Cited by 1,330Selenium in Biological SystemsOrganoselenium and organotellurium chemistryTrace Elements in Health

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Selenium in Human Health and Disease

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Fairweather-Tait, Susan J., Bao, Yongping, Broadley, Martin R., Collings, Rachel, Ford, Dianne, Hesketh, John E., Hurst, Rachel·2011·Antioxidants & Redox Signaling

DOI 10.1089/ars.2010.3275

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Abstract

This review covers current knowledge of selenium in the environment, dietary intakes, metabolism and status, functions in the body, thyroid hormone metabolism, antioxidant defense systems and oxidative metabolism, and the immune system. Selenium toxicity and links between deficiency and Keshan disease and Kashin-Beck disease are described. The relationships between selenium intake/status and various health outcomes, in particular gastrointestinal and prostate cancer, cardiovascular disease, diabetes, and male fertility, are reviewed, and recent developments in genetics of selenoproteins are outlined. The rationale behind current dietary reference intakes of selenium is explained, and examples of differences between countries and/or expert bodies are given. Throughout the review, gaps in knowledge and research requirements are identified. More research is needed to improve our understanding of selenium metabolism and requirements for optimal health. Functions of the majority of the selenoproteins await characterization, the mechanism of absorption has yet to be identified, measures of status need to be developed, and effects of genotype on metabolism require further investigation. The relationships between selenium intake/status and health, or risk of disease, are complex but require elucidation to inform clinical practice, to refine dietary recommendations, and to develop effective public health policies.

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Selenium and human health
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Background

See all 1,330

Authors: Fairweather-Tait, S. J., Bao, Y., Broadley, M. R., Collings, R., Ford, D., Hesketh, J. E., & Hurst, R.
Affiliations: University of East Anglia
University of East Anglia (GB)
University of Nottingham (GB)
Newcastle University (GB)
ORCID: Bao, Yongping
Broadley, Martin R.
Collings, Rachel
Ford, Dianne
Hurst, Rachel
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2011-04
Volume: 14
Issue: 7
Pages: 1337-1383
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/ars.2010.3275
OpenAlex: W2074769261
Cited by: 1,330
References: 426
Citations by year: 2026: 78 · 2025: 92 · 2024: 80 · 2023: 97 · 2022: 138 · 2021: 143 · 2020: 122 · 2019: 94 · 2018: 79 · 2017: 69 · 2016: 56 · 2015: 70 · 2014: 75 · 2013: 59 · 2012: 43
FWCI: 4.76
Type: journal article
Language: en
Open access: green
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Antioxidants and Redox Signaling (publishedVersion)
PubMed (publishedVersion)
UEA Digital Repository (University of East Anglia) (submittedVersion)
Newcastle University ePrints (Newcastle Univesity)
Funders: Biotechnology and Biological Sciences Research Council (BB/G013969/1)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
Physical Sciences › Chemistry › Organic Chemistry › Organoselenium and organotellurium chemistry
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: selenium, selenoproteins, selenium metabolism, selenium status, dietary selenium intake, selenium toxicity, Keshan disease, Kashin-Beck disease, thyroid hormone metabolism, antioxidant defense, oxidative stress, immune function, gastrointestinal cancer, prostate cancer, cardiovascular disease, diabetes mellitus, male fertility, Dietary Reference Intakes
MeSH terms: Animals, Anti-Inflammatory Agents, Antioxidants, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Enterovirus Infections, Fertility Agents, Health, Humans, Intestinal Absorption, Mutation, Cardiomyopathies, Neoplasms, Nutritional Requirements, Selenium, Thyroid Hormones, Nutrition Policy, Selenoproteins, Kashin-Beck Disease

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