The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease
Open accessAbstract
Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor known to induce expression of a variety of cytoprotective and detoxification genes. Several of the genes commonly regulated by Nrf2 have been implicated in protection from neurodegenerative conditions. Work from several laboratories has uncovered the potential for Nrf2-mediated transcription to protect from neurodegeneration resulting from mechanisms involving oxidative stress. For this reason, Nrf2 may be considered a therapeutic target for conditions that are known to involve free radical damage. Because common mechanisms of neurodegeneration, such as mitochondrial dysfunction and build-up of reactive oxygen species, are currently being uncovered, targeting Nrf2 may be valuable in combating conditions with variable causes and etiologies. Most effectively to target this protein in neurodegenerative conditions, a description of the involvement of Nrf2 and potential for neuroprotection must come from laboratory models. Herein, we review the current literature that suggests that Nrf2 may be a valuable therapeutic target for neurodegenerative disease, as well as experiments that illustrate potential mechanisms of protection.
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Cites
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Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway
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Cited by
Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways
Wardyn, J. D., Ponsford, A. H., & Sanderson, C. M. (2015) · Biochemical Society Transactions · doi:10.1042/bst20150014 · Cited by 1,200
NRF2 and cancer: the good, the bad and the importance of context
Sporn, M. B., & Liby, K. T. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3278 · Cited by 1,067
Rada, P., Rojo, A. I., Chowdhry, S., McMahon, M., Hayes, J. D., & Cuadrado, A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01204-10 · Cited by 759
Small Molecule Modulators of Keap1‐ Nrf2‐ ARE Pathway as Potential Preventive and Therapeutic Agents
Magesh, S., Chen, Y., & Hu, L. (2012) · Medicinal Research Reviews · doi:10.1002/med.21257 · Cited by 760
“22 Other triterpenoid natural products, such as avicin D (29)190 and gedunin (30),175 were also shown to increase the expression of certain cytoprotective enzymes via Nrf2 activation.”
BackgroundChen, P.-C., Vargas, M. R., Pani, A. K., Smeyne, R. J., Johnson, D. A., Kan, Y. W., & Johnson, J. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813361106 · Cited by 579
Self-citation
Metadata
- Authors
- Calkins, M. J., Johnson, D. A., Townsend, J. A., Vargas, M. R., Dowell, J. A., Williamson, T. P., Kraft, A. D., Lee, J.-M., Li, J., & Johnson, J. A.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2009-03
- Volume
- 11
- Issue
- 3
- Pages
- 497-508
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2073688363
- Cited by
- 438
- References
- 81
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Calkins, M. J., Johnson, D. A., Townsend, J. A., Vargas, M. R., Dowell, J. A., Williamson, T. P., Kraft, A. D., Lee, J.-M., Li, J., & Johnson, J. A. (2009). The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease. Antioxidants & Redox Signaling. https://doi.org/10.1089/ars.2008.2242
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