c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont
Open accessPublished version of a preprint
Abstract
Both microbial and host genetic factors contribute to the pathogenesis of autoimmune diseases. There is accumulating evidence that microbial species that potentiate chronic inflammation, as in inflammatory bowel disease, often also colonize healthy individuals. These microorganisms, including the Helicobacter species, can induce pathogenic T cells and are collectively referred to as pathobionts. However, how such T cells are constrained in healthy individuals is not yet understood. Here we report that host tolerance to a potentially pathogenic bacterium, Helicobacter hepaticus, is mediated by the induction of RORγt+FOXP3+ regulatory T (iT reg) cells that selectively restrain pro-inflammatory T helper 17 (T H 17) cells and whose function is dependent on the transcription factor c-MAF. Whereas colonization of wild-type mice by H. hepaticus promoted differentiation of RORγt-expressing microorganism-specific iT reg cells in the large intestine, in disease-susceptible IL-10-deficient mice, there was instead expansion of colitogenic T H 17 cells. Inactivation of c-MAF in the T reg cell compartment impaired differentiation and function, including IL-10 production, of bacteria-specific iT reg cells, and resulted in the accumulation of H. hepaticus-specific inflammatory T H 17 cells and spontaneous colitis. By contrast, RORγt inactivation in T reg cells had only a minor effect on the bacteria-specific T reg and T H 17 cell balance, and did not result in inflammation. Our results suggest that pathobiont-dependent inflammatory bowel disease is driven by microbiota-reactive T cells that have escaped this c-MAF-dependent mechanism of iT reg-T H 17 homeostasis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
GM-CSF+ T cells co-express a great variety of other cytokines including IL-2, IL-3, IL-4, IL-6, IL-13, IL-17A, IL-22, IFNγ, and TNF.
“This conclusion is further supported by the findings that GM-CSF+ T cells co-express a great variety of other cytokines including IL-2, IL-3, IL-4, IL-6, IL-13, IL-17A, IL-22, IFNγ, and TNF [33, 36, 76, 175].”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [33]
GM-CSF expression is part of a general pathogenic program together with other pro-inflammatory molecules such as BHLHE40, IFNγ, and CXCR6 that can be induced across multiple T helper cell subsets.
“Hence, we propose GM-CSF expression as part of a general pathogenic program together with other pro-inflammatory molecules such as BHLHE40, IFNγ, and CXCR6 that can be induced across multiple T helper cell subsets [33, 38, 177].”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219 · see citing works
Adjusting batch effects in microarray expression data using empirical Bayes methods
Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658 · see citing works
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · see citing works
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173 · see citing works
Self-citationPhenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544 · cited 1× · see citing works
“HH-E2 tetramer was kindly produced by the NIH Tetramer Core Facility 37 .”
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872 · see citing works
Role of the gut microbiota in immunity and inflammatory disease
Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3430 · Cited by 2,256 · see citing works
Read, S., Malmström, V., & Powrie, F. M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.295 · Cited by 2,206 · see citing works
TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
Zhou, L., Lopes, J. E., Chong, M. M. W., Ivanov, I. I., Min, R., Victora, G. D., Shen, Y., Du, J., Rubtsov, Y. P., Rudensky, A. Y., et al. (2008) · Nature · doi:10.1038/nature06878 · Cited by 1,866 · see citing works
Self-citationIvanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770 · see citing works
Self-citationThe Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
Round, J. L., Lee, S. M., Li, J., Tran, G., Jabri, B., Chatila, T. A., & Mazmanian, S. K. (2011) · Science · doi:10.1126/science.1206095 · Cited by 1,604 · see citing works
Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces
Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.017 · Cited by 1,586 · see citing works
Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells
Wu, H.-J., Ivanov, I. I., Darce, J., Hattori, K., Shima, T., Umesaki, Y., Littman, D. R., Benoist, C., & Mathis, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.06.001 · Cited by 1,577 · see citing works
Self-citationProinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
Lee, Y. K., Menezes, J. S., Umesaki, Y., & Mazmanian, S. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000082107 · Cited by 1,323 · see citing works
Fate mapping of IL-17-producing T cells in inflammatory responses
Hirota, K., Duarte, J. H., Veldhoen, M., Hornsby, E., Li, Y., Cua, D. J., Ahlfors, H., Wilhelm, C., Tolaini, M., Menzel, U., et al. (2011) · Nature Immunology · doi:10.1038/ni.1993 · Cited by 1,176 · see citing works
A Validated Regulatory Network for Th17 Cell Specification
Ciofani, M., Madar, A., Galan, C., Sellars, M., Mace, K., Pauli, F., Agarwal, A., Huang, W., Parkurst, C. N., Muratet, M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.016 · Cited by 1,160 · see citing works
Self-citationVisualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.
Kearney, E. R., Pape, K., Loh, D., & Jenkins, M. (1994) · Immunity · doi:10.1016/1074-7613(94)90084-1 · Cited by 1,126 · see citing works
The alarmin IL-33 promotes regulatory T-cell function in the intestine
Schiering, C., Krausgruber, T., Chomka, A., Fröhlich, A., Adelmann, K., Wohlfert, E. A., Pott, J., Griseri, T., Bollrath, J., Hegazy, A. N., et al. (2014) · Nature · doi:10.1038/nature13577 · Cited by 1,007 · see citing works
Self-citationCD4 <sup>+</sup> Regulatory T Cells Control T <sub>H</sub> 17 Responses in a Stat3-Dependent Manner
Chaudhry, A., Rudra, D., Treuting, P., Samstein, R. M., Liang, Y., Kas, A., & Rudensky, A. Y. (2009) · Science · doi:10.1126/science.1172702 · Cited by 1,000 · see citing works
Moon, J. J., Chu, H., Pepper, M., McSorley, S. J., Jameson, S. C., Kedl, R. M., & Jenkins, M. K. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.007 · Cited by 977 · see citing works
Gorelik, L., & Flavell, R. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80170-3 · Cited by 959 · see citing works
Individual intestinal symbionts induce a distinct population of RORγ <sup>+</sup> regulatory T cells
Sefik, E., Geva-Zatorsky, N., Oh, S., Konnikova, L., Zemmour, D., McGuire, A. M., Burzyn, D., Ortiz-Lopez, A., Lobera, M., Yang, J., et al. (2015) · Science · doi:10.1126/science.aaa9420 · Cited by 879 · see citing works
The microbiota regulates type 2 immunity through RORγt <sup>+</sup> T cells
Ohnmacht, C., Park, J.-H., Cording, S., Wing, J. B., Atarashi, K., Obata, Y., Gaboriau-Routhiau, V., Marques, R., Dulauroy, S., Fedoseeva, M., et al. (2015) · Science · doi:10.1126/science.aac4263 · Cited by 863 · see citing works
Interleukin-23 drives innate and T cell–mediated intestinal inflammation
Hue, S., Ahern, P., Buonocore, S., Kullberg, M. C., Cua, D. J., McKenzie, B. S., Powrie, F., & Maloy, K. J. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061099 · Cited by 823 · see citing works
Apetoh, L., Quintana, F. J., Pot, C., Joller, N., Xiao, S., Kumar, D., Burns, E. J., Sherr, D. H., Weiner, H. L., & Kuchroo, V. K. (2010) · Nature Immunology · doi:10.1038/ni.1912 · Cited by 725 · see citing works
Yadav, M., Louvet, C., Davini, D., Gardner, J. M., Martinez-Llordella, M., Bailey-Bucktrout, S., Anthony, B. A., Sverdrup, F. M., Head, R., Kuster, D. J., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120822 · Cited by 649 · see citing works
Weiss, J. M., Bilate, A. M., Gobert, M., Ding, Y., Curotto de Lafaille, M. A., Parkhurst, C. N., Xiong, H., Dolpady, J., Frey, A. B., Ruocco, M. G., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120914 · Cited by 621 · see citing works
Self-citationIL-23 plays a key role in Helicobacter hepaticus –induced T cell–dependent colitis
Kullberg, M. C., Jankovic, D. L., Feng, C. G., Hüe, S., Gorelick, P. L., McKenzie, B. S., Cua, D. J., Powrie, F. M., Cheever, A. W., Maloy, K. J., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061082 · Cited by 584 · see citing works
Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996. 274: 94-96.
Altman, J. D., Moss, P. A. H., Goulder, P., Barouch, D. H., McHeyzer‐Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (2011) · PubMed · Cited by 572 · see citing works
Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine
Kim, K. S., Hong, S., Han, D., Yi, J., Jung, J., Yang, B., Lee, J. Y., Lee, M., & Surh, C. D. (2016) · Science · doi:10.1126/science.aac5560 · Cited by 541 · see citing works
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORγt+ T cells
Lochner, M., Peduto, L., Cherrier, M., Sawa, S., Vives, F. L., Varona, R., Riethmacher, D., Si‐Tahar, M., Santo, J. P. D., & Eberl, G. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080034 · Cited by 533 · see citing works
IMGT®, the international ImMunoGeneTics information system®
Lefranc, M., Giudicelli, V., Ginestoux, C., Jabado-Michaloud, J., Folch, G., Bellahcene, F., Wu, Y., Gemrot, E., Brochet, X., Lane, J., et al. (2004) · Nucleic Acids Res. · doi:10.1093/nar/gkn838 · Cited by 521 · see citing works
Focused specificity of intestinal TH17 cells towards commensal bacterial antigens
Yang, Y., Torchinsky, M. B., Gobert, M., Xiong, H., Xu, M., Linehan, J. L., Alonzo, F., Ng, C., Chen, A., Lin, X., et al. (2014) · Nature · doi:10.1038/nature13279 · Cited by 520 · see citing works
Self-citationPathobionts of the gastrointestinal microbiota and inflammatory disease
Chow, J., Tang, H., & Mazmanian, S. K. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.07.010 · Cited by 445 · see citing works
T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade
Ostanin, D. V., Bao, J. R., Koboziev, I., Gray, L. T., Robinson-Jackson, S. A., Kosloski-Davidson, M., Price, V. H., & Grisham, M. B. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90462.2008 · Cited by 444 · see citing works
Yang, B.-H., Hagemann, S., Mamareli, P., Lauer, U., Hoffmann, U., Beckstette, M., Föhse, L., Prinz, I., Pezoldt, J., Suerbaum, S., et al. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.74 · Cited by 435 · see citing works
Haribhai, D., Williams, J. B., Jia, S., Nickerson, D. W., Schmitt, E. G., Edwards, B., Ziegelbauer, J., Yassai, M. B., Li, S.-H., Relland, L. M., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.029 · Cited by 430 · see citing works
Mach, N., Gillessen, S., Wilson, S. B., Sheehan, C., Mihm, M. C., & Dranoff, G. (2000) · PubMed · Cited by 409 · see citing works
Acute Gastrointestinal Infection Induces Long-Lived Microbiota-Specific T Cell Responses
Hand, T. W., dos Santos, L. M., Bouladoux, N. J., Molloy, M. J., Pagán, A. J., Pepper, M., Maynard, C. L., Elson, C. O., & Belkaid, Y. (2012) · Science · doi:10.1126/science.1220961 · Cited by 393 · see citing works
Self-citationCutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells
Awasthi, A., Riol‐Blanco, L., Jäger, A., Korn, T., Pot, C., Galileos, G., Bettelli, E., Kuchroo, V. K., & Oukka, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900732 · Cited by 365 · see citing works
Paired analysis of TCRα and TCRβ chains at the single-cell level in mice
Dash, P., McClaren, J. L., Oguin, T. H., Rothwell, W. T., Todd, B., Morris, M. Y., Becksfort, J. B., Reynolds, C., Brown, S. A., Doherty, P. C., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44752 · Cited by 199 · see citing works
The Transcription Factor c-Maf Controls Touch Receptor Development and Function
Wende, H., Lechner, S. G., Chéret, C., Bourane, S., Sheean, M. E., Pattyn, A., Reuter, K., Munier, F. L., Carroll, P., Lewin, G. R., et al. (2012) · Science · doi:10.1126/science.1214314 · Cited by 176 · see citing works
Ise, W., Kohyama, M., Nutsch, K., Lee, H. M., Suri, A., Unanue, E. R., Murphy, T. L., & MURPHY, K. M. M. (2009) · Nature Immunology · doi:10.1038/ni.1835 · Cited by 171 · see citing works
Cassette vectors directing expression of T cell receptor genes in transgenic mice
Kouskoff, V., Signorelli, K. L., Benoist, C. O., & Mathis, D. J. (1995) · Journal of Immunological Methods · doi:10.1016/0022-1759(95)00002-r · Cited by 162 · see citing works
Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation
Chai, J. N., Peng, Y., Rengarajan, S., Solomon, B. D., Ai, T. L., Shen, Z., Perry, J. S. A., Knoop, K. A., Tanoue, T., Narushima, S., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aal5068 · Cited by 150 · see citing works
MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice
Hoshi, N., Schenten, D., Nish, S. A., Walther, Z., Gagliani, N., Flavell, R. A., Reizis, B., Shen, Z., Fox, J. G., Iwasaki, A., et al. (2012) · Nature Communications · doi:10.1038/ncomms2113 · Cited by 129 · see citing works
Prediction of Peptide-MHC Binding Using Profiles
Reche, P. A., & Reinherz, E. L. (2007) · Methods in molecular biology · doi:10.1007/978-1-60327-118-9_13 · Cited by 108 · see citing works
Identification of a CD4+ T cell-stimulating antigen of pathogenic bacteria by expression cloning.
Sanderson, S., Campbell, D., & Shastri, N. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.6.1751 · Cited by 62 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation
Ouyang, W., & O’Garra, A. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.020 · Cited by 1,084 · see citing works
Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis
Song, X., Sun, X., Oh, S. F., Wu, M., Zhang, Y., Zheng, W., Geva-Zatorsky, N., Jupp, R., Mathis, D., Benoist, C., et al. (2020) · Nature · doi:10.1038/s41586-019-1865-0 · Cited by 1,024 · see citing works
Host–microbiota interactions in inflammatory bowel disease
Caruso, R., Lo, B. C., & Núñez, G. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-019-0268-7 · Cited by 776 · see citing works
Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease
Friedrich, M., Pohin, M., & Powrie, F. M. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.017 · Cited by 750 · see citing works
The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis
Kitamoto, S., Nagao‐Kitamoto, H., Jiao, Y., Gillilland, M. G., Hayashi, A., Imai, J., Sugihara, K., Miyoshi, M., Brazil, J. C., Kuffa, P., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.048 · Cited by 685 · see citing works
<i>Akkermansia muciniphila</i> induces intestinal adaptive immune responses during homeostasis
Ansaldo, E., Slayden, L. C., Ching, K. L., Koch, M. A., Wolf, N. K., Plichta, D. R., Brown, E. M., Graham, D. B., Xavier, R. J., Moon, J. J., et al. (2019) · Science · doi:10.1126/science.aaw7479 · Cited by 566 · see citing works
Britton, G. J., Contijoch, E. J., Mogno, I., Vennaro, O. H., Llewellyn, S. R., Ng, R., Li, Z., Mortha, A., Merad, M., Das, A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.015 · Cited by 549 · see citing works
Immunomodulatory potential of gut microbiome-derived short-chain fatty acids (SCFAs)
Ratajczak, W., Rył, A., Mizerski, A., Walczakiewicz, K., Sipak‐Szmigiel, O., & Laszczyńska, M. (2019) · Acta Biochimica Polonica · doi:10.18388/abp.2018_2648 · Cited by 520 · see citing works
MAFG-driven astrocytes promote CNS inflammation
Wheeler, M. A., Clark, I. C., Tjon, E. C., Li, Z., Zandee, S. E. J., Couturier, C. P., Watson, B. R., Scalisi, G., Alkwai, S., Rothhammer, V., et al. (2020) · Nature · doi:10.1038/s41586-020-1999-0 · Cited by 501 · see citing works
IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting
Moschen, A. R., Tilg, H., & Raine, T. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0084-8 · Cited by 477 · see citing works
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease
Lee, J., Hall, J. A., Kroehling, L., Wu, L., Najar, T. A., Nguyen, H. H., Lin, W.-Y., Yeung, S. T., Silva, H. M., Li, D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.11.026 · Cited by 472 · see citing works
Self-citationMicrobiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy
Abdel-Gadir, A., Victor, E. S., Gerber, G. K., Rivas, M. N., Wang, S., Harb, H., Wang, L., Li, N., Crestani, E., Spielman, S. C., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0461-z · Cited by 392 · see citing works
Intricacies of TGF-β signaling in Treg and Th17 cell biology
Wang, J., Zhao, X., & Wan, Y. Y. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01036-7 · Cited by 377 · see citing works
Compartmentalized gut lymph node drainage dictates adaptive immune responses
Esterházy, D., Canesso, M. C. C., Mesin, L., Muller, P. A., Castro, T. B. R., Lockhart, A. A. K., Eljalby, M., Faria, A. M. C., & Mucida, D. (2019) · Nature · doi:10.1038/s41586-019-1125-3 · Cited by 330 · see citing works
Savage, P. A., Klawon, D. E. J., & Miller, C. H. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-100219-020937 · Cited by 321 · see citing works
Overacre-Delgoffe, A. E., Bumgarner, H. J., Cillo, A. R., Burr, A. H. P., Tometich, J. T., Bhattacharjee, A., Bruno, T. C., Vignali, D. A. A., & Hand, T. W. (2021) · Immunity · doi:10.1016/j.immuni.2021.11.003 · Cited by 318 · see citing works
Plichta, D. R., Graham, D. B., Subramanian, S., & Xavier, R. J. (2019) · Cell · doi:10.1016/j.cell.2019.07.045 · Cited by 314 · see citing works
The microbiome in threatened species conservation
West, A. G., Waite, D. W., Deines, P., Bourne, D. G., Digby, A., McKenzie, V. J., & Taylor, M. W. (2018) · Biological Conservation · doi:10.1016/j.biocon.2018.11.016 · Cited by 305 · see citing works
Mining the microbiota for microbial and metabolite-based immunotherapies
Skelly, A. N., Sato, Y., Kearney, S., & Honda, K. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0144-5 · Cited by 306 · see citing works
Control of Immunity by the Microbiota
Ansaldo, E., Farley, T. K., & Belkaid, Y. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-112348 · Cited by 299 · see citing works
Self-citationILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut
Lyu, M., Suzuki, H., Kang, L., Gaspal, F., Zhou, W., Goc, J., Zhou, L., Zhou, J., Zhang, W., Bank, J. L. C., et al. (2022) · Nature · doi:10.1038/s41586-022-05141-x · Cited by 295 · see citing works
TH17 cell heterogeneity and its role in tissue inflammation
Schnell, A., Littman, D. R., & Kuchroo, V. K. (2023) · Nature Immunology · doi:10.1038/s41590-022-01387-9 · Cited by 286 · see citing works
Self-citationIntestinal epithelial cells: At the interface of the microbiota and mucosal immunity
Soderholm, A. T., & Pedicord, V. A. (2019) · Immunology · doi:10.1111/imm.13117 · Cited by 281 · see citing works
Chen, Y., Cui, W., Xiao, L., & Yang, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.761981 · Cited by 286 · see citing works
Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota
Akagbosu, B., Tayyebi, Z., Shibu, G., Paucar Iza, Y. A., Deep, D., Parisotto, Y. F., Fisher, L., Pasolli, H. A., Thevin, V., Elmentaite, R., et al. (2022) · Nature · doi:10.1038/s41586-022-05309-5 · Cited by 273 · see citing works
Effector T Helper Cell Subsets in Inflammatory Bowel Diseases
Imam, T., Park, S., Kaplan, M. H., & Olson, M. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01212 · Cited by 269 · see citing works
The microbiome in inflammatory bowel diseases: from pathogenesis to therapy
Liu, S., Zhao, W., Lan, P., & Mou, X. (2020) · Protein & Cell · doi:10.1007/s13238-020-00745-3 · Cited by 266 · see citing works
A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation
Kedmi, R., Najar, T. A., Mesa, K. R., Grayson, A., Kroehling, L., Hao, Y., Hao, S., Pokrovskii, M. V., Xu, M., Talbot, J., et al. (2022) · Nature · doi:10.1038/s41586-022-05089-y · Cited by 261 · see citing works
Self-citationEmerging Functions of Regulatory T Cells in Tissue Homeostasis
Sharma, A., & Rudra, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00883 · Cited by 263 · see citing works
Microbiome: Focus on Causation and Mechanism
Fischbach, M. A. (2018) · Cell · doi:10.1016/j.cell.2018.07.038 · Cited by 248 · see citing works
Zhang, Z., Tang, H., Chen, P., Xie, H., & Tao, Y. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0074-5 · Cited by 251 · see citing works
Transforming growth factor–β1 in regulatory T cell biology
Moreau, J. M., Velegraki, M., Bolyard, C. M., Rosenblum, M. D., & Li, Z. (2022) · Science Immunology · doi:10.1126/sciimmunol.abi4613 · Cited by 247 · see citing works
The microbiota-immune axis as a central mediator of gut-brain communication
Fung, T. C. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104714 · Cited by 228 · see citing works
IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology
Wei, H.-X., Wang, B., & Li, B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01315 · Cited by 210 · see citing works
Thymic development of gut-microbiota-specific T cells
Zegarra-Ruiz, D. F., Kim, D. V., Norwood, K., Kim, M., Wu, W.-J. H., Saldana-Morales, F. B., Hill, A. A., Majumdar, S., Orozco, S., Bell, R. S., et al. (2021) · Nature · doi:10.1038/s41586-021-03531-1 · Cited by 208 · see citing works
Metabolic Control of Treg Cell Stability, Plasticity, and Tissue-Specific Heterogeneity
Shi, H., & Chi, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02716 · Cited by 204 · see citing works
Buret, A. G., Motta, J., Allain, T., Ferraz, J. G., & Wallace, J. L. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-018-0495-4 · Cited by 205 · see citing works
Immunology of Inflammatory Bowel Disease: Molecular Mechanisms and Therapeutics
Lu, Q., Yang, M.-F., Liang, Y.-J., Xu, J., Xu, H.-M., Nie, Y.-Q., Wang, L.-S., Yao, J., & Li, D.-F. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s353038 · Cited by 211 · see citing works
Functions and regulation of T cell-derived interleukin-10
Neumann, C., Scheffold, A., & Rutz, S. (2019) · Seminars in Immunology · doi:10.1016/j.smim.2019.101344 · Cited by 198 · see citing works
Engineered skin bacteria induce antitumor T cell responses against melanoma
Chen, Y. E., Bousbaine, D., Veinbachs, A., Atabakhsh, K., Dimas, A., Yu, V. K., Zhao, A., Enright, N. J., Nagashima, K., Belkaid, Y., et al. (2023) · Science · doi:10.1126/science.abp9563 · Cited by 191 · see citing works
Self-citationProfound Treg perturbations correlate with COVID-19 severity
Galván-Peña, S., Léon, J., Chowdhary, K., Michelson, D. A., Vijaykumar, B., Yang, L., Magnuson, A. M., Chen, F., Manickas-Hill, Z., Trocha, A. K., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2111315118 · Cited by 185 · see citing works
Wang, B., Zhang, L., Wang, Y., Dai, T., Qin, Z., Zhou, F., & Zhang, L. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00986-0 · Cited by 185 · see citing works
Neumann, C., Blume, J., Roy, U., Teh, P. P., Vasanthakumar, A., Beller, A. V., Liao, Y., Heinrich, F., Arenzana, T. L., Hackney, J. A., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0316-2 · Cited by 179 · see citing works
An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint
Ramanan, D., Sefik, E., Galván-Peña, S., Wu, M., Yang, L., Yang, Z., Kostic, A. D., Golovkina, T. V., Kasper, D. L., Mathis, D. J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.030 · Cited by 173 · see citing works
Ladinsky, M. S., Araújo, L. P., Zhang, X., Veltri, J., Galán-Díez, M., Soualhi, S., Lee, C., Irie, K., Pinker, E. Y., Narushima, S., et al. (2019) · Science · doi:10.1126/science.aat4042 · Cited by 170 · see citing works
Natural polysaccharides exhibit anti-tumor activity by targeting gut microbiota
Liu, L., Li, M., Yu, M., Shen, M., Wang, Q., Yu, Y., & Xie, J. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.10.083 · Cited by 169 · see citing works
Yan, Y., Ramanan, D., Rozenberg, M., McGovern, K., Rastelli, D., Vijaykumar, B., Yaghi, O., Voisin, T., Mosaheb, M., Chiu, I., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.02.002 · Cited by 165 · see citing works
Molecular diversification of regulatory T cells in nonlymphoid tissues
DiSpirito, J. R., Zemmour, D., Ramanan, D., Cho, J., Žilionis, R., Klein, A. M., Benoist, C. O., & Mathis, D. J. (2018) · Science Immunology · doi:10.1126/sciimmunol.aat5861 · Cited by 163 · see citing works
Pursuing Human-Relevant Gut Microbiota-Immune Interactions
Spencer, S. P., Fragiadakis, G. K., & Sonnenburg, J. L. (2019) · Immunity · doi:10.1016/j.immuni.2019.08.002 · Cited by 160 · see citing works
Goblet cell associated antigen passages support the induction and maintenance of oral tolerance
Kulkarni, D. H., Gustafsson, J. K., Knoop, K. A., McDonald, K. G., Bidani, S. S., Davis, J. E., Floyd, A. N., Hogan, S. P., Hsieh, C., & Newberry, R. D. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0240-7 · Cited by 162 · see citing works
Regulatory T cell adaptation in the intestine and skin
Whibley, N., Tucci, A., & Powrie, F. M. (2019) · Nature Immunology · doi:10.1038/s41590-019-0351-z · Cited by 160 · see citing works
Disease Tolerance as an Inherent Component of Immunity
Martins, R., Carlos, A. R., Braza, F., Thompson, J. A., Bastos-Amador, P., Ramos, S., & Soares, M. P. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041739 · Cited by 149 · see citing works
Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism
Campbell, C., & Rudensky, A. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.010 · Cited by 154 · see citing works
Gabryšová, L., Alvarez-Martinez, M., Luisier, R., Cox, L. S., Sodenkamp, J., Hosking, C., Pérez‐Mazliah, D., Whicher, C., Kannan, Y., Potempa, K., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0083-5 · Cited by 152 · see citing works
Antigen-presenting ILC3 regulate T cell–dependent IgA responses to colonic mucosal bacteria
Melo-González, F., Kammoun, H., Evren, E., Dutton, E. E., Papadopoulou, M., Bradford, B. M., Tanes, C., Fardus‐Reid, F., Swann, J. R., Bittinger, K. L., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20180871 · Cited by 152 · see citing works
Effects of Hydrogen Sulfide on the Microbiome: From Toxicity to Therapy
Buret, A. G., Allain, T., Motta, J.-P., & Wallace, J. L. (2022) · Antioxidants & Redox Signaling · doi:10.1089/ars.2021.0004 · Cited by 151 · see citing works
Emerging concepts in intestinal immune control of obesity-related metabolic disease
Khan, S. M., Luck, H., Winer, S., & Winer, D. A. (2021) · Nature Communications · doi:10.1038/s41467-021-22727-7 · Cited by 150 · see citing works
The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells
Zuberbuehler, M. K., Parker, M. E., Wheaton, J. D., Espinosa, J. R., Salzler, H. R., Park, E., & Ciofani, M. (2018) · Nature Immunology · doi:10.1038/s41590-018-0274-0 · Cited by 138 · see citing works
The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells
Perucha, E., Melchiotti, R., Bibby, J. A., Wu, W. H., Frederiksen, K. S., Roberts, C. A., Hall, Z., Friec, G. L., Robertson, K. A., Lavender, P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08332-9 · Cited by 132 · see citing works
Periportal macrophages protect against commensal-driven liver inflammation
Miyamoto, Y., Kikuta, J., Matsui, T., Hasegawa, T., Fujii, K., Okuzaki, D., Liu, Y.-C., Yoshioka, T., Seno, S., Motooka, D., et al. (2024) · Nature · doi:10.1038/s41586-024-07372-6 · Cited by 135 · see citing works
Gut Microbiome and Osteoporosis
Ding, K., Hua, F., & Ding, W. (2020) · Aging and disease · doi:10.14336/ad.2019.0523 · Cited by 134 · see citing works
The role of transcription factors in shaping regulatory T cell identity
Trujillo-Ochoa, J. L., Kazemian, M., & Afzali, B. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00893-7 · Cited by 136 · see citing works
Ames, S. R., Lotoski, L. C., & Azad, M. B. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2190305 · Cited by 140 · see citing works
Advances and novel developments in mechanisms of allergic inflammation
Han, X., Krempski, J. W., & Nadeau, K. (2020) · Allergy · doi:10.1111/all.14632 · Cited by 129 · see citing works
Regulatory T cells in the face of the intestinal microbiota
Ramanan, D., Pratama, A., Zhu, Y., Venezia, O., Sassone-Corsi, M., Chowdhary, K., Galván-Peña, S., Sefik, E., Brown, C., Gélineau, A., et al. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00890-w · Cited by 126 · see citing works
The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries
Hanna, B. S., Wang, G., Galván-Peña, S., Mann, A. O., Ramirez, R. N., Muñoz-Rojas, A. R., Smith, K., Wan, M., Benoist, C., & Mathis, D. (2023) · Immunity · doi:10.1016/j.immuni.2023.01.033 · Cited by 126 · see citing works
Transcriptional and posttranslational regulation of Th17/Treg balance in health and disease
Zhang, W., Liu, X., Zhu, Y., Liu, X., Gu, Y., Dai, X., & Li, B. (2021) · European Journal of Immunology · doi:10.1002/eji.202048794 · Cited by 126 · see citing works
T Cell Responses to the Microbiota
Ivanov, I. I., Tuganbaev, T., Skelly, A. N., & Honda, K. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101320-011829 · Cited by 128 · see citing works
Gut Microbiota-Kidney Cross-Talk in Acute Kidney Injury
Gong, J., Noel, S., Pluznick, J. L., Hamad, A. R. A., & Rabb, H. (2018) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2018.10.009 · Cited by 118 · see citing works
Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy
Wu, L., Hollinshead, K. E. R., Hao, Y., Au, C., Kroehling, L., Ng, C., Lin, W.-Y., Li, D., Silva, H. M., Shin, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.014 · Cited by 117 · see citing works
Self-citationCampbell, C., Dikiy, S., Bhattarai, S. K., Chinen, T., Matheis, F., Calafiore, M., Hoyos, B. E., Hanash, A. M., Mucida, D., Bucci, V., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.013 · Cited by 118 · see citing works
Gut microbiota and bone metabolism
Lu, L., Chen, X., Liu, Y., & Yu, X. (2021) · The FASEB Journal · doi:10.1096/fj.202100451r · Cited by 120 · see citing works
Sivasami, P., Elkins, C. M., Diaz-Saldana, P. P., Goss, K. L., Peng, A. C.-Y., Hamersky, M., Bae, J., Xu, M., Pollack, B. P., Horwitz, E. M., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.06.021 · Cited by 116 · see citing works
Self-citationInterleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung
Faustino, L., Griffith, J. W., Rahimi, R. A., Nepal, K., Hamilos, D. L., Cho, J. L., Medoff, B. D., Moon, J. J., Vignali, D. A. A., & Luster, A. D. (2020) · Nature Immunology · doi:10.1038/s41590-020-0785-3 · Cited by 113 · see citing works
Bernshtein, B., Curato, C., Ιωάννου, Μ., Thaiss, C. A., Gross-Vered, M., Kolesnikov, M., Wang, Q., David, E., Chappell‐Maor, L., Harmelin, A., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aau6571 · Cited by 112 · see citing works
Brockmann, L., Tran, A., Huang, Y., Edwards, M., Ronda, C., Wang, H. H., & Ivanov, I. I. (2023) · Immunity · doi:10.1016/j.immuni.2023.11.003 · Cited by 112 · see citing works
Wegorzewska, M. M., Glowacki, R. W. P., Hsieh, S. A., Donermeyer, D. L., Hickey, C. A., Horvath, S. C., Martens, E. C., Stappenbeck, T. S., & Allen, P. M. (2019) · Science Immunology · doi:10.1126/sciimmunol.aau9079 · Cited by 109 · see citing works
Liu, Q., Zhu, F., Liu, X., Lu, Y., Yao, K., Tian, N., Tong, L., Figge, D. A., Wang, X., Han, Y., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00575-z · Cited by 113 · see citing works
Much More Than IL-17A: Cytokines of the IL-17 Family Between Microbiota and Cancer
Brevi, A., Cogrossi, L. L., Grazia, G., Masciovecchio, D., Impellizzieri, D., Lacanfora, L., Grioni, M., & Bellone, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.565470 · Cited by 113 · see citing works
Britton, G. J., Contijoch, E. J., Spindler, M. P., Aggarwala, V., Dogan, B., Bongers, G., Mateo, L. S., Baltus, A. E., Das, A., Gevers, D., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922189117 · Cited by 104 · see citing works
Lo, B. C., Kryczek, I., Yu, J., Vatan, L., Caruso, R., Matsumoto, M., Sato, Y., Shaw, M. H., Inohara, N., Xie, Y., et al. (2024) · Science · doi:10.1126/science.adh8342 · Cited by 108 · see citing works
Unexpected Help: Follicular Regulatory T Cells in the Germinal Center
Xie, M. M., & Dent, A. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01536 · Cited by 104 · see citing works
The Many Functions of Foxp3+ Regulatory T Cells in the Intestine
Cosovanu, C., & Neumann, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.600973 · Cited by 104 · see citing works
The metabolic, protective, and immune functions of Akkermansia muciniphila
Ghotaslou, R., Nabizadeh, E., Memar, M. Y., Law, W. M. H., Ozma, M. A., Abdi, M., Yekani, M., Kadkhoda, H., Hosseinpour, R., Bafadam, S., et al. (2022) · Microbiological Research · doi:10.1016/j.micres.2022.127245 · Cited by 104 · see citing works
Traxinger, B. R., Richert-Spuhler, L. E., & Lund, J. M. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00471-x · Cited by 101 · see citing works
A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes
Bousbaine, D., Fisch, L., London, M., Bhagchandani, P., Castro, T. B. R., Mimee, M., Olesen, S. W., Reis, B. S., VanInsberghe, D., Bortolatto, J., et al. (2022) · Science · doi:10.1126/science.abg5645 · Cited by 103 · see citing works
Crittenden, S., Goepp, M., Pollock, J., Robb, C. T., Smyth, D. J., Zhou, Y., Andrews, R., Tyrrell, V. J., Gkikas, K., Adima, A., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd7954 · Cited by 100 · see citing works
Understanding immune–microbiota interactions in the intestine
Ahern, P. P., & Maloy, K. J. (2019) · Immunology · doi:10.1111/imm.13150 · Cited by 99 · see citing works
Conditioning of the immune system by the microbiome
Graham, D. B., & Xavier, R. J. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.05.002 · Cited by 99 · see citing works
Dietary and Microbial Determinants in Food Allergy
Victor, E. S., Crestani, E., & Chatila, T. A. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.025 · Cited by 98 · see citing works
An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells
Aschenbrenner, D., Foglierini, M., Jarrossay, D., Hu, D., Weiner, H. L., Kuchroo, V. K., Lanzavecchia, A., Notarbartolo, S., & Sallusto, F. (2018) · Nature Immunology · doi:10.1038/s41590-018-0200-5 · Cited by 96 · see citing works
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease
Lee, J., Hall, J. A., Kroehling, L., Wu, L., Najar, T. A., Nguyen, H. H., Lin, W.-Y., Yeung, S. T., Silva, H. M., Li, D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.12.008 · Cited by 97 · see citing works
Self-citationRegulatory T cells function in established systemic inflammation and reverse fatal autoimmunity
Hu, W., Wang, Z.-M., Feng, Y., Schizas, M., Hoyos, B. E., van der Veeken, J., Verter, J. G., Bou-Puerto, R., & Rudensky, A. Y. (2021) · Nature Immunology · doi:10.1038/s41590-021-01001-4 · Cited by 92 · see citing works
van der Veeken, J., Campbell, C., Pritykin, Y., Schizas, M., Verter, J. G., Hu, W., Wang, Z.-M., Matheis, F., Mucida, D., Charbonnier, L., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.05.010 · Cited by 92 · see citing works
Pokrovskii, M. V., Hall, J. A., Ochayon, D. E., Yi, R., Chaimowitz, N. S., Seelamneni, H., Carriero, N. J., Watters, A., Waggoner, S. N., Littman, D. R., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.001 · Cited by 93 · see citing works
Self-citationThe Gut–CNS Axis in Multiple Sclerosis
Kadowaki, A., & Quintana, F. J. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.06.002 · Cited by 92 · see citing works
Zhang, H., Madi, A., Yosef, N., Chihara, N., Awasthi, A., Pot, C., Lambden, C., Srivastava, A., Burkett, P. R., Nyman, J., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108433 · Cited by 91 · see citing works
Distribution and storage of inflammatory memory in barrier tissues
Ordovas-Montañes, J., Beyaz, S., Rakoff-Nahoum, S., & Shalek, A. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-019-0263-z · Cited by 85 · see citing works
Role of orally induced regulatory T cells in immunotherapy and tolerance
Bertolini, T. B., Biswas, M., Terhorst, C., Daniell, H., Herzog, R. W., & Piñeros, A. R. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104251 · Cited by 89 · see citing works
Pawlak, M., Ho, A. W., & Kuchroo, V. K. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.09.001 · Cited by 89 · see citing works
- Authors
- Xu, M., Pokrovskii, M., Ding, Y., Yi, R., Au, C., Harrison, O. J., Galan, C., Belkaid, Y., Bonneau, R., & Littman, D. R.
- Affiliations
- New York University (US)
- University of Rochester Medicine (US)
- Courant Institute of Mathematical Sciences (US)
- Howard Hughes Medical Institute (US)
- National Institutes of Health (US)
- Corresponding author
- Littman, Dan R.
- ORCID
- Venue
- Nature
- Published
- 2018-02
- Volume
- 554
- Issue
- 7692
- Pages
- 373-377
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5814346
- OpenAlex
- W2786985471
- Cited by
- 498
- References
- 50
- Citations by year
- 2026: 33 · 2025: 63 · 2024: 45 · 2023: 66 · 2022: 64 · 2021: 64 · 2020: 65 · 2019: 66 · 2018: 32
- FWCI
- 24.38
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-02-05)
- Open access
- green
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Cancer Research Institute
- National Institutes of Health (1s10od018338-01, 1s10od010584-01a1)
- School of Medicine, New York University (P30CA016087)
- National Cancer Institute (P30CA016087)
- National Institute of Allergy and Infectious Diseases (T32AI100853)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK103358)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- c-Maf, regulatory T cells, Helicobacter hepaticus, pathobionts, inflammatory bowel disease, Th17 cells, IL-10, RORγt, Foxp3, gut microbiota, immune tolerance, commensal bacteria, spontaneous colitis, IL-10-deficient mice, microbiota-targeted therapy
- MeSH terms
- Animals, Colitis, Female, Homeostasis, Immune Tolerance, Intestines, Male, Interleukin-10, Helicobacter hepaticus, T-Lymphocytes, Regulatory, Proto-Oncogene Proteins c-maf, Mice, Forkhead Transcription Factors, Host-Pathogen Interactions, Bioengineering, Nuclear Receptor Subfamily 1, Group F, Member 3, Th17 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
