works
High-fidelity mRNA amplification for gene profiling
Wang, E., Miller, L. D., Ohnmacht, G. A., Liu, E. T., & Marincola, F. M. (2000) · Nature Biotechnology · doi:10.1038/74546 · Cited by 675 · see citing works
Endometriosis
Olive, D. L., & Schwartz, L. B. (1993) · New England Journal of Medicine · doi:10.1056/nejm199306173282407 · Cited by 675 · see citing works
The contributions of sex, genotype and age to transcriptional variance in Drosophila melanogaster
Jin, W., Riley-Berger, R., Wolfinger, R. D., White, K. P., Passador-Gurgel, G., & Gibson, G. C. (2001) · Nature Genetics · doi:10.1038/ng766 · Cited by 644 · see citing works
The stress-activated protein kinase pathways
Tibbles, L. A., & Woodgett, J. R. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050369 · Cited by 641 · see citing works
The Matrix Metalloproteinase System: Changes, Regulation, and Impact throughout the Ovarian and Uterine Reproductive Cycle
Curry, T. E., & Osteen, K. G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0005 · Cited by 606 · see citing works
Issues in cDNA microarray analysis: quality filtering, channel normalization, models of variations and assessment of gene effects
Tseng, G. C. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.12.2549 · Cited by 574 · see citing works
Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium
Cooke, P. S., Buchanan, D. L., Young, P., Setiawan, T., Brody, J. R., Korach, K. S., Taylor, J., Lubahn, D. B., & Cunha, G. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6535 · Cited by 556 · see citing works
Highly optimized tolerance: A mechanism for power laws in designed systems
Carlson, J. M., & Doyle, J. C. (1999) · Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics · doi:10.1103/physreve.60.1412 · Cited by 555 · see citing works
The TAK1-NLK Mitogen-Activated Protein Kinase Cascade Functions in the Wnt-5a/Ca 2+ Pathway To Antagonize Wnt/β-Catenin Signaling
Ishitani, T., Kishida, S., Hyodo‐Miura, J., Ueno, N., Yasuda, J., Waterman, M. L., Shibuyà, H., Moon, R. T., Ninomiya‐Tsuji, J., & Matsumoto, K. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.131-139.2003 · Cited by 540 · see citing works
Accuracy and calibration of commercial oligonucleotide and custom cDNA microarrays
Yuen, T. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e48 · Cited by 520 · see citing works
Regulation and function of the JNK subgroup of MAP kinases
Minden, A., & Karin, M. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(97)00018-8 · Cited by 486 · see citing works
Big Mitogen-activated Protein Kinase 1 (BMK1) Is a Redox-sensitive Kinase
Abe, J., Kusuhara, M., Ulevitch, R. J., Berk, B. C., & Lee, J.-D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.28.16586 · Cited by 441 · see citing works
Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor
Kato, Y., Tapping, R. I., Huang, S., Watson, M. H., Ulevitch, R. J., & Lee, J.-D. (1998) · Nature · doi:10.1038/27234 · Cited by 439 · see citing works
Post-analysis follow-up and validation of microarray experiments
Chuaqui, R. F., Bonner, R. F., Best, C. J. M., Gillespie, J. W., Flaig, M. J., Hewitt, S. M., Phillips, J. L., Krizman, D. B., Tangrea, M. A., Ahram, M. A., et al. (2002) · Nature Genetics · doi:10.1038/ng1034 · Cited by 439 · see citing works
Analysis of the glutathione S-transferase (GST) gene family
Nebert, D. W., & Vasiliou, V. (2004) · Human Genomics · doi:10.1186/1479-7364-1-6-460 · Cited by 392 · see citing works
Oxidative stress and peritoneal endometriosis
Van Langendonckt, A., Casanas-Roux, F., & Donnez, J. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)02959-x · Cited by 391 · see citing works
p38 MAP kinase: a convergence point in cancer therapy
Olson, J. M., & Hallahan, A. R. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.01.007 · Cited by 335 · see citing works
Genetics of dermatofibrosarcoma protuberans family of tumors: From ring chromosomes to tyrosine kinase inhibitor treatment
Sirvent, N., Maire, G., & Pédeutour, F. (2003) · Genes Chromosomes and Cancer · doi:10.1002/gcc.10202 · Cited by 311 · see citing works
Theories of endometriosis
Vinatier, D., Orazi, G., Cosson, M., & Dufour, P. (2001) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(00)00405-x · Cited by 299 · see citing works
Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis
Wu, Y., Halverson, G., Basir, Z., Strawn, E., Yan, P., & Guo, S.-W. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.01.034 · Cited by 283 · see citing works
Self-citation
Leukocyte adhesion: CD11/CD18 integrins and intercellular adhesion molecules
Gahmberg, C. G. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80117-2 · Cited by 282 · see citing works
Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure
Hayashi, M., Kim, S.-W., Imanaka‐Yoshida, K., Yoshida, T., Abel, E. D., Eliceiri, B. P., Yang, Y. C., Ulevitch, R. J., & Lee, J.-D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19890 · Cited by 279 · see citing works
Oxidative stress may be a piece in the endometriosis puzzle.
Szczepańska, M., Koźlik, J., Skrzypczak, J., & Mikołajczyk, M. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00266-8 · Cited by 269 · see citing works
Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure
Hayashi, M., Kim, S.-W., Imanaka‐Yoshida, K., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419890 · Cited by 241 · see citing works
Laparoscopic appearances of peritoneal endometriosis
Martin, D. C., Hubert, G. D., Vander Zwaag, R., & El-Zeky, F. A. (1989) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60429-6 · Cited by 239 · see citing works
Quantitative quality control in microarray image processing and data acquisition
Wang, X. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.15.e75 · Cited by 234 · see citing works
Cyclic Changes in the Matrix Metalloproteinase System in the Ovary and Uterus1
Curry, T. E., & Osteen, K. G. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.5.1285 · Cited by 224 · see citing works
Interleukin-8 concentrations are elevated in peritoneal fluid of women with endometriosis
Ryan, I. P., Tseng, J. F., Schriock, E. D., Khorram, O., Landers, D. V., & Taylor, R. N. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57506-2 · Cited by 222 · see citing works
Expression and localization of matrilysin, a matrix metalloproteinase, in human endometrium during the reproductive cycle
Rodgers, W. H., steen, K. G., Matrisian, L. M., Navre, M., Giudice, L. C., & Gorstein, F. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(12)90922-9 · Cited by 217 · see citing works
Classification of endometriotic implants by morphologic appearance and capacity to synthesize prostaglandin F
Vernon, M. W., Beard, J. S., Graves, K., & Wilson, E. A. (1986) · Fertility and Sterility · doi:10.1016/s0015-0282(16)49814-6 · Cited by 204 · see citing works
STATISTICAL ANALYSIS OF A GENE EXPRESSION MICROARRAY EXPERIMENT WITH REPLICATION
Kerr, K. F., Afshari, C. A., Bennett, L., Bushel, P. R., Martinez, J. M., Walker, N. J., & Churchill, G. A. (2002) · Cited by 187 · see citing works
ERK5 MAPK Regulates Embryonic Angiogenesis and Acts as a Hypoxia-sensitive Repressor of Vascular Endothelial Growth Factor Expression
Sohn, S. J., Sarvis, B. K., Cado, D., & Winoto, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207573200 · Cited by 186 · see citing works
Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-3 mRNA expression in ectopic and eutopic endometrium in women with endometriosis: a rationale for endometriotic invasiveness
Chung, H., Wen, Y., Chun, S., NEZHAT, C. R., Woo, B.-H., & Polan, M. L. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01670-8 · Cited by 176 · see citing works
Fluid Shear Stress Stimulates Big Mitogen-activated Protein Kinase 1 (BMK1) Activity in Endothelial Cells
Chen, Y., Takahashi, M., Okuda, M., Lee, J., & Berk, B. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.143 · Cited by 176 · see citing works
Erk5 Participates in Neuregulin Signal Transduction and Is Constitutively Active in Breast Cancer Cells Overexpressing ErbB2
Esparı́s-Ogando, A., Dı́az-Rodrı́guez, E., Montero, J. C., Yuste, L., Crespo, P., & Pandiella, A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.1.270-285.2002 · Cited by 174 · see citing works
Stage and localization of pelvic endometriosis and pain
Fedele, L., Parazzini, F., Bianchi, S., Arcaini, L., & Candiani, G. B. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)53232-4 · Cited by 173 · see citing works
Subtle appearance of pelvic endometriosis
Stripling, M. C., Martin, D. C., Chatman, D. L., Zwaag, R. V., & Poston, W. M. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59767-2 · Cited by 167 · see citing works
Interleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor1
Arici, A. M., Seli, E. U., Zeyneloğlu, H. B., Senturk, L. M., Oral, E., & Olive, D. L. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.4.4743 · Cited by 166 · see citing works
Big Mitogen-Activated Protein Kinase (BMK1)/ERK5 Protects Endothelial Cells From Apoptosis
Pi, X., Chen, Y., & Berk, B. C. (2003) · Circulation Research · doi:10.1161/01.res.0000112406.27800.6f · Cited by 157 · see citing works
Expression of interstitial collagenase (matrix metalloproteinase-1) is related to the activity of human endometriotic lesions
Kokorine, I., Nisolle, M., Donnez, J., Eeckhout, Y., Courtoy, P. J., & Marbaix, É. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81510-5 · Cited by 148 · see citing works
Performance evaluation of commercial short-oligonucleotide microarrays and the impact of noise in making cross-platform correlations
Shippy, R., Sendera, T. J., Lockner, R., Palaniappan, C., Kaysser-Kranich, T., Watts, G. S., & Alsobrook, J. P. (2004) · BMC Genomics · doi:10.1186/1471-2164-5-61 · Cited by 147 · see citing works
Cancer robustness: Tumour tactics
Kitano, H. (2003) · Nature · doi:10.1038/426125a · Cited by 146 · see citing works
The intercellular adhesion molecule (ICAM) family of proteins
Hayflick, J. S., Kilgannon, P., & Gallatin, W. M. (1998) · Immunologic Research · doi:10.1007/bf02786454 · Cited by 140 · see citing works
Oncogenic protein tyrosine kinases
Jones, A. V., & Cross, N. C. P. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4272-z · Cited by 134 · see citing works
DNA microarray analysis of gene expression markers of endometriosis
Eyster, K. M., Boles, A. L., Brannian, J. D., & Hansen, K. A. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02955-7 · Cited by 130 · see citing works
Genome-wide cDNA microarray analysis of gene-expression profiles involved in ovarian endometriosis.
Arimoto, T., Katagiri, T., Oda, K., Tsunoda, T., Yasugi, T., Osuga, Y., Yoshikawa, H., Nishii, O., Yano, T., Taketani, Y., et al. (2003) · PubMed · Cited by 125 · see citing works
The distribution of endometriosis in the pelvis by age groups and fertility
Redwine, D. B. (1987) · Fertility and Sterility · doi:10.1016/s0015-0282(16)49956-5 · Cited by 122 · see citing works
Immunohistochemical assessment of superoxide dismutase expression in the endometrium in endometriosis and adenomyosis
Ota, H., Igarashi, S., Hatazawa, J., & Tanaka, T. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00152-1 · Cited by 119 · see citing works
Steroid and Growth Factor Regulation of Matrix Metalloproteinase Expression and Endometriosis
Osteen, K. G., Bruner, K. L., & Sharpe-Timms, K. L. (1996) · Seminars in Reproductive Medicine · doi:10.1055/s-2007-1016334 · Cited by 117 · see citing works
DNA microarray analysis of gene expression profiles in deep endometriosis using laser capture microdissection
Matsuzaki, S., Canis, M. J., Vaurs‐Barrière, C., Pouly, J.-L., Boespflug‐Tanguy, O., Penault-Llorca, F. M., Dechelotte, P., Dastugue, B., Okamura, K., & Mage, G. (2004) · Molecular Human Reproduction · doi:10.1093/molehr/gah097 · Cited by 117 · see citing works
Endometriosis: A Disease of Oxidative Stress?
Murphy, A. A., Santanam, N., & Parthasarathy, S. (1998) · Seminars in Reproductive Medicine · doi:10.1055/s-2007-1016286 · Cited by 116 · see citing works
Is endometriosis an endometrial disease?
Vinatier, D., Cosson, M., & Dufour, P. (2000) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(99)00263-8 · Cited by 115 · see citing works
Resolution of clonal origins for endometriotic lesions using laser capture microdissection and the human androgen receptor (HUMARA) assay
Wu, Y., Basir, Z., Kajdacsy-Balla, A., Strawn, E., Macias, V., Montgomery, K., & Guo, S.-W. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(02)04821-5 · Cited by 114 · see citing works
Peritoneal fluid concentrations of interleukin-8 in women with endometriosis: relationship to stage of disease
Gazvani, M. R., Christmas, S. E., Quenby, S. M., Kirwan, J. P., Johnson, P. M., & Kingsland, C. R. (1998) · Human Reproduction · doi:10.1093/humrep/13.7.1957 · Cited by 114 · see citing works
Effects of oxidants and antioxidants on proliferation of endometrial stromal cells
Foyouzi, N., Berkkanoğlu, M., Arici, A. M., Kwintkiewicz, J., Izquierdo, D. M., & Dulęba, A. J. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.02.133 · Cited by 101 · see citing works
Human endometrial stromal cells as a source of soluble intercellular adhesion molecule (ICAM)-l molecules
Somigliana, E., Vigand, P., Gaffuri, B., Guarneri, D., Busacca, M., & Vignali, M. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019353 · Cited by 100 · see citing works
Aberrant expression of glutathione peroxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis
Ota, H., Igarashi, S., Kato, N., & Tanaka, T. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)00638-5 · Cited by 98 · see citing works
The reproducibility of the revised American Fertility Society classification of endometriosis
Hornstein, M. D., Gleason, R. E., Orav, E. J., Haas, S. T., Friedman, A. J., Rein, M. S., Hill, J. A., & Barbieri, R. L. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55921-4 · Cited by 92 · see citing works
Localization of Matrix Metalloproteinase-2 in Uterine Endometrium and Ectopic Implants
Wenzl, R. J., & Heinzl, H. (1998) · Gynecologic and Obstetric Investigation · doi:10.1159/000009978 · Cited by 80 · see citing works
Emerging role of genomics in endometriosis research
Taylor, R. N., Lundeen, S. G., & Giudice, L. C. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03325-3 · Cited by 77 · see citing works
Molecularly targeted treatment for dermatofibrosarcoma protuberans
McArthur, G. A. (2004) · Seminars in Oncology · doi:10.1053/j.seminoncol.2004.03.038 · Cited by 77 · see citing works
Quantitative quality control in microarray experiments and the application in data filtering, normalization and false positive rate prediction
Wang, X., Hessner, M. J., Wu, Y., Pati, N. T., & Ghosh, S. (2003) · Bioinformatics · doi:10.1093/bioinformatics/btg154 · Cited by 74 · see citing works
Moving disease biology from the lab to the clinic
Anderson, K. C. (2003) · Cancer · doi:10.1002/cncr.11137 · Cited by 71 · see citing works
Discussion
Knapp, V. J. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00196-x · Cited by 68 · see citing works
Reliability of the visual diagnosis of ovarian endometriosis
Vercellini, P., Vendola, N., Bocciolone, L., Rognoni, M. T., Carinelli, S. G., & Candiani, G. B. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54744-x · Cited by 68 · see citing works
The expression of soluble intercellular adhesion molecule-1 in endometriosis
Wu, M., Yang, B., Hsu, C., Lee, Y.-C., & Huang, K. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00384-7 · Cited by 67 · see citing works
Interleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor
Arici, A. M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.4.1201 · Cited by 66 · see citing works
Matrix Metalloproteinases and Tace Play A Role in The Pathogenesis of Endometriosis
Gottschal, C., Malberg, K., Arndt, M., Schmitt, J., Roessner, A., Schultze, D., Kleinstein, J., & Ansorge, S. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-46826-3_49 · Cited by 63 · see citing works
Aberrant expression of intercellular adhesion molecule-1 and killer inhibitory receptors induces immune tolerance in women with pelvic endometriosis
Maeda, N., Izumiya, C., Oguri, H., Kusume, T., Yamamoto, Y., & Fukaya, T. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)03249-6 · Cited by 62 · see citing works
Altered expression of a cell-cycle suppressor gene, Tob-1, in endometriotic cells by cDNA array analyses
Lebovic, D. I., Baldocchi, R. A., Mueller, M. D., & Taylor, R. N. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03319-8 · Cited by 60 · see citing works
Distribution of heat shock proteins in eutopic and ectopic endometrium in endometriosis and adenomyosis
Ota, H., Igarashi, S., Hatazawa, J., & Tanaka, T. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81470-7 · Cited by 60 · see citing works
Role of BMK1 in Regulation of Growth Factor-Induced Cellular Responses
Kato, Y., Chao, T.-H., Hayashi, M., Tapping, R. I., & Lee, J.-D. (2000) · Immunologic Research · doi:10.1385/ir:21:2-3:233 · Cited by 58 · see citing works
The relevancy of the matrix metalloproteinase system to the pathophysiology of endometriosis
Han-E, Z. (2005) · Frontiers in bioscience · doi:10.2741/1552 · Cited by 57 · see citing works
Three color cDNA microarrays: quantitative assessment through the use of fluorescein-labeled probes
Hessner, M. J. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng014 · Cited by 56 · see citing works
RU486-induced growth inhibition of human endometrial cells
Murphy, A. A., Zhou, M. H., Malkapuram, S., Santanam, N., Parthasarathy, S., & Sidell, N. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01606-x · Cited by 55 · see citing works
Granulocyte Colony-stimulating Factor Induces Erk5 Activation, Which Is Differentially Regulated by Protein-tyrosine Kinases and Protein Kinase C
Dong, F., Gutkind, J. S., & Larner, A. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008748200 · Cited by 54 · see citing works
Expression of interleukin-8 receptors in endometriosis
Ulukuş, M., Ulukus, E. C., Seval, Y., Zheng, W., & Arici, A. M. (2004) · Human Reproduction · doi:10.1093/humrep/deh675 · Cited by 52 · see citing works
The current staging system for endometriosis: does it help?
Roberts, C. P., & Rock, J. A. (2003) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(02)00056-6 · Cited by 50 · see citing works
Redefining endometriosis: Endometriosis is an entity with extreme pleiomorphism
Leyendecker, G. (2000) · Human Reproduction · doi:10.1093/humrep/15.1.4 · Cited by 49 · see citing works
Classification of human tumors using gene expression profiles obtained after microarray analysis of fine-needle aspiration biopsy samples
Centeno, B. A., Enkemann, S. A., Coppola, D., Huntsman, S. A., Bloom, G. C., & Yeatman, T. J. (2005) · Cancer · doi:10.1002/cncr.20737 · Cited by 49 · see citing works
Endometriosis and Free Radicals
Ota, H., Igarashi, S., Hatazawa, J., & Tanaka, T. (1999) · Gynecologic and Obstetric Investigation · doi:10.1159/000052866 · Cited by 48 · see citing works
Regulation of Interleukin-8 Expression in Human Endometrial Endothelial Cells: A Potential Mechanism for the Pathogenesis of Endometriosis
Luk, J., Seval, Y., Kayisli, U. A., Ulukuş, M., Ulukuş, Ç., & Arici, A. M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1813 · Cited by 47 · see citing works
Differential Expression of Interleukins (IL)‐13 and IL‐15 in Ectopic and Eutopic Endometrium of Women With Endometriosis and Normal Fertile Women
Chegini, N., Roberts, M., & Ripps, B. A. (2003) · American Journal of Reproductive Immunology · doi:10.1034/j.1600-0897.2003.00028.x · Cited by 47 · see citing works
Genomic alterations in the endometrium may be a proximate cause for endometriosis
Guo, S., Wu, Y., Strawn, E., Basir, Z., Wang, Y., Halverson, G., Montgomery, K., & Kajdacsy-Balla, A. (2004) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2004.02.004 · Cited by 46 · see citing works
Role of immunoreactions and mast cells in pathogenesis of human endometriosis -morphologic study and gene expression analysis-
Konno, R., Yamada‐Okabe, H., Fujiwara, H., Uchiide, I., Shibahara, H., Ohwada, M., Ihara, T., Sugamata, M., & Suzuki, M. (2003) · Human Cell · doi:10.1111/j.1749-0774.2003.tb00146.x · Cited by 45 · see citing works
Atherosclerosis, Oxidation and Endometriosis
Santanam, N., Song, M., Rong, R., Murphy, A. A., & Parthasarathy, S. (2002) · Free Radical Research · doi:10.1080/1071576021000049908 · Cited by 41 · see citing works
Gonadotropin-releasing hormone and TGF-β activate MAP kinase and differentially regulate fibronectin expression in endometrial epithelial and stromal cells
Luo, X., Ding, L., & Chegini, N. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00200.2004 · Cited by 38 · see citing works
Recurrence of Chocolate Cysts after Laparoscopic Ablation
Jones, K., & Sutton, C. (2002) · The Journal of the American Association of Gynecologic Laparoscopists · doi:10.1016/s1074-3804(05)60410-0 · Cited by 36 · see citing works
[Expression of MMP-3 and TIMP-1 in the endometriosis and the influence of danazol].
Saito, T., Mizumoto, H., Kuroki, K., Fujii, M., Mori, S., & Kudo, R. (1995) · PubMed · Cited by 35 · see citing works
Soluble ICAM-1 levels in the serum of endometriotic patients appear to be independent of medical treatment
Matalliotakis, I., Vassiliadis, S., Goumenou, A. G., Athanassakis, I., Koumantakis, G. E., Neonaki, M., & Koumantakis, E. E. (2001) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(01)00064-x · Cited by 34 · see citing works
Conditions to Ensure Competitive Hybridization in Two-Color Microarray: A Theoretical and Experimental Analysis
Wang, Y., Wang, X., Guo, S., & Ghosh, S. (2002) · BioTechniques · doi:10.2144/02326mt05 · Cited by 29 · see citing works
Expression of the Human Cytochrome c1 Gene is Controlled through Multiple Sp1‐Binding Sites and an Initiator Region
Li, R., Luciaková, K., & Nelson, B. D. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.00649.x · Cited by 25 · see citing works
Platelet-derived growth factor promotes endometrial epithelial cell proliferation
Munson, L., Upadhyaya, N. B., & Meter, S. V. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90434-4 · Cited by 22 · see citing works
A defective expression of ICAM-1 (CD54) on secretory endometrial cells is associated with endometriosis
Prefumo, F., Semino, C., Melioli, G., & Venturini, P. L. (2002) · Immunology Letters · doi:10.1016/s0165-2478(01)00311-x · Cited by 17 · see citing works
Elucidation of sialyltransferase as a tumour marker.
De, A. K., & Re, H. (1990) · PubMed · Cited by 6 · see citing works

Flagged first, then by citations

1 of the 120 references couldn’t be matched to a known paper.

Sorted by citations

Endometriosis
Bulun, S. E. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804690 · Cited by 1,772 · see citing works
Endometriosis
Bulun, S. E., Yilmaz, B. D., Sison, C., Miyazaki, K., Bernardi, L., Liu, S., Kohlmeier, A., Yin, P., Milad, M., & Wei, J. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00242 · Cited by 844 · see citing works
Recurrence of endometriosis and its control
Guo, S.-W. (2009) · Human Reproduction Update · doi:10.1093/humupd/dmp007 · Cited by 719 · see citing works
Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening
Boretto, M., Maenhoudt, N., Luo, X., Hennes, A., Boeckx, B., Bui, B. N., Heremans, R., Perneel, L., Kobayashi, H., Zundert, I. V., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0360-z · Cited by 507 · see citing works
The distinguishing cellular and molecular features of the endometriotic ovarian cyst: from pathophysiology to the potential endometrioma-mediated damage to the ovary
Sanchez, A. M., Viganò, P., Somigliana, E., Panina-Bordignon, P., Vercellini, P., & Candiani, M. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt053 · Cited by 357 · see citing works
“…inside of the cyst involves very numerous studies and their description is beyond the scope of this review (Cox et al., 2001; Arimoto et al., 2003; Wu et al., 2006; Eyster et al., 2007; Hever et al., 2007; Mettler et al., 2007; Borghese et al., 2008; Zafrakas et al., 2008; Di Carlo et al., 2009;…”
Background
Redox Considerations in Female Reproductive Function and Assisted Reproduction: From Molecular Mechanisms to Health Implications
Agarwal, A. K., Gupta, S., Sekhon, L. H., & Shah, R. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1964 · Cited by 360 · see citing works
“Cell proliferation and angiogenesis are cellular responses to OS that also may be determined by differential gene expression (246).”
MicroRNA-regulated pathways associated with endometriosis
Ohlsson Teague, E. M. C., Van der Hoek, K. H., Van der Hoek, M. B., Perry, N., Wagaarachchi, P., Robertson, S. A., Print, C. G., & Hull, L. M. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0387 · Cited by 357 · see citing works
Contemporary genetic technologies and female reproduction
The Evian Annual Reproduction (EVAR) Workshop Group 2010, Fauser, B. C. J. M., Diedrich, K., Bouchard, P., Domı́nguez, F., Matzuk, M. M., Franks, S., Hamamah, S., Simón, C., Devroey, P., et al. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmr033 · Cited by 341 · see citing works
“Gene expression microarray studies have identified a number of candidate gene families that may be differentially regulated in endometriosis (Kao et al., 2003; Wu et al., 2006; Burney et al., 2007; Hull et al., 2008; Ohlsson Teague et al., 2009).”
Background
Priorities for Endometriosis Research: Recommendations From an International Consensus Workshop
Rogers, P. A. W., D’Hooghe, T. M., Fazleabas, A., Gargett, C. E., Giudice, L. C., Montgomery, G. W., Rombauts, L., Salamonsen, L. A., & Zondervan, K. T. (2009) · Reproductive Sciences · doi:10.1177/1933719108330568 · Cited by 346 · see citing works
Epigenetics of endometriosis
Guo, S.-W. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap064 · Cited by 328 · see citing works
“…that many genes are deregulated in endometriosis (Carson et al., 2002; Arimoto et al., 2003; Kao et al., 2003; Matsuzaki et al., 2005; Wu et al., 2006a; Burney et al., 2007; Chand et al., 2007; Eyster et al., 2007; Flores et al., 2007; Hever et al., 2007; Konno et al., 2007; Mettler…”
Background
Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why
Lessey, B. A., & Kim, J. J. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.05.031 · Cited by 286 · see citing works
Wnt Signalling in Implantation, Decidualisation and Placental Differentiation – Review
Sonderegger, S., Pollheimer, J., & Knöfler, M. (2010) · Placenta · doi:10.1016/j.placenta.2010.07.011 · Cited by 265 · see citing works
“Moreover, elevated expression of Wnt7a, Wnt2 and FZD1 was observed in endometriotic tissues [84,85].”
Background
The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression
Pan, Q., Luo, X., Toloubeydokhti, T., & Chegini, N. (2007) · Molecular Human Reproduction · doi:10.1093/molehr/gam063 · Cited by 261 · see citing works
“Conventional and recent large-scale gene expression studies have provided further evidence reflecting the molecular environments that differentiate normal endometrium from disorders affecting this tissue, including endometrial cancer, adenomyosis and endometriosis (Eyster et al., 2002; Kao et al., 2002; Riesewijk et a…”
Influential
Retracted
Role of oxidative stress in endometriosis
Gupta, S., Agarwal, A., Krajcir, N., & Alvarez, J. G. (2006) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)62026-3 · Cited by 240 · see citing works
Review on the role of glutathione on oxidative stress and infertility
Oyewopo, A. O., Johnson, O., Adeleke, O. S., & Christiania, O. (2017) · JBRA · doi:10.5935/1518-0557.20180003 · Cited by 226 · see citing works
Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis
Wu, Y., Strawn, E., Basir, Z., Halverson, G., & Guo, S.-W. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.05.077 · Cited by 193 · see citing works
Self-citation
Whole genome deoxyribonucleic acid microarray analysis of gene expression in ectopic versus eutopic endometrium
Eyster, K. M., Klinkova, O. V., Kennedy, V., & Hansen, K. A. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.01.056 · Cited by 192 · see citing works
Immune-inflammation gene signatures in endometriosis patients
Ahn, S. H., Khalaj, K., Young, S. L., Lessey, B. A., Koti, M., & Tayade, C. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.07.005 · Cited by 187 · see citing works
“(52) profiled gene expression differences between Ahn et al.”
Background
Mechanisms of endometrial progesterone resistance
Al-Sabbagh, M., Lam, E. W.-F., & Brosens, J. J. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.10.035 · Cited by 183 · see citing works
“Progesterone resistance is also a hallmark of ectopic implants and probably plays a role in ovarian and tubal dysfunction associated with the endometriosis (Bulun, 2009; Wu et al., 2006a,b).”
Endometriosis and Ovarian Cancer
Wei, J., William, J., & Bulun, S. E. (2011) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e31821f4b85 · Cited by 174 · see citing works
“from the gene profiles can differentiate ectopic from eutopic endometria and classify different subtypes of endometrioses from the peritoneum and ovary (72).”
Background
Endometrial-Peritoneal Interactions during Endometriotic Lesion Establishment
Hull, M. L., Rangel‐Escareño, C., Godsland, J. M., Doig, J. R., Johnson, C. M., Phillips, S. C., Smith, S. K., Tavaré, S., Print, C. G., & Jones, D. S. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.071128 · Cited by 174 · see citing works
“In addition, laser capture microdissection of glandular epithelial cells from eutopic and ectopic sites identified differentially expressed transcripts associated with several biological processes in epithelial cells.(13) Taken together, these studies have identified large numbers of endometriosisassociated RNA transc…”
Background
Molecular and Cellular Pathogenesis of Endometriosis
Klemmt, P. A. B., & Starzinski‐Powitz, A. (2017) · Current Women s Health Reviews · doi:10.2174/1573404813666170306163448 · Cited by 175 · see citing works
Differential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis
Filigheddu, N., Gregnanin, I., Porporato, P. E., Surico, D., Perego, B., Galli, L., Patrignani, C., Graziani, A., & Surico, N. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/369549 · Cited by 162 · see citing works
The Pathogenesis of Adenomyosis vis-à-vis Endometriosis
Guo, S.-W. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020485 · Cited by 165 · see citing works
“In fact, over 1000 genes are documented to be differentially expressed between adenomyotic lesions and eutopic endometrium [65] and close to 1000 genes are differentially expressed between ectopic and eutopic endometrium [66].”
Background
Progesterone Resistance in Endometriosis: an Acquired Property?
McKinnon, B. D., Mueller, M. D., & Montgomery, G. W. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.05.006 · Cited by 153 · see citing works
Research Resource: Gene Expression Profile for Ectopic Versus Eutopic Endometrium Provides New Insights into Endometriosis Oncogenic Potential
Borghese, B., Mondon, F., Noël, J., Fayt, I., Mignot, T.-M., Vaiman, D., & Chapron, C. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0322 · Cited by 150 · see citing works
PI3K-Akt-mTOR and MAPK signaling pathways in polycystic ovarian syndrome, uterine leiomyomas and endometriosis: an update
Makker, A., Goel, M. M., Das, V., & Ak, A. (2011) · Gynecological Endocrinology · doi:10.3109/09513590.2011.583955 · Cited by 142 · see citing works
“together with microarray data [64] advocate involvement of”
Background
Nuclear Factor-κB (NF-κB): An Unsuspected Major Culprit in the Pathogenesis of Endometriosis That Is Still at Large?
Guo, S. (2006) · Gynecologic and Obstetric Investigation · doi:10.1159/000096047 · Cited by 140 · see citing works
Hypoxia-Induced MicroRNA-20a Expression Increases ERK Phosphorylation and Angiogenic Gene Expression in Endometriotic Stromal Cells
Lin, S., Wang, C.-C., Wu, M., Yang, S., Li, Y.-H., & Tsai, S. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1450 · Cited by 131 · see citing works
Expression of angiogenic factors in endometriosis: relationship to fibrinolytic and metalloproteinase systems
Gilabert–Estellés, J., Ramón, L., España, F., Gilabert, J., Vila, V., Regañón, E., Castelló, R., Chirivella, M., & Estellés, A. (2007) · Human Reproduction · doi:10.1093/humrep/dem149 · Cited by 126 · see citing works
“Moreover, in the last few years, several papers based on microarray methods have shown differences in gene expression of MMP components, between normal and eutopic endometrium from women with endo- metriosis (Wu et al., 2006).”
Eutopic endometrium in women with endometriosis: ground zero for the study of implantation defects
Lessey, B., Lebovic, D., & Taylor, R. (2013) · Seminars in Reproductive Medicine · doi:10.1055/s-0032-1333476 · Cited by 113 · see citing works
The mTOR/AKT Inhibitor Temsirolimus Prevents Deep Infiltrating Endometriosis in Mice
Leconte, M., Nicco, C., Ngô, C., Chéreau, C., Chouzenoux, S., Marut, W., Guibourdenche, J., Arkwright, S., Weill, B. J., Chapron, C., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.04.020 · Cited by 115 · see citing works
Histological and Immunohistochemical Characterization of the Similarity and Difference Between Ovarian Endometriomas and Deep Infiltrating Endometriosis
Liu, X., Zhang, Q., & Guo, S.-W. (2018) · Reproductive Sciences · doi:10.1177/1933719117718275 · Cited by 110 · see citing works
Molecular profiling of experimental endometriosis identified gene expression patterns in common with human disease
Flores, I., Rivera, E., Ruiz, L. A., Santiago, O. I., Vernon, M. W., & Appleyard, C. B. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.07.1550 · Cited by 107 · see citing works
Metformin Suppresses Interleukin (IL)-1β-Induced IL-8 Production, Aromatase Activation, and Proliferation of Endometriotic Stromal Cells
Takemura, Y., Osuga, Y., Yoshino, O., Hasegawa, A., Hirata, T., Hirota, Y., Nose, E., Morimoto, C., Harada, M., Koga, K., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2486 · Cited by 102 · see citing works
Abnormal activation of Ras/Raf/MAPK and RhoA/ROCKII signalling pathways in eutopic endometrial stromal cells of patients with endometriosis
Yotova, I., Quan, P., Leditznig, N., Beer, U., Wenzl, R. J., & Tschugguel, W. (2011) · Human Reproduction · doi:10.1093/humrep/der010 · Cited by 101 · see citing works
Female Infertility and Antioxidants
Sekhon, L. H., Gupta, S., Kim, Y., & Agarwal, A. K. (2010) · Current Women s Health Reviews · doi:10.2174/157340410791321381 · Cited by 101 · see citing works
“Differential gene expression of ectopic and normal endometrial tissue has been identified, including differential gene expression of glutathione-S-transferase, an enzyme in the metabolism of the potent antioxidant glutathione [45].”
Background
Association of Pelvic Inflammatory Disease with Risk of Endometriosis: A Nationwide Cohort Study Involving 141,460 Individuals
Tai, F.-W., Chang, C. Y., Chiang, J., Lin, W.-C., & Wan, L. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7110379 · Cited by 99 · see citing works
The role of iron in the pathogenesis of endometriosis
Kobayashi, H., Yamada, Y., Kanayama, S., Furukawa, N., 野口, 武., Haruta, S., Yoshida, S., Sakata, M., Sado, T., & Oi, H. (2009) · Gynecological Endocrinology · doi:10.1080/09513590802366204 · Cited by 97 · see citing works
Gene expression profiles and functional characterization of human immortalized endometriotic epithelial and stromal cells
Banu, S. K., Lee, J., Starzinski‐Powitz, A., & Arosh, J. A. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.07.1358 · Cited by 96 · see citing works
New insights into the pathophysiology of endometriosis: from chronic inflammation to danger signal
Kajihara, H., Yamada, Y., Kanayama, S., Furukawa, N., 野口, 武., Haruta, S., Yoshida, S., Sado, T., Oi, H., & Kobayashi, H. (2010) · Gynecological Endocrinology · doi:10.3109/09513590.2010.507292 · Cited by 96 · see citing works
“Recent studies showed that the oxidative stress may be associated with the development of endometriosis: (1) women with endometriosis had increased levels of low-density lipoprotein (LDL) and HSP70b0 as well as decreased levels of paraoxonase-1 (PON-1) compared with controls [23]; (2) the concentrations of receptor fo…”
Background
Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis?
Guo, S., & Groothuis, P. G. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy020 · Cited by 93 · see citing works
Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF‐κB signaling pathway
Chowdhury, I., Banerjee, S., Driss, A., Xu, W., Mehrabi, S., Nezhat, C., Sidell, N., Taylor, R. N., & Thompson, W. E. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27360 · Cited by 95 · see citing works
“…Al‐Abed, Naccache, & Akoum, 2009; Carvalho, Podgaec, Bellodi‐Privato, Falcone, & Abrão, 2011; Dai, Leng, Lang, Li, & Zhang, 2012; Eyster, Klinkova, Kennedy, & Hansen, 2007; Honda, Barrueto, Gogusev, Im, &Morin, 2008; Hu, Tay, & Zhao, 2006; Hull et al., 2008; Mihalyi et al., 2010; Wu et al., 2006).”
Transcriptome meta-analysis reveals differences of immune profile between eutopic endometrium from stage I-II and III-IV endometriosis independently of hormonal milieu
Poli‐Neto, O. B., Meola, J., Silva, J. C. R. E., & Tiezzi, D. G. (2020) · Scientific Reports · doi:10.1038/s41598-019-57207-y · Cited by 97 · see citing works
Cancer-associated mutations in endometriosis: shedding light on the pathogenesis and pathophysiology
Guo, S.-W. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmz047 · Cited by 96 · see citing works
“Moreover, PR-B has been reported to be hypermethylated in ectopic endometrium (Wu et al., 2006a,b,c) and partially methylated in eutopic endometrium from women with endometriosis (Rocha-Junior et al., 2019), which may account for reduced PR-B expression and subsequent progesterone resistance.”
BackgroundInfluential
Transcriptional profiling of endometriosis tissues identifies genes related to organogenesis defects
Crispi, S., Piccolo, M. T., D’Avino, A., Donizetti, A., Viceconte, R., Spyrou, M., Calogero, R., Baldi, A., & Signorile, P. G. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24358 · Cited by 92 · see citing works
“To the best of our knowledge, very few studies compared ectopic and eutopic lesions analyzing only some of the different cell type contained in the lesion (Matsuzaki et al., 2006; Wu et al., 2006).”
Background
Dienogest inhibits BrdU uptake with G0/G1 arrest in cultured endometriotic stromal cells
Fu, L., Osuga, Y., Morimoto, C., Hirata, T., Hirota, Y., Yano, T., & Taketani, Y. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.03.042 · Cited by 87 · see citing works
Serial analysis of gene expression reveals differential expression between endometriosis and normal endometrium. Possible roles for AXL and SHC1 in the pathogenesis of endometriosis
Honda, H., Barrueto, F. F., Gogusev, J., Im, D. D., & Morin, P. J. (2008) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-6-59 · Cited by 84 · see citing works
The Expression and Ovarian Steroid Regulation of Endometrial Micro-RNAs
Toloubeydokhti, T., Pan, Q., Luo, X., Bukulmez, O., & Chegini, N. (2008) · Reproductive Sciences · doi:10.1177/1933719108324132 · Cited by 83 · see citing works
“Gene expression profiling has provided considerable evidence in support of altered expression of a number of genes in various endometrial disorders, including EN as compared to normal endometrium.(20-25) Accumulated evidence also suggests that miRNAs play a key regulatory function in gene expression stability through…”
Background
Retracted
Interaction between sex hormones and WNT/β-catenin signal transduction in endometrial physiology and disease
van der Horst, P. H., Wang, Y., van der Zee, M., Burger, C. W., & Blok, L. J. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.010 · Cited by 80 · see citing works
Obstetrical Complications in Women with Endometriosis: A Cohort Study in Japan
Harada, T., Taniguchi, F., Onishi, K., Kurozawa, Y., Hayashi, K., Harada, T., & Japan Environment & Children’s Study Group (2016) · PLoS ONE · doi:10.1371/journal.pone.0168476 · Cited by 76 · see citing works
Whole-exome sequencing of endometriosis identifies frequent alterations in genes involved in cell adhesion and chromatin-remodeling complexes
Li, X., Zhang, Y., Zhao, L., Wang, L., Wu, Z., Mei, Q., Nie, J., Li, X., Li, Y., Fu, X., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu330 · Cited by 74 · see citing works
Inhibition of METTL3/m6A/miR126 promotes the migration and invasion of endometrial stromal cells in endometriosis
Li, X., Xiong, W., Long, X., Dai, X., Peng, Y., Xu, Y., Zhang, Z., Zhang, L., & Liu, Y. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab152 · Cited by 70 · see citing works
New concepts on the etiology of endometriosis
Cousins, F. L., McKinnon, B. D., Mortlock, S., Fitzgerald, H. C., Zhang, C., Montgomery, G. W., & Gargett, C. E. (2023) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15549 · Cited by 82 · see citing works
Genome-wide expressions in autologous eutopic and ectopic endometrium of fertile women with endometriosis
Khan, M. A., Sengupta, J., Mittal, S., & Ghosh, D. (2012) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-10-84 · Cited by 69 · see citing works
“More over, it is notable that two types of endometriosis, namely ovarian endometriosis and peritoneal endometriosis reportedly show differential characteristics [4,9].”
Background
P-selectin as a potential therapeutic target for endometriosis
Guo, S., Ding, D., Geng, J.-G., Wang, L., & Liu, X. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.01.001 · Cited by 68 · see citing works
Hypoxia‐inhibited dual‐specificity phosphatase‐2 expression in endometriotic cells regulates cyclooxygenase‐2 expression
Wu, M., Lin, S., Hsiao, K., & Tsai, S. (2011) · The Journal of Pathology · doi:10.1002/path.2963 · Cited by 65 · see citing works
“Elevation of activated ERK and MAPK signaling pathway were observed in endometriotic tissues of women with endometriosis [17, 18].”
Background
Aberrant gene expression profile in a mouse model of endometriosis mirrors that observed in women
Pelch, K. E., Schroder, A. L., Kimball, P. A., Sharpe-Timms, K. L., Davis, J., & Nagel, S. C. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.03.086 · Cited by 64 · see citing works
Genome-wide profiling of long noncoding ribonucleic acid expression patterns in ovarian endometriosis by microarray
Sun, P.-R., Jia, S., Lin, H., Leng, J., & Lang, J. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.12.035 · Cited by 63 · see citing works
Adverse obstetrical outcomes for women with endometriosis and adenomyosis: A large cohort of the Japan Environment and Children’s Study
Harada, T., Taniguchi, F., Amano, H., Kurozawa, Y., Ideno, Y., Hayashi, K., Harada, T., & Japan Environment and Children’s Study Group (2019) · PLoS ONE · doi:10.1371/journal.pone.0220256 · Cited by 61 · see citing works
Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis
Guo, S. (2018) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12221 · Cited by 58 · see citing works
Genomic Alterations in Ectopic and Eutopic Endometria of Women with Endometriosis
Wu, Y., Strawn, E., Basir, Z., Wang, Y., Halverson, G., Jailwala, P., & Guo, S. (2006) · Gynecologic and Obstetric Investigation · doi:10.1159/000093130 · Cited by 58 · see citing works
Differentially expressed genes in human endometrial endothelial cells derived from eutopic endometrium of patients with endometriosis compared with those from patients without endometriosis
Sha, G., Wu, D. T., Zhang, L., Chen, X., Lei, M., Sun, H., Lin, S., & Lang, J.-H. (2007) · Human Reproduction · doi:10.1093/humrep/dem266 · Cited by 58 · see citing works
“They have paid attention to epithelial and/or stromal compartments through laser capture microdissection or have used entire endometrial tissue without discriminating between the cellular compartments (Wu et al., 2006).”
Background
Structure, Function, and Evaluation of the Female Reproductive Tract
Lessey, B. A., & Young, S. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00009-3 · Cited by 58 · see citing works
Bentamapimod (JNK Inhibitor AS602801) Induces Regression of Endometriotic Lesions in Animal Models
Palmer, S. S., Altan, M., Denis, D., Tos, E. G., Gotteland, J., Osteen, K. G., Bruner‐Tran, K. L., & Nataraja, S. G. (2015) · Reproductive Sciences · doi:10.1177/1933719115600553 · Cited by 54 · see citing works
Comparison of c-DNA microarray analysis of gene expression between eutopic endometrium and ectopic endometrium (endometriosis)
Mettler, L., Salmassi, A., Schollmeyer, T., Schmutzler, A. G., Püngel, F., & Jonat, W. (2007) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-007-9116-y · Cited by 54 · see citing works
COUP-TFII Regulates Human Endometrial Stromal Genes Involved in Inflammation
Li, X., Large, M. J., Creighton, C. J., Lanz, R. B., Jeong, J., Young, S. L., Lessey, B. A., Palomino, W. A., Tsai, S. Y., & DeMayo, F. J. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1191 · Cited by 52 · see citing works
A system-wide analysis of differentially expressed genes in ectopic and eutopic endometrium
Wren, J. D., Wu, Y., & Guo, S. (2007) · Human Reproduction · doi:10.1093/humrep/dem129 · Cited by 50 · see citing works
“…2003; Kao et al., 2003; Matsuzaki et al., 2004; Smith, 2004; Fan et al., 2005; Matsuzaki et al., 2005a; Matsuzaki et al., 2005b; Kato et al., 2006; Wu et al., 2006a), differing by focus, study design, microarray platform , quality control measure, data analysis, cell type used for RNA extraction,…”
BackgroundInfluential
Extracellularly Signal-Regulated Kinase Activity in the Human Endometrium: Possible Roles in the Pathogenesis of Endometriosis
Murk, W. K., Atabekoğlu, C. S., Çakmak, H., Heper, A. O., Ensarı, A., Kayisli, U. A., & Arici, A. M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2051 · Cited by 49 · see citing works
“This is consistent with microarray analyses reporting that genes activating the ERK1/2 MAPK signalingcascadeareup-regulatedinpatientswithendometriosis (21, 22 ).”
Result
Intracellular Wnt/Beta-Catenin Signaling Underlying 17beta-Estradiol-Induced Matrix Metalloproteinase 9 Expression in Human Endometriosis1
Zhang, L., Xiong, W., Xiong, Y., Liu, H., Li, N., Du, Y., & Liu, Y. (2016) · Biology of Reproduction · doi:10.1095/biolreprod.115.135574 · Cited by 49 · see citing works
“Several studies have found that the aberrant activation of Wnt/β-catenin signaling may be involved in the pathophysiology of endometriosis [26-28].”
Background
Two unsuccessful clinical trials on endometriosis and a few lessons learned
Guo, S.-W., & Olive, D. L. (2007) · Gynecologic and Obstetric Investigation · doi:10.1159/000098413 · Cited by 49 · see citing works
Self-citation
Endometriotic stromal cells lose the ability to regulate cell-survival signaling in endometrial epithelial cells in vitro
Zhang, H., Li, M., Zheng, X., Sun, Y., Wen, Z., & Zhao, X. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap069 · Cited by 49 · see citing works
Laser capture microdissection and cDNA array analysis of endometrium identify CCL16 and CCL21 as epithelial-derived inflammatory mediators associated with endometriosis
Chand, A. L., Murray, A. S., Jones, R. L., Hannan, N. J., Salamonsen, L. A., & Rombauts, L. J. F. (2007) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-5-18 · Cited by 49 · see citing works
Potential mechanisms of postmenopausal endometriosis
Bendon, C. L., & Becker, C. M. (2012) · Maturitas · doi:10.1016/j.maturitas.2012.04.010 · Cited by 48 · see citing works
miR-29c is downregulated in the ectopic endometrium and exerts its effects on endometrial cell proliferation, apoptosis and invasion by targeting c-Jun
Long, M., Wan, X., La, X., Gong, X., & Cai, X. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2082 · Cited by 45 · see citing works
Immunoreactivity of progesterone receptor isoform B and nuclear factor kappa-B as biomarkers for recurrence of ovarian endometriomas
Shen, F., Wang, Y., Lu, Y., Yuan, L., Liu, X., & Guo, S. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.04.040 · Cited by 44 · see citing works
Variability of genome-wide DNA methylation and mRNA expression profiles in reproductive and endocrine disease related tissues
Rahmioğlu, N., Drong, A., Lockstone, H. E., Tapmeier, T. T., Hellner, K., Saare, M., Laisk, T., Dew, C., Tough, E., Nicholson, G., et al. (2017) · Epigenetics · doi:10.1080/15592294.2017.1367475 · Cited by 44 · see citing works
High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couples
Leach, R. E., Jessmon, P., Coutifaris, C., Kruger, M. L., Myers, E. R., Ali‐Fehmi, R., Carson, S. A., Legro, R. S., Schlaff, W. D., Carr, B. R., et al. (2012) · Human Reproduction · doi:10.1093/humrep/der436 · Cited by 43 · see citing works
“, 2005) and in endometriosis (Eyster et al., 2002; Arimoto et al., 2003; Matsuzaki et al., 2004, Matsuzaki et al., 2005; Matsuzaki et al., 2006; Wu et al., 2006) and endometrial cancer (Hever et al.”
Background
Targeting the Wnt/β-catenin pathway in endometriosis: a potentially effective approach for treatment and prevention
Matsuzaki, S., Botchorishvili, R., Pouly, J. L., & Canis, M. J. (2014) · Molecular and Cellular Therapies · doi:10.1186/s40591-014-0036-9 · Cited by 43 · see citing works
“Several studies, including those from our laboratory, have suggested that aberrant activation of the Wnt/β-catenin pathway may be involved in the pathophysiology of endometriosis [2-9].”
Background
Laser-assisted microdissection for real-time PCR sample preparation
Pinzani, P., Orlando, C., & Pazzagli, M. (2006) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2005.12.006 · Cited by 43 · see citing works
Transcriptional expression of type-I interferon response genes and stability of housekeeping genes in the human endometrium and endometriosis
Vestergaard, A. L., Knudsen, U. B., Munk, T., Rosbach, H. K., & Martensen, P. M. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gaq100 · Cited by 42 · see citing works
“Previous studies of transcriptional levels in Eu versus Ec endometrium have used a single reference gene, such as GAPDH (Matsuzaki et al., 2006; Colette et al., 2009; Watanabe et al., 2009) and 18S (Wu et al., 2006; Lee et al., 2010).”
Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysis.
Vouk, K., Šmuc, T., Guggenberger, C., Ribič-pucelj, M., Šinkovec, J., Husen, B., Thole, H., Houba, P. H. J., Thaete, C., Adamski, J., et al. (2011) · Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.03.010 · Cited by 40 · see citing works
Evolving Spectrum:
Jensen, J. R., & Coddington, C. C. (2010) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e3181db7b84 · Cited by 39 · see citing works
Activated Platelets Induce Estrogen Receptor β Expression in Endometriotic Stromal Cells
Zhang, Q., Ding, D., Liu, X., & Guo, S.-W. (2015) · Gynecologic and Obstetric Investigation · doi:10.1159/000377629 · Cited by 38 · see citing works
Identification of Susceptibility Genes for Peritoneal, Ovarian, and Deep Infiltrating Endometriosis Using a Pooled Sample-Based Genome-Wide Association Study
Borghese, B., Tost, J., de Surville, M., Busato, F., Letourneur, F., Mondon, F., Vaiman, D., & Chapron, C. (2015) · BioMed Research International · doi:10.1155/2015/461024 · Cited by 38 · see citing works
“SUP, OMA, and DIE have different responsiveness to progesterone [18], differential gene expressions [19, 20], and specific putative variants that may influence one form and not the others [21– 23].”
Macrophages infiltrating endometriosis-like lesions exhibit progressive phenotype changes in a heterologous mouse model
Johan, M. Z., Ingman, W. V., Robertson, S. A., & Hull, M. L. (2019) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2019.01.002 · Cited by 35 · see citing works
Large-scale gene expression studies of the endometrium: what have we learnt?
Sherwin, R., Catalano, R. D., & Sharkey, A. (2006) · Reproduction · doi:10.1530/rep.1.00355 · Cited by 35 · see citing works
“There is now a wealth of data studying both individual genes and using microarray methods that show differences in gene expression between normal and eutopic endometrium from women with endometriosis (reviewed in Wu et al. 2006).”
Background
The Targeted Delivery of Interleukin 4 Inhibits Development of Endometriotic Lesions in a Mouse Model
Quattrone, F., Sanchez, A. M., Pannese, M., Hemmerle, T., Viganò, P., Candiani, M., Petraglia, F., Neri, D., & Panina‐Bordignon, P. (2015) · Reproductive Sciences · doi:10.1177/1933719115578930 · Cited by 35 · see citing works
Secreted frizzled-related protein 2 (SFRP2) expression promotes lesion proliferation via canonical WNT signaling and indicates lesion borders in extraovarian endometriosis
Heinosalo, T., Gabriel, M., Kallio, L., Adhikari, P. R., Huhtinen, K., Laajala, T. D., Kaikkonen, E., Mehmood, A., Suvitie, P. A., Kujari, H. P., et al. (2018) · Human Reproduction · doi:10.1093/humrep/dey026 · Cited by 35 · see citing works
“…tissues (Anastas and Moon, 2013), and there is evidence that WNT signaling also plays a role in the endometrium and endometrial diseases (Talbi et al., 2006; Wu et al., 2006; Eyster et al., 2007; Aghajanova et al., 2010; Matsuzaki et al., 2010; Matsuzaki and Darcha, 2013; Zhang et al., 2016a).”
Background
Glycemic Index, Glycemic Load, Fiber, and Gluten Intake and Risk of Laparoscopically Confirmed Endometriosis in Premenopausal Women
Schwartz, N. R. M., Afeiche, M. C., Terry, K. L., Farland, L. V., Chavarro, J. E., Missmer, S. A., & Harris, H. R. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac107 · Cited by 37 · see citing works
Altered glycosylation in peri-implantation phase endometrium in women with stages III and IV endometriosis
Miller, D. L., Jones, C. J. P., Aplin, J., & Nardo, L. G. (2009) · Human Reproduction · doi:10.1093/humrep/dep401 · Cited by 34 · see citing works
“Differences in the methylation status of the progesterone receptor B-isoform (PR-B) promoter have been seen between eutopic endometrium and controls (Wu et al., 2006b) but these also did not reach statistical significance.”
Background
High-throughput mRNA sequencing of stromal cells from endometriomas and endometrium
Rekker, K., Saare, M., Eriste, E., Tasa, T., Kukuškina, V., Roost, A. M., Anderson, K. B., Samuel, K., Karro, H., Salumets, A., et al. (2017) · Reproduction · doi:10.1530/rep-17-0092 · Cited by 33 · see citing works
Differential Proteome Profiling of Eutopic Endometrium from Women with Endometriosis To Understand Etiology of Endometriosis
Rai, P., Kota, V., Deendayal, M., & Shivaji, S. (2010) · Journal of Proteome Research · doi:10.1021/pr100657s · Cited by 32 · see citing works
Role of Wnt signalling in early pregnancy
Nayeem, S. B., Arfuso, F., Dharmarajan, A., & Keelan, J. A. (2014) · Reproduction Fertility and Development · doi:10.1071/rd14079 · Cited by 30 · see citing works
The Endometriotic Tissue Lining the Internal Surface of Endometrioma
Sanchez, A., Viganò, P., Somigliana, E., Cioffi, R., Panina-Bordignon, P., & Candiani, M. (2015) · Reproductive Sciences · doi:10.1177/1933719114529374 · Cited by 23 · see citing works
“Based on the statistical analysis that took into account lesion location and menstrual cycle, the genes identified include some ILs and their receptors (ie, IL-8, IL-15, and IL-15R), growth factors (platelet-derived growth factor b), and a member of the transforming growth factor (TGF) family (TGF-b3).(33)”
BackgroundMethodInfluential
Knockdown of prohibitin expression promotes glucose metabolism in eutopic endometrial stromal cells from women with endometriosis
Qi, X., Zhang, Y., Ji, H., Wu, X., Wang, F., Xie, M., Shu, L., Jiang, S., Mao, Y., Cui, Y., et al. (2014) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2014.09.004 · Cited by 29 · see citing works
“A reasonable explanation may be that eutopic and ectopic stromal cells have different gene expression profiles (Wu et al., 2006).”
Background
Assessment of the proliferative status of epithelial cell types in the endometrium of young and menopausal transition women
Niklaus, A. L., Aubuchon, M., Zapantis, G., Li, P., Qian, H., Isaac, B., Kim, M., Adel, G., Pollard, J. W., & Santoro, N. F. (2007) · Human Reproduction · doi:10.1093/humrep/dem032 · Cited by 28 · see citing works
“Previous studies that have utilized LCM for endometrial related research have only used this technology to collectively examine both epithelial cell types (Wu et al., 2003, 2006) or only that of GE (Matsuzaki et al., 2004, 2005, 2006).”
Method
Epithelial Cells of Deep Infiltrating Endometriosis Harbor Mutations in Cancer Driver Genes
Koppolu, A. A., Maksym, R., Paskal, W., Machnicki, M. M., Rak, B., Pępek, M., Garbicz, F., Pełka, K., Kuśmierczyk, Z., Jacko, J., et al. (2021) · Cells · doi:10.3390/cells10040749 · Cited by 27 · see citing works
“They suggested the importance of over seventy pathways with over one hundred genes involved in the disease pathogenesis [32].”
Background
A Functional Promoter Polymorphism in NFKB1 Increases Susceptibility to Endometriosis
Zhou, B., Rao, L., Peng, Y., Wang, Y., Qie, M., Zhang, Z., Song, Y., & Zhang, L. (2010) · DNA and Cell Biology · doi:10.1089/dna.2009.0992 · Cited by 27 · see citing works
“Recent large-scale gene expression proﬁling studies have revealed that many genes are dysregulated in endometriosis (Matsuzaki et al. , 2005; Wu et al. , 2006).”
Metformin regulates stromal-epithelial cells communication via Wnt2/β-catenin signaling in endometriosis
Zhang, H., Xue, J., Li, M., Ζhao, X., Wei, D., & Li, C. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.06.011 · Cited by 27 · see citing works
“Aberrant Wnt2 expression (Wu et al., 2006) and abnormal activation of Wnt/b-catenin signaling (Matsuzaki et al.”

Research Resource: Gene Expression Profile for Ectopic Versus Eutopic Endometrium Provides New Insights into Endometriosis Oncogenic Potential
Borghese, B., Mondon, F., Noël, J., Fayt, I., Mignot, T.-M., Vaiman, D., & Chapron, C. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0322 · Cited by 150 · see citing works
Whole genome deoxyribonucleic acid microarray analysis of gene expression in ectopic versus eutopic endometrium
Eyster, K. M., Klinkova, O. V., Kennedy, V., & Hansen, K. A. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.01.056 · Cited by 192 · see citing works
DNA Microarray Analysis of Gene Expression in Eutopic Endometrium from Patients with Endometriosis
Hwang, K. R., Choi, Y. M., Kim, J., Jeon, H. W., & Hong, M. A. (2017) · Advances in Reproductive Sciences · doi:10.4236/arsci.2017.54009 · Cited by 5 · see citing works
Endometriosis-Specific Genes Identified by Real-Time Reverse Transcription-Polymerase Chain Reaction Expression Profiling of Endometriosis Versus Autologous Uterine Endometrium
Hu, W.-P., Tay, S. K., & Zhao, Y. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1594 · Cited by 57 · see citing works
Differential Gene Expression Analysis in Endometriosis.
Meola, J. (2008) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Authors: Wu, Y., Kajdacsy-Balla, A., Strawn, E., Basir, Z., Halverson, G., Jailwala, P., Wang, Y., Wang, X., Ghosh, S., & Guo, S.-W.
Affiliations: Medical College of Wisconsin (US)
Department of Pathology (A.K.-B.), University of Illinois, Chicago, Illinois 60612
University of California, Santa Barbara (US)
Corresponding author: Guo, Sun-Wei
ORCID: Wu, Yan
Jailwala, Parthav
Wang, Yuedong
Wang, Xujing
Ghosh, Soumitra
Guo, Sun-Wei
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2006-01-01
Volume: 147
Issue: 1
Pages: 232-246
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2005-0426
OpenAlex: W2032547793
Cited by: 208
References: 120
Citations by year: 2025: 4 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 12 · 2018: 14 · 2017: 11 · 2016: 8 · 2015: 11 · 2014: 13 · 2013: 11 · 2012: 12
FWCI: 13.72
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Medical College of Wisconsin
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
Keywords: endometriosis, ectopic endometrium, eutopic endometrium, gene expression profiling, differentially expressed genes, endometrioma, gene clusters, oxidative stress, focal adhesions, Wnt signaling, MAPK signaling, endometriosis pathogenesis
MeSH terms: Base Sequence, Endometrium, Female, Humans, Menstrual Cycle, Ovarian Diseases, Pregnancy, Pregnancy, Ectopic, Reference Values, Transcription, Genetic, DNA Primers, Reverse Transcriptase Polymerase Chain Reaction, Expressed Sequence Tags, Oligonucleotide Array Sequence Analysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Transcriptional characterizations of differences between eutopic and ectopic endometrium

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks