Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

INCREASED RISK OF BLADDER CANCER ASSOCIATED WITH A GLUTATHIONE PEROXIDASE 1 CODON 198 VARIANT

Ichimura, Y., Habuchi, T., Tsuchiya, N., Wang, L., Oyama, C., Sato, K., Nishiyama, H., Ogawa, O., & Kato, T. (2004) · The Journal of Urology · doi:10.1097/01.ju.0000130942.40597.9d · Cited by 149

Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide

Lillig, C. H., Lönn, M. E., Enoksson, M., Fernandes, A. P., & Holmgren, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401896101 · Cited by 147

Thioredoxins are required for protection against a reductive stress in the yeast Saccharomyces cerevisiae

Trotter, E. W., & Grant, C. M. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03216.x · Cited by 146

Effects of hypoxia on tumor metabolism

Kim, J., Gao, P., & Dang, C. V. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9060-4 · Cited by 146

Probucol Increases Glutathione Peroxidase-1 Activity and Displays Long-Lasting Protection against Methylmercury Toxicity in Cerebellar Granule Cells

Farina, M., Campos, F., Vendrell, I., Berenguer, J., Barzi, M., Pons, S., & Sunol, C. E. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp219 · Cited by 144

Hyperhomocystinemia Impairs Endothelial Function and eNOS Activity via PKC Activation

Jiang, X., Yang, F., Tan, H., Liao, D., Bryan, R. M., Randhawa, J. K., Rumbaut, R. E., Durante, W., Schafer, A. I., Yang, X., et al. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000189559.87328.e4 · Cited by 144

Selenium concentrations and glutathione peroxidase activities in whole blood of New Zealand residents

Thomson, C. D., Rea, H. M., Doesburg, V. M., & Robinson, M. F. (1977) · British Journal Of Nutrition · doi:10.1079/bjn19770049 · Cited by 141

Selenoprotein deficiency accelerates prostate carcinogenesis in a transgenic model

Diwadkar‐Navsariwala, V., Prins, G. S., Swanson, S. M., Birch, L. A., Ray, V., Hedayat, S., Lantvit, D. L., & Diamond, A. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508218103 · Cited by 140

Eukaryotic selenoprotein synthesis: Mechanistic insight incorporating new factors and new functions for old factors

Squires, J. E., & Berry, M. J. (2008) · IUBMB Life · doi:10.1002/iub.38 · Cited by 140

Homocysteine Down-regulates Cellular Glutathione Peroxidase (GPx1) by Decreasing Translation

Handy, D. E., Zhang, Y., & Loscalzo, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501452200 · Cited by 138

Irreversible Inactivation of Glutathione Peroxidase 1 and Reversible Inactivation of Peroxiredoxin II by H 2 O 2 in Red Blood Cells

Cho, C., Lee, S., Lee, G. T., Woo, H. A., Choi, E., & Rhee, S. G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2701 · Cited by 134

Inactivation of Glutathione Peroxidase by Peroxynitrite

Padmaja, S., Squadrito, G. L., & Pryor, W. A. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0407 · Cited by 134

Expression of Antioxidant Enzymes in Diseases of the Human Pancreas: Another Link Between Chronic Pancreatitis and Pancreatic Cancer

Cullen, J. J., Mitros, F. A., & Oberley, L. W. (2003) · Pancreas · doi:10.1097/00006676-200301000-00005 · Cited by 134

Selenium regulation of transcript abundance and translational efficiency of glutathione peroxidase-1 and -4 in rat liver

Sachdev, S. W., & Sunde, R. A. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3570851 · Cited by 132

Selective Inhibition of Selenocysteine tRNA Maturation and Selenoprotein Synthesis in Transgenic Mice Expressing Isopentenyladenosine-Deficient Selenocysteine tRNA

Moustafa, M. E., Carlson, B. A., El-Saadani, M. A., Kryukov, G. V., Sun, Q.-A., Harney, J. W., Hill, K. E., Combs, G. F., Feigenbaum, L., Mansur, D. B., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.11.3840-3852.2001 · Cited by 131

Eukaryotic Initiation Factor 4a3 Is a Selenium-Regulated RNA-Binding Protein that Selectively Inhibits Selenocysteine Incorporation

Budiman, M. E., Bubenik, J. L., Miniard, A. C., Middleton, L. M., Gerber, C. A., Cash, A., & Driscoll, D. M. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.026 · Cited by 130

Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress

Remmen, H. V., Qi, W., Sabia, M., Freeman, G. L., Estlack, L. E., Yang, H. C., Guo, Z. M., Huang, T., Strong, R., Lee, S., et al. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.03.016 · Cited by 130

Loss of heterozygosity of the human cytosolic glutathione peroxidase I gene in lung cancer

Moscow, J. A., Schmidt, L. S., Ingram, D. T., Gnarra, J. R., Johnson, B. E., & Cowan, K. H. (1994) · Carcinogenesis · doi:10.1093/carcin/15.12.2769 · Cited by 129

Regulation of the protein disulfide proteome by mitochondria in mammalian cells

Yang, Y., Song, Y., & Loscalzo, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702027104 · Cited by 129

Status of selenium in prostate cancer prevention

Combs, G. F. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601974 · Cited by 128

GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer

Hansen, R. D., Sæbø, M., Skjelbred, C. F., Nexø, B. A., Hagen, P. C., Bock, G., Lothe, I. M. B., Johnson, E., Aase, S., Hansteen, I., et al. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.04.019 · Cited by 128

Identification of oxygen responsive elements in the 5'-flanking region of the human glutathione peroxidase gene.

Cowan, D. B., Weisel, R. D., Williams, W. G., & Mickle, D. A. G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74196-9 · Cited by 126

Doxorubicin treatment in vivo activates caspase‐12 mediated cardiac apoptosis in both male and female rats

Jang, Y. M., Kendaiah, S., Drew, B., Phillips, T., Selman, C., Julian, D. A., & Leeuwenburgh, C. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.10.053 · Cited by 126

Glutathione peroxidase knockout mice are susceptible to myocardial ischemia reperfusion injury.

Yoshida, T., Maulik, N., Engelman, R. M., Ho, Y.-S., Magnenat, J.-L., Rousou, J. A., Flack, J. E., Deaton, D. W., & Das, D. K. (1997) · PubMed · Cited by 125

H2O2 detection from intact mitochondria as a measure for one-electron reduction of dioxygen requires a non-invasive assay system11Dedicated to Prof. E. Elstner, on the occasion of his 60th anniversary.

Staniek, K., & Nohl, H. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00083-3 · Cited by 124

The Outcome of Selenium and Vitamin E Cancer Prevention Trial (SELECT) Reveals the Need for Better Understanding of Selenium Biology

Hatfield, D. L., & Gladyshev, V. N. (2009) · Molecular Interventions · doi:10.1124/mi.9.1.6 · Cited by 124

Sequences in the 3'-untranslated region of the human cellular glutathione peroxidase gene are necessary and sufficient for selenocysteine incorporation at the UGA codon

Shen, Q., Chu, F., & Newburger, P. E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82146-9 · Cited by 123

Nucleolin Is a Protein Kinase C-ζ Substrate

Zhou, G., Seibenhener, M. L., & Wooten, M. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.49.31130 · Cited by 123

The Oxidation of Selenocysteine Is Involved in the Inactivation of Glutathione Peroxidase by Nitric Oxide Donor

Asahi, M., Fujii, J., Takao, T., Kuzuya, T., Hori, M., Shimonishi, Y., & Taniguchi, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19152 · Cited by 122

A Role of Mitochondrial Glutathione Peroxidase in Modulating Mitochondrial Oxidations in Liver

Sies, H., & MOSS, K. M. (1978) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1978.tb12178.x · Cited by 122

Contrasting Patterns of Regulation of the Antioxidant Selenoproteins, Thioredoxin Reductase, and Glutathione Peroxidase, in Cancer Cells

Gladyshev, V. N., Factor, V. M., Housseau, F., & Hatfield, D. L. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9495 · Cited by 121

Interactions Between Hyperglycemia and Hypoxia

Nyengaard, J. R., Ido, Y., Kilo, C., & Williamson, J. R. (2004) · Diabetes · doi:10.2337/diabetes.53.11.2931 · Cited by 121

Epithelium-Specific Glutathione Peroxidase, Gpx2, Is Involved in the Prevention of Intestinal Inflammation in Selenium-Deficient Mice

Esworthy, R. S., Yang, L., Frankel, P. H., & Chu, F. (2005) · Journal of Nutrition · doi:10.1093/jn/135.4.740 · Cited by 120

Knowing when not to stop: selenocysteine incorporation in eukaryotes

Low, S. (1996) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(96)10025-6 · Cited by 119

Recent Advances in Understanding Aminoglycoside Ototoxicity and Its Prevention

Wu, W.-J., Sha, S., & Schacht, J. (2002) · Audiology and Neurotology · doi:10.1159/000058305 · Cited by 117

Harnessing an endogenous cardioprotective mechanism: Cellular sources and sites of action of adenosine

Mullane, K. (1995) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(95)90073-x · Cited by 117

Readthrough of dystrophin stop codon mutations induced by aminoglycosides

Howard, M. T., Anderson, C. B., Fass, U. W., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20052 · Cited by 116

Interaction of Gold(I) with the Active Site of Selenium-Glutathione Peroxidase

Chaudière, J., & Tappel, A. L. (1984) · Journal of Inorganic Biochemistry · doi:10.1016/0162-0134(84)85030-8 · Cited by 114

Interacting nutritional and infectious etiologies of Keshan disease

Levander, O. A., & Beck, M. A. (1997) · Biological Trace Element Research · doi:10.1007/bf02778980 · Cited by 114

Common Germline Genetic Variation in Antioxidant Defense Genes and Survival After Diagnosis of Breast Cancer

Udler, M. S., Maia, A.-T., Cebrián, A., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.10.0099 · Cited by 114

Involvement of Reductive Stress in the Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Heat Shock Protein 27

Zhang, X., Min, X., Li, C., Benjamin, I. J., Qian, B., Zhang, X., Ding, Z., Gao, X., Yao, Y., Ma, Y., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.147066 · Cited by 114

Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation

Berry, M. J. (1992) · Endocrinology · doi:10.1210/en.131.4.1848 · Cited by 114

The Redox State of SECIS Binding Protein 2 Controls Its Localization and Selenocysteine Incorporation Function

Papp, L. V., Lu, J., Striebel, F., Kennedy, D. D., Holmgren, A., & Khanna, K. K. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02284-05 · Cited by 112

Variation in the Selenoenzyme Genes and Risk of Advanced Distal Colorectal Adenoma

Peters, U., Chatterjee, N., Hayes, R. B., Schoen, R. E., Wang, Y., Chanock, S. J., & Foster, C. B. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-2947 · Cited by 112

Glutathione peroxidase 1 (GPX1) genetic polymorphism, erythrocyte GPX activity, and prostate cancer risk

Arsova‐Sarafinovska, Z., Matevska-Geshkovska, N., Eken, A., Petrovski, D., Banev, S., Dzikova, S., Georgiev, V., Sikole, A., Erdem, O., Sayal, A., et al. (2008) · International Urology and Nephrology · doi:10.1007/s11255-008-9407-y · Cited by 112

Glutathione Peroxidase-1 and Homocysteine for Cardiovascular Risk Prediction

Schnabel, R. B., Lackner, K. J., Rupprecht, H. J., Espinola–Klein, C., Torzewski, M., Lubos, E., Bickel, C., Cambien, F., Tiret, L., Münzel, T. F., et al. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.053 · Cited by 111

Enhanced skin carcinogenesis in transgenic mice with high expression of glutathione peroxidase or both glutathione peroxidase and superoxide dismutase.

Lu, Y., Lou, Y. R., Yen, P., Newmark, H. L., Mirochnitchenko, O., Inouye, M., & Huang, M. (1997) · PubMed · Cited by 111

Versatility of Selenium Catalysis in PHGPx Unraveled by LC/ESI-MS/MS

Mauri, P., Benazzi, L., Flohé, L., Maiorino, M., Pietta, P. G., Pilawa, S., Roveri, A., & Ursini, F. (2003) · Biological Chemistry · doi:10.1515/bc.2003.065 · Cited by 110

Deficiency of Glutathione Peroxidase-1 Sensitizes Hyperhomocysteinemic Mice to Endothelial Dysfunction

Dayal, S., Brown, K. L., Weydert, C. J. D., Oberley, L. W., Arning, E., Bottiglieri, T., Faraci, F. M., & Lentz, S. R. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000041629.92741.dc · Cited by 110

Overexpression of Glutathione Peroxidase With Two Isoforms of Superoxide Dismutase Protects Mouse Islets From Oxidative Injury and Improves Islet Graft Function

Mysore, T. B., Shinkel, T. A., Collins, J., Salvaris, E. J., Fisicaro, N., Murray-Segal, L. J., Johnson, L. E. A., Lepore, D. A., Walters, S. N., Stokes, R., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2109 · Cited by 109

Redox Regulation of Pancreatic Cancer Cell Growth: Role of Glutathione Peroxidase in the Suppression of the Malignant Phenotype

Liu, J., Hinkhouse, M. M., Sun, W., Weydert, C. J. D., Ritchie, J. M., Oberley, L. W., & Cullen, J. J. (2004) · Human Gene Therapy · doi:10.1089/104303404322886093 · Cited by 109

Selenocysteine insertion or termination: factors affecting UGA codon fate and complementary anticodon:codon mutations

Berry, M. J., Harney, J. W., Ohama, T., & LHatfield, D. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.18.3753 · Cited by 108

p53 Biological Network: At the Crossroads of the Cellular-Stress Response Pathway and Molecular Carcinogenesis

Hussain, S. P., & Harris, C. C. (2006) · Journal of Nippon Medical School · doi:10.1272/jnms.73.54 · Cited by 108

Selenoprotein-Related Disease in a Young Girl Caused by Nonsense Mutations in the SBP2 Gene

Azevedo, M. F., Barra, G. B., Naves, L. A., Ribeiro Velasco, L. F., Godoy Garcia Castro, P., de Castro, L. C. G., Amato, A. A., Miniard, A., Driscoll, D., Schomburg, L., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2611 · Cited by 106

Selenium and GPx-1 overexpression protect mammalian cells against UV-induced DNA damage

Baliga, M. S., Wang, H., Zhuo, P., Schwartz, J. L., & Diamond, A. M. (2007) · Biological Trace Element Research · doi:10.1007/bf02685998 · Cited by 106

Overexpression of seleno-glutathione peroxidase by gene transfer enhances the resistance of T47D human breast cells to clastogenic oxidants.

Mirault, M.-É., Tremblay, A., Beaudoin, N., et al. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54772-4 · Cited by 104

Polymorphisms in Oxidative Stress–Related Genes Are Not Associated with Prostate Cancer Risk in Heavy Smokers

Choi, J., Neuhouser, M. L., Barnett, M. J., et al. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0040 · Cited by 104

Association between GPx1 Pro198Leu polymorphism, GPx1 activity and plasma selenium concentration in humans

Jabłońska, E., Gromadzińska, J., Reszka, E., Wąsowicz, W., Sobala, W., Szeszenia‐Dąbrowska, N., & Boffetta, P. (2009) · European Journal of Nutrition · doi:10.1007/s00394-009-0023-0 · Cited by 104

Glutathion-Peroxidase, IV1–3, Intrazelluläre Verteilung des Glutathion-Peroxidase-Systems in der Rattenleber

Flohé, L., & Schlegel, W. (1971) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1971.352.2.1401 · Cited by 104

Role of mitochondrial reactive oxygen species in hypoxia-dependent increase in intracellular calcium in pulmonary artery myocytes

Wang, Q., Zheng, Y., Dong, L., Ho, Y.-S., Guo, Z., & Wang, Y.-X. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.008 · Cited by 103

Glutathione pathway genes and lung cancer risk in young and old populations

Yang, P. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh203 · Cited by 103

Selenium supplementation improves antioxidant capacity in vitro and in vivo in patients with coronary artery disease

Schnabel, R. B., Lubos, E., Messow, C., Sinning, C., Zeller, T., Wild, P. S., Peetz, D., Handy, D. E., Münzel, T. F., Loscalzo, J., et al. (2008) · American Heart Journal · doi:10.1016/j.ahj.2008.09.004 · Cited by 100

cDNA sequence coding for human glutathione peroxidase

Sukenaga, Y., Ishida, K., Takeda, T., & Takagi, K. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.17.7178 · Cited by 100

Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation.

Berry, M. J., Maia, A. L., Kieffer, J. D., Harney, J. W., & Larsen, P. R. (1992) · Endocrinology · doi:10.1210/endo.131.4.1396330 · Cited by 99

Opposite Roles of Selenium-dependent Glutathione Peroxidase-1 in Superoxide Generator Diquat- and Peroxynitrite-induced Apoptosis and Signaling

Fu, Y., Sies, H., & Lei, X. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106946200 · Cited by 98

Glutathione peroxidase-1 deficiency leads to increased nuclear light scattering, membrane damage, and cataract formation in gene-knockout mice.

Reddy, V. N., Giblin, F. J., Lin, L.-R., Dang, L., Unakar, N. J., Musch, D. C., Boyle, D. L., TAKEMOTO, L. J., Ho, Y., Knoernschild, T., et al. (2001) · PubMed · Cited by 97

Selenium Regulation of Glutathione Peroxidase in Human Hepatoma Cell Line Hep3B

Baker, R. D., Baker, S. S., Larosa, K., Whitney, C., & Newburger, P. E. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1320 · Cited by 97

GPx-1 Gene Delivery Modulates NFκB Activation Following Diverse Environmental Injuries Through a Specific Subunit of the IKK Complex

Li, Q., Sanlioglu, S., Li, S.-J., Ritchie, T., Oberley, L., & Engelhardt, J. (2001) · Antioxidants and Redox Signaling · doi:10.1089/15230860152409068 · Cited by 96

Attenuation of doxorubicin-induced contractile and mitochondrial dysfunction in mouse heart by cellular glutathione peroxidase

Xiong, Y., Liu, X., Lee, C.-P., Chua, B. H. L., & Ho, Y.-S. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.02.024 · Cited by 96

Activation of glutathione peroxidase via Nrf1 mediates genistein’s protection against oxidative endothelial cell injury

Hernandez-Montes, E., Pollard, S. E., Vauzour, D., Jofre‐Monseny, L., Rota, C., Rimbach, G. H., Weinberg, P. D., & Spencer, J. P. E. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.197 · Cited by 96

Gene × Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study

Cox, D. G., Tamimi, R. M., & Hunter, D. J. (2006) · BMC Cancer · doi:10.1186/1471-2407-6-217 · Cited by 95

Reactive Oxygen Species–Mediated Signal Transduction in the Endothelium

Chen, K., & Keaney, J. F. (2004) · Endothelium · doi:10.1080/10623320490482655 · Cited by 94

Seryl-tRNA in Mammalian Tissues: Chromatographic Differences in Brain and Liver and a Specific Response to the Codon, UGA

Hatfield, D. L., & Portugal, F. H. (1970) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.67.3.1200 · Cited by 94

Antioxidant Enzyme Activity and Coronary Heart Disease: Meta-analyses of Observational Studies

Flores‐Mateo, G., Carrillo-Santisteve, P., Elosúa, R., Güallar, E., Marrugat, J., Bleys, J., & Covas, M. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp112 · Cited by 94

Glutathione Peroxidase-1 Activity, Atherosclerotic Burden, and Cardiovascular Prognosis

Espinola–Klein, C., Rupprecht, H. J., Bickel, C., Schnabel, R. B., Genth‐Zotz, S., Torzewski, M., Lackner, K. J., Münzel, T. F., & Blankenberg, S. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.10.041 · Cited by 93

GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer

Raaschou‐Nielsen, O., Sørensen, M., Hansen, R. D., et al. (2006) · Cancer Letters · doi:10.1016/j.canlet.2006.05.006 · Cited by 93

Site-Specific Antiatherogenic Effect of Probucol in Apolipoprotein E–Deficient Mice

Witting, P. K., Pettersson, K. S., Letters, J., & Stocker, R. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.8.e26 · Cited by 92

Changes in Expression of Antioxidant Enzymes Affect Cell-Mediated LDL Oxidation and Oxidized LDL–Induced Apoptosis in Mouse Aortic Cells

Guo, Z., Remmen, H. V., Yang, H., Chen, X., Mele, J., Vijg, J., Epstein, C. J., Ho, Y.-S., & Richardson, A. G. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0701.092092 · Cited by 91

Functional and physical interaction between the selenium-binding protein 1 (SBP1) and the glutathione peroxidase 1 selenoprotein

Fang, W., Goldberg, M. L., Pohl, N. M., Bi, X., Tong, C., Xiong, B., Koh, T. J., Diamond, A. M., & Yang, W. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq114 · Cited by 91

Sequence of a cDNA coding for human glutathione peroxidase confirms TGA encodes active site selenocysteine

Mullenbach, G. T., Tabrizi, A., Irvine, B. D., Bell, G. I., & Hallewell, R. A. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.13.5484 · Cited by 90

Glutathione Peroxidase-1 Plays a Major Role in Protecting Against Angiotensin II–Induced Vascular Dysfunction

Chrissobolis, S., Didion, S. P., Kinzenbaw, D. A., Schrader, L. I., Dayal, S., Lentz, S. R., & Faraci, F. M. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.103572 · Cited by 90

Site-Specific Antiatherogenic Effect of the Antioxidant Ebselen in the Diabetic Apolipoprotein E–Deficient Mouse

Chew, P., Yuen, D. Y. C., Koh, P., Stefanovic, N., Febbraio, M. A., Kola, I., Cooper, M. E., & de Haan, J. B. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.186619 · Cited by 90

Oxidant-specific Folding of Yap1p Regulates Both Transcriptional Activation and Nuclear Localization

Gulshan, K., Rovinsky, S. A., Coleman, S. T., & Moye-Rowley, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504716200 · Cited by 89

Interaction of glutathione peroxidase-1 and selenium in endemic dilated cardiomyopathy

Lei, C., Niu, X., Wei, J., Zhu, J., & Zhu, Y. (2008) · Clinica Chimica Acta · doi:10.1016/j.cca.2008.09.025 · Cited by 89

Attenuation of 6‐OHDA‐induced neurotoxicity in glutathione peroxidase transgenic mice

Bensadoun, J., Mirochnitchenko, O. V., Inouye, M., Aebischer, P., & Zurn, A. D. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00345.x · Cited by 89

Glutathione Peroxidase-1 Protects from CD95-induced Apoptosis

Gouazé‐Andersson, V., Andrieu‐Abadie, N., Cuvillier, O., Malagarie‐Cazenave, S., Frisach, M., Mirault, M.-É., & Levade, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203067200 · Cited by 88

Potential Contribution of NF-κB in Neuronal Cell Death in the Glutathione Peroxidase-1 Knockout Mouse in Response to Ischemia-Reperfusion Injury

Crack, P. J., Taylor, J. M., Ali, U., Mansell, A. S., & Hertzog, P. J. (2006) · Stroke · doi:10.1161/01.str.0000221708.17159.64 · Cited by 88

Selective control of cytosolic glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase mRNA stability by selenium supply

Bermano, G., Arthur, J. R., & Hesketh, J. E. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00493-0 · Cited by 87

The effect of hOGG1 and glutathione peroxidase I genotypes and 3p chromosomal loss on 8-hydroxydeoxyguanosine levels in lung cancer

Hardie, L. J. (2000) · Carcinogenesis · doi:10.1093/carcin/21.2.167 · Cited by 87

The nature of the sex-linked differences in glutathione peroxidase activity and aerobic oxidation of glutathione in male and female rat liver

Pinto, R. E., & Bartley, W. (1969) · Biochemical Journal · doi:10.1042/bj1150449 · Cited by 86

Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography

Nemoto, M., Nishimura, R., Sasaki, T., Hiki, Y., Miyashita, Y., Nishioka, M., Fujimoto, K., Sakuma, T., Ohashi, T., Fukuda, K., et al. (2007) · Cardiovascular Diabetology · doi:10.1186/1475-2840-6-23 · Cited by 86

GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, interaction with alcohol consumption and smoking, and risk of colorectal cancer

Hansen, R. D., Krath, B. N., Frederiksen, K., et al. (2009) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2009.01.009 · Cited by 85

Lack of Glutathione Peroxidase 1 Accelerates Cardiac-Specific Hypertrophy and Dysfunction in Angiotensin II Hypertension

Ardanaz, N., Yang, X.-P., Cifuentes-Pagano, E., Haurani, M. J., Jackson, K. W., Liao, T., Carretero, O. A., & Pagano, P. J. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.135715 · Cited by 85

Tagging Single-Nucleotide Polymorphisms in Antioxidant Defense Enzymes and Susceptibility to Breast Cancer

Cebrián, A., Pharoah, P. D. P., Ahmed, S., Smith, P. L., Luccarini, C., Luben, R., Redman, K., Munday, H., Easton, D. F., Dunning, A. M., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1857 · Cited by 85

Lead Exposure, Polymorphisms in Genes Related to Oxidative Stress, and Risk of Adult Brain Tumors

Bhatti, P., Stewart, P. A., Hutchinson, A. A., Rothman, N., Linet, M. S., Inskip, P. D., & Rajaraman, P. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0197 · Cited by 84

An RNA-Binding Protein Recognizes a Mammalian Selenocysteine Insertion Sequence Element Required for Cotranslational Incorporation of Selenocysteine

Lesoon, A., Mehta, A., Singh, R. P., et al. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.1977 · Cited by 83

Substitution of Cysteine for Selenocysteine in the Catalytic Center of Type III Iodothyronine Deiodinase Reduces Catalytic Efficiency and Alters Substrate Preference

Kuiper, G. G. J. M., Klootwijk, W., & Visser, T. J. (2003) · Endocrinology · doi:10.1210/en.2003-0084 · Cited by 83

Cloning and sequencing of the cDNA encoding a human testis phospholipid hydroperoxide glutathione peroxidase*

Esworthy, R. S., Doan, K., Doroshow, J. H., & Chu, F. (1994) · Gene · doi:10.1016/0378-1119(94)90400-6 · Cited by 82

Genetic Variants of GPX1 and SOD2 and Breast Cancer Risk at the Ontario Site of the Breast Cancer Family Registry

Knight, J. A., Onay, U. V., Wells, S., Li, H., Shi, E., Andrulis, I. L., & Özçelik, H. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-03-0164 · Cited by 82

Glutathione peroxidase 1 and glutathione are required to protect mouse astrocytes from iron‐mediated hydrogen peroxide toxicity

Liddell, J. R., Hoepken, H. H., Crack, P. J., Robinson, S. R., & Dringen, R. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20957 · Cited by 82

Nucleolin binds to a subset of selenoprotein mRNAs and regulates their expression

Miniard, A. C., Middleton, L. M., Budiman, M. E., Gerber, C. A., & Driscoll, D. M. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq247 · Cited by 82

Endothelial nitric oxide synthase activation leads to dilatory H2O2 production in mouse cerebral arteries

Drouin, A., Thorin‐Trescases, N., Hamel, É., Falck, J. R., & Thorin, É. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.10.005 · Cited by 82

Association between manganese superoxide dismutase (MnSOD) Val-9Ala polymorphism and cancer risk – A meta-analysis

Wang, S., Wang, F., Shi, X., Dai, J., Peng, Y., Guo, X., Wang, X., Shen, H., & Hu, Z. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2009.04.024 · Cited by 81

Glutathion-Peroxidase, I. Reindarstellung und Molekulargewichtsbestimmungen

Flohé, L., Eisele, B., & Wendel, A. (1971) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1971.352.1.151 · Cited by 81

Coupled tRNASec-Dependent Assembly of the Selenocysteine Decoding Apparatus

Zavacki, A. M., Mansell, J. B., Chung, M., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00064-9 · Cited by 80

Post-transcriptional regulation of glutathione peroxidase gene expression by selenium in the HL-60 human myeloid cell line

Chada, S., Whitney, C., & Newburger, P. E. (1989) · Blood · doi:10.1182/blood.v74.7.2535.2535 · Cited by 79

Reversible Cardiomyopathy Due to Selenium Deficiency

Reeves, W. C., Marcuard, S. P., Willis, S. E., et al. (1989) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607189013006663 · Cited by 79

Lack of glutathione peroxidase-1 exacerbates Aβ-mediated neurotoxicity in cortical neurons

Crack, P. J., Cimdins, K., Ali, U., Hertzog, P. J., & Iannello, R. C. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-005-0352-y · Cited by 79

Study on the pathogenic factors of kashin‐beck disease

Peng, A., Yang, C., Rui, H., et al. (1992) · Journal of Toxicology and Environmental Health · doi:10.1080/15287399209531597 · Cited by 77

Threading the needle: getting selenocysteine into proteins

Donovan, J., & Copeland, P. R. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2878 · Cited by 77

Adenosine-Dependent Induction of Glutathione Peroxidase 1 in Human Primary Endothelial Cells and Protection Against Oxidative Stress

Zhang, Y., Handy, D. E., & Loscalzo, J. (2005) · Circulation Research · doi:10.1161/01.res.0000164401.21929.cf · Cited by 77

Glutathione peroxidase 1 Pro198Leu variant contributes to the metabolic syndrome in men in a large Japanese cohort

Kuzuya, M., Ando, F., Iguchi, A., & Shimokata, H. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1939 · Cited by 75

Role of the 3′ untranslated region in the regulation of cytosolic glutathione peroxidase and phospholipid-hydroperoxide glutathione peroxidase gene expression by selenium supply

Bermano, G., Arthur, J. R., & Hesketh, J. E. (1996) · Biochemical Journal · doi:10.1042/bj3200891 · Cited by 75

Allelic Loss of the Gene for the GPX1 Selenium-Containing Protein Is a Common Event in Cancer

Hu, Y., Benya, R. V., Carroll, R. E., & Diamond, A. M. (2005) · Journal of Nutrition · doi:10.1093/jn/135.12.3021s · Cited by 74

Selenium Supplementation of Children in a Selenium-Deficient Area in China : Blood Selenium Levels and Glutathione Peroxidase Activities

Alfthan, G., Xu, G.-L., Tan, W., et al. (2000) · Biological Trace Element Research · doi:10.1385/bter:73:2:113 · Cited by 74

Absence of glutathione peroxidase‐1 exacerbates cerebral ischemia‐reperfusion injury by reducing post‐ischemic microvascular perfusion

Wong, C. H. Y., Bozinovski, S., Hertzog, P. J., Hickey, M. J., & Crack, P. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05605.x · Cited by 74

Genetic Polymorphisms in Antioxidant Enzymes Modulate Hepatic Iron Accumulation and Hepatocellular Carcinoma Development in Patients with Alcohol-Induced Cirrhosis

Sutton, A., Nahon, P., Pessayre, D., Rufat, P., Poiré, A., Ziol, M., Vidaud, D., Barget, N., Ganne‐Carrié, N., Charnaux, N., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2566 · Cited by 74

Lentivirus-mediated expression of glutathione peroxidase: Neuroprotection in murine models of Parkinson's disease

Ridet, J., Bensadoun, J., Déglon, N., et al. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.06.003 · Cited by 73

Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death

de Haan, J. B., Bladier, C., Lotfi-Miri, M., Taylor, J. M., Hutchinson, P. E., Crack, P. J., Hertzog, P. J., & Kola, I. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.10.020 · Cited by 72

Aging decreases expression and activity of glutathione peroxidase-1 in human endothelial progenitor cells

He, T., Joyner, M. J., & Katušić, Z. S. (2009) · Microvascular Research · doi:10.1016/j.mvr.2009.08.009 · Cited by 71

Structure and function of the 5'-flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1).

Moscow, J. A., Morrow, C. S., He, R., et al. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42647-6 · Cited by 70

Polymorphism of selected enzymes involved in detoxification and biotransformation in relation to lung cancer

Grešner, P., Gromadzińska, J., & Wąsowicz, W. (2007) · Lung Cancer · doi:10.1016/j.lungcan.2007.02.002 · Cited by 69

Overexpression of Glutathione Peroxidase Increases the Resistance of Neuronal Cells to Aβ‐Mediated Neurotoxicity

Barkats, M., Millecamps, S., Abrioux, P., Geoffroy, M., & Mallet, J. J. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751438.x · Cited by 68

Mitochondrial oxidative stress is modulated by oleic acid via an epidermal growth factor receptor-dependent activation of glutathione peroxidase

Duval, C., Augè, N., Frisach, M., Casteilla, L., Salvayre, R., & Nègre‐Salvayre, A. (2002) · Biochemical Journal · doi:10.1042/bj20020625 · Cited by 67

Polymorphism analysis of six selenoprotein genes: support for a selective sweep at the glutathione peroxidase 1 locus (3p21) in Asian populations

Foster, C. B., Aswath, K., Chanock, S. J., McKay, H. F., & Peters, U. (2006) · BMC Genetics · doi:10.1186/1471-2156-7-56 · Cited by 65

Manganese Superoxide Dismutase Protects from TNF-α–Induced Apoptosis by Increasing the Steady-State Production of H 2 O 2

Dasgupta, J., Subbaram, S., Connor, K. M., Rodriguez, A. M., Tirosh, O., Beckman, J. S., Jourd’heuil, D., & Melendez, J. A. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1295 · Cited by 65

Endothelial dysfunction is associated with increased levels of biomarkers in essential hypertension

de la Sierra, A., & Larrousse, M. (2009) · Journal of Human Hypertension · doi:10.1038/jhh.2009.91 · Cited by 65

Glutathione peroxidase 1 protects mitochondria against hypoxia/reoxygenation damage in mouse hearts

Thu, V. T., Kim, H. K., Ha, S. H., Yoo, J. Y., Park, W. S., Kim, N., Oh, G. T., & Han, J. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0811-7 · Cited by 65

Diabetic vascular dysfunction: Links to glucose‐induced reductive stress and VEGF

Tilton, R. G. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10092 · Cited by 65

Overexpression of Catalase in the Mitochondrial or Cytosolic Compartment Increases Sensitivity of HepG2 Cells to Tumor Necrosis Factor-α-induced Apoptosis

Bai, J., & Cederbaum, A. I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000438200 · Cited by 65

Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years

Rosenberger, A., Illig, T., Korb, K., Klopp, N., Zietemann, V., Wölke, G., Meese, E. U., Sybrecht, G. W., Kronenberg, F., Cebulla, M., et al. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-60 · Cited by 64

Selenocysteine versus Cysteine Reactivity: A Theoretical Study of Their Oxidation by Hydrogen Peroxide

Cardey, B., & Enescu, M. (2007) · The Journal of Physical Chemistry A · doi:10.1021/jp0658445 · Cited by 63

The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old

Soerensen, M., Christensen, K., Stevnsner, T., & Christiansen, L. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.01.005 · Cited by 63

Glutathione-peroxidase-1 null muscle progenitor cells are globally defective

Lee, S., Shin, H. S., Shireman, P. K., Vasilaki, A., Remmen, H. V., & CSETE, M. E. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.07.005 · Cited by 61

Role of Glutathione Peroxidase and Phospholipid Hydroperoxide Glutathione Peroxidase in the Reduction of Lysophospholipid Hydroperoxides

Marinho, H. S., Antunes, F., & Pinto, R. E. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00468-6 · Cited by 59

Oxidized forms of ovine erythrocyte glutathione peroxidase cyanide inhibition of a 4-glutathione:4-selenoenzyme

Kraus, R. J., Prohaska, J. R., & Ganther, H. E. (1980) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(80)90004-2 · Cited by 59

Glutathione peroxidase activity modulates recovery in the injured immature brain

Aoyagi, K., Potts, M. B., Trivedi, A. A., Pfankuch, T., Raber, J., Wendland, M. F., Claus, C. P., Koh, S., Ferriero, D. M., & Noble‐Haeusslein, L. J. (2009) · Annals of Neurology · doi:10.1002/ana.21600 · Cited by 59

Effects of Selenium Deficiency on Expression of Selenoproteins in Bovine Arterial Endothelial Cells.

Hara, S., SHOJI, Y., Sakurai, A., et al. (2001) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.24.754 · Cited by 58

Correction of CFTR malfunction and stimulation of Ca2+-activated Cl− channels restore HCO3 − secretion in cystic fibrosis bile ductular cells

Zsembery, Á., Jessner, W., Sitter, G., et al. (2002) · Hepatology · doi:10.1053/jhep.2002.30423 · Cited by 57

Hydroxyurea-Induced Expression of Glutathione Peroxidase 1 in Red Blood Cells of Individuals with Sickle Cell Anemia

Cho, C., Kato, G. J., Yang, S. H., Bae, S. W., Lee, J. S., Gladwin, M. T., & Rhee, S. G. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2978 · Cited by 57

Demonstration of Glutathione Peroxidase in Rat Liver Peroxisomes and Its Intraorganellar Distribution

Singh, A. K., Dhaunsi, G. S., Gupta, M. P., Orak, J. K., Asayama, K., & Singh, I. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1508 · Cited by 57

Mice Lacking Glutathione Peroxidase-1 Activity Show Increased Tunel Staining and an Accelerated Inflammatory Response in Brain Following a Cold-Induced Injury

Flentjar, N. J., Crack, P. J., Boyd, R. L., Malin, M., de Haan, J. B., Hertzog, P. J., Kola, I., & Iannello, R. C. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7927 · Cited by 57

No Association between GPX1 Pro198Leu and Breast Cancer Risk

Cox, D. G., Hankinson, S. E., Kraft, P., et al. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.1821.13.11 · Cited by 57

Cellular FLIP is expressed in cardiomyocytes and down-regulated in TUNEL-positive grafted cardiac tissues

Imanishi, T. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00154-1 · Cited by 56

Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet

de Haan, J. B., Witting, P. K., Stefanovic, N., Pete, J., Daskalakis, M., Kola, I., Stocker, R., & Smolich, J. J. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m500377-jlr200 · Cited by 56

Nonsense-mediated Decay of mRNA for the Selenoprotein Phospholipid Hydroperoxide Glutathione Peroxidase Is Detectable in Cultured Cells but Masked or Inhibited in Rat Tissues

Sun, X., Li, X., Moriarty, P. M., Henics, T., LaDuca, J. R., & Maquat, L. E. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.4.1009 · Cited by 56

The pentose phosphate cycle is regulated by NADPHNADP ratio in rat liver

Fabregat, I., Vitórica, J., Satrústegui, J., & Machado, A. (1985) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(85)90610-1 · Cited by 54

Glutathione peroxidase 1 and a high cellular glutathione concentration are essential for effective organic hydroperoxide detoxification in astrocytes

Liddell, J. R., Dringen, R., Crack, P. J., & Robinson, S. R. (2006) · Glia · doi:10.1002/glia.20433 · Cited by 54

Diminished Akt phosphorylation in neurons lacking glutathione peroxidase‐1 (Gpx1) leads to increased susceptibility to oxidative stress‐induced cell death

Taylor, J. M., Ali, U., Iannello, R. C., Hertzog, P. J., & Crack, P. J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02863.x · Cited by 54

Glutathione peroxidase 1 gene polymorphism and risk of recurrence in patients with superficial bladder cancer

Zhao, H., Liang, D., Grossman, H. B., et al. (2005) · Urology · doi:10.1016/j.urology.2005.04.033 · Cited by 53

Nucleolin Is a Second Component of the CD154 mRNA Stability Complex That Regulates mRNA Turnover in Activated T Cells

Singh, K., Laughlin, J., Kosinski, P. A., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.976 · Cited by 53

Reactive oxygen species mediate arachidonic acid-induced dilation in porcine coronary microvessels

Oltman, C. L., Kane, N. L., Miller, F. J., et al. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00456.2003 · Cited by 53

Genetic variant in glutathione peroxidase 1 gene is associated with an increased risk of coronary artery disease in a Chinese population

Tang, N., Wang, L., Yang, L., Gu, H., Sun, Q., Cong, R.-H., Zhou, B., Zhu, H., & Wang, B. (2008) · Clinica Chimica Acta · doi:10.1016/j.cca.2008.05.013 · Cited by 52

Overexpression of Cu/Zn-superoxide dismutase and/or catalase in mice inhibits aorta smooth muscle cell proliferation

Shi, M. (2004) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2003.12.019 · Cited by 52

Selenium status in relation to reduced glutathione peroxidase activity in aspirin‐sensitive asthma

Pearson, D., SUAREZ‐MENDEZ, V. J., Day, J. P., et al. (1991) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1991.tb00831.x · Cited by 52

Cardiac peroxiredoxins undergo complex modifications during cardiac oxidant stress

Schröder, E., Brennan, J. P., & Eaton, P. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00017.2008 · Cited by 52

Molecular Consequences of Genetic Variations in the Glutathione Peroxidase 1 Selenoenzyme

Zhuo, P., Goldberg, M. L., Herman, L. C., Lee, B., Wang, H., Brown, R. L., Foster, C. B., Peters, U., & Diamond, A. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1791 · Cited by 51

Allelic Loss at the GPx-1 Locus in Cancer of the Head and Neck

Hu, Y. J., Dolan, M. E., Bae, R. D., et al. (2004) · Biological Trace Element Research · doi:10.1385/bter:101:2:097 · Cited by 51

Selenoprotein deficiency enhances radiation‐induced micronuclei formation

Baliga, M. S., Diwadkar‐Navsariwala, V., Koh, T. J., Fayad, R., Fantuzzi, G., & Diamond, A. M. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800020 · Cited by 51

GPX1 Pro198Leu polymorphism and breast cancer risk: a meta-analysis

Hu, J., Zhou, G., Wang, N., & Wang, Y. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0841-z · Cited by 50

Identification of selenocysteine in glutathione peroxidase by mass spectroscopy

Kraus, R. J., Foster, S. J., & Ganther, H. E. (1983) · Biochemistry · doi:10.1021/bi00294a026 · Cited by 50

Overexpression of catalase delays G0/G1- to S-phase transition during cell cycle progression in mouse aortic endothelial cells

Onumah, O. E., Jules, G. E., Zhao, Y., Zhou, L., Yang, H. C., & Guo, Z. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.03.018 · Cited by 50

The Syndrome of Inherited Partial SBP2 Deficiency in Humans

Dumitrescu, A. M., Cosmo, C. D., Liao, X.-H., Weiss, R. E., & Refetoff, S. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2892 · Cited by 49

Hydrogen peroxide inhibits IL-12 p40 induction in macrophages by inhibiting c-rel translocation to the nucleus through activation of calmodulin protein

Khan, N., Rahim, S. S., Boddupalli, C. S., Ghousunnissa, S., Padma, S., Pathak, N., Thiagarajan, D., Hasnain, S. E., & Mukhopadhyay, S. (2005) · Blood · doi:10.1182/blood-2005-04-1707 · Cited by 48

Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer

Kote‐Jarai, Z., Durocher, F., Edwards, S. M., et al. (2002) · Prostate Cancer and Prostatic Diseases · doi:10.1038/sj.pcan.4500569 · Cited by 48

No Association Between Glutathione Peroxidase Pro198Leu Polymorphism and Breast Cancer Risk

Ahn, J., Gammon, M. D., Santella, R. M., et al. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0459 · Cited by 48

Transcriptional Up-Regulation of the Mouse Cytosolic Glutathione Peroxidase Gene in Erythroid Cells is Due to a Tissue-Specific 3' Enhancer Containing Functionally Important CACC/GT Motifs and Binding Sites for GATA and Ets Transcription Factors

O’Prey, J., Ramsay, S., Chambers, I., & Harrison, P. R. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6290 · Cited by 47

The effect of selenium-fortified table salt in the prevention of Keshan disease on a population of 1.05 million.

Cheng, Y., & Qian, P. C. (1990) · PubMed · Cited by 47

Inactivation of Enzymes of the Glutathione Antioxidant System by Treatment of Cultured Human Keratinocytes with Peroxides

Vessey, D. A., & Lee, K.-H. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12476735 · Cited by 45

Cellular Glutathione Peroxidase Protects Mice Against Lethal Oxidative Stress Induced by Various Doses of Diquat

Fu, Y., Cheng, W., Ross, D. A., et al. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-127.x · Cited by 45

Hyperoxia, unlike phorbol ester, induces glutathione peroxidase through a protein kinase C-independent mechanism

Jornot, L., & Junod, A. F. (1997) · Biochemical Journal · doi:10.1042/bj3260117 · Cited by 44

Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms

Lim, C. C., Bryan, N. S., Jain, M., Garcia-Saura, M. F., Fernandez, B. O., Sawyer, D. B., Handy, D. E., Loscalzo, J., Feelisch, M., & Liao, R. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00673.2009 · Cited by 44

Upregulation of Glutathione Peroxidase Offsets Stretch-Induced Proatherogenic Gene Expression in Human Endothelial Cells

Wagner, A. H., Kautz, O., Fricke, K., Zerr-Fouineau, M., Demicheva, E., Güldenzoph, B., Bermejo, J. L., Korff, T., & Hecker, M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.194738 · Cited by 44

Functional Interaction between the c-Abl and Arg Protein-tyrosine Kinases in the Oxidative Stress Response

Cao, C., Leng, Y., Li, C., & Kufe, D. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300058200 · Cited by 43

Exact ultrastructural localization of glutathione peroxidase in normal rat hepatocytes: advantages of microwave fixation.

Utsunomiya, H., Komatsu, N., Yoshimura, S., et al. (1991) · Journal of Histochemistry & Cytochemistry · doi:10.1177/39.9.1918936 · Cited by 42

Mutation Accumulation in the Intestine and Colon of Mice Deficient in Two Intracellular Glutathione Peroxidases

Lee, D.-H., Esworthy, R. S., Chu, C., Pfeifer, G. P., & Chu, F. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0732 · Cited by 41

[Effects of oxidative DNA damage and genetic polymorphism of the glutathione peroxidase 1 (GPX1) and 8-oxoguanine glycosylase 1 (hOGG1) on lung cancer].

Lee, C., Lee, K. Y., Choe, K., et al. (2006) · PubMed · Cited by 41

Glutathione peroxidase‐1 modulates lipopolysaccharideinduced adhesion molecule expression in endothelial cells by altering CD14 expression

Lubos, E., Mahoney, C. E., Leopold, J. A., Zhang, Y., Loscalzo, J., & Handy, D. E. (2010) · The FASEB Journal · doi:10.1096/fj.09-147421 · Cited by 40

Overexpression of human GPX1 modifies Bax to Bcl-2 apoptotic ratio in human endothelial cells

Faucher, K., Rabinovitch-Chable, H., Cook‐Moreau, J., Barrière, G., Sturtz, F. G., & Rigaud, M. (2005) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-005-5075-8 · Cited by 40

Aminoglycosides Decrease Glutathione Peroxidase-1 Activity by Interfering with Selenocysteine Incorporation

Handy, D. E., Hang, G., Scolaro, J. A., Metes, N., Razaq, N., Yang, Y. A., & Loscalzo, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m511295200 · Cited by 40

Cloning and characterization of the rat glutathione peroxidase gene

Ho, Y.-S., & Howard, A. J. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80198-p · Cited by 38

Unique features of selenocysteine incorporation function within the context of general eukaryotic translational processes

Berry, M. J., & Small-Howard, A. L. (2005) · Biochemical Society Transactions · doi:10.1042/bst20051493 · Cited by 37

Hydrogen peroxide restrains endothelium-derived nitric oxide bioactivity—Role for iron-dependent oxidative stress

Thomas, S. R., Schulz, E., & Keaney, J. F. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.05.012 · Cited by 37

cGMP increases antioxidant function and attenuates oxidant cell death in mouse lung microvascular endothelial cells by a protein kinase G-dependent mechanism

Stephens, R. S., Rentsendorj, O., Servinsky, L. E., Moldobaeva, A., Damico, R. L., & Pearse, D. B. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00442.2009 · Cited by 37

Targeted disruption of Bcl‐xL in mouse keratinocytes inhibits both UVB‐ and chemically induced skin carcinogenesis

Kim, D. J., Kataoka, K., Sano, S., Connolly, K. M., Kiguchi, K., & DiGiovanni, J. (2009) · Molecular Carcinogenesis · doi:10.1002/mc.20527 · Cited by 36

Assessment of Genetic Risk Factors for Thoracic Aortic Aneurysm in Hypertensive Patients

Kato, K., Oguri, M., Kato, N., Hibino, T., Yajima, K., Yoshida, T., Metoki, N., Yoshida, H., Satoh, K., Watanabe, S., et al. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.229 · Cited by 36

Phospholipid Hydroperoxide Glutathione Peroxidase Induces a Delay in G1of the Cell Cycle

Wang, H. P., Schafer, F. Q., Goswami, P. C., et al. (2003) · Free Radical Research · doi:10.1080/1071576031000088283 · Cited by 36

Catalase overexpression impairs TNF‐α induced NF‐κB activation and sensitizes MCF‐7 cells against TNF‐α

Lüpertz, R., Chovolou, Y., Kampkötter, A., et al. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21538 · Cited by 35

Plasma selenium content, platelet glutathione peroxidase and superoxide dismutase activity of residents in Kashin-Beck disease affected area in China.

Wu, J., & Xu, G.-L. (1987) · PubMed · Cited by 35

Role of Hydrogen Peroxide and the Impact of Glutathione Peroxidase-1 in Regulation of Cerebral Vascular Tone

Modrick, M. L., Didion, S. P., Lynch, C. M., et al. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.37 · Cited by 34

A human eDNA sequence for a novel glutathione peroxidase-related protein

Akasaka, M., Mizoguchi, J., & Takahashi, K. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.15.4619 · Cited by 33

Probing the presumed catalytic triad of a selenium-containing peroxidase by mutational analysis.

Maiorino, M., Aumann, K.-D., Brigelius‐Flohé, R., et al. (1998) · PubMed · Cited by 32

Readthrough of nonsense mutation W822X in the SCN5A gene can effectively restore expression of cardiac Na+ channels

Teng, S., Gao, L., Paajanen, V., Pu, J., & Fan, Z. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp116 · Cited by 30

No Association between GPX Pro198Leu and Risk of Basal Cell Carcinoma

Vogel, U. B., Olsen, A., Wallin, H., et al. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.1412.13.8 · Cited by 30

Genetic risk for restenosis after coronary stenting

Oguri, M., Kato, K., Hibino, T., et al. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.12.019 · Cited by 29

Mitochondrial GPx1 Decreases Induced but Not Basal Oxidative Damage to mtDNA in T47D Cells

Legault, J., Carrier, C., Petrov, P., Renard, P., Remacle, J., & Mirault, M.-É. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2800 · Cited by 29

The characterization and purification of a human transcription factor modulating the glutathione peroxidase gene in response to oxygen tension

Merante, F., Altamentova, S. M., Mickle, D. A. G., Weisel, R. D., Thatcher, B. J., Martin, B. M., Marshall, J. G., Tumiati, L. C., Cowan, D. B., & Li, R. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1017921110363 · Cited by 28

Unique features of selenocysteine incorporation function within the context of general eukaryotic translational processes

Small-Howard, A. L., & Berry, M. J. (2005) · Biochemical Society Transactions · doi:10.1042/bst0331493 · Cited by 28

Keshan disease and mitochondrial cardiomyopathy

Yang, F. (2006) · Science in China Series C Life Sciences · doi:10.1007/s11427-006-2041-y · Cited by 26

MAP kinase‐dependent, NF‐κB‐independent regulation of inhibitor of apoptosis protein genes by TNF‐α

Furusu, A., Nakayama, K., Xu, Q., Konta, T., & Kitamura, M. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20881 · Cited by 26

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638

Glutathione peroxidases

Brigelius-Flohé, R., & Maiorino, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.11.020 · Cited by 1,904

Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis

Förstermann, U., Xia, N., & Li, H. (2017) · Circulation Research · doi:10.1161/circresaha.116.309326 · Cited by 1,519

Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants

Jomova, K., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03696-4 · Cited by 1,445

Redox regulation of mitochondrial function

Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588

New fluorogenic substrates for horseradish peroxidase: Rapid and sensitive assays for hydrogen peroxide and the peroxidase

Zaitsu, K., & Ohkura, Y. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90017-2 · Cited by 196

Biological origin of free radicals, and mechanisms of antioxidant protection

Gutteridge, J. M. C. (1994) · Chemico-Biological Interactions · doi:10.1016/0009-2797(94)90033-7 · Cited by 317

A model of peroxidase activity with inhibition by hydrogen peroxide

Nicell, J. A., & Wright, H. (1997) · Enzyme and Microbial Technology · doi:10.1016/s0141-0229(97)00001-x · Cited by 264

Superoxide-independent hydrogen peroxide release by activated macrophages.

Russo, M., Teixeira, H. C., Marcondes, M., et al. (1989) · PubMed · Cited by 93

Effects of Peroxidase and Hydrogen Peroxide on the Dityrosine Formation and the Mixing Characteristics of Wheat-Flour Dough

TAKASAKI, S., Kato, Y., Murata, M., Homma, S., & Kawakishi, S. (2005) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.69.1686 · Cited by 59