Selenium and the Selenoprotein Thioredoxin Reductase in the Prevention, Treatment and Diagnostics of Cancer

Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group

Clark, L. (1996) · JAMA · doi:10.1001/jama.276.24.1957 · Cited by 2,722 · see citing works

Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1

Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono, K., & Ichijo, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.9.2596 · Cited by 2,377 · see citing works

Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers

Lippman, S. M., Klein, E. A., Goodman, P. J., Lucia, M. S., Thompson, I. M., Ford, L. G., Parnes, H. L., Minasian, L. M., Gaziano, J. M., Hartline, J. A., et al. (2008) · JAMA · doi:10.1001/jama.2008.864 · Cited by 2,120 · see citing works

From Selenium to Selenoproteins: Synthesis, Identity, and Their Role in Human Health

Papp, L. V., Lu, J., Holmgren, A., & Khanna, K. K. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1528 · Cited by 1,332 · see citing works

Glutathione in Cancer Biology and Therapy

Estrela, J. M., Ortega, A., & Obrador, E. (2006) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360500523878 · Cited by 1,041 · see citing works

Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

Shih, A. Y., Johnson, D. A., Wong, G., Kraft, A. D., Jiang, L., Erb, H., Johnson, J. A., & Murphy, T. H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03394.2003 · Cited by 786 · see citing works

Chemopreventive Agents

Combs, G. F., & Gray, W. P. (1998) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00014-x · Cited by 667 · see citing works

Aberrant and Alternative Splicing in Cancer

Venables, J. P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1910 · Cited by 630 · see citing works

Selenium and its relationship to cancer: an update

Whanger, P. D. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20031015 · Cited by 615 · see citing works

Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis

Bjelaković, G., Nikolova, D., Simonetti, R. G., & Gluud, C. N. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17138-9 · Cited by 612 · see citing works

The thioredoxin system in cancer

Arnér, E. S. J., & Holmgren, A. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.10.009 · Cited by 589 · see citing works

PREDIAGNOSTIC SERUM SELENIUM AND RISK OF CANCER

Willett, W., Morris, J. S., Pressel, S., Taylor, J., Polk, B. F., Stampfer, M., ROSNER, B. A., Schneider, K. A., & Hames, C. G. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90116-2 · Cited by 548 · see citing works

Human Placenta Thioredoxin Reductase

Gromer, S., Arscott, L. D., Williams, C. H., Schirmer, R. H., & Becker, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20096 · Cited by 538 · see citing works

Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide

Lu, J., Chew, E.-H., & Holmgren, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701549104 · Cited by 526 · see citing works

Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial

Duffield‐Lillico, A. J., Dalkin, B. L., Reid, M. E., Turnbull, B. W., Slate, E. H., Jacobs, E. T., Marshall, J. R., Clark, L. C., & for the Nutritional Prevention of Cancer Study Group (2003) · British Journal of Urology · doi:10.1046/j.1464-410x.2003.04167.x · Cited by 514 · see citing works

Cancer mortality correlation studies-III: Statistical associations with dietary selenium intakes

Schrauzer, G. N., White, D. A., & Schneider, C. J. (1977) · Bioinorganic Chemistry · doi:10.1016/s0006-3061(00)80126-x · Cited by 491 · see citing works

The thioredoxin system—From science to clinic

Gromer, S., Urig, S., & Becker, K. (2003) · Medicinal Research Reviews · doi:10.1002/med.10051 · Cited by 482 · see citing works

The role of the redox protein thioredoxin in cell growth and cancer

Powis, G., Mustacich, D. J., & Coon, A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00313-0 · Cited by 443 · see citing works

Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells

Marzano, C., Gandin, V., Folda, A., Scutari, G., Bindoli, A., & Rigobello, M. P. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.021 · Cited by 415 · see citing works

Thioredoxin reductase as a pathophysiological factor and drug target

Becker, K., Gromer, S., Schirmer, R. H., & Müller, S. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01703.x · Cited by 389 · see citing works

The Chemistry and Toxicity of Selenium Compounds, with Special Reference to the Selenium Problem.

Painter, E. P. (1941) · Chemical Reviews · doi:10.1021/cr60090a001 · Cited by 371 · see citing works

Reduction of the selenotrisulfide derivative of glutathione to a persulfide analog by gluthathione reductase

Ganther, H. E. (1971) · Biochemistry · doi:10.1021/bi00798a013 · Cited by 357 · see citing works

Cancer-associated regulation of alternative splicing

Venables, J. P., Klinck, R., Koh, C., Gervais-Bird, J., Bramard, A., Inkel, L., Durand, M., Couture, S., Froehlich, U., Lapointe, E., et al. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1608 · Cited by 340 · see citing works

On the potential of thioredoxin reductase inhibitors for cancer therapy

Urig, S., & Becker, K. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.09.004 · Cited by 338 · see citing works

The thioredoxin-thioredoxin reductase system: over-expression in human cancer.

Lincoln, D. T., Emadi, E. M. A., Tonissen, K. F., & Clarke, F. M. (2003) · PubMed · Cited by 337 · see citing works

The connection between splicing and cancer

Srebrow, A., & Kornblihtt, A. R. (2006) · Journal of Cell Science · doi:10.1242/jcs.03053 · Cited by 335 · see citing works

Human Thioredoxin Reductase Directly Reduces Lipid Hydroperoxides by NADPH and Selenocystine Strongly Stimulates the Reaction via Catalytically Generated Selenols

Björnstedt, M., Hámberg, M., Kumar, S., Xue, J., & Holmgren, A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.20.11761 · Cited by 312 · see citing works

Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia.

Berggren, M. I., Gallegos, A. C., Gasdaska, J. R., Gasdaska, P. Y., Warneke, J. A., & Powis, G. (1996) · PubMed · Cited by 306 · see citing works

Unbalanced alternative splicing and its significance in cancer

Venables, J. P. (2006) · BioEssays · doi:10.1002/bies.20390 · Cited by 300 · see citing works

Selenium compounds have disparate abilities to impose oxidative stress and induce apoptosis

Stewart, M. S., Spallholz, J. E., Neldner, K. H., & Pence, B. C. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00147-6 · Cited by 294 · see citing works

Selenomethionine regulation of p53 by a ref1-dependent redox mechanism

Seo, Y. R., Kelley, M. R., & Smith, M. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212319799 · Cited by 280 · see citing works

Thioredoxin Reductase 1 Deficiency Reverses Tumor Phenotype and Tumorigenicity of Lung Carcinoma Cells

Yoo, M., Xu, X., Carlson, B. A., Gladyshev, V. N., & Hatfield, D. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c600012200 · Cited by 269 · see citing works

Splice variants as cancer biomarkers

Brinkman, B. M. N. (2004) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2004.05.015 · Cited by 265 · see citing works

Thioredoxin signaling as a target for cancer therapy

Powis, G., & Kirkpatrick, D. L. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.04.003 · Cited by 265 · see citing works

Alternative splicing: an emerging topic in molecular and clinical oncology

Pajares, M. J., Ezponda, T., Catena, R., Calvo, A., Pı́o, R., & Montuenga, L. M. (2007) · The Lancet Oncology · doi:10.1016/s1470-2045(07)70104-3 · Cited by 261 · see citing works

Selenium Distribution and Human Cancer Mortality

Shamberger, R. J., & Willis, C. E. (1971) · CRC Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408367109151308 · Cited by 261 · see citing works

Sodium Selenite Induces Superoxide-Mediated Mitochondrial Damage and Subsequent Autophagic Cell Death in Malignant Glioma Cells

Kim, E. H., Sohn, S., Kwon, H. J., Kim, S. U., Kim, M.-J., Lee, S.-J., & Choi, K. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4217 · Cited by 251 · see citing works

Selenite is a substrate for calf thymus thioredoxin reductase and thioredoxin and elicits a large non‐stoichiometric oxidation of NADPH in the presence of oxygen

Kumar, S., Björnstedt, M., & Holmgren, A. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb17068.x · Cited by 248 · see citing works

The thioredoxin reductase/thioredoxin system: Novel redox targets for cancer therapy

Biaglow, J. E., & Miller, R. A. (2005) · Cancer Biology & Therapy · doi:10.4161/cbt.4.1.1434 · Cited by 245 · see citing works

Alternative Splicing in Colon, Bladder, and Prostate Cancer Identified by Exon Array Analysis

Thorsen, K., Sørensen, K. D., Brems-Eskildsen, A. S., Modin, C., Gaustadnes, M., Hein, A.-M. K., Kruhøffer, M., Laurberg, S., Borre, M., Wang, K., et al. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700590-mcp200 · Cited by 245 · see citing works

Selenium is an essential trace nutrient for growth of WI-38 diploid human fibroblasts.

McKeehan, W. L., Hamilton, W. G., & Ham, R. G. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.6.2023 · Cited by 244 · see citing works

Methylarsenicals and Arsinothiols Are Potent Inhibitors of Mouse Liver Thioredoxin Reductase

Lin, S., Cullen, W. R., & Thomas, D. J. (1999) · Chemical Research in Toxicology · doi:10.1021/tx9900775 · Cited by 230 · see citing works

A report of high-dose selenium supplementation: response and toxicities

Reid, M. E., Stratton, M. S., Duffield‐Lillico, A. J., Fakih, M., Natarajan, R., Clark, L. C., & Marshall, J. R. (2004) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2004.03.004 · Cited by 225 · see citing works

Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds

Witte, A.-B., Anestål, K., Jerremalm, E., Ehrsson, H., & Arnér, E. S. J. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.04.025 · Cited by 225 · see citing works

Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase.

Björnstedt, M., Kumar, S., & Holmgren, A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42403-9 · Cited by 211 · see citing works

The Mammalian Cytosolic Selenoenzyme Thioredoxin Reductase Reduces Ubiquinone

Xia, L., Nordman, T., Olsson, J. M., Damdimopoulos, A. E., Björkhem‐Bergman, L., Nalvarte, I., Eriksson, L. C., Arnér, E. S. J., Spyrou, G., & Björnstedt, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210456200 · Cited by 209 · see citing works

Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: Role of NF‐E2‐related factor‐2

Sakurai, A., Nishimoto, M., Himeno, S., Imura, N., Tsujimoto, M., Kunimoto, M., & Hara, S. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20246 · Cited by 207 · see citing works

Selenoproteins and human health: Insights from epidemiological data

Rayman, M. P. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.03.014 · Cited by 199 · see citing works

Alternative Splicing and Tumor Progression

Ghigna, C., Valacca, C., & Biamonti, G. (2008) · Current Genomics · doi:10.2174/138920208786847971 · Cited by 198 · see citing works

Generation of reactive oxygen species from the reaction of selenium compounds with thiols and mammary tumor cells

Lin, Y., & Spallholz, J. E. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90080-g · Cited by 196 · see citing works

Sodium selenite-induced oxidative stress and apoptosis in human hepatoma HepG2 cells

Shen, H., Yang, C., & Ong, C. N. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990531)81:5 · Cited by 194 · see citing works

Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma.

Soini, Y., Kahlos, K., Näpänkangas, U., Kaarteenaho–Wiik, R., Säily, M., Koistinen, P., Pääakkö, P., Holmgren, A., & Kinnula, V. L. (2001) · PubMed · Cited by 188 · see citing works

Selenium and immune responses

Kiremidjian-Schumacher, L., & Stotzky, G. (1987) · Environmental Research · doi:10.1016/s0013-9351(87)80194-9 · Cited by 187 · see citing works

Discovery of novel splice forms and functional analysis of cancer-specific alternative splicing in human expressed sequences

Xu, Q. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg786 · Cited by 183 · see citing works

Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex

Arnér, E. S. J., Nakamura, H., Sasada, T., Yodoi, J., Holmgren, A., & Spyrou, G. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00698-0 · Cited by 178 · see citing works

Extracellular thiol-assisted selenium uptake dependent on the x c − cystine transporter explains the cancer-specific cytotoxicity of selenite

Olm, E., Fernandes, A. P., Hebert, C., Rundlöf, A.-K., Larsen, E. H., Danielsson, O., & Björnstedt, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902204106 · Cited by 174 · see citing works

Thioredoxin reductase as a novel molecular target for cancer therapy

Nguyen, P., Awwad, R. T., Smart, D. D., Spitz, D. R., & Gius, D. R. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.04.028 · Cited by 173 · see citing works

Catalytic Oxidation of Glutathione and Other Sulfhydryl Compounds by Selenite

Tsen, C. C., & Tappel, A. L. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77374-8 · Cited by 171 · see citing works

Distinct effects of methylseleninic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in DU145 human prostate cancer cells.

Jiang, C., Wang, Z., Ganther, H. E., & Lü, J. (2002) · PubMed · Cited by 167 · see citing works

Motexafin Gadolinium, a Tumor-selective Drug Targeting Thioredoxin Reductase and Ribonucleotide Reductase

Hashemy, S. I., Ungerstedt, J. S., Avval, F. Z., & Holmgren, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511373200 · Cited by 164 · see citing works

Electrophilic Prostaglandins and Lipid Aldehydes Repress Redox-sensitive Transcription Factors p53 and Hypoxia-inducible Factor by Impairing the Selenoprotein Thioredoxin Reductase

Moos, P. J., Edes, K., Cassidy, P., Massuda, E., & Fitzpatrick, F. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211134200 · Cited by 163 · see citing works

Arsenicals Inhibit Thioredoxin Reductase in Cultured Rat Hepatocytes

Lin, S., Razo, L. M. D., Stýblo, M., Wang, C., Cullen, W., & Thomas, D. J. (2001) · Chemical Research in Toxicology · doi:10.1021/tx0001878 · Cited by 162 · see citing works

Mutagenesis of structural half-cystine residues in human thioredoxin and effects on the regulation of activity by selenodiglutathione

Ren, X., Bjoernstedt, M., Shen, B., Ericson, M. L., & Holmgren, A. (1993) · Biochemistry · doi:10.1021/bi00088a023 · Cited by 160 · see citing works

Inhibition of NF-κB DNA binding and nitric oxide induction in human T cells and lung adenocarcinoma cells by selenite treatment

Kim, I. Y., & Stadtman, T. C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.12904 · Cited by 154 · see citing works

Human Thioredoxin Reductase Is Efficiently Inhibited by (2,2‘:6‘,2‘ ‘-Terpyridine)platinum(II) Complexes. Possible Implications for a Novel Antitumor Strategy

Becker, K., Herold‐Mende, C. C., Park, J. J., Lowe, G. M., & Schirmer, R. H. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm001014i · Cited by 150 · see citing works

Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy

Sieja, K., & Talerczyk, M. (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2003.12.013 · Cited by 150 · see citing works

Selenium and the thioredoxin and glutaredoxin systems.

Björnstedt, M., Kumar, S., Björkhem, L., Spyrou, G. P., & Holmgren, A. (1997) · PubMed · Cited by 149 · see citing works

Mitochondrial thioredoxin reductase inhibition by gold(I) compounds and concurrent stimulation of permeability transition and release of cytochrome c.

Rigobello, M., Scutari, G., Folda, A., & Bindoli, A. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2003.09.038 · Cited by 148 · see citing works

Extracellular Production of Hydrogen Selenide Accounts for Thiol-assisted Toxicity of Selenite against Saccharomyces cerevisiae

Tarze, A., Dauplais, M., Grigoras, I., Lazard, M., Duong, N.-T. H., Bessueille-Barbier, F., Blanquet, S., & Plateau, P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610078200 · Cited by 147 · see citing works

Selenite induces apoptosis in sarcomatoid malignant mesothelioma cells through oxidative stress

Nilsonne, G., Sun, X., Nyström, C., Rundlöf, A.-K., Fernandes, A. P., Björnstedt, M., & Dobra, K. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.04.031 · Cited by 138 · see citing works

Mechanism of Dithiocarbamate Inhibition of Apoptosis: Thiol Oxidation by Dithiocarbamate Disulfides Directly Inhibits Processing of the Caspase-3 Proenzyme

Nobel, S., Burgess, D. H., Zhivotovsky, B., Burkitt, M. J., Orrenius, S., & Slater, A. F. G. (1997) · Chemical Research in Toxicology · doi:10.1021/tx970006a · Cited by 132 · see citing works

The selenium metabolite selenodiglutathione induces p53 and apoptosis: relevance to the chemopreventive effects of selenium?

Lanfear, J., Fleming, J., Wu, L. L., Webster, G., & Harrison, P. R. (1994) · Carcinogenesis · doi:10.1093/carcin/15.7.1387 · Cited by 129 · see citing works

Sublethal concentrations of diverse gold compounds inhibit mammalian cytosolic thioredoxin reductase (TrxR1)

Omata, Y., Folan, M., Shaw, M., Messer, R. L. W., Lockwood, P. E., Hobbs, D. T., Bouillaguet, S., Sano, H., Lewis, J. B., & Wataha, J. C. (2006) · Toxicology in Vitro · doi:10.1016/j.tiv.2006.01.012 · Cited by 129 · see citing works

Targeting Thioredoxin Reductase 1 Reduction in Cancer Cells Inhibits Self-Sufficient Growth and DNA Replication

Yoo, M., Xu, X.-M., Carlson, B. A., Patterson, A. D., Gladyshev, V. N., & Hatfield, D. L. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001112 · Cited by 128 · see citing works

Thioredoxin Reductase in Human Hepatoma Cells Is Transcriptionally Regulated by Sulforaphane and Other Electrophiles via an Antioxidant Response Element

Hintze, K. J., Wald, K., Zeng, H., Jeffery, E. H., & Finley, J. W. (2003) · Journal of Nutrition · doi:10.1093/jn/133.9.2721 · Cited by 128 · see citing works

Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds, determined by an improved assay for DNA cytosine methyltransferase and DNA cytosine methylation

Fiala, E. S. (1998) · Carcinogenesis · doi:10.1093/carcin/19.4.597 · Cited by 124 · see citing works

The protective role of selenium on the toxicity of cisplatin-contained chemotherapy regimen in cancer patients

Hu, J., Chen, Y., Zhang, Y., Zhou, M., Song, X., Zhang, B., Luo, L., Xu, P.-M., Zhao, Y.-N., Zhao, Y., et al. (1997) · Biological Trace Element Research · doi:10.1007/bf02785304 · Cited by 123 · see citing works

Dual role of glutathione in selenite-induced oxidative stress and apoptosis in human hepatoma cells

Shen, H. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00206-9 · Cited by 123 · see citing works

Selenotrisulfides. II. Cross-linking of reduced pancreatic ribonuclease with selenium

Ganther, H. E., & Corcoran, C. (1969) · Biochemistry · doi:10.1021/bi00834a044 · Cited by 123 · see citing works

Studies of safe maximal daily dietary selenium intake in a seleniferous area in China. I. Selenium intake and tissue selenium levels of the inhabitants.

Yang, G.-H., Zhou, R., Yin, S. N., Gu, L., Yan, B., Liu, Y., Liu, Y., & Li, X. (1989) · PubMed · Cited by 122 · see citing works

Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes

Pagmantidis, V., Méplan, C., van Schothorst, E. M., Keijer, J., & Hesketh, J. E. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.181 · Cited by 121 · see citing works

Contrasting Patterns of Regulation of the Antioxidant Selenoproteins, Thioredoxin Reductase, and Glutathione Peroxidase, in Cancer Cells

Gladyshev, V. N., Factor, V. M., Housseau, F., & Hatfield, D. L. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9495 · Cited by 121 · see citing works

Selenite Inhibits the c-Jun N-terminal Kinase/Stress-activated Protein Kinase (JNK/SAPK) through a Thiol Redox Mechanism

Park, H.-S., Park, E., Kim, M.-S., Ahn, K., Kim, I. Y., & Choi, E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2527 · Cited by 119 · see citing works

Superoxide radical–initiated apoptotic signalling pathway in selenite-treated HepG2 cells: mitochondria serve as the main target

Shen, H.-M., Yang, C.-F., Ding, W.-X., Liu, J., & Ong, C.-N. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00421-4 · Cited by 119 · see citing works

Methyl-Selenium Compounds Inhibit Prostate Carcinogenesis in the Transgenic Adenocarcinoma of Mouse Prostate Model with Survival Benefit

Wang, L., Bonorden, M. J. L., Li, G., Lee, H., Hu, H., Zhang, Y., Liao, J. D., Cleary, M. P., & Lü, J. (2009) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0173 · Cited by 118 · see citing works

Chemical Forms of Selenium in Rat Tissues after Administration of Selenite or Selenomethionine

Beilstein, M. A., & Whanger, P. D. (1986) · Journal of Nutrition · doi:10.1093/jn/116.9.1711 · Cited by 115 · see citing works

Dimethyldiselenide and Methylseleninic Acid Generate Superoxide in an In Vitro Chemiluminescence Assay in the Presence of Glutathione: Implications for the Anticarcinogenic Activity of L-Selenomethionine and L-Se-Methylselenocysteine

Spallholz, J. E., Shriver, B. J., & Reid, T. W. (2001) · Nutrition and Cancer · doi:10.1207/s15327914nc401_8 · Cited by 115 · see citing works

Se-Methylselenocysteine induces apoptosis through caspase activation in HL-60 cells

Kim, T., Jung, U., Cho, D.-Y., & Chung, A. (2001) · Carcinogenesis · doi:10.1093/carcin/22.4.559 · Cited by 111 · see citing works

Differential involvement of reactive oxygen species in apoptosis induced by two classes of selenium compounds in human prostate cancer cells

Li, G., Hu, H., Jiang, C., Schuster, T. F., & Lü, J. (2007) · International Journal of Cancer · doi:10.1002/ijc.22480 · Cited by 109 · see citing works

Expression of p53 Enhances Selenite-Induced Superoxide Production and Apoptosis in Human Prostate Cancer Cells

Zhao, R., Xiang, N., Domann, F. E., & Zhong, W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2216 · Cited by 108 · see citing works

Speciation and Bioavailability of Selenium in Yeast-Based Intervention Agents Used in Cancer Chemoprevention Studies

Larsen, E. H., Hansen, M., Paulin, H., Moesgaard, S., Reid, M. E., & Rayman, M. P. (2004) · Journal of AOAC International · doi:10.1093/jaoac/87.1.225 · Cited by 106 · see citing works

Induction of the mitochondrial permeability transition by selenium compounds mediated by oxidation of the protein thiol groups and generation of the superoxide

Kim, T. S., Yun, B. Y., & Kim, I. Y. (2003) · Biochemical Pharmacology · doi:10.1016/j.bcp.2003.08.021 · Cited by 105 · see citing works

Effects of selenium and zinc supplementation on nutritional status in patients with cancer of digestive tract

Federico, A., Iodice, P., Federico, P., Rio, A. D., Mellone, M., Catalano, G., & Federico, P. (2001) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601157 · Cited by 101 · see citing works

Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway

Hu, H., Jiang, C., Schuster, T. F., Li, G.-X., Daniel, P. T., & Lü, J. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0063 · Cited by 101 · see citing works

Evidence for intriguingly complex transcription of human thioredoxin reductase 1

Rundlöf, A.-K., Janard, M., Miranda‐Vizuete, A., & Arnér, E. S. J. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.12.004 · Cited by 99 · see citing works

Selenium in the treatment of radiation-associated secondary lymphedema

Micke, O., Bruns, F., Mücke, R., Schäfer, U., Glatzel, M., DeVries, A., Schönekaes, K., Kisters, K., & Büntzel, J. (2003) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)04390-0 · Cited by 98 · see citing works

AP‐1 DNA‐binding activity is inhibited by selenite and selenodiglutathione

Spyrou, G., Björnstedt, M., Kumar, S., & Holmgren, A. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00599-5 · Cited by 96 · see citing works

Selenium activates p53 and p38 pathways and induces caspase-independent cell death in cervical cancer cells

Rudolf, E., Rudolf, K., & Červinka, M. (2007) · Cell Biology and Toxicology · doi:10.1007/s10565-007-9022-1 · Cited by 95 · see citing works

The Core Promoter of Human Thioredoxin Reductase 1

Rundlöf, A.-K., Carlsten, M., & Arnér, E. S. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101452200 · Cited by 90 · see citing works

Tumor-selective killing by selenite in patient-matched pairs of normal and malignant prostate cells

Husbeck, B., Nonn, L., Peehl, D. M., & Knox, S. J. (2005) · The Prostate · doi:10.1002/pros.20337 · Cited by 90 · see citing works

Selenocysteine β-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide

Suzuki, K. T., Kurasaki, K., & Suzuki, N. (2007) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2007.03.007 · Cited by 88 · see citing works

Methylation and demethylation of intermediates selenide and methylselenol in the metabolism of selenium

Ohta, Y., & Suzuki, K. T. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.09.011 · Cited by 88 · see citing works

Evolutionarily conserved and diverged alternative splicing events show different expression and functional profiles

Kan, Z. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki834 · Cited by 86 · see citing works

A Global View of Cancer-Specific Transcript Variants by Subtractive Transcriptome-Wide Analysis

He, C., Zhou, F., Zuo, Z., Cheng, H., & Zhou, R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004732 · Cited by 81 · see citing works

Expression profiles of thioredoxin family proteins in human lung cancer tissue: correlation with proliferation and differentiation

Fernandes, A. P., Capitanio, A., Selenius, M., Brodin, O., Rundlöf, A.-K., & Björnstedt, M. (2009) · Histopathology · doi:10.1111/j.1365-2559.2009.03381.x · Cited by 81 · see citing works

Reduction of Methionine Selenoxide to Selenomethionine by Glutathione

Assmann, A., Briviba, K., & Sies, H. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0462 · Cited by 79 · see citing works

Drug-resistant human lung cancer cells are more sensitive to selenium cytotoxicity

Björkhem‐Bergman, L., Jönsson, K., Eriksson, L. C., Olsson, J. M., Lehmann, S., Paul, C., & Björnstedt, M. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)00981-4 · Cited by 77 · see citing works

Selenium prevents tumor development in a rat model for chemical carcinogenesis

Björkhem‐Bergman, L. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh290 · Cited by 77 · see citing works

Studies on Analogues of L-Cysteine and L-Cystine

Weisberger, A. S., & Suhrland, L. G. (1956) · Blood · doi:10.1182/blood.v11.1.19.19 · Cited by 77 · see citing works

Selenite and selenate inhibit human lymphocyte growth via different mechanisms.

Spyrou, G. P., Björnstedt, M., Skog, S., & Holmgren, A. (1996) · PubMed · Cited by 75 · see citing works

Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances cell death due to redox shift

Rigobello, M. P., Gandin, V., Folda, A., Rundlöf, A.-K., Fernandes, A. P., Bindoli, A., Marzano, C., & Björnstedt, M. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.027 · Cited by 75 · see citing works

Influence of Dietary Methionine on the Metabolism of Selenomethionine in Rats

Butler, J. A., Beilstein, M. A., & Whanger, P. D. (1989) · Journal of Nutrition · doi:10.1093/jn/119.7.1001 · Cited by 71 · see citing works

[22] Selenite and selenodiglutathione: Reactions with thioredoxin systems

Jornstedt, M. B., Kumar, S., & Holmgren, A. (1995) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(95)52024-4 · Cited by 70 · see citing works

Selenite Negatively Regulates Caspase-3 through a Redox Mechanism

Park, H.-S., Huh, S.-H., Kim, Y., Shim, J., Lee, S. H., Park, I., Jung, Y., Kim, I. Y., & Choi, E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8487 · Cited by 69 · see citing works

Selenite (75Se) as a tumor-localizing agent in man.

Cavalieri, R. R., Scott, K. G., & Sairenji, E. (1966) · PubMed · Cited by 68 · see citing works

Identification of alternatively spliced mRNA variants related to cancers by genome-wide ESTs alignment

Hui, L., Zhang, X., Wu, X., Lin, Z., Wang, Q., Li, Y., & Hu, G. (2004) · Oncogene · doi:10.1038/sj.onc.1207362 · Cited by 68 · see citing works

Selenium in the Treatment of Head and Neck Lymphedema

Bruns, F., Büntzel, J., Mücke, R., Schönekaes, K., Kisters, K., & Micke, O. (2004) · Medical Principles and Practice · doi:10.1159/000078313 · Cited by 68 · see citing works

Expression of Antioxidant Enzymes in Astrocytic Brain Tumors

Haapasalo, H. K., Kyläniemi, M., Paunu, N., Kinnula, V. L., & Soini, Y. (2003) · Brain Pathology · doi:10.1111/j.1750-3639.2003.tb00015.x · Cited by 68 · see citing works

Arsenic trioxide and auranofin inhibit selenoprotein synthesis: implications for chemotherapy for acute promyelocytic leukaemia

Talbot, S. R., Nelson, R., & Self, W. T. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.161 · Cited by 64 · see citing works

Reduction of Postoperative Lymphedema after Oral Tumor Surgery with Sodium Selenite

Zimmermann, T. P., Leonhardt, H., Kersting, S., Albrecht, S., Range, U., & Eckelt, U. (2005) · Biological Trace Element Research · doi:10.1385/bter:106:3:193 · Cited by 62 · see citing works

The 58 kDa mouse selenoprotein is a BCNU‐sensitive thioredoxin reductase

Gromer, S., Schirmer, R. H., & Becker, K. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00816-8 · Cited by 62 · see citing works

EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation

Båvner, A. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki667 · Cited by 61 · see citing works

Selenite-induced apoptosis of osteoclasts mediated by the mitochondrial pathway.

Chung, Y., Kim, T. S., Lee, S.-Y., Lee, S.-H., Choi, Y., Kim, N., Min, B.-M., Jeong, D., & Kim, I. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2005.06.019 · Cited by 60 · see citing works

Selenite-induced apoptosis in doxorubicin-resistant cells and effects on the thioredoxin system

Jönsson‐Videsäter, K., Björkhem‐Bergman, L., Hossain, A., Söderberg, A., Eriksson, L. C., Paul, C., Rosén, A., & Björnstedt, M. (2003) · Biochemical Pharmacology · doi:10.1016/j.bcp.2003.09.021 · Cited by 60 · see citing works

Integrating Metabolomics and Transcriptomics for Probing Se Anticancer Mechanisms

Fan, T. W. ‐., Higashi, R. M., & Lane, A. N. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600959599 · Cited by 55 · see citing works

Analysis of Methionine/Selenomethionine Oxidation and Methionine Sulfoxide Reductase Function Using Methionine-Rich Proteins and Antibodies against Their Oxidized Forms

Le, D. T., Liang, X., Fomenko, D. E., Raza, A. S., Chong, C., Carlson, B. A., Hatfield, D. L., & Gladyshev, V. N. (2008) · Biochemistry · doi:10.1021/bi800422s · Cited by 54 · see citing works

Selenite Incubated with NADPH and Mammalian Thioredoxin Reductase Yields Selenide, Which Inhibits Lipoxygenase and Changes the Electron Spin Resonance Spectrum of the Active Site Iron

Björnstedt, M., Odlander, B., Kuprin, S., Claesson, H., & Holmgren, A. (1996) · Biochemistry · doi:10.1021/bi9528762 · Cited by 54 · see citing works

Treatment of lung cancer cells with cytotoxic levels of sodium selenite: Effects on the thioredoxin system

Selenius, M., Fernandes, A. P., Brodin, O., Björnstedt, M., & Rundlöf, A.-K. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.02.028 · Cited by 53 · see citing works

Selenite is a potent cytotoxic agent for human primary AML cells

Olm, E., Jönsson‐Videsäter, K., Ribera‐Cortada, I., Fernandes, A. P., Eriksson, L. C., Lehmann, S., Rundlöf, A.-K., Paul, C., & Björnstedt, M. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.03.010 · Cited by 49 · see citing works

Inhibitory effects of thioredoxin reductase antisense RNA on the growth of human hepatocellular carcinoma cells

Gan, L., Yang, X., Liu, Q., & Xu, H. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20585 · Cited by 49 · see citing works

The role of thioredoxin reductase activity in selenium-induced cytotoxicity

Madeja, Z., Sroka, J., Nyström, C., Björkhem‐Bergman, L., Nordman, T., Damdimopoulos, A. E., Nalvarte, I., Eriksson, L. C., Spyrou, G., Olsson, J. M., et al. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.02.023 · Cited by 49 · see citing works

Inhibition of androgen receptor signaling by selenite and methylseleninic acid in prostate cancer cells: two distinct mechanisms of action

Husbeck, B., Bhattacharyya, R. S., Feldman, D., & Knox, S. J. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0056 · Cited by 49 · see citing works

Effect of long-term selenium yeast intervention on activity and gene expression of antioxidant and xenobiotic metabolising enzymes in healthy elderly volunteers from the Danish Prevention of Cancer by Intervention by Selenium (PRECISE) Pilot Study

Ravn‐Haren, G., Krath, B. N., Overvad, K., Cold, S., Moesgaard, S., Larsen, E. H., & Dragsted, L. O. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507882948 · Cited by 49 · see citing works

Genomic organisation and alternative splicing of mouse and human thioredoxin reductase 1 genes

Osborne, S. A., & Tonissen, K. F. (2001) · BMC Genomics · doi:10.1186/1471-2164-2-10 · Cited by 46 · see citing works

Methylseleninic acid inhibits microvascular endothelial G1 cell cycle progression and decreases tumor microvessel density

Wang, Z., Hu, H., Li, G., Lee, H., Jiang, C., Kim, S., & Lü, J. (2007) · International Journal of Cancer · doi:10.1002/ijc.23077 · Cited by 43 · see citing works

Subchronic oral toxicity studies of Se-methylselenocysteine, an organoselenium compound for breast cancer prevention

Johnson, W. D., Morrissey, R. L., Kapetanović, I. M., Crowell, J. A., & McCormick, D. L. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.11.001 · Cited by 43 · see citing works

Effect of selenium on the immunocompetence of patients with head and neck cancer and on adoptive immunotherapy of early and established lesions

Kiremidjian‐Schumacher, L., & Roy, M.-C. (2001) · BioFactors · doi:10.1002/biof.5520140121 · Cited by 42 · see citing works

Human Thioredoxin Reductase Gene Localization to Chromosomal Position 12q23–q24.1 and mRNA Distribution in Human Tissue

Gasdaska, J. R., Gasdaska, P. Y., Gallegos, A. C., & Powis, G. (1996) · Genomics · doi:10.1006/geno.1996.0554 · Cited by 42 · see citing works

Quantification of alternative mRNA species and identification of thioredoxin reductase 1 isoforms in human tumor cells

Rundlöf, A.-K., Fernandes, A. P., Selenius, M., Babic, M., Shariatgorji, M., Nilsonne, G., Ilag, L. L., Dobra, K., & Björnstedt, M. (2006) · Differentiation · doi:10.1111/j.1432-0436.2006.00121.x · Cited by 41 · see citing works

Upregulation of 9 genes, including that for thioredoxin, during epithelial differentiation of mesothelioma cells

Sun, X., Dobra, K., Björnstedt, M., & Hjerpe, A. (2000) · Differentiation · doi:10.1046/j.1432-0436.2000.660404.x · Cited by 41 · see citing works

Sodium selenite as prophylaxis against erysipelas in secondary lymphedema.

Kasseroller, R. G. (1998) · PubMed · Cited by 35 · see citing works

Expression of p21 predicts PSA failure in locally advanced prostate cancer treated by prostatectomy

Lacombe, L., Maillette, A., Meyer, F., Veilleux, C., Moore, L., & Fradet, Y. (2001) · International Journal of Cancer · doi:10.1002/1097-0215(20010520)95:3 · Cited by 35 · see citing works

Mechanisms of selenium chemoprevention and therapy in prostate cancer

Nadiminty, N., & Gao, A. C. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700369 · Cited by 35 · see citing works

Selenite Activates Caspase-Independent Necrotic Cell Death in Jurkat T Cells and J774.2 Macrophages by Affecting Mitochondrial Oxidant Generation

Shilo, S., & Tirosh, O. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603322110850 · Cited by 33 · see citing works

Antioxidant enzymes in oligodendroglial brain tumors: association with proliferation, apoptotic activity and survival

Järvelä, S., Bragge, H., Paunu, N., Timo, J., Paljärvi, L., Hannu, K., Pauli, H., Vuokko, K., Ylermi, S., & Hannu, H. (2005) · Journal of Neuro-Oncology · doi:10.1007/s11060-005-9030-z · Cited by 30 · see citing works

Increased levels of cytosolic thioredoxin reductase activity and mRNA in rat liver nodules

Björkhem, L., Teclebrhan, H., Kesen, E., Olsson, J. M., Eriksson, L. C., & Björnstedt, M. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00113-1 · Cited by 30 · see citing works

Upregulation of 9 genes, including that for thioredoxin, during epithelial differentiation of mesothelioma cells

Sun, X., Dobra, K., Björnstedt, M., et al. (2000) · Differentiation · doi:10.1111/j.1432-0436.2000.660404.x · Cited by 25 · see citing works

Increased Expression of Specific Thioredoxin Family Proteins; A Pilot Immunohistochemical Study on Human Hepatocellular Carcinoma

Cunnea, P., Fernandes, A. P., Capitanio, A., Eken, S., Spyrou, G. P., & Björnstedt, M. (2007) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463200702000103 · Cited by 23 · see citing works

Selenium metabolism in rats with long-term ingestion of Se-methylselenocysteine using enriched stable isotopes

Tsuji, Y., Suzuki, N., Suzuki, K. T., & Ogra, Y. (2009) · The Journal of Toxicological Sciences · doi:10.2131/jts.34.191 · Cited by 23 · see citing works

Phenotype-dependent apoptosis signalling in mesothelioma cells after selenite exposure

Nilsonne, G., Olm, E., Szulkin, A., Mundt, F., Stein, A., Kocic, B., Rundlöf, A.-K., Fernandes, A. P., Björnstedt, M., & Dobra, K. (2009) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-28-92 · Cited by 23 · see citing works

Effects of the antioxidant Pycnogenol® on cellular redox systems in U1285 human lung carcinoma cells

Gandin, V., Nyström, C., Rundlöf, A.-K., Jönsson‐Videsäter, K., Schönlau, F., Hörkkö, J., Björnstedt, M., & Fernandes, A. P. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06800.x · Cited by 22 · see citing works

Symptomatic treatment of brain tumor patients with sodium selenite, oxygen, and other supportive measures

Pakdaman, A. (1998) · Biological Trace Element Research · doi:10.1007/bf02820015 · Cited by 22 · see citing works

Phytochemicals in Broccoli Transcriptionally Induce Thioredoxin Reductase

Hintze, K. J., Wald, K., & Finley, J. W. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0580059 · Cited by 21 · see citing works

Effect of auranofin, an antirheumatic drug, on neutrophil apoptosis

Liu, J., Akahoshi, T., Namai, R., Matsui, T., & Kondo, H. (2000) · Inflammation Research · doi:10.1007/s000110050615 · Cited by 20 · see citing works

Inhibition Of Thioredoxin Reductase (E.C. 1.6.4.5.) By Antitumor Quinones

Bey-Liing, M., & Powis, G. (1990) · Free Radical Research Communications · doi:10.3109/10715769009053370 · Cited by 19 · see citing works

Detection of Thioredoxin in Gastric Cancer: Association with Histological Type

Noda, N., Ochiai, A., Miyazaki, K., Sügimura, T., Terada, M., & Wakasugi, H. (2000) · Antioxidants and Redox Signaling · doi:10.1089/15230860050192297 · Cited by 12 · see citing works

Se-methylselenocysteine sensitized TRAIL-mediated apoptosis via down-regulation of Bcl-2 expression

Kwon, H. N. (2009) · International Journal of Oncology · doi:10.3892/ijo_00000274 · Cited by 12 · see citing works

Bioactivation of Selenocysteine Derivatiives by β-Lyases Present in Common Gastrointestinal Bacterial Species

Schwiertz, A., Deubel, S., & Birringer, M. (2008) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.78.45.169 · Cited by 10 · see citing works

Prevention of the development of melphalan resistance in vitro by selenite

Caffrey, P. B., Zhu, M. J., & Frenkel, G. D. (1998) · Biological Trace Element Research · doi:10.1007/bf02789095 · Cited by 8 · see citing works

Selenoproteins: Molecular Pathways and Physiological Roles

Labunskyy, V. M., Hatfield, D. L., & Gladyshev, V. N. (2014) · Physiological Reviews · doi:10.1152/physrev.00039.2013 · Cited by 1,412 · see citing works

Selenium in human health and disease

Fairweather-Tait, S. J., Bao, Y., Broadley, M. R., Collings, R., Ford, D., Hesketh, J. E., & Hurst, R. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3275 · Cited by 1,330 · see citing works

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T., & Hayes, J. D. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.021 · Cited by 837 · see citing works

Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling

Hanschmann, E., Godoy, J. R., Berndt, C., Hudemann, C., & Lillig, C. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4599 · Cited by 649 · see citing works

Selenium and Selenoproteins: It’s Role in Regulation of Inflammation

Hariharan, S., & Dharmaraj, S. (2020) · Inflammopharmacology · doi:10.1007/s10787-020-00690-x · Cited by 659 · see citing works

Thioredoxin and Thioredoxin Target Proteins: From Molecular Mechanisms to Functional Significance

Lee, S., Kim, S. M., & Lee, R. T. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4322 · Cited by 434 · see citing works

Selenium: a double-edged sword for defense and offence in cancer

Brozmanová, J., Mániková, D., Vlčková, V., & Chovanec, M. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0595-8 · Cited by 333 · see citing works

Redox-Active Selenium Compounds—From Toxicity and Cell Death to Cancer Treatment

Misra, S., Boylan, M. L., Selvam, A. K., Spallholz, J. E., & Björnstedt, M. (2015) · Nutrients · doi:10.3390/nu7053536 · Cited by 325 · see citing works

p53, Oxidative Stress, and Aging

Liu, D., & Xu, Y. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3644 · Cited by 315 · see citing works

Oxidative stress and metal carcinogenesis

Lee, J., Son, Y., Pratheeshkumar, P., & Shi, X. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.06.002 · Cited by 277 · see citing works

Selenium Compounds, Apoptosis and Other Types of Cell Death: An Overview for Cancer Therapy

Sanmartín, C., Plano, D., Sharma, A. K., & Palop, J. A. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13089649 · Cited by 275 · see citing works

Composition and Evolution of the Vertebrate and Mammalian Selenoproteomes

Mariotti, M., Ridge, P. G., Zhang, Y., Lobanov, A. V., Pringle, T. H., Guigó, R., Hatfield, D. L., & Gladyshev, V. N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033066 · Cited by 261 · see citing works

Biological activity of selenium: Revisited

Wrobel, J. K., Power, R. F., & Toborek, M. J. (2015) · IUBMB Life · doi:10.1002/iub.1466 · Cited by 260 · see citing works

Selenium stimulates the antitumour immunity: Insights to future research

Razaghi, A., Poorebrahim, M., Sarhan, D., & Björnstedt, M. (2021) · European Journal of Cancer · doi:10.1016/j.ejca.2021.07.013 · Cited by 233 · see citing works

Selenium and selenoprotein function in brain disorders

Pillai, R., Uyehara‐Lock, J. H., & Bellinger, F. P. (2014) · IUBMB Life · doi:10.1002/iub.1262 · Cited by 201 · see citing works

Green Synthesis of Selenium and Tellurium Nanoparticles: Current Trends, Biological Properties and Biomedical Applications

Zambonino, M. C., Quizhpe, E. M., Jaramillo, F. E., Rahman, A., Vispo, N. S., Jeffryes, C. S., & Dahoumane, S. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22030989 · Cited by 180 · see citing works

Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens

Alehagen, U., Johansson, P., Björnstedt, M., Rosén, A., & Dahlström, U. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.04.156 · Cited by 175 · see citing works

Crystal structure of the human thioredoxin reductase–thioredoxin complex

Fritz‐Wolf, K., Kehr, S., Stumpf, M., Rahlfs, S., & Becker, K. (2011) · Nature Communications · doi:10.1038/ncomms1382 · Cited by 173 · see citing works

ROS Signaling by NOX4 Drives Fibroblast-to-Myofibroblast Differentiation in the Diseased Prostatic Stroma

Sampson, N., Kozieł, R., Zenzmaier, C., Bubendorf, L., Plas, E., Jansen‐Dürr, P., & Berger, P. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0340 · Cited by 158 · see citing works

Selenium and its’ role in the maintenance of genomic stability

Ferguson, L. R., Karunasinghe, N., Zhu, S., & Wang, A. H. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.12.011 · Cited by 151 · see citing works

Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent

Wang, L., Yang, Z., Fu, J., Yin, H., Xiong, K., Tan, Q., Jin, H., Li, J., Wang, T., Tang, W.-C., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.034 · Cited by 151 · see citing works

The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works

Preparation, physicochemical characterization, and anti-proliferation of selenium nanoparticles stabilized by Polyporus umbellatus polysaccharide

Gao, X., Li, X., Mu, J., Ho, C., Su, J., Zhang, Y., Lin, X., Chen, Z., Li, B., & Xie, Y. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.02.199 · Cited by 145 · see citing works

Thioredoxin Reductase and its Inhibitors

Saccoccia, F., Angelucci, F., Boumis, G., Carotti, D., Desiato, G., Miele, A. E., & Bellelli, A. (2014) · Current Protein and Peptide Science · doi:10.2174/1389203715666140530091910 · Cited by 139 · see citing works

Selenium compounds are substrates for glutaredoxins: a novel pathway for selenium metabolism and a potential mechanism for selenium-mediated cytotoxicity

Wallenberg, M., Olm, E., Hebert, C., Björnstedt, M., & Fernandes, A. P. (2010) · Biochemical Journal · doi:10.1042/bj20100368 · Cited by 138 · see citing works

Selenium Cytotoxicity in Cancer

Wallenberg, M., Misra, S., & Björnstedt, M. (2014) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12207 · Cited by 135 · see citing works

Potential Anticancer Activity of Auranofin

Onodera, T., Momose, I., & Kawada, M. (2019) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c18-00767 · Cited by 133 · see citing works

Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules

Fujimura, K., Sasaki, A. T., & Anderson, P. J. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks566 · Cited by 127 · see citing works

Selenium induces a multi‐targeted cell death process in addition to ROS formation

Wallenberg, M., Misra, S., Wasik, A. M., Marzano, C., Björnstedt, M., Gandin, V., & Fernandes, A. P. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12214 · Cited by 130 · see citing works

Thioredoxin reductase as a pharmacological target

Bjørklund, G., Zou, L., Wang, J., Chasapis, C. T., & Peana, M. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105854 · Cited by 128 · see citing works

Adaptive dysfunction of selenoproteins from the perspective of the triage theory: why modest selenium deficiency may increase risk of diseases of aging

McCann, J. C., & Ames, B. N. (2011) · The FASEB Journal · doi:10.1096/fj.11-180885 · Cited by 125 · see citing works

A New Mechanism of Action for the Anticancer Drug Mitomycin C: Mechanism-Based Inhibition of Thioredoxin Reductase

Paz, M. M., Zhang, X., Lu, J., & Holmgren, A. (2012) · Chemical Research in Toxicology · doi:10.1021/tx3002065 · Cited by 121 · see citing works

Progress in the unraveling of the endoplasmic reticulum stress/autophagy pathway and cancer: Implications for future therapeutic approaches

Schleicher, S. M., Moretti, L., Varki, V., & Lu, J. (2010) · Drug Resistance Updates · doi:10.1016/j.drup.2010.04.002 · Cited by 117 · see citing works

Antitumor Effects of Selenium

Kim, S. J., Choi, M. C., Park, J. M., & Chung, A. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111844 · Cited by 116 · see citing works

Gold(i) complex of N,N′-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties—potent tight-binding inhibition of thioredoxin reductase

Yan, K., Lok, C., Bierła, K., & Che, C. (2010) · Chemical Communications · doi:10.1039/c0cc01058h · Cited by 110 · see citing works

Reduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years: Follow-Up Results of a Prospective Randomized Double-Blind Placebo-Controlled Trial in Elderly Citizens

Alehagen, U., Aaseth, J., & Johansson, P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141641 · Cited by 103 · see citing works

Selenium and Clinical Trials: New Therapeutic Evidence for Multiple Diseases

Sanmartín, C., Plano, D., Font, M., & Palop, J. A. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711797379249 · Cited by 101 · see citing works

Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly

Alehagen, U., Aaseth, J., Alexander, J., & Johansson, P. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193120 · Cited by 100 · see citing works

Synthesis and antiproliferative activity of novel selenoester derivatives

Domínguez‐Álvarez, E., Plano, D., Font, M., Calvo, A., Prior, C., Jacob, C., Palop, J. A., & Sanmartín, C. (2013) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.11.034 · Cited by 100 · see citing works

Strategies for the development of selenium-based anticancer drugs

Collery, P. (2018) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2018.02.024 · Cited by 97 · see citing works

Serum selenium and single-nucleotide polymorphisms in genes for selenoproteins: relationship to markers of oxidative stress in men from Auckland, New Zealand

Karunasinghe, N., Han, D. Y., Zhu, S., Yu, J., Lange, K., Duan, H., Medhora, R., Singh, N., Kan, J., Alzaher, W., et al. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0259-1 · Cited by 92 · see citing works

Differential effects of amino acid surface decoration on the anticancer efficacy of selenium nanoparticles

Feng, Y., Su, J., Zhao, Z., Zheng, W., Wu, H., Zhang, Y., & Chen, T. (2013) · Dalton Transactions · doi:10.1039/c3dt52468j · Cited by 89 · see citing works

Sodium selenate activated Wnt/β-catenin signaling and repressed amyloid-β formation in a triple transgenic mouse model of Alzheimer's disease

Jin, N., Zhu, H., Liang, X., Huang, W., Xie, Q., Xiao, P., Ni, J., & Liu, Q. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.07.006 · Cited by 85 · see citing works

Multifunctional AuI‐based AIEgens: Manipulating Molecular Structures and Boosting Specific Cancer Cell Imaging and Theranostics

Zhang, J., Zou, H., Lei, J., He, B., He, X., Sung, H. H. Y., Kwok, R. T. K., Lam, J. W. Y., Zheng, L., & Tang, B. Z. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202000048 · Cited by 81 · see citing works

Understanding How Minerals Contribute to Optimal Immune Function

Ştefanache, A., Lungu, I. I., Butnariu, I.-A., Călin, G., Guțu, C., Marcu, C., Grierosu, C., Goroftei, E. R. B., Duceac, L.-D., Dabija, M. G., et al. (2023) · Journal of Immunology Research · doi:10.1155/2023/3355733 · Cited by 91 · see citing works

Optimising Selenium for Modulation of Cancer Treatments

Evans, S. O., Khairuddin, P. F., & Jameson, M. B. (2017) · Anticancer Research · doi:10.21873/anticanres.12106 · Cited by 73 · see citing works

Sodium Selenide Toxicity Is Mediated by O2-Dependent DNA Breaks

Peyroche, G., Saveanu, C., Dauplais, M., Lazard, M., Beuneu, F., Decourty, L., Malabat, C., Jacquier, A., Blanquet, S., & Plateau, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036343 · Cited by 68 · see citing works

The Role of the Thioredoxin System in Brain Diseases

Bjørklund, G., Zou, L., Peana, M., Chasapis, C. T., Hangan, T., Lu, J., & Maes, M. H. J. (2022) · Antioxidants · doi:10.3390/antiox11112161 · Cited by 65 · see citing works

Ingestion of selenium and other antioxidants during prostate cancer radiotherapy: A good thing?

Tabassum, A., Bristow, R. G., & Venkateswaran, V. K. (2010) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2009.12.008 · Cited by 64 · see citing works

Selenite cataracts: Activation of endoplasmic reticulum stress and loss of Nrf2/Keap1-dependent stress protection

Periyasamy, P., Bidasee, K. R., & Shinohara, T. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.06.028 · Cited by 63 · see citing works

Nrf2 in Cancer, Detoxifying Enzymes and Cell Death Programs

Jenkins, T., & Gouge, J. (2021) · Antioxidants · doi:10.3390/antiox10071030 · Cited by 62 · see citing works

Therapeutic Targeting of Redox Signaling in Myofibroblast Differentiation and Age-Related Fibrotic Disease

Sampson, N., Berger, P., & Zenzmaier, C. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/458276 · Cited by 60 · see citing works

Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium

Zachariah, M., Maamoun, H., Milano, L., Rayman, M. P., Meira, L. B., & Agouni, A. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30175 · Cited by 58 · see citing works

Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis

Carlson, B. A., Yoo, M., Tobe, R., Mueller, C., Naranjo‐Suarez, S., Hoffmann, V. J., Gladyshev, V. N., & Hatfield, D. L. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs230 · Cited by 58 · see citing works

Thioredoxin Signaling Pathways in Cancer

Zhang, J., Li, X., Zhao, Z., Cai, W., & Fang, J. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0074 · Cited by 57 · see citing works

Redox Signaling as a Therapeutic Target to Inhibit Myofibroblast Activation in Degenerative Fibrotic Disease

Sampson, N., Berger, P., & Zenzmaier, C. (2014) · BioMed Research International · doi:10.1155/2014/131737 · Cited by 54 · see citing works

Selenium in the prevention of human cancers

Björnstedt, M., & Fernandes, A. P. (2010) · The EPMA Journal · doi:10.1007/s13167-010-0033-2 · Cited by 53 · see citing works

Anti-Cancer Effects of Auranofin in Human Lung Cancer Cells by Increasing Intracellular ROS Levels and Depleting GSH Levels

Cui, X. Y., Park, S. H., & Park, W. H. (2022) · Molecules · doi:10.3390/molecules27165207 · Cited by 53 · see citing works

Interaction of adenanthin with glutathione and thiol enzymes: Selectivity for thioredoxin reductase and inhibition of peroxiredoxin recycling

Soethoudt, M., Peskin, A. V., Dickerhof, N., Paton, L. N., Pace, P., & Winterbourn, C. C. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.09.025 · Cited by 51 · see citing works

Selenite Induces Posttranscriptional Blockade of HLA-E Expression and Sensitizes Tumor Cells to CD94/NKG2A-Positive NK Cells

Enqvist, M., Nilsonne, G., Hammarfjord, O., Wallin, R. P. A., Björkström, N. K., Björnstedt, M., Hjerpe, A., Ljunggren, H., Dobra, K., Malmberg, K., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100610 · Cited by 51 · see citing works

Water-Soluble Au 25 Clusters with Single-Crystal Structure for Mitochondria-Targeting Radioimmunotherapy

Hua, Y., Shao, Z., Zhai, A., Zhang, L., Wang, Z., Zhao, G., Xie, F., Liu, J., Zhao, X., Chen, X. S., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c01068 · Cited by 46 · see citing works

Selenium and coenzyme Q10 interrelationship in cardiovascular diseases – A clinician's point of view

Alehagen, U., & Aaseth, J. (2014) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2014.11.006 · Cited by 45 · see citing works

Selenium and Coenzyme Q10 Supplementation Improves Renal Function in Elderly Deficient in Selenium: Observational Results and Results from a Subgroup Analysis of a Prospective Randomised Double-Blind Placebo-Controlled Trial

Alehagen, U., Aaseth, J., Alexander, J., Brismar, K., & Larsson, A. O. (2020) · Nutrients · doi:10.3390/nu12123780 · Cited by 45 · see citing works

Thioredoxin reductase selenoproteins from different organisms as potential drug targets for treatment of human diseases

Gencheva, R., Cheng, Q., & Arnér, E. S. J. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.07.020 · Cited by 46 · see citing works

Methylselenol Formed by Spontaneous Methylation of Selenide Is a Superior Selenium Substrate to the Thioredoxin and Glutaredoxin Systems

Fernandes, A. P., Wallenberg, M., Gandin, V., Misra, S., Tisato, F., Marzano, C., Rigobello, M. P., Kumar, S., & Björnstedt, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050727 · Cited by 45 · see citing works

Role of thioredoxin reductase 1 in dysplastic transformation of human breast epithelial cells triggered by chronic oxidative stress

Dong, C., Zhang, L., Sun, R., Liu, J., Yin, H., Li, X., Zheng, X., & Zeng, H. (2016) · Scientific Reports · doi:10.1038/srep36860 · Cited by 43 · see citing works

Selenium Significantly Inhibits Adipocyte Hypertrophy and Abdominal Fat Accumulation in OLETF Rats via Induction of Fatty Acid β-Oxidation

Kim, J. E., Choi, S. Y., Lee, H. R., Hwang, I. S., Lee, Y. J., An, B. S., Lee, S. H., Kim, H. J., Kang, B. C., & Hwang, D. Y. (2012) · Biological Trace Element Research · doi:10.1007/s12011-012-9519-1 · Cited by 42 · see citing works

Mitochondria-Targeted Approach: Remarkably Enhanced Cellular Bioactivities of TPP2a as Selective Inhibitor and Probe toward TrxR

Liang, B., Shao, W., Zhu, C., Wen, G., Yue, X., Wang, R., Quan, J., Du, J., & Bu, X. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00708 · Cited by 42 · see citing works

The Cell Culture Medium Affects Growth, Phenotype Expression and the Response to Selenium Cytotoxicity in A549 and HepG2 Cells

Selenius, L. A., Wallenberg, M., Wiklander, R. J., Danielsson, O., & Björnstedt, M. (2019) · Antioxidants · doi:10.3390/antiox8050130 · Cited by 42 · see citing works

Lower serum levels of selenium, copper, and zinc are related to neuromotor impairments in children with konzo

Bumoko, G. M. M., Sadiki, N. H., Rwatambuga, A., Kayembe, P. K., Okitundu, D., Ngoyi, D. M., Muyembe, J. J., Banea, J. P., Boivin, M. J., & Tshala-Katumbay, D. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.01.007 · Cited by 38 · see citing works

Reduction of selenium-binding protein 1 sensitizes cancer cells to selenite via elevating extracellular glutathione: A novel mechanism of cancer-specific cytotoxicity of selenite

Wang, Y., Fang, W., Huang, Y., Hu, F., Ying, Q., Yang, W., & Xiong, B. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.11.015 · Cited by 37 · see citing works

Alantolactone promotes ER stress‐mediated apoptosis by inhibition of TrxR1 in triple‐negative breast cancer cell lines and in a mouse model

Yin, C., Dai, X., Huang, X., Zhu, W., Chen, X., Zhou, Q., Wang, C., Zhao, C., Zou, P., Liang, G., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14139 · Cited by 37 · see citing works

Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology

Stojsavljević, A., Rovčanin, B., Krstić, Đ. D., Jagodić, J., Borković-Mitić, S., Paunovic, I. R., Zivaljevic, V. R., Mitić, B., Gavrović-Jankulović, M. Đ., & Manojlović, D. (2019) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2019.06.009 · Cited by 37 · see citing works

Serum Essential Elements and Survival after Cancer Diagnosis

Lubiński, J., Lener, M. R., Marciniak, W., Pietrzak, S., Derkacz, R., Cybulski, C., Gronwald, J., Dębniak, T., Jakubowska, A., Huzarski, T., et al. (2023) · Nutrients · doi:10.3390/nu15112611 · Cited by 36 · see citing works

Effect of Sodium Selenate on Hippocampal Proteome of 3×Tg-AD Mice—Exploring the Antioxidant Dogma of Selenium against Alzheimer’s Disease

Iqbal, J., Zhang, K., Jin, N., Zhao, Y., Liu, Q., Ni, J., & Shen, L. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00034 · Cited by 35 · see citing works

Protective Role of Selenium Compounds on the Proliferation, Apoptosis, and Angiogenesis of a Canine Breast Cancer Cell Line

Liu, Y.-Z., Li, W., Guo, M., Li, C., & Qiu, C. (2015) · Biological Trace Element Research · doi:10.1007/s12011-015-0387-3 · Cited by 35 · see citing works

The Selenium Metabolite Methylselenol Regulates the Expression of Ligands That Trigger Immune Activation through the Lymphocyte Receptor NKG2D

Hagemann-Jensen, M., Uhlenbrock, F., Kehlet, S. N., Andresen, L. O., Gabel‐Jensen, C., Ellgaard, L., Gammelgaard, B., & Skov, S. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.591537 · Cited by 34 · see citing works

Selenium

Christophersen, O. A., Lyons, G. H., Haug, A., & Steinnes, E. (2012) · Environmental pollution · doi:10.1007/978-94-007-4470-7_16 · Cited by 33 · see citing works

Susceptibility of the Antioxidant Selenoenyzmes Thioredoxin Reductase and Glutathione Peroxidase to Alkylation-Mediated Inhibition by Anticancer Acylfulvenes

Liu, X., Pietsch, K. E., & Sturla, S. J. (2011) · Chemical Research in Toxicology · doi:10.1021/tx2000152 · Cited by 31 · see citing works

Neutralization by Metal Ions of the Toxicity of Sodium Selenide

Dauplais, M., Lazard, M., Blanquet, S., & Plateau, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054353 · Cited by 31 · see citing works

Less increase of copeptin and MR‐proADM due to intervention with selenium and coenzyme Q10 combined: Results from a 4‐year prospective randomized double‐blind placebo‐controlled trial among elderly S wedish citizens

Alehagen, U., Aaseth, J., & Johansson, P. (2015) · BioFactors · doi:10.1002/biof.1245 · Cited by 31 · see citing works

Acetylation Regulates Thioredoxin Reductase Oligomerization and Activity

Wright, D., Altaany, Z., Bi, Y., Alperstein, Z., & O’Donoghue, P. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7082 · Cited by 30 · see citing works

Minerals and Cancer: Overview of the Possible Diagnostic Value

Venturelli, S., Leischner, C., Helling, T., Renner, O., Burkard, M., & Marongiu, L. (2022) · Cancers · doi:10.3390/cancers14051256 · Cited by 30 · see citing works

Selenite inhibits glutamine metabolism and induces apoptosis by regulating GLS1 protein degradation via APC/C-CDH1 pathway in colorectal cancer cells

Zhao, J., Zhou, R., Hui, K., Yang, Y., Zhang, Q., Ci, Y., Shi, L., Xu, C., Huang, F., & Hu, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.13600 · Cited by 30 · see citing works

A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis

Liu, J., Mu, C., Yue, W., Li, J., Ma, B., Zhao, L., Liu, L., Chen, Q., Chen, Y., Liu, H., et al. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.038 · Cited by 29 · see citing works

Variation in Blood and Colorectal Epithelia’s Key Trace Elements Along with Expression of Mismatch Repair Proteins from Localized and Metastatic Colorectal Cancer Patients

Ranjbary, A. G., Mehrzad, J., Dehghani, H., Abdollahi, A., & Hosseinkhani, S. (2019) · Biological Trace Element Research · doi:10.1007/s12011-019-01749-9 · Cited by 29 · see citing works

Selenium

Alexander, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-444-59453-2.00052-4 · Cited by 29 · see citing works

Trends and recent progresses of selenium nanoparticles as novel autophagy regulators for therapeutic development

Chen, D., Lu, H., Ma, Y., Huang, Y., Zhang, T., Fan, S., Lin, W., Huang, Y., Jin, H., Ruan, Y., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1116051 · Cited by 28 · see citing works

The Metallome of Lung Cancer and its Potential Use as Biomarker

Leblic, B. C., Arias‐Borrego, A., Pereira‐Vega, A., Gómez‐Ariza, J. L., & García‐Barrera, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030778 · Cited by 27 · see citing works

Less fibrosis in elderly subjects supplemented with selenium and coenzyme Q 10—A mechanism behind reduced cardiovascular mortality?

Alehagen, U., Aaseth, J., Alexander, J., Svensson, E., Johansson, P., & Larsson, A. O. (2017) · BioFactors · doi:10.1002/biof.1404 · Cited by 27 · see citing works

Dietary Supplementation with Selenium and Coenzyme Q10 Prevents Increase in Plasma D-Dimer While Lowering Cardiovascular Mortality in an Elderly Swedish Population

Alehagen, U., Aaseth, J., Lindahl, T. L., Larsson, A. O., & Alexander, J. (2021) · Nutrients · doi:10.3390/nu13041344 · Cited by 27 · see citing works

Supplemental selenium and coenzyme Q10 reduce glycation along with cardiovascular mortality in an elderly population with low selenium status – A four-year, prospective, randomised, double-blind placebo-controlled trial

Alehagen, U., Aaseth, J., Alexander, J., Johansson, P., & Larsson, A. O. (2020) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2020.126541 · Cited by 27 · see citing works

Synthesis and Antibacterial Activity of Metal(loid) Nanostructures by Environmental Multi-Metal(loid) Resistant Bacteria and Metal(loid)-Reducing Flavoproteins

Figueroa, M., Fernández, V. R., Arenas‐Salinas, M., Ahumada, D., Muñoz-Villagrán, C., Cornejo, F. A., Vargas, E., Latorre, M., Morales, E. H., Vásquez, C., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00959 · Cited by 26 · see citing works

Metal Complexes Stimulating Immunogenic Pyroptosis as Burgeoning Antitumor Strategy

Zheng, Y., Peng, K., Cao, Q., & Mao, Z. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202507186 · Cited by 25 · see citing works

Organofluorine Isoselenocyanate Analogues of Sulforaphane: Synthesis and Anticancer Activity

Cierpiał, T., Łuczak, J., Kwiatkowska, M., Kiełbasiński, P., Mielczarek, L., Wiktorska, K., Chilmończyk, Z., Milczarek, M., & Karwowska, K. (2016) · ChemMedChem · doi:10.1002/cmdc.201600442 · Cited by 24 · see citing works

Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos

Gao, M., Hu, J., Zhu, Y., Wang, X., Zeng, S., Hong, Y., & Zhao, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094783 · Cited by 23 · see citing works

Methylseleninic Acid Sensitizes Ovarian Cancer Cells to T-Cell Mediated Killing by Decreasing PDL1 and VEGF Levels

Nair, D., Rådestad, E., Khalkar, P., Díaz-Argelich, N., Schröder, A., Klynning, C., Ungerstedt, J. S., Uhlin, M., & Fernandes, A. P. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00407 · Cited by 23 · see citing works

Selenium-mediated protection in reversing the sensitivity of bacterium to the bactericidal antibiotics

Li, Z., Tan, J., Shao, L., Dong, X., Ye, R. D., & Chen, D. (2017) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2017.02.007 · Cited by 22 · see citing works

Interaction of selenite and tellurite with thiol-dependent redox enzymes: Kinetics and mitochondrial implications

Rigobello, M. P., Folda, A., Citta, A., Scutari, G., Gandin, V., Fernandes, A. P., Rundlöf, A.-K., Marzano, C., Björnstedt, M., & Bindoli, A. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.03.006 · Cited by 22 · see citing works

Selenium nutritional status and thyroid dysfunction

de Souza, L. S. L., Campos, R. D. O., Filho, J. D. S. B., de Jesus, J. D. S., Anunciação, S. M., Cassemiro, J. F., Rende, P. R. F., Hecht, F., & Ramos, H. E. (2025) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-4292-2023-0348 · Cited by 21 · see citing works

Mechanisms of the regulation of thioredoxin reductase activity in cancer cells by the chemopreventive agent selenium.

Gallegos, A. C., Berggren, M. I., Gasdaska, J. R., & Powis, G. (1997) · PubMed · Cited by 123 · see citing works

Selenium and the thioredoxin redox system: effects on cell growth and death.

Powis, G., Gasdaska, J. R., Gasdaska, P. Y., Berggren, M. I., Kirkpatrick, D. L., Engman, L., Cotgreave, I. A., Angulo, M., & Baker, A. F. (1997) · PubMed · Cited by 70 · see citing works

Thioredoxin reductase and selenium in carcinogenesis and multidrug resistance

Björkhem‐Bergman, L. (2004) · Open Archive (Karolinska Institutet)

Selenium as a cancer-protective agent

Nedvědová, M. (2012) · Digital Repository (National Repository of Grey Literature)

Thioredoxin Reductase 1 as an Anticancer Drug Target

Schmidt, E. E., & Arnér, E. S. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-41283-2_16 · Cited by 9 · see citing works