The DOI matches its Crossref record; 420 of the 420 references it cites were found in a registry or an index.
Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities
Open accessAbstract
Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can cause oxidative damage to DNA, proteins, and membrane lipids. Glutathione peroxidase-1 (GPx-1) is an intracellular antioxidant enzyme that enzymatically reduces hydrogen peroxide to water to limit its harmful effects. Certain reactive oxygen species, such as hydrogen peroxide, are also essential for growth factor-mediated signal transduction, mitochondrial function, and maintenance of normal thiol redox-balance. Thus, by limiting hydrogen peroxide accumulation, GPx-1 also modulates these processes. This review explores the molecular mechanisms involved in regulating the expression and function of GPx-1, with an emphasis on the role of GPx-1 in modulating cellular oxidant stress and redox-mediated responses. As a selenocysteine-containing enzyme, GPx-1 expression is subject to unique forms of regulation involving the trace mineral selenium and selenocysteine incorporation during translation. In addition, GPx-1 has been implicated in the development and prevention of many common and complex diseases, including cancer and cardiovascular disease. This review discusses the role of GPx-1 in these diseases and speculates on potential future therapies to harness the beneficial effects of this ubiquitous antioxidant enzyme. Antioxid. Redox Signal. 15, 1957–1997.
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“GPx reduces lipid hydroperoxides to alcohols and hydrogen peroxide to water (Lubos et al. 2011).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Lubos et al. 2011
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Selenium: Biochemical Role as a Component of Glutathione Peroxidase
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
Brigelius-Flohé, R., & Maiorino, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.11.020 · Cited by 1,904
Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis
Förstermann, U., Xia, N., & Li, H. (2017) · Circulation Research · doi:10.1161/circresaha.116.309326 · Cited by 1,519
Jomova, K., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03696-4 · Cited by 1,445
Redox regulation of mitochondrial function
Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588
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Metadata
- Authors
- Lubos, E., Loscalzo, J., & Handy, D. E.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Brigham and Women's Hospital (US)
- Corresponding author
- Handy, Diane E.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2011-10
- Volume
- 15
- Issue
- 7
- Pages
- 1957-1997
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- PMC
- PMC3159114
- OpenAlex
- W1963668163
- Cited by
- 1,280
- References
- 420
- Citations by year
- 2026: 85 · 2025: 126 · 2024: 146 · 2023: 136 · 2022: 138 · 2021: 131 · 2020: 107 · 2019: 94 · 2018: 61 · 2017: 56 · 2016: 55 · 2015: 40 · 2014: 45 · 2013: 24 · 2012: 27
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- National Institutes of Health (HL 61795, HL081587)
- National Heart, Lung, and Blood Institute (HL61795, HL 089734, HL081587, P01HL081587, R21HL089734, R01HL061795)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Physical Sciences › Chemistry › Organic Chemistry › Organoselenium and organotellurium chemistry
- Keywords
- glutathione peroxidase 1, reactive oxygen species, hydrogen peroxide, oxidative stress, antioxidant enzymes, selenocysteine incorporation, selenium, mitochondrial function, cancer, cardiovascular disease
- MeSH terms
- Glutathione Peroxidase GPX1, Amino Acid Sequence, Animals, Cardiovascular Diseases, Diabetes Mellitus, Enzyme Inhibitors, Gene Expression Regulation, Glutathione Peroxidase, Humans, Molecular Sequence Data, Neoplasms, Oxidation-Reduction, Polymorphism, Genetic, Protein Conformation, Risk Factors, Gene Expression, Cell Death, Selenocysteine, Reactive Oxygen Species, Oxidative Stress, Genetic Predisposition to Disease
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