Effects of Hydrogen Sulfide on the Microbiome: From Toxicity to Therapy

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The Battle for Iron between Bacterial Pathogens and Their Vertebrate Hosts

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Hydrogen sulfide (H 2 S) metabolism in mitochondria and its regulatory role in energy production

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Escherichia coli Pathobionts Associated with Inflammatory Bowel Disease

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Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras

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Sulfide as a Mucus Barrier-Breaker in Inflammatory Bowel Disease?

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A Pathobiont of the Microbiota Balances Host Colonization and Intestinal Inflammation

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Gastrointestinal biofilms in health and disease

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Spatial variation of the colonic microbiota in patients with ulcerative colitis and control volunteers

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DNA damage and toxicogenomic analyses of hydrogen sulfide in human intestinal epithelial FHs 74 Int cells

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Mechanism of H 2 S-mediated protection against oxidative stress in Escherichia coli

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Recent Advances in Metabolic Pathways of Sulfate Reduction in Intestinal Bacteria

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Hydrogen Sulfide Signaling in the Gastrointestinal Tract

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H2S signaling in plants and applications in agriculture

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Pathobiont release from dysbiotic gut microbiota biofilms in intestinal inflammatory diseases: a role for iron?

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Hydrogen sulfide protects from colitis and restores intestinal microbiota biofilm and mucus production

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A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia

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Cysteine-derived hydrogen sulfide and gut health

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Giardia duodenalis induces pathogenic dysbiosis of human intestinal microbiota biofilms

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Microbial biofilms and the human intestinal microbiome

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Inflammation-associated Adherent-invasive Escherichia coli Are Enriched in Pathways for Use of Propanediol and Iron and M-cell Translocation

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Anti-Inflammatory and Cytoprotective Actions of Hydrogen Sulfide: Translation to Therapeutics

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Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis

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Label or Concept – What Is a Pathobiont?

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Metabolism of hydrogen gases and bile acids in the gut microbiome

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Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors

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Hydrogen sulfide in physiology and pathogenesis of bacteria and viruses

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Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface

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Antimicrobial properties of hydrophobic compounds in garlic: Allicin, vinyldithiin, ajoene and diallyl polysulfides (Review)

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“On demand” redox buffering by H 2 S contributes to antibiotic resistance revealed by a bacteria-specific H 2 S donor

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A proof‐of‐concept, Phase 2 clinical trial of the gastrointestinal safety of a hydrogen sulfide‐releasing anti‐inflammatory drug

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Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis

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Hydrogen sulfide donors in research and drug development

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Hydrogen Sulfide as a Toxic Product in the Small–Large Intestine Axis and its Role in IBD Development

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Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis

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Do nitric oxide, carbon monoxide and hydrogen sulfide really qualify as ‘gasotransmitters’ in bacteria?

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Active thrombin produced by the intestinal epithelium controls mucosal biofilms

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Therapeutic importance of hydrogen sulfide in age-associated neurodegenerative diseases

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Giardia duodenalis -induced alterations of commensal bacteria kill Caenorhabditis elegans : a new model to study microbial-microbial interactions in the gut

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Hydrogen Sulfide in Bone Tissue Regeneration and Repair: State of the Art and New Perspectives

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Modulation of colonic hydrogen sulfide production by diet and mesalazine utilizing a novel gas-profiling technology

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The Response of Acinetobacter baumannii to Hydrogen Sulfide Reveals Two Independent Persulfide-Sensing Systems and a Connection to Biofilm Regulation

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Hydrogen sulfide as a vasculoprotective factor

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Iron Sequestration in Microbiota Biofilms As A Novel Strategy for Treating Inflammatory Bowel Disease

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Adherent-Invasive Escherichia coli Production of Cellulose Influences Iron-Induced Bacterial Aggregation, Phagocytosis, and Induction of Colitis

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In Helicobacter pylori , LuxS Is a Key Enzyme in Cysteine Provision through a Reverse Transsulfuration Pathway

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Lifespan and healthspan benefits of exogenous H2S in C. elegans are independent from effects downstream of eat-2 mutation

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Campylobacter jejuni Increases Flagellar Expression and Adhesion of Noninvasive Escherichia coli: Effects on Enterocytic Toll-Like Receptor 4 and CXCL-8 Expression

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Enhanced Analgesic Effects and Gastrointestinal Safety of a Novel, Hydrogen Sulfide-Releasing Anti-Inflammatory Drug (ATB-352): A Role for Endogenous Cannabinoids

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Increased Mucosal Thrombin is Associated with Crohn’s Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation

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A new gateway into cells

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Advances in pathogenesis and therapeutic strategies for osteoporosis

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Desulfovibrio in the Gut: The Enemy within?

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Physical Exercise and the Gut Microbiome: A Bidirectional Relationship Influencing Health and Performance

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The oral-gut axis: Salivary and fecal microbiome dysbiosis in patients with inflammatory bowel disease

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Hydrogen Sulfide Produced by Gut Bacteria May Induce Parkinson’s Disease

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Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity <i>via</i> AMPK/SOD2 Pathway

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Signaling Paradigms of H2S-Induced Vasodilation: A Comprehensive Review

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Cu-doped SnO2/rGO nanocomposites for ultrasensitive H2S detection at low temperature

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Gut microbiota biofilms: From regulatory mechanisms to therapeutic targets

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Fluorescent small molecule donors

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Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

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Hydrogen Sulfide and Gut Microbiota: Their Synergistic Role in Modulating Sirtuin Activity and Potential Therapeutic Implications for Neurodegenerative Diseases

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Postbiotics as Antiinflammatory and Immune‐Modulating Bioactive Compounds in Metabolic Dysfunction‐Associated Steatotic Liver Disease

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Pathogenesis of COVID‐19 described through the lens of an undersulfated and degraded epithelial and endothelial glycocalyx

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Exploring the Relationship Between Diet, Lifestyle and Gut Microbiome in Colorectal Cancer Development: A Recent Update

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The role of colonic microbiota amino acid metabolism in gut health regulation

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Bacterial microcompartments and energy metabolism drive gut colonization by Bilophila wadsworthia

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Who is in the driver's seat? Parvimonas micra : An understudied pathobiont at the crossroads of dysbiotic disease and cancer

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Sulfur Metabolism of the Gut Microbiome and Colorectal Cancer: The Threat to the Younger Generation

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Engineered bacteria titrate hydrogen sulfide and induce concentration-dependent effects on the host in a gut microphysiological system

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Hydrogen Sulfide (H2S): As a Potent Modulator and Therapeutic Prodrug in Cancer

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Miniaturized Capsule System Toward Real‐Time Electrochemical Detection of H 2 S in the Gastrointestinal Tract

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Exploring gut microbial metabolites as key players in inhibition of cancer progression: Mechanisms and therapeutic implications

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Genetic predisposition of the gastrointestinal microbiome and primary biliary cholangitis: a bi-directional, two-sample Mendelian randomization analysis

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Effect of Probiotic Bacteria on the Gut Microbiome of Mice with Lipopolysaccharide-Induced Inflammation

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The Role of Bacteria-Derived Hydrogen Sulfide in Multiple Axes of Disease

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Gut microbiota-derived metabolites are novel targets for improving insulin resistance

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An exploratory study investigating the impact of the bladder tumor microbiome on Bacillus Calmette Guerin (BCG) response in non-muscle invasive bladder cancer

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Role of Gut Microbial Metabolites in Ischemic and Non-Ischemic Heart Failure

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Biofilms Exposed: Innovative Imaging and Therapeutic Platforms for Persistent Infections

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Dietary Fat Effect on the Gut Microbiome, and Its Role in the Modulation of Gastrointestinal Disorders in Children with Autism Spectrum Disorder

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NMR Metabolomics Reveal Urine Markers of Microbiome Diversity and Identify Benzoate Metabolism as a Mediator between High Microbial Alpha Diversity and Metabolic Health

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Hydrogen Sulfide in Diabetic Complications Revisited: The State of the Art, Challenges, and Future Directions

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Local delivery of gaseous signaling molecules for orthopedic disease therapy

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Solobacterium moorei promotes the progression of adenomatous polyps by causing inflammation and disrupting the intestinal barrier

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Microbiota metabolites affect sleep as drivers of brain‑gut communication (Review)

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Diallyl trisulfide inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung cancer via modulating gut microbiota and the PPARγ/NF-κB pathway

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Discovery of a Gut Bacterial Pathway for Ergothioneine Catabolism

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Association of human gut microbiota composition and metabolic functions with Ficus hirta Vahl dietary supplementation

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Coenzyme A metabolism: a key driver of gut microbiota dynamics and metabolic profiles

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H2S-activated fluorescent probe enables dual-channel fluorescence tracking of drug release in tumor cells

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The Alteration of the Gut Microbiome during Ramadan Offers a Novel Perspective on Ramadan Fasting: A Pilot Study

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The role of fiber in modulating plant protein-induced metabolic responses

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Impact of diet on hydrogen sulfide production: implications for gut health

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Effects of Exogenous Hydrogen Sulfide on Diabetic Metabolic Disorders in db/db Mice Are Associated With Gut Bacterial and Fungal Microbiota

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Association between diabetes and cancer. Current mechanistic insights into the association and future challenges

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A bibliometric review of triazine hybrids: synthesis, reactions, and applications spanning the last quarter-century (2000–2025)

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Evolution of E. coli in a mouse model of inflammatory bowel disease leads to a disease-specific bacterial genotype and trade-offs with clinical relevance

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Gut microbiota from patients with Parkinson’s disease causes motor deficits in honeybees

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Gut microbial metabolites: The bridge connecting diet and atherosclerosis, and next-generation targets for dietary interventions

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Perceived dietary intolerances, habitual intake and diet quality of patients with an ileoanal pouch: Associations with pouch phenotype (and behaviour)

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Benefits of crenotherapy in digestive tract pathology (Review)

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Targeted vaccine development against Bilophila wadsworthia to curb colon diseases: A multiepitope approach based on reverse vaccinology and computational analysis

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Microbial molecules, metabolites, and malignancy

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Rapid determination of hydrogen sulfide-related metabolites in human urine by UHPLC-ESI-MS/MS with fluorinated ion-pairing reagents

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Dietary Acid Load and Cancer Risk: A Review of the Uruguayan Experience

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The role of IL-10 in regulating inflammation and gut microbiome in mice consuming milk kefir and orally challenged with S . Typhimurium

Pereira, M. D. F. A., de Ávila, L. G. M., Cruz, B. C. D. S., Silva, B. C., de Oliveira, L. L., Gonçalves, R. V., Ribon, A. D. O. B., Mendes, T. A. D. O., & Pelúzio, M. D. C. G. (2023) · Food & Function · doi:10.1039/d2fo04063h · Cited by 9 · see citing works

Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria

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The Role of Microbiota in the Pathogenesis of Bullous Pemphigoid and Pemphigus Vulgaris: Evidence, Controversies, and Perspectives

Gorini, F., Coi, A., Santoro, M. C., Tonacci, A., Sansone, F., Mariotti, E. B., Donati, M., Verdelli, A., Nasca, M. R., Amerio, P., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136076 · Cited by 8 · see citing works

Microclimate Assessment in a 19th‐Century Heritage Building From Romania

Caciora, T. I., Ilieș, D. C., Costea, M., Blaga, L., BERDENOV, Z. G., Ilieș, A. B., Hassan, T. H., Pereș, A. C., Safarov, B., Josan, I., et al. (2024) · Indoor Air · doi:10.1155/2024/2989136 · Cited by 8 · see citing works

Adverse childhood trauma and reoccurrence of illness impact the gut microbiome, which affects suicidal behaviors and the phenome of major depression: towards enterotypic-phenotypesPreprint

Maes, M., Vasupanrajit, A., Jirakran, K., Klomkliew, P., Chanchaem, P., Tunvirachaisakul, C., Plaimas, K., Suratanee, A., & Payungporn, S. (2023) · medRxiv · doi:10.1101/2023.01.14.23284564 · Cited by 8 · see citing works

pH-responsive Oral liposomal delivery of hydrogen sulfide donor GYY4137 enables colon-targeted therapy for inflammatory bowel disease

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Gut-Microbiome Interactions: Characterization, Therapeutic Implications and Machine Learning

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Unveiling Hydrogen Sulfide: A New Frontier in Neuroprotection and Neuromodulation

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Dietary Manipulation on Gut Microbiome in Patients with Diabetes and Colorectal cancer

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Interactive Effects of Sulfide Addition and Heat Pretreatment on Hydrogen Production via Dark Fermentation

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The Dose-Dependent Influence of Type 2 Resistant Starch on Gut Microbial Communities and Metabolic Outputs: An In Vitro Simulation

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The response rule of wetland microorganisms by coupling of partial nitrification process and constructed wetland

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Hydrogen therapy after resuscitation improves myocardial injury involving inhibition of autophagy in an asphyxial rat model of cardiac arrest

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EGCG inhibits cystathionine gamma-lyase MccB from Staphylococcus aureus by making a hemiacetal compound with pyridoxal phosphate

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The prebiotic landscape: history, health and physiological benefits, and regulatory challenges – an IPA perspective part 1

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Power and poison: The intersections of H2S and O2 metabolism

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The fate of dietary protein in the gastrointestinal tract and implications for colonic disease

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Metal–Organic Frameworks for H 2 S Removal: Identification of Optimal Adsorbents and Influence of H 2 S Molecular Models

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Development of a Transcriptional Biosensor for Hydrogen Sulfide That Functions under Aerobic and Anaerobic Conditions

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Impact of Reactive Sulfur Species on Entamoeba histolytica: Modulating Viability, Motility, and Biofilm Degradation Capacity

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Prostate Cancer at the Microbial Crossroads: Illuminating a New Frontier in Precision Medicine

Kwon, W., Kim, H., & Song, Y. S. (2025) · The World Journal of Men s Health · doi:10.5534/wjmh.250045 · Cited by 4 · see citing works

Lonicerae flos and turmeric extracts alleviate necrotic enteritis in broilers by modulating gut-liver health and microbiota

Liu, X., Ji, Y., Lv, H., Wang, Z., Lv, Z., Guo, Y., & Nie, W. (2025) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-025-01246-1 · Cited by 4 · see citing works

Beyond Random Fecal Microbial Transplants

Sartor, R. B. (2024) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2024.11.002 · Cited by 4 · see citing works

A sensitive and ratiometric fluorescent probe for imaging cytosolic H 2 S generation

Zhang, Y., Chen, Y., Shi, X., Bai, Y., He, W., & Guo, Z. (2022) · New Journal of Chemistry · doi:10.1039/d2nj04533h · Cited by 4 · see citing works

Deciphering Microbial Carbohydrate Metabolism: Unveiling Mechanistic Insights Into Type 2 Diabetes

Kumar, N., Sain, S., & Solanki, B. (2025) · Advanced Gut & Microbiome Research · doi:10.1155/agm3/4395850 · Cited by 4 · see citing works

Hydrochemical and Microbiological Investigations and the Therapeutic Potential of Some Mineral Waters from Bihor County, Romania

Linc, R., Pantea, E., Șerban, E., Ciurba, A.-P., & Serban, G. (2023) · Sustainability · doi:10.3390/su152115640 · Cited by 4 · see citing works

Polysaccharide‐based H2S donors: Thiol‐ene functionalization of amylopectin with H2S ‐releasing N ‐thiocarboxyanhydrides

Chinn, A. F., Williams, N. R., Miller, K. M., & Matson, J. B. (2024) · Journal of Polymer Science · doi:10.1002/pol.20240262 · Cited by 4 · see citing works

Medical Gases as Emerging Regulators of Paediatric Endocrine and Neurodevelopmental Pathways: A Mini‐Review

Paparella, R., Panvino, F., Pucarelli, I., & Tarani, L. (2026) · Acta Paediatrica · doi:10.1111/apa.70429 · Cited by 3 · see citing works

From dysbiosis to dysfunction: specific gut microbes and metabolites in the pathogenesis of Parkinson’s disease

Chi, F., Chen, K., Yin, Y., Hakovirta, J. R., & Saris, P. E. J. (2026) · Sustainable Microbiology · doi:10.1093/sumbio/qvag002 · Cited by 5 · see citing works

The roles of hydrogen sulfide and reactive sulfur species in bacterial life within the human body

Nonoyama, S., Shimizu, T., & Masuda, S. (2026) · Nitric Oxide · doi:10.1016/j.niox.2026.02.002 · Cited by 3 · see citing works

Gulf War Illness Is Associated with Host Gut Microbiome Dysbiosis and Is Linked to Altered Species Abundance in Veterans from the BBRAIN Cohort

Trivedi, A., Bose, D., Moffat, K. S., Pearson, E., Walsh, D. M., Cohen, D. E., Skupsky, J., Chao, L. L., Golier, J. A., Janulewicz, P. A., et al. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21081102 · Cited by 3 · see citing works

Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface

Wallace, J. L., Motta, J., & Buret, A. G. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00249.2017 · Cited by 120 · see citing works

Hydrogen sulfide in physiology and diseases of the digestive tract

Singh, S., & Lin, H. (2015) · Microorganisms · doi:10.3390/microorganisms3040866 · Cited by 260 · see citing works

Cysteine-derived hydrogen sulfide and gut health

Blachier, F., Beaumont, M., & Kim, E. (2018) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000526 · Cited by 182 · see citing works

Hydrogen sulfide protects from colitis and restores intestinal microbiota biofilm and mucus production

Motta, J.-P., Flannigan, K. L., Agbor, T. A., Beatty, J. K., Blackler, R. W., Workentine, M. L., Da Silva, G. J., Wang, R., Buret, A. G., & Wallace, J. L. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000345 · Cited by 200 · see citing works

OP04 Microbiota regulation of host hydrogen sulfide bioavailability and metabolism

Shen, X., Carlström, M., Borniquel, S., Jädert, C., Kevil, C. G., & Lundberg, J. O. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.06.034