The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
High-Mobility Group Box 1, Oxidative Stress, and Disease
Open accessAbstract
Oxidative stress and associated reactive oxygen species can modify lipids, proteins, carbohydrates, and nucleic acids, and induce the mitochondrial permeability transition, providing a signal leading to the induction of autophagy, apoptosis, and necrosis. High-mobility group box 1 (HMGB1) protein, a chromatin-binding nuclear protein and damage-associated molecular pattern molecule, is integral to oxidative stress and downstream apoptosis or survival. Accumulation of HMGB1 at sites of oxidative DNA damage can lead to repair of the DNA. As a redox-sensitive protein, HMGB1 contains three cysteines (Cys23, 45, and 106). In the setting of oxidative stress, it can form a Cys23-Cys45 disulfide bond; a role for oxidative homo- or heterodimerization through the Cys106 has been suggested for some of its biologic activities. HMGB1 causes activation of nicotinamide adenine dinucleotide phosphate oxidase and increased reactive oxygen species production in neutrophils. Reduced and oxidized HMGB1 have different roles in extracellular signaling and regulation of immune responses, mediated by signaling through the receptor for advanced glycation end products and/or Toll-like receptors. Antioxidants such as ethyl pyruvate, quercetin, green tea, N-acetylcysteine, and curcumin are protective in the setting of experimental infection/sepsis and injury including ischemia-reperfusion, partly through attenuating HMGB1 release and systemic accumulation. Antioxid. Redox Signal. 14, 1315–1335.
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Cites
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Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221
Neurodegenerative diseases and oxidative stress
Barnham, K. J., Masters, C. L., & Bush, A. I. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1330 · Cited by 3,683 · cited 1×
“Increased and=or sustained levels of oxidative stress and related mediators play a major role in most chronic human diseases, including atherosclerosis (22), diabetes (94), cardiovascular diseases (66), cancer (16), neurodegenerative disorders (14), and chronic liver (246) and lung (161) diseases.”
BackgroundRole of reactive oxygen species (ROS) in apoptosis induction
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Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
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“Indeed, many stimuli that induce ROS generation also induce autophagy, including nutrient starvation, mitochondrial toxins, and hypoxia (193).”
BackgroundRAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
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Molecular mechanisms of N-acetylcysteine actions
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Cited by
The Beclin 1 network regulates autophagy and apoptosis
Kang, R., Zeh, H. J., Lotze, M. T., & Tang, D. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.191 · Cited by 2,485
Self-citationKang, R., Chen, R., Zhang, Q., Hou, W., Wu, S., Cao, L., Huang, J., Yu, Y., Fan, X.-G., Yan, Z., et al. (2014) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.05.001 · Cited by 956
Self-citationThe mechanism of HMGB1 secretion and release
Chen, R., Kang, R., & Tang, D. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00736-w · Cited by 849
Self-citationSalminen, A., Kauppinen, A., & Kaarniranta, K. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2011.12.006 · Cited by 763
Sepsis: Current Dogma and New Perspectives
Deutschman, C. S., & Tracey, K. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.001 · Cited by 677
Metadata
- Authors
- Tang, D., Kang, R., Zeh, H. J., & Lotze, M. T.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2011-04
- Volume
- 14
- Issue
- 7
- Pages
- 1315-1335
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2059718338
- Cited by
- 468
- References
- 26
- FWCI
- 17.13
- Type
- journal article
- Language
- en
- Open access
- green
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