Cited by 285Schizophrenia research and treatmentAntioxidant Activity and Oxidative StressTryptophan and brain disorders

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Antioxidants, Redox Signaling, and Pathophysiology in Schizophrenia: An Integrative View

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Yao, Jeffrey K., Keshavan, Matcheri S.·2011·Antioxidants & Redox Signaling

DOI 10.1089/ars.2010.3603PMC PMC3159108

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Abstract

Schizophrenia (SZ) is a brain disorder that has been intensively studied for over a century; yet, its etiology and multifactorial pathophysiology remain a puzzle. However, significant advances have been made in identifying numerous abnormalities in key biochemical systems. One among these is the antioxidant defense system (AODS) and redox signaling. This review summarizes the findings to date in human studies. The evidence can be broadly clustered into three major themes: perturbations in AODS, relationships between AODS alterations and other systems ( i.e. , membrane structure, immune function, and neurotransmission), and clinical implications. These domains of AODS have been examined in samples from both the central nervous system and peripheral tissues. Findings in patients with SZ include decreased nonenzymatic antioxidants, increased lipid peroxides and nitric oxides, and homeostatic imbalance of purine catabolism. Reductions of plasma antioxidant capacity are seen in patients with chronic illness as well as early in the course of SZ. Notably, these data indicate that many AODS alterations are independent of treatment effects. Moreover, there is burgeoning evidence indicating a link among oxidative stress, membrane defects, immune dysfunction, and multineurotransmitter pathologies in SZ. Finally, the body of evidence reviewed herein provides a theoretical rationale for the development of novel treatment approaches. Antioxid. Redox Signal. 15, 2011–2035.

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Authors: Yao, J. K., & Keshavan, M. S.
Affiliations: University of Pittsburgh (US)
Beth Israel Deaconess Medical Center (US)
Corresponding author: Yao, Jeffrey K.
ORCID: Keshavan, Matcheri S.
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2011-10
Volume: 15
Issue: 7
Pages: 2011-2035
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/ars.2010.3603
PMC: PMC3159108
OpenAlex: W2063765492
Cited by: 285
References: 296
Citations by year: 2026: 14 · 2025: 13 · 2024: 8 · 2023: 10 · 2022: 13 · 2021: 20 · 2020: 17 · 2019: 25 · 2018: 16 · 2017: 27 · 2016: 26 · 2015: 23 · 2014: 25 · 2013: 26 · 2012: 13
FWCI: 2.15
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Antioxidants and Redox Signaling (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
Office of Research and Development (MH58141)
VA Pittsburgh Healthcare System
National Institute of Mental Health (MH-58141, R01MH045203, MH45203, R01MH058141)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: schizophrenia, antioxidant defense, redox signaling, oxidative stress, lipid peroxidation, nitric oxide, purine catabolism, plasma antioxidant capacity, membrane structure, immune dysfunction, neurotransmission, schizophrenia pathophysiology, novel treatment approaches
MeSH terms: Animals, Antioxidants, Blood Proteins, Cell Membrane, Glutathione, Humans, Inflammation, Synaptic Transmission, Nitric Oxide, Oxidation-Reduction, Schizophrenia, Signal Transduction, Reactive Oxygen Species, Neurotransmitter Agents, Oxidative Stress, Lipid Metabolism

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Antioxidants, Redox Signaling, and Pathophysiology in Schizophrenia: An Integrative View

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