Cited by 67Fatty Acid Research and HealthAttention Deficit Hyperactivity DisorderDevelopmental and Educational Neuropsychology

The Influence of Short-Chain Essential Fatty Acids on Children with Attention-Deficit/Hyperactivity Disorder: A Double-Blind Placebo-Controlled Study

Raz, Raanan, Carasso, Rafael L., Yehuda, Shlomo·2009·Journal of Child and Adolescent Psychopharmacology

Abstract

Essential fatty acids (EFA) are needed for normal sensory, cognitive, and motor function. The EFA blood profile seems to be different in children with attention-deficit/hyperactivity disorder (ADHD) as compared to matched controls. Previous open EFA supplementation trials were successful in demonstrating significant therapeutic effects in this population, whereas most of the randomized controlled trials failed to show any benefit over placebo. The current randomized, double-blind, placebo-controlled trial tested the influence of short-chain EFA supplementation on ADHD children, using parent and teacher questionnaires and a computerized continuous performance test. A total of 73 unmedicated children aged 7-13 years with a diagnosis of ADHD participated in the study; 63 children completed the study. The EFA supplement contained 480 mg of linoleic acid and 120 mg of alpha-linolenic acid, and the placebo contained 1000 mg of vitamin C (daily amounts); both were given for a 7-week supplementation period. Analysis of variance for repeated measures revealed that both treatments ameliorated some of the symptoms, but no significant differences were found between the groups in any of the treatment effects.

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Registry

Crossref · 10.1089/cap.2008.070

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27 of 27 references verified0 citation errors · 0 not checkable

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  • Short-chain fatty acids and omega-3/omega-6 fatty acids have not been found to be efficacious in treating ADHD.

    “Short-chain fatty acids [108] and omega-3/omega-6 fatty acids [109] have not been found to be efficacious.”

    From Advances in understanding and treating ADHD (2011) · cites this paper as [108]

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Authors
Raz, R., Carasso, R. L., & Yehuda, S.
Affiliations
  • Bar-Ilan University (IL)
  • Hillel Yaffe Medical Center (IL)
Corresponding author
Raz, Raanan
Venue
Journal of Child and Adolescent Psychopharmacology
Published
2009-04
Volume
19
Issue
2
Pages
167-177
ISSN
  • 1044-5463 (ISSN-L)
  • 1557-8992
OpenAlex
W1966648066
Cited by
67
References
27
Citations by year
2026: 1 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 2 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 13 · 2013: 5 · 2012: 6
FWCI
6.44
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Child and Adolescent Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
Keywords
attention deficit hyperactivity disorder, essential fatty acids, short-chain fatty acids, linoleic acid, alpha-linolenic acid, dietary supplementation, children, ADHD symptoms, continuous performance test
MeSH terms
Adolescent, Attention Deficit Disorder with Hyperactivity, Child, Dose-Response Relationship, Drug, Double-Blind Method, Drug Combinations, Fatty Acids, Essential, Female, Humans, Male, Psychological Tests, Psychomotor Performance, Surveys and Questionnaires, alpha-Linolenic Acid, Linoleic Acid

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