The DOI matches its Crossref record; 426 of the 426 references it cites were found in a registry or an index.
Selenium in Human Health and Disease
Open accessAbstract
This review covers current knowledge of selenium in the environment, dietary intakes, metabolism and status, functions in the body, thyroid hormone metabolism, antioxidant defense systems and oxidative metabolism, and the immune system. Selenium toxicity and links between deficiency and Keshan disease and Kashin-Beck disease are described. The relationships between selenium intake/status and various health outcomes, in particular gastrointestinal and prostate cancer, cardiovascular disease, diabetes, and male fertility, are reviewed, and recent developments in genetics of selenoproteins are outlined. The rationale behind current dietary reference intakes of selenium is explained, and examples of differences between countries and/or expert bodies are given. Throughout the review, gaps in knowledge and research requirements are identified. More research is needed to improve our understanding of selenium metabolism and requirements for optimal health. Functions of the majority of the selenoproteins await characterization, the mechanism of absorption has yet to be identified, measures of status need to be developed, and effects of genotype on metabolism require further investigation. The relationships between selenium intake/status and health, or risk of disease, are complex but require elucidation to inform clinical practice, to refine dietary recommendations, and to develop effective public health policies.
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In the citing paper
“an intake of Se of 30 μg·day−1 is inadequate for humans, while intakes exceeding 900 μg·day−1 are potentially harmful [9]”
From Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review (2015) · cites this paper as [9]
In the citing paper
“In general, higher animals and humans directly acquire organic Se compounds (SeMet and SeCys are the major Se species in the diet) but they can also internalize inorganic Se [9].”
From Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review (2015) · cites this paper as [9]
In the citing paper
“Selenium exhibits strong antioxidant properties and protects against DNA damage [88,89].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [88]
In the citing paper
“It occurs in two forms: inorganic (selenates and selenites) and organic (selenomethionine and selenocysteine) [88].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [88]
In the citing paper
“Selenium should be supplied to the human body with foods of plant and animal origin [26,88] (Table 1).”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [88]
In the citing paper
“Selenium (Se) is one of the most important trace elements without which the body cannot function properly.”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [88]
Citations
Cites
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Cited by
Sorted by citations
Rayman, M. P. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61452-9 · Cited by 3,563
Selenium for preventing cancer
Vinceti, M., Filippini, T., Del Giovane, C., Dennert, G., Zwahlen, M., Brinkman, M., Zeegers, M. P., Horneber, M., D'Amico, R., & Crespi, C. M. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005195.pub4 · Cited by 649
Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review
Winkel, L., Vriens, B., Jones, G., Schneider, L., Pilon-Smits, E., & Bañuelos, G. (2015) · Nutrients · doi:10.3390/nu7064199 · Cited by 476
“Adequate Se intake levels have a relatively narrow range between deficiency and toxicity: current estimates indicate that an intake of Se of 30 μg·day−1 is inadequate for humans, while intakes exceeding 900 μg·day−1 are potentially harmful [9].”
BackgroundDietary calcium and zinc deficiency risks are decreasing but remain prevalent
Kumssa, D. B., Joy, E. J. M., Ander, E. L., Watts, M. J., Young, S. D., Walker, S., & Broadley, M. R. (2015) · Scientific Reports · doi:10.1038/srep10974 · Cited by 455
Bioactive Compounds for Skin Health: A Review
Michalak, M., Pierzak, M., Kręcisz, B., & Suliga, E. (2021) · Nutrients · doi:10.3390/nu13010203 · Cited by 345
“Selenium should be supplied to the human body with foods of plant and animal origin [26,88] (Table 1).”
Background
Metadata
- Authors
- Fairweather-Tait, S. J., Bao, Y., Broadley, M. R., Collings, R., Ford, D., Hesketh, J. E., & Hurst, R.
- Affiliations
- University of East Anglia
- University of East Anglia (GB)
- University of Nottingham (GB)
- Newcastle University (GB)
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2011-04
- Volume
- 14
- Issue
- 7
- Pages
- 1337-1383
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2074769261
- Cited by
- 1,330
- References
- 426
- Citations by year
- 2026: 78 · 2025: 92 · 2024: 80 · 2023: 97 · 2022: 138 · 2021: 143 · 2020: 122 · 2019: 94 · 2018: 79 · 2017: 69 · 2016: 56 · 2015: 70 · 2014: 75 · 2013: 59 · 2012: 43
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/G013969/1)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Physical Sciences › Chemistry › Organic Chemistry › Organoselenium and organotellurium chemistry
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- selenium, selenoproteins, selenium metabolism, selenium status, dietary selenium intake, selenium toxicity, Keshan disease, Kashin-Beck disease, thyroid hormone metabolism, antioxidant defense, oxidative stress, immune function, gastrointestinal cancer, prostate cancer, cardiovascular disease, diabetes mellitus, male fertility, Dietary Reference Intakes
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antioxidants, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Enterovirus Infections, Fertility Agents, Health, Humans, Intestinal Absorption, Mutation, Cardiomyopathies, Neoplasms, Nutritional Requirements, Selenium, Thyroid Hormones, Nutrition Policy, Selenoproteins, Kashin-Beck Disease
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