Cited by 285Schizophrenia research and treatmentAntioxidant Activity and Oxidative StressTryptophan and brain disorders

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Antioxidants, Redox Signaling, and Pathophysiology in Schizophrenia: An Integrative View

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Yao, Jeffrey K., Keshavan, Matcheri S.·2011·Antioxidants & Redox Signaling

DOI 10.1089/ars.2010.3603PMC PMC3159108

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Abstract

Schizophrenia (SZ) is a brain disorder that has been intensively studied for over a century; yet, its etiology and multifactorial pathophysiology remain a puzzle. However, significant advances have been made in identifying numerous abnormalities in key biochemical systems. One among these is the antioxidant defense system (AODS) and redox signaling. This review summarizes the findings to date in human studies. The evidence can be broadly clustered into three major themes: perturbations in AODS, relationships between AODS alterations and other systems ( i.e. , membrane structure, immune function, and neurotransmission), and clinical implications. These domains of AODS have been examined in samples from both the central nervous system and peripheral tissues. Findings in patients with SZ include decreased nonenzymatic antioxidants, increased lipid peroxides and nitric oxides, and homeostatic imbalance of purine catabolism. Reductions of plasma antioxidant capacity are seen in patients with chronic illness as well as early in the course of SZ. Notably, these data indicate that many AODS alterations are independent of treatment effects. Moreover, there is burgeoning evidence indicating a link among oxidative stress, membrane defects, immune dysfunction, and multineurotransmitter pathologies in SZ. Finally, the body of evidence reviewed herein provides a theoretical rationale for the development of novel treatment approaches. Antioxid. Redox Signal. 15, 2011–2035.

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Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Oxyl radicals, redox-sensitive signalling cascades and antioxidants
Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930
Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,786
Oxidative Stress, Glutamate, and Neurodegenerative Disorders
Coyle, J. T., & Puttfarcken, P. (1993) · Science · doi:10.1126/science.7901908 · Cited by 3,762
Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury
Janero, D. R. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90131-2 · Cited by 2,735
Psychiatric disorders in America: the epidemiologic catchment area study
(1991) · Choice Reviews Online · doi:10.5860/choice.28-5931 · Cited by 2,561
Oxidative damage and mitochondrial decay in aging.
Shigenaga, M. K., Hagen, T. M., & Ames, B. N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.10771 · Cited by 2,055
Schizophrenia
van Os, J., & Kapur, S. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60995-8 · Cited by 1,971

Flagged first, then by citations

Show all 296 references

Research works printed but not linked: 18

Bartosz G. Commentary on: free radicals and the developmental pathology of schizophrenic burnout. Integr Psychiatry, 5:43–44. 1987.
Cadet JL, , Lohr JB. Free radicals and the developmental pathology of schizophrenic burnout. Integr Psychiatry, 5:40–48. 1987.
Frankel EN. Lipid oxidation. Dundee, Scotland: The Oily Press Ltd., 1998.
10.1177/153537029922200312 · DOI
Halliwell B, , Gutteridge JMC. Oxygen radicals and the central nervous system. TINS, 8:22–26. 1984.
Horrobin DF. Niacin flushing, prostaglandin E and evening primrose oil: a possible objective test for monitoring therapy in schizophrenia. J Orthomo Psychiatr, 9:33–34. 1980.
Javitt DC, , Laruelle M. Neurochemical theories. Text Book of Schizophrenia. Lieberman JA, , Stroup TS, , Perkins DO. Washington, DC: The American Psychiatric Publishing, 2006; 85–116.
Keshaven MS, , Pettegrew JW, , Ward R. Are membrane phospholipid changes in schizophrenia familial? Biol Psychiatry, 33:45A. 1993.
Mahadik SP, , Yao JK. Phospholipids in schizophrenia. Textbook of Schizophrenia. Lieberman JA, , Stroup TS, , Perkins DO. Washington, DC: The American Psychiatric Publishing, Inc., 2006; 117–135.
Mahadik SP, , Parikh V, , Khan MM. The role of oxidative stress in modulating membrane and phospholipid function in schizophrenia. Phospholipid Spectrum Disorders in Psychiatry and Neurology. Peet M, , Glen I, , Horrobin D. Carnforth, UK: Marius Press, 2003; 277–288.
Pillai A, , Reddy R, , Yao JK. Oxidative stress in schizophrenia. Fatty Acids and Oxidative Stress in Neuropsychiatric Disorders. Reddy R, , Yao JK. New York: Nova Biochemical Books, 2007; 29–42.
Pryor WA, , Stone K. Oxidants in cigarette smoke. Ann N Y Acad Sci, 686:29. 1992.
Sinet PM, , Debray Q, , Carmagnol F, , Pelicier Y, , Nicole A, , Jerome H. Normal erythrocyte SOD values in two human diseases: schizophrenia and cystic fibrosis. Oxy Radicals and Their Scavenger Systems, Cellular and Medical Aspects, II Greenwald RA, , Cohen G. New York: Elsevier, 1983; 302–304.
Suzuki K. Chemistry and metabolism of brain lipids. Basic Neurochemistry, 3rd Siegel GJ, , Albers RW, , Agranoff BW, , Katzman R. Boston, MA: Little, Brown & Co., 1981; 355–370.
10.1016/S1570-0232(04)00595-1 · DOI
Yao JK, , van Kammen DP, , Reddy RD, , Kelley ME. Superoxide dismutase and negative symptoms in schizophrenia. Biol Psychiatry, 43:123S–124S. 1998. · DOI
Yao JK. Abnormalities of fatty acid metabolism in red cells, platelets and brain in schizophrenia. Phospholipid Spectrum Disorders in Psychiatry and Neurology, 2nd Peet M, , Glen I, , Horrobin DF. Lancashire, UK: Marius Press, 2003; 193–212.
Zhang ZJ, , Ramchand CN, , Ramchand R, , Milner E, , Telang SD, , Peet M. Glutathione peroxidase (GSHPx) activity in plasma and fibroblasts from schizophrenics and control. Biol Psychiatry, 29:103–104. 1998.

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Yap, M.-Y. A., Lo, Y., Talbot, K., & Ong, W. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.10.001 · Cited by 8
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Ismail, A. F. M., Eassawy, M. M. T., & Salem, A. A. M. (2014) · Journal of Agricultural Chemistry and Biotechnology · doi:10.21608/jacb.2014.50047 · Cited by 7
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Lorenc‐Koci, E. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0440-2_14 · Cited by 7
ADME analysis, metabolic prediction, and molecular docking of lipoic acid with SARS-CoV-2 Omicron spike protein
dos Santos, C. A. L., Monteiro, A. A. D. A., Costa, A. R., Barros, L. M., Aloufi, A. D., Almutairi, M. M., Hassan, W., Kamdem, J. P., Duarte, A. E., Ali, A., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-93121-2 · Cited by 6
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Lisi, A. D., Valle, A. D., Menchetti, M., Crisafulli, C., & Fabbri, C. (2025) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000002014 · Cited by 8
Potential involvement of oxidative stress in induction of neurodegenerative diseases: Actions, mechanisms and neurotherapeutic potential of natural antioxidants
Oliveira, G. L. D. S., de Oliveira, F. R. D. A. M., & de Freitas, R. M. (2014) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · doi:10.5897/ajpp2013.3963 · Cited by 6
Serum free thiols in recently diagnosed patients with schizophrenia spectrum disorder: A potentially useful biomarker of oxidative stress
Borkent, J., Ioannou, M., Folkertsma, T. S., Wardenaar, K. J., Haarman, B. C. M., van Goor, H., Sommer, I. E., & Bourgonje, A. R. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115075 · Cited by 6

Authors: Yao, J. K., & Keshavan, M. S.
Affiliations: University of Pittsburgh (US)
Beth Israel Deaconess Medical Center (US)
Corresponding author: Yao, Jeffrey K.
ORCID: Keshavan, Matcheri S.
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2011-10
Volume: 15
Issue: 7
Pages: 2011-2035
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/ars.2010.3603
PMC: PMC3159108
OpenAlex: W2063765492
Cited by: 285
References: 296
Citations by year: 2026: 14 · 2025: 13 · 2024: 8 · 2023: 10 · 2022: 13 · 2021: 20 · 2020: 17 · 2019: 25 · 2018: 16 · 2017: 27 · 2016: 26 · 2015: 23 · 2014: 25 · 2013: 26 · 2012: 13
FWCI: 2.15
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Antioxidants and Redox Signaling (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
Office of Research and Development (MH58141)
VA Pittsburgh Healthcare System
National Institute of Mental Health (MH-58141, R01MH045203, MH45203, R01MH058141)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: schizophrenia, antioxidant defense, redox signaling, oxidative stress, lipid peroxidation, nitric oxide, purine catabolism, plasma antioxidant capacity, membrane structure, immune dysfunction, neurotransmission, schizophrenia pathophysiology, novel treatment approaches
MeSH terms: Animals, Antioxidants, Blood Proteins, Cell Membrane, Glutathione, Humans, Inflammation, Synaptic Transmission, Nitric Oxide, Oxidation-Reduction, Schizophrenia, Signal Transduction, Reactive Oxygen Species, Neurotransmitter Agents, Oxidative Stress, Lipid Metabolism

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Antioxidants, Redox Signaling, and Pathophysiology in Schizophrenia: An Integrative View

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